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Q9XYL0

- CTDS_DICDI

UniProt

Q9XYL0 - CTDS_DICDI

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Protein

Probable C-terminal domain small phosphatase

Gene

fcpA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

May function as a phosphatase involved in the regulation of cell growth and differentiation.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 1 magnesium ion per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei142 – 14214-aspartylphosphate intermediateBy similarity
Metal bindingi142 – 1421MagnesiumBy similarity
Active sitei144 – 1441Proton donorBy similarity
Metal bindingi144 – 1441Magnesium; via carbonyl oxygenBy similarity
Sitei198 – 1981Transition state stabilizerBy similarity
Sitei236 – 2361Transition state stabilizerBy similarity
Metal bindingi253 – 2531MagnesiumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. hyperosmotic response Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_218739. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-terminal domain small phosphatase (EC:3.1.3.16)
Alternative name(s):
Developmental gene 1148 protein
Gene namesi
Name:fcpA
Synonyms:ctdsp, DG1148
ORF Names:DDB_G0294376
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0294376. fcpA.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Probable C-terminal domain small phosphatasePRO_0000328057Add
BLAST

Proteomic databases

PRIDEiQ9XYL0.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9XYL0.
SMRiQ9XYL0. Positions 139-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini132 – 290159FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi89 – 946Poly-Gln
Compositional biasi97 – 11014Poly-GlnAdd
BLAST

Sequence similaritiesi

Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ9XYL0.
KOiK15731.
OMAiCCHIDNG.
PhylomeDBiQ9XYL0.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XYL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSSPITQVS NPNDSLNHSS TNLIPSSHNS LNNYPQKSVK GNRKKKGSII
60 70 80 90 100
NKLFCCFVPS NDQNNGNNIN TDNGASNNDK LQQQKQYNQQ QQQQYNQHQQ
110 120 130 140 150
QQQQQQQQQQ YINKDSSQQN GEIPLMVPMI PRHVGLKTLV LDLDETLVHS
160 170 180 190 200
SFKPVHNPDF IVPVEIEGTI HQVYVVKRPF VDDFLRAIAE KFEIVVFTAS
210 220 230 240 250
LAKYADPVLD FLDTGRVIHY RLFRESCHNH KGNYVKDLSR LGRDLKSTII
260 270 280 290 300
VDNSPSSYLF HPENAIPIDS WFDDKDDREL LDLLPLLDDL IKVEDVRLVL

DESRNN
Length:306
Mass (Da):35,116
Last modified:November 1, 1999 - v1
Checksum:i9D9A7C7BD2844099
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF111941 Genomic DNA. Translation: AAD28548.1.
AAFI02000259 Genomic DNA. Translation: EAL60295.1.
RefSeqiXP_628708.1. XM_628706.1.

Genome annotation databases

EnsemblProtistsiDDB0229894; DDB0229894; DDB_G0294376.
GeneIDi3385372.
KEGGiddi:DDB_G0294376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF111941 Genomic DNA. Translation: AAD28548.1 .
AAFI02000259 Genomic DNA. Translation: EAL60295.1 .
RefSeqi XP_628708.1. XM_628706.1.

3D structure databases

ProteinModelPortali Q9XYL0.
SMRi Q9XYL0. Positions 139-304.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9XYL0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0229894 ; DDB0229894 ; DDB_G0294376 .
GeneIDi 3385372.
KEGGi ddi:DDB_G0294376.

Organism-specific databases

dictyBasei DDB_G0294376. fcpA.

Phylogenomic databases

InParanoidi Q9XYL0.
KOi K15731.
OMAi CCHIDNG.
PhylomeDBi Q9XYL0.

Enzyme and pathway databases

Reactomei REACT_218739. XBP1(S) activates chaperone genes.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view ]
Pfami PF03031. NIF. 1 hit.
[Graphical view ]
SMARTi SM00577. CPDc. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
PROSITEi PS50969. FCP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dictyostelium discoideum Developmental gene DG1148. Disruption of this gene results in morphological defect."
    Iranfar N., Loomis W.F.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiCTDS_DICDI
AccessioniPrimary (citable) accession number: Q9XYL0
Secondary accession number(s): Q54AK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3