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Q9XYL0 (CTDS_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable C-terminal domain small phosphatase

EC=3.1.3.16
Alternative name(s):
Developmental gene 1148 protein
Gene names
Name:fcpA
Synonyms:ctdsp, DG1148
ORF Names:DDB_G0294376
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May function as a phosphatase involved in the regulation of cell growth and differentiation By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 magnesium ion per monomer By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 FCP1 homology domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhyperosmotic response

Inferred from expression pattern PubMed 17517120. Source: dictyBase

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 306306Probable C-terminal domain small phosphatase
PRO_0000328057

Regions

Domain132 – 290159FCP1 homology
Compositional bias89 – 946Poly-Gln
Compositional bias97 – 11014Poly-Gln

Sites

Active site14214-aspartylphosphate intermediate By similarity
Active site1441Proton donor By similarity
Metal binding1421Magnesium By similarity
Metal binding1441Magnesium; via carbonyl oxygen By similarity
Metal binding2531Magnesium By similarity
Site1981Transition state stabilizer By similarity
Site2361Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9XYL0 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 9D9A7C7BD2844099

FASTA30635,116
        10         20         30         40         50         60 
MNSSPITQVS NPNDSLNHSS TNLIPSSHNS LNNYPQKSVK GNRKKKGSII NKLFCCFVPS 

        70         80         90        100        110        120 
NDQNNGNNIN TDNGASNNDK LQQQKQYNQQ QQQQYNQHQQ QQQQQQQQQQ YINKDSSQQN 

       130        140        150        160        170        180 
GEIPLMVPMI PRHVGLKTLV LDLDETLVHS SFKPVHNPDF IVPVEIEGTI HQVYVVKRPF 

       190        200        210        220        230        240 
VDDFLRAIAE KFEIVVFTAS LAKYADPVLD FLDTGRVIHY RLFRESCHNH KGNYVKDLSR 

       250        260        270        280        290        300 
LGRDLKSTII VDNSPSSYLF HPENAIPIDS WFDDKDDREL LDLLPLLDDL IKVEDVRLVL 


DESRNN 

« Hide

References

« Hide 'large scale' references
[1]"Dictyostelium discoideum Developmental gene DG1148. Disruption of this gene results in morphological defect."
Iranfar N., Loomis W.F.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF111941 Genomic DNA. Translation: AAD28548.1.
AAFI02000259 Genomic DNA. Translation: EAL60295.1.
RefSeqXP_628708.1. XM_628706.1.

3D structure databases

ProteinModelPortalQ9XYL0.
SMRQ9XYL0. Positions 139-304.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9XYL0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0229894; DDB0229894; DDB_G0294376.
GeneID3385372.
KEGGddi:DDB_G0294376.

Organism-specific databases

dictyBaseDDB_G0294376. fcpA.

Phylogenomic databases

OMACCHIDNG.
PhylomeDBQ9XYL0.

Family and domain databases

Gene3D3.40.50.1000. 1 hit.
InterProIPR011948. Dullard_phosphatase.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamPF03031. NIF. 1 hit.
[Graphical view]
SMARTSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR02251. HIF-SF_euk. 1 hit.
PROSITEPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCTDS_DICDI
AccessionPrimary (citable) accession number: Q9XYL0
Secondary accession number(s): Q54AK8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase