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Protein

ATP synthase subunit alpha, mitochondrial

Gene

atp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei398Required for activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi197 – 204ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alpha, mitochondrial
Alternative name(s):
ATP synthase subunit atp-1Imported
Gene namesi
Name:atp-1Imported
ORF Names:H28O16.1Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiH28O16.1a ; CE18826 ; WBGene00010419 ; atp-1
H28O16.1d ; CE36263 ; WBGene00010419 ; atp-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000239935? – 538ATP synthase subunit alpha, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9XXK1
PaxDbiQ9XXK1
PeptideAtlasiQ9XXK1
PRIDEiQ9XXK1

2D gel databases

World-2DPAGE0020:Q9XXK1

PTM databases

iPTMnetiQ9XXK1

Expressioni

Gene expression databases

BgeeiWBGene00010419

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.Curated

Protein-protein interaction databases

BioGridi38531, 3 interactors
DIPiDIP-25446N
IntActiQ9XXK1, 2 interactors
STRINGi6239.H28O16.1a

Structurei

3D structure databases

ProteinModelPortaliQ9XXK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Sequence analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1353 Eukaryota
COG0056 LUCA
GeneTreeiENSGT00550000074846
HOGENOMiHOG000130111
InParanoidiQ9XXK1
KOiK02132
OMAiGNAQIKS
OrthoDBiEOG091G0D1M
PhylomeDBiQ9XXK1

Family and domain databases

CDDicd01132 F1_ATPase_alpha, 1 hit
Gene3Di1.20.150.20, 1 hit
2.40.30.20, 1 hit
HAMAPiMF_01346 ATP_synth_alpha_bact, 1 hit
InterProiView protein in InterPro
IPR023366 ATP_synth_asu-like_sf
IPR000793 ATP_synth_asu_C
IPR038376 ATP_synth_asu_C_sf
IPR033732 ATP_synth_F1_a
IPR005294 ATP_synth_F1_asu
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF00306 ATP-synt_ab_C, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039088 F_ATPase_subunit_alpha, 1 hit
SUPFAMiSSF50615 SSF50615, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00962 atpA, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform aImported (identifier: Q9XXK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSKRIVTAL NTAVKVQNAG IATTARGMAG ASGSEVSKIL EERILGTETG
60 70 80 90 100
INLEETGKVL SIGDGIARVY GLKNIQAEEM VEFDSGIKGM AMNLDVDNVG
110 120 130 140 150
VVVFGNDKVI REGDIVKRTG AIVDVPVGDG LLGRVVDALG NPIDGKGPIA
160 170 180 190 200
NARRSRVEVK APGIIPRLSV REPMVTGVKA VDSLVPIGRG QRELIIGDRQ
210 220 230 240 250
TGKTAIAIDT IINQKRFNDA GDDKKKLFCI YVAVGQKRST VAQIVKRLTD
260 270 280 290 300
AGAMDYTIVV SATASDAAPL QFLAPYSGCA MGEHFRDNGK HALIIFDDLS
310 320 330 340 350
KQAVAYRQMS LLLRRPPGRE AYPGDVFYLH SRLLERAAKM NNSLGGGSLT
360 370 380 390 400
ALPVIETQAG DVSAYIPTNV ISITDGQIFL ETELFYKGVR PAINVGLSVS
410 420 430 440 450
RVGSAAQTKA MKQVAGSMKL ELAQYREVAA FAQFGSDLDA STQQLLNRGV
460 470 480 490 500
RLTELLKQGQ YVPMGIEEQV GVIYAGVKGY LDKVDPSAIT KFEKEFLAHL
510 520 530
RSSQQALLKT IREEGQISPQ TDAQLKDVVV NFLATFKP
Note: No experimental confirmation available.Curated
Length:538
Mass (Da):57,788
Last modified:November 1, 1999 - v1
Checksum:iCC0358C33A4D66D2
GO
Isoform dImported (identifier: Q9XXK1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:511
Mass (Da):55,020
Checksum:iB37181C9E8947140
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0520611 – 27Missing in isoform d. CuratedAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAA19429.1
BX284601 Genomic DNA Translation: CAF31480.1
PIRiT23128
RefSeqiNP_001021526.1, NM_001026355.3 [Q9XXK1-1]
NP_001021529.1, NM_001026358.4 [Q9XXK1-4]
UniGeneiCel.22874

Genome annotation databases

EnsemblMetazoaiH28O16.1a.1; H28O16.1a.1; WBGene00010419 [Q9XXK1-1]
H28O16.1a.2; H28O16.1a.2; WBGene00010419 [Q9XXK1-1]
H28O16.1a.3; H28O16.1a.3; WBGene00010419 [Q9XXK1-1]
H28O16.1a.4; H28O16.1a.4; WBGene00010419 [Q9XXK1-1]
H28O16.1a.5; H28O16.1a.5; WBGene00010419 [Q9XXK1-1]
H28O16.1a.6; H28O16.1a.6; WBGene00010419 [Q9XXK1-1]
GeneIDi173134
KEGGicel:CELE_H28O16.1
UCSCiH28O16.1a c. elegans [Q9XXK1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiATPA_CAEEL
AccessioniPrimary (citable) accession number: Q9XXK1
Secondary accession number(s): Q7K7K6, Q7YTU5, Q7YTU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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