Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9XYL0

- CTDS_DICDI

UniProt

Q9XYL0 - CTDS_DICDI

Protein

Probable C-terminal domain small phosphatase

Gene

fcpA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May function as a phosphatase involved in the regulation of cell growth and differentiation.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 1 magnesium ion per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei142 – 14214-aspartylphosphate intermediateBy similarity
    Metal bindingi142 – 1421MagnesiumBy similarity
    Active sitei144 – 1441Proton donorBy similarity
    Metal bindingi144 – 1441Magnesium; via carbonyl oxygenBy similarity
    Sitei198 – 1981Transition state stabilizerBy similarity
    Sitei236 – 2361Transition state stabilizerBy similarity
    Metal bindingi253 – 2531MagnesiumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. hyperosmotic response Source: dictyBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_218739. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable C-terminal domain small phosphatase (EC:3.1.3.16)
    Alternative name(s):
    Developmental gene 1148 protein
    Gene namesi
    Name:fcpA
    Synonyms:ctdsp, DG1148
    ORF Names:DDB_G0294376
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0294376. fcpA.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306Probable C-terminal domain small phosphatasePRO_0000328057Add
    BLAST

    Proteomic databases

    PRIDEiQ9XYL0.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XYL0.
    SMRiQ9XYL0. Positions 139-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini132 – 290159FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi89 – 946Poly-Gln
    Compositional biasi97 – 11014Poly-GlnAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

    Phylogenomic databases

    KOiK15731.
    OMAiCCHIDNG.
    PhylomeDBiQ9XYL0.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR011948. Dullard_phosphatase.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view]
    PfamiPF03031. NIF. 1 hit.
    [Graphical view]
    SMARTiSM00577. CPDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
    PROSITEiPS50969. FCP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9XYL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSSPITQVS NPNDSLNHSS TNLIPSSHNS LNNYPQKSVK GNRKKKGSII    50
    NKLFCCFVPS NDQNNGNNIN TDNGASNNDK LQQQKQYNQQ QQQQYNQHQQ 100
    QQQQQQQQQQ YINKDSSQQN GEIPLMVPMI PRHVGLKTLV LDLDETLVHS 150
    SFKPVHNPDF IVPVEIEGTI HQVYVVKRPF VDDFLRAIAE KFEIVVFTAS 200
    LAKYADPVLD FLDTGRVIHY RLFRESCHNH KGNYVKDLSR LGRDLKSTII 250
    VDNSPSSYLF HPENAIPIDS WFDDKDDREL LDLLPLLDDL IKVEDVRLVL 300
    DESRNN 306
    Length:306
    Mass (Da):35,116
    Last modified:November 1, 1999 - v1
    Checksum:i9D9A7C7BD2844099
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF111941 Genomic DNA. Translation: AAD28548.1.
    AAFI02000259 Genomic DNA. Translation: EAL60295.1.
    RefSeqiXP_628708.1. XM_628706.1.

    Genome annotation databases

    EnsemblProtistsiDDB0229894; DDB0229894; DDB_G0294376.
    GeneIDi3385372.
    KEGGiddi:DDB_G0294376.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF111941 Genomic DNA. Translation: AAD28548.1 .
    AAFI02000259 Genomic DNA. Translation: EAL60295.1 .
    RefSeqi XP_628708.1. XM_628706.1.

    3D structure databases

    ProteinModelPortali Q9XYL0.
    SMRi Q9XYL0. Positions 139-304.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9XYL0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0229894 ; DDB0229894 ; DDB_G0294376 .
    GeneIDi 3385372.
    KEGGi ddi:DDB_G0294376.

    Organism-specific databases

    dictyBasei DDB_G0294376. fcpA.

    Phylogenomic databases

    KOi K15731.
    OMAi CCHIDNG.
    PhylomeDBi Q9XYL0.

    Enzyme and pathway databases

    Reactomei REACT_218739. XBP1(S) activates chaperone genes.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR011948. Dullard_phosphatase.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view ]
    Pfami PF03031. NIF. 1 hit.
    [Graphical view ]
    SMARTi SM00577. CPDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
    PROSITEi PS50969. FCP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dictyostelium discoideum Developmental gene DG1148. Disruption of this gene results in morphological defect."
      Iranfar N., Loomis W.F.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiCTDS_DICDI
    AccessioniPrimary (citable) accession number: Q9XYL0
    Secondary accession number(s): Q54AK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3