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Q9XYL0

- CTDS_DICDI

UniProt

Q9XYL0 - CTDS_DICDI

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Protein
Probable C-terminal domain small phosphatase
Gene
fcpA, ctdsp, DG1148, DDB_G0294376
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

May function as a phosphatase involved in the regulation of cell growth and differentiation By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 1 magnesium ion per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei142 – 14214-aspartylphosphate intermediate By similarity
Metal bindingi142 – 1421Magnesium By similarity
Active sitei144 – 1441Proton donor By similarity
Metal bindingi144 – 1441Magnesium; via carbonyl oxygen By similarity
Sitei198 – 1981Transition state stabilizer By similarity
Sitei236 – 2361Transition state stabilizer By similarity
Metal bindingi253 – 2531Magnesium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. hyperosmotic response Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_218739. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-terminal domain small phosphatase (EC:3.1.3.16)
Alternative name(s):
Developmental gene 1148 protein
Gene namesi
Name:fcpA
Synonyms:ctdsp, DG1148
ORF Names:DDB_G0294376
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0294376. fcpA.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Probable C-terminal domain small phosphatase
PRO_0000328057Add
BLAST

Proteomic databases

PRIDEiQ9XYL0.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9XYL0.
SMRiQ9XYL0. Positions 139-304.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini132 – 290159FCP1 homology
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi89 – 946Poly-Gln
Compositional biasi97 – 11014Poly-Gln
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

KOiK15731.
OMAiCCHIDNG.
PhylomeDBiQ9XYL0.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XYL0-1 [UniParc]FASTAAdd to Basket

« Hide

MNSSPITQVS NPNDSLNHSS TNLIPSSHNS LNNYPQKSVK GNRKKKGSII    50
NKLFCCFVPS NDQNNGNNIN TDNGASNNDK LQQQKQYNQQ QQQQYNQHQQ 100
QQQQQQQQQQ YINKDSSQQN GEIPLMVPMI PRHVGLKTLV LDLDETLVHS 150
SFKPVHNPDF IVPVEIEGTI HQVYVVKRPF VDDFLRAIAE KFEIVVFTAS 200
LAKYADPVLD FLDTGRVIHY RLFRESCHNH KGNYVKDLSR LGRDLKSTII 250
VDNSPSSYLF HPENAIPIDS WFDDKDDREL LDLLPLLDDL IKVEDVRLVL 300
DESRNN 306
Length:306
Mass (Da):35,116
Last modified:November 1, 1999 - v1
Checksum:i9D9A7C7BD2844099
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF111941 Genomic DNA. Translation: AAD28548.1.
AAFI02000259 Genomic DNA. Translation: EAL60295.1.
RefSeqiXP_628708.1. XM_628706.1.

Genome annotation databases

EnsemblProtistsiDDB0229894; DDB0229894; DDB_G0294376.
GeneIDi3385372.
KEGGiddi:DDB_G0294376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF111941 Genomic DNA. Translation: AAD28548.1 .
AAFI02000259 Genomic DNA. Translation: EAL60295.1 .
RefSeqi XP_628708.1. XM_628706.1.

3D structure databases

ProteinModelPortali Q9XYL0.
SMRi Q9XYL0. Positions 139-304.
ModBasei Search...

Proteomic databases

PRIDEi Q9XYL0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0229894 ; DDB0229894 ; DDB_G0294376 .
GeneIDi 3385372.
KEGGi ddi:DDB_G0294376.

Organism-specific databases

dictyBasei DDB_G0294376. fcpA.

Phylogenomic databases

KOi K15731.
OMAi CCHIDNG.
PhylomeDBi Q9XYL0.

Enzyme and pathway databases

Reactomei REACT_218739. XBP1(S) activates chaperone genes.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view ]
Pfami PF03031. NIF. 1 hit.
[Graphical view ]
SMARTi SM00577. CPDc. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR02251. HIF-SF_euk. 1 hit.
PROSITEi PS50969. FCP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dictyostelium discoideum Developmental gene DG1148. Disruption of this gene results in morphological defect."
    Iranfar N., Loomis W.F.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiCTDS_DICDI
AccessioniPrimary (citable) accession number: Q9XYL0
Secondary accession number(s): Q54AK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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