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Protein

Probable C-terminal domain small phosphatase

Gene

fcpA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May function as a phosphatase involved in the regulation of cell growth and differentiation.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1424-aspartylphosphate intermediateBy similarity1
Metal bindingi142MagnesiumBy similarity1
Active sitei144Proton donorBy similarity1
Metal bindingi144Magnesium; via carbonyl oxygenBy similarity1
Sitei198Transition state stabilizerBy similarity1
Sitei236Transition state stabilizerBy similarity1
Metal bindingi253MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • hyperosmotic response Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-terminal domain small phosphatase (EC:3.1.3.16)
Alternative name(s):
Developmental gene 1148 protein
Gene namesi
Name:fcpA
Synonyms:ctdsp, DG1148
ORF Names:DDB_G0294376
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componenti: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0294376. fcpA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003280571 – 306Probable C-terminal domain small phosphataseAdd BLAST306

Proteomic databases

PaxDbiQ9XYL0.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0229894.

Structurei

3D structure databases

ProteinModelPortaliQ9XYL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini132 – 290FCP1 homologyPROSITE-ProRule annotationAdd BLAST159

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 94Poly-Gln6
Compositional biasi97 – 110Poly-GlnAdd BLAST14

Sequence similaritiesi

Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1605. Eukaryota.
COG5190. LUCA.
InParanoidiQ9XYL0.
KOiK15731.
OMAiCCHIDNG.
PhylomeDBiQ9XYL0.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XYL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSPITQVS NPNDSLNHSS TNLIPSSHNS LNNYPQKSVK GNRKKKGSII
60 70 80 90 100
NKLFCCFVPS NDQNNGNNIN TDNGASNNDK LQQQKQYNQQ QQQQYNQHQQ
110 120 130 140 150
QQQQQQQQQQ YINKDSSQQN GEIPLMVPMI PRHVGLKTLV LDLDETLVHS
160 170 180 190 200
SFKPVHNPDF IVPVEIEGTI HQVYVVKRPF VDDFLRAIAE KFEIVVFTAS
210 220 230 240 250
LAKYADPVLD FLDTGRVIHY RLFRESCHNH KGNYVKDLSR LGRDLKSTII
260 270 280 290 300
VDNSPSSYLF HPENAIPIDS WFDDKDDREL LDLLPLLDDL IKVEDVRLVL

DESRNN
Length:306
Mass (Da):35,116
Last modified:November 1, 1999 - v1
Checksum:i9D9A7C7BD2844099
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111941 Genomic DNA. Translation: AAD28548.1.
AAFI02000259 Genomic DNA. Translation: EAL60295.1.
RefSeqiXP_628708.1. XM_628706.1.

Genome annotation databases

EnsemblProtistsiEAL60295; EAL60295; DDB_G0294376.
GeneIDi3385372.
KEGGiddi:DDB_G0294376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111941 Genomic DNA. Translation: AAD28548.1.
AAFI02000259 Genomic DNA. Translation: EAL60295.1.
RefSeqiXP_628708.1. XM_628706.1.

3D structure databases

ProteinModelPortaliQ9XYL0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0229894.

Proteomic databases

PaxDbiQ9XYL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL60295; EAL60295; DDB_G0294376.
GeneIDi3385372.
KEGGiddi:DDB_G0294376.

Organism-specific databases

dictyBaseiDDB_G0294376. fcpA.

Phylogenomic databases

eggNOGiKOG1605. Eukaryota.
COG5190. LUCA.
InParanoidiQ9XYL0.
KOiK15731.
OMAiCCHIDNG.
PhylomeDBiQ9XYL0.

Miscellaneous databases

PROiQ9XYL0.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTDS_DICDI
AccessioniPrimary (citable) accession number: Q9XYL0
Secondary accession number(s): Q54AK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.