Reviewed, UniProtKB/Swiss-Prot Q9XYL0 (CTDS_DICDI)

Names and origin

Protein names

Recommended name:
    Probable C-terminal domain small phosphatase
    EC=3.1.3.16
Alternative name(s):
    Developmental gene 1148 protein

Gene names

Name:	fcpA
Synonyms:	ctdsp, DG1148
ORF Names:	DDB_G0294376

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May function as a phosphatase involved in the regulation of cell growth and differentiation By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 1 magnesium ion per monomer By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 FCP1 homology domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hyperosmotic response Inferred from expression pattern. Source: dictyBase
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Probable C-terminal domain small phosphatase		PRO_0000328057
Regions
	Domain	132 – 290	159	FCP1 homology
	Compositional bias	89 – 94	6	Poly-Gln
	Compositional bias	97 – 110	14	Poly-Gln
Sites
	Active site	142	1	4-aspartylphosphate intermediate By similarity
	Active site	144	1	Proton donor By similarity
	Metal binding	142	1	Magnesium By similarity
	Metal binding	144	1	Magnesium; via carbonyl oxygen By similarity
	Metal binding	253	1	Magnesium By similarity
	Site	198	1	Transition state stabilizer By similarity
	Site	236	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9XYL0-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 9D9A7C7BD2844099	FASTA	306	35,116
	10 20 30 40 50 60 MNSSPITQVS NPNDSLNHSS TNLIPSSHNS LNNYPQKSVK GNRKKKGSII NKLFCCFVPS 70 80 90 100 110 120 NDQNNGNNIN TDNGASNNDK LQQQKQYNQQ QQQQYNQHQQ QQQQQQQQQQ YINKDSSQQN 130 140 150 160 170 180 GEIPLMVPMI PRHVGLKTLV LDLDETLVHS SFKPVHNPDF IVPVEIEGTI HQVYVVKRPF 190 200 210 220 230 240 VDDFLRAIAE KFEIVVFTAS LAKYADPVLD FLDTGRVIHY RLFRESCHNH KGNYVKDLSR 250 260 270 280 290 300 LGRDLKSTII VDNSPSSYLF HPENAIPIDS WFDDKDDREL LDLLPLLDDL IKVEDVRLVL DESRNN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Dictyostelium discoideum Developmental gene DG1148. Disruption of this gene results in morphological defect." Iranfar N., Loomis W.F. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF111941 Genomic DNA. Translation: AAD28548.1. AAFI02000259 Genomic DNA. Translation: EAL60295.1.
RefSeq	XP_628708.1.
3D structure databases
HSSP	HSSP built from PDB template 1T9Z based on UniProtKB Q9GZU7.
SMR	Q9XYL0. Positions 139-304.
ModBase	Search...
Genome annotation databases
GeneID	3385372.
KEGG	ddi:DDB_0229894.
Organism-specific databases
dictyBase	DDB_G0294376. fcpA.
Phylogenomic databases
eggNOG	KOG1605.
OMA	MANSSAN.
Enzyme and pathway databases
BRENDA	3.1.3.16. 424.
Family and domain databases
InterPro	IPR011948. Dullard. IPR004274. NIF. [Graphical view]
Pfam	PF03031. NIF. 1 hit. [Graphical view]
SMART	SM00577. CPDc. 1 hit. [Graphical view]
TIGRFAMs	TIGR02251. HIF-SF_euk. 1 hit.
PROSITE	PS50969. FCP1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CTDS_DICDI

Accession

Primary (citable) accession number: Q9XYL0
Secondary accession number(s): Q54AK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	November 1, 1999
Last modified:	February 9, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)