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Protein

Probable C-terminal domain small phosphatase

Gene

fcpA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May function as a phosphatase involved in the regulation of cell growth and differentiation.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei142 – 14214-aspartylphosphate intermediateBy similarity
Metal bindingi142 – 1421MagnesiumBy similarity
Active sitei144 – 1441Proton donorBy similarity
Metal bindingi144 – 1441Magnesium; via carbonyl oxygenBy similarity
Sitei198 – 1981Transition state stabilizerBy similarity
Sitei236 – 2361Transition state stabilizerBy similarity
Metal bindingi253 – 2531MagnesiumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. hyperosmotic response Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable C-terminal domain small phosphatase (EC:3.1.3.16)
Alternative name(s):
Developmental gene 1148 protein
Gene namesi
Name:fcpA
Synonyms:ctdsp, DG1148
ORF Names:DDB_G0294376
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0294376. fcpA.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Probable C-terminal domain small phosphatasePRO_0000328057Add
BLAST

Proteomic databases

PRIDEiQ9XYL0.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9XYL0.
SMRiQ9XYL0. Positions 139-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini132 – 290159FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi89 – 946Poly-Gln
Compositional biasi97 – 11014Poly-GlnAdd
BLAST

Sequence similaritiesi

Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ9XYL0.
KOiK15731.
OMAiCCHIDNG.
PhylomeDBiQ9XYL0.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XYL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSPITQVS NPNDSLNHSS TNLIPSSHNS LNNYPQKSVK GNRKKKGSII
60 70 80 90 100
NKLFCCFVPS NDQNNGNNIN TDNGASNNDK LQQQKQYNQQ QQQQYNQHQQ
110 120 130 140 150
QQQQQQQQQQ YINKDSSQQN GEIPLMVPMI PRHVGLKTLV LDLDETLVHS
160 170 180 190 200
SFKPVHNPDF IVPVEIEGTI HQVYVVKRPF VDDFLRAIAE KFEIVVFTAS
210 220 230 240 250
LAKYADPVLD FLDTGRVIHY RLFRESCHNH KGNYVKDLSR LGRDLKSTII
260 270 280 290 300
VDNSPSSYLF HPENAIPIDS WFDDKDDREL LDLLPLLDDL IKVEDVRLVL

DESRNN
Length:306
Mass (Da):35,116
Last modified:November 1, 1999 - v1
Checksum:i9D9A7C7BD2844099
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111941 Genomic DNA. Translation: AAD28548.1.
AAFI02000259 Genomic DNA. Translation: EAL60295.1.
RefSeqiXP_628708.1. XM_628706.1.

Genome annotation databases

EnsemblProtistsiDDB0229894; DDB0229894; DDB_G0294376.
GeneIDi3385372.
KEGGiddi:DDB_G0294376.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111941 Genomic DNA. Translation: AAD28548.1.
AAFI02000259 Genomic DNA. Translation: EAL60295.1.
RefSeqiXP_628708.1. XM_628706.1.

3D structure databases

ProteinModelPortaliQ9XYL0.
SMRiQ9XYL0. Positions 139-304.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9XYL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0229894; DDB0229894; DDB_G0294376.
GeneIDi3385372.
KEGGiddi:DDB_G0294376.

Organism-specific databases

dictyBaseiDDB_G0294376. fcpA.

Phylogenomic databases

InParanoidiQ9XYL0.
KOiK15731.
OMAiCCHIDNG.
PhylomeDBiQ9XYL0.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Dictyostelium discoideum Developmental gene DG1148. Disruption of this gene results in morphological defect."
    Iranfar N., Loomis W.F.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiCTDS_DICDI
AccessioniPrimary (citable) accession number: Q9XYL0
Secondary accession number(s): Q54AK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 1, 1999
Last modified: January 7, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.