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Protein

Arginine kinase

Gene

AK

Organism
Stichopus japonicus (Sea cucumber)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine = ADP + N(omega)-phospho-L-arginine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei181ATPPROSITE-ProRule annotation1
Binding sitei222SubstrateBy similarity1
Binding sitei226ATPPROSITE-ProRule annotation1
Binding sitei274SubstrateBy similarity1
Binding sitei316SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi118 – 122ATPPROSITE-ProRule annotation5
Nucleotide bindingi283 – 287ATPPROSITE-ProRule annotation5
Nucleotide bindingi311 – 316ATPPROSITE-ProRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine kinase (EC:2.7.3.3)
Short name:
AK
Gene namesi
Name:AK
OrganismiStichopus japonicus (Sea cucumber)
Taxonomic identifieri307972 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaHolothuroideaAspidochirotaceaAspidochirotidaStichopodidaeApostichopus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002120051 – 370Arginine kinaseAdd BLAST370

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PRIDEiQ9XY07.

Interactioni

Subunit structurei

Homodimer.

Structurei

Secondary structure

1370
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 8Combined sources3
Helixi11 – 14Combined sources4
Helixi24 – 28Combined sources5
Helixi31 – 37Combined sources7
Helixi48 – 56Combined sources9
Helixi72 – 75Combined sources4
Helixi77 – 87Combined sources11
Beta strandi93 – 95Combined sources3
Helixi103 – 105Combined sources3
Turni113 – 115Combined sources3
Beta strandi116 – 125Combined sources10
Turni133 – 135Combined sources3
Helixi138 – 153Combined sources16
Helixi157 – 159Combined sources3
Beta strandi161 – 168Combined sources8
Helixi171 – 179Combined sources9
Helixi190 – 194Combined sources5
Turni195 – 204Combined sources10
Beta strandi206 – 210Combined sources5
Beta strandi213 – 235Combined sources23
Helixi236 – 258Combined sources23
Turni266 – 268Combined sources3
Helixi275 – 277Combined sources3
Beta strandi283 – 289Combined sources7
Helixi291 – 294Combined sources4
Helixi299 – 305Combined sources7
Beta strandi308 – 312Combined sources5
Beta strandi324 – 330Combined sources7
Beta strandi333 – 335Combined sources3
Helixi337 – 359Combined sources23
Helixi365 – 367Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JU5X-ray1.75A/B/C/D1-370[»]
3JU6X-ray2.45A/B/C/D1-370[»]
ProteinModelPortaliQ9XY07.
SMRiQ9XY07.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9XY07.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 89Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd BLAST84
Domaini115 – 358Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd BLAST244

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.135.10. 1 hit.
3.30.590.10. 1 hit.
InterProiView protein in InterPro
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR022413. ATP-guanido_PTrfase_N.
IPR036802. ATP-guanido_PTrfase_N_sf.
IPR014746. Gln_synth/guanido_kin_cat_dom.
PANTHERiPTHR11547. PTHR11547. 1 hit.
PfamiView protein in Pfam
PF00217. ATP-gua_Ptrans. 1 hit.
PF02807. ATP-gua_PtransN. 1 hit.
SUPFAMiSSF48034. SSF48034. 1 hit.
SSF55931. SSF55931. 1 hit.
PROSITEiView protein in PROSITE
PS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
PS51509. PHOSPHAGEN_KINASE_N. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9XY07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLNQKKYP AKDDFPNFEG HKSLLSKYLT ADMYAKLRDV ATPSGYTLDR
60 70 80 90 100
AIQNGVDNPD FHLGLLAGDE ETYTVFADLF DPVIEEYHNG FKKTDNHKTD
110 120 130 140 150
LDASKILDDV LDPAYVISSR VRTGRNIRGM ALSPHVCRSE RRAIEKMVSE
160 170 180 190 200
ALNSLAADLK GKYYSLMKMD EKTQQQLIDD HFLFDRPVSR HFTSGGMARD
210 220 230 240 250
FPDGRGIWHN DKKNFLVWIN EEDHTRIISM QMGGNMKEVF ERFTRGLTEV
260 270 280 290 300
EKHIKDKTGK EFMKNDHLGF VLTCPSNLGT GVRCSVHAKL PHMAKDKRFE
310 320 330 340 350
EICTKMRLQK RGTSGEFTES VGGVYDISNL DRLGSSEVEQ VNCVIKGVKV
360 370
LIEMEKKLEK GESIDDLVPK
Length:370
Mass (Da):42,048
Last modified:November 1, 1999 - v1
Checksum:iFD9DA776E685EDAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025275 mRNA. Translation: BAA76385.1.

Similar proteinsi

Entry informationi

Entry nameiKARG_STIJA
AccessioniPrimary (citable) accession number: Q9XY07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1999
Last modified: October 25, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families