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Protein

DNA helicase

Gene

mcm-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, HelicaseSAAS annotationImported, Hydrolase
Biological processDNA replicationSAAS annotation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-69052 Switching of origins to a post-replicative state
R-CEL-69300 Removal of licensing factors from origins

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicaseSAAS annotation (EC:3.6.4.12SAAS annotation)
Gene namesi
Name:mcm-2Imported
ORF Names:CELE_Y17G7B.5Imported, Y17G7B.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiY17G7B.5a ; CE19038 ; WBGene00003154 ; mcm-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

EPDiQ9XXI9
PaxDbiQ9XXI9
PeptideAtlasiQ9XXI9

Expressioni

Gene expression databases

BgeeiWBGene00003154
ExpressionAtlasiQ9XXI9 baseline and differential

Interactioni

Protein-protein interaction databases

DIPiDIP-26513N
IntActiQ9XXI9 2 interactors.
STRINGi6239.Y17G7B.5a

Structurei

3D structure databases

ProteinModelPortaliQ9XXI9
SMRiQ9XXI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini448 – 654MCMInterPro annotationAdd BLAST207

Sequence similaritiesi

Belongs to the MCM family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0477 Eukaryota
COG1241 LUCA
GeneTreeiENSGT00910000144177
HOGENOMiHOG000224124
InParanoidiQ9XXI9
KOiK02540
OMAiKYDCVKC
OrthoDBiEOG091G026H
PhylomeDBiQ9XXI9

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR031327 MCM
IPR008045 MCM2
IPR018525 MCM_CS
IPR001208 MCM_dom
IPR027925 MCM_N
IPR033762 MCM_OB
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
PANTHERiPTHR11630 PTHR11630, 1 hit
PTHR11630:SF44 PTHR11630:SF44, 1 hit
PfamiView protein in Pfam
PF00493 MCM, 1 hit
PF12619 MCM2_N, 1 hit
PF14551 MCM_N, 1 hit
PF17207 MCM_OB, 1 hit
PRINTSiPR01657 MCMFAMILY
PR01658 MCMPROTEIN2
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00350 MCM, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00847 MCM_1, 1 hit
PS50051 MCM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9XXI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADRANNDDD VDRQPLPIAD DADDDVDGID EMFNNEDEDP EDEEGENLFG
60 70 80 90 100
DDMERDYREQ PELDQYSESG MDDASDVGSL SVSARRAAER EMAQRDQLLD
110 120 130 140 150
DDALMYEDGD SEEVDTRRRG RGRRGRGDAA DDDSVPMEEE DIPVDILENI
160 170 180 190 200
RGRTIRDHVS DEAVAKEIER RFKNFLRSFH EPGNKQTKYI QMIKSMAADN
210 220 230 240 250
RESLEVSFTD LSDDNGEQNI SYFLPEAPNE MLAIMDRAAT EVVMNMYPFY
260 270 280 290 300
SRVCNEIKVR ISQLPVEEDI RMLRQVHLNM LIRTAGVVTI ASGILPQLAV
310 320 330 340 350
VKYDCVACGY LLGPFVQQND EEVRPTICPS CQGKGPFELN VENTVYHNYQ
360 370 380 390 400
RITMQESPNK VAAGRLPRSK DVILLGDLCD SCKPGDEIEV TGVYTNNFDG
410 420 430 440 450
SLNYKQGFPV FNTLIHANHI TNKDKMASDQ LTDEDIKAIR ELSQDPNISQ
460 470 480 490 500
RVFSSIAPSI YGHDDVKRAI ALALFRGEAK NPGAKHRLRG DINVLLCGDP
510 520 530 540 550
GTAKSQFLRY AAHIAPRSVL TTGQGASAVG LTAYVQRHPV TREWTLEAGA
560 570 580 590 600
MVLADKGVCL IDEFDKMSDQ DRTSIHEAME QQSISISKAG IVTSLHARCT
610 620 630 640 650
VIAASNPIGG RYNPTRTFAE NVDLTEPILS RFDVLCVIRD SVDSVEDERL
660 670 680 690 700
AKFVVGNHRT HHPDAKKIVK EGDELEEDQM DERTGVRLIP QDLLRKYIIY
710 720 730 740 750
AREKCHPTLP EQHSEKFSNI FAQMRKESMA TGSVAITVRH VESMIRLSEA
760 770 780 790 800
HAKLHLRSYV NDEDCAAAIR VMLESFVNTQ KASIMRMMKK TFSRHLTENR
810 820 830 840 850
SANELLLFIL KQLIRQQMHY ATARAAAGTI LQSVTIPESE FIEKAQQLRI
860 870 880
ENVKPFYTSE IFASNNFLYD PSKKTIVQEI F
Length:881
Mass (Da):99,323
Last modified:November 1, 1999 - v1
Checksum:i859E85B2838D5618
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CAA19452.1
PIRiT26498
RefSeqiNP_001022416.1, NM_001027245.5
UniGeneiCel.16967

Genome annotation databases

EnsemblMetazoaiY17G7B.5a.1; Y17G7B.5a.1; WBGene00003154
Y17G7B.5a.2; Y17G7B.5a.2; WBGene00003154
GeneIDi174841
KEGGicel:CELE_Y17G7B.5
UCSCiY17G7B.5b c. elegans

Similar proteinsi

Entry informationi

Entry nameiQ9XXI9_CAEEL
AccessioniPrimary (citable) accession number: Q9XXI9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported