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Protein

DNA helicase

Gene

mcm-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, HelicaseSAAS annotationImported, Hydrolase
Biological processDNA replicationSAAS annotation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-69052. Switching of origins to a post-replicative state.
R-CEL-69300. Removal of licensing factors from origins.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA helicaseSAAS annotation (EC:3.6.4.12SAAS annotation)
Gene namesi
Name:mcm-2Imported
ORF Names:CELE_Y17G7B.5Imported, Y17G7B.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiY17G7B.5a; CE19038; WBGene00003154; mcm-2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

EPDiQ9XXI9.
PaxDbiQ9XXI9.
PeptideAtlasiQ9XXI9.

Expressioni

Gene expression databases

BgeeiWBGene00003154.
ExpressionAtlasiQ9XXI9. baseline.

Interactioni

Protein-protein interaction databases

DIPiDIP-26513N.
IntActiQ9XXI9. 2 interactors.
MINTiMINT-1119477.
STRINGi6239.Y17G7B.5a.

Structurei

3D structure databases

ProteinModelPortaliQ9XXI9.
SMRiQ9XXI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini448 – 654MCMInterPro annotationAdd BLAST207

Sequence similaritiesi

Belongs to the MCM family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0477. Eukaryota.
COG1241. LUCA.
GeneTreeiENSGT00880000137969.
HOGENOMiHOG000224124.
InParanoidiQ9XXI9.
KOiK02540.
OMAiKYDCVKC.
OrthoDBiEOG091G026H.
PhylomeDBiQ9XXI9.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR031327. MCM.
IPR008045. MCM2.
IPR018525. MCM_CS.
IPR001208. MCM_dom.
IPR027925. MCM_N.
IPR033762. MCM_OB.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
PANTHERiPTHR11630:SF89. PTHR11630:SF89. 1 hit.
PfamiView protein in Pfam
PF00493. MCM. 1 hit.
PF12619. MCM2_N. 1 hit.
PF14551. MCM_N. 1 hit.
PF17207. MCM_OB. 1 hit.
PRINTSiPR01657. MCMFAMILY.
PR01658. MCMPROTEIN2.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00350. MCM. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00847. MCM_1. 1 hit.
PS50051. MCM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9XXI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADRANNDDD VDRQPLPIAD DADDDVDGID EMFNNEDEDP EDEEGENLFG
60 70 80 90 100
DDMERDYREQ PELDQYSESG MDDASDVGSL SVSARRAAER EMAQRDQLLD
110 120 130 140 150
DDALMYEDGD SEEVDTRRRG RGRRGRGDAA DDDSVPMEEE DIPVDILENI
160 170 180 190 200
RGRTIRDHVS DEAVAKEIER RFKNFLRSFH EPGNKQTKYI QMIKSMAADN
210 220 230 240 250
RESLEVSFTD LSDDNGEQNI SYFLPEAPNE MLAIMDRAAT EVVMNMYPFY
260 270 280 290 300
SRVCNEIKVR ISQLPVEEDI RMLRQVHLNM LIRTAGVVTI ASGILPQLAV
310 320 330 340 350
VKYDCVACGY LLGPFVQQND EEVRPTICPS CQGKGPFELN VENTVYHNYQ
360 370 380 390 400
RITMQESPNK VAAGRLPRSK DVILLGDLCD SCKPGDEIEV TGVYTNNFDG
410 420 430 440 450
SLNYKQGFPV FNTLIHANHI TNKDKMASDQ LTDEDIKAIR ELSQDPNISQ
460 470 480 490 500
RVFSSIAPSI YGHDDVKRAI ALALFRGEAK NPGAKHRLRG DINVLLCGDP
510 520 530 540 550
GTAKSQFLRY AAHIAPRSVL TTGQGASAVG LTAYVQRHPV TREWTLEAGA
560 570 580 590 600
MVLADKGVCL IDEFDKMSDQ DRTSIHEAME QQSISISKAG IVTSLHARCT
610 620 630 640 650
VIAASNPIGG RYNPTRTFAE NVDLTEPILS RFDVLCVIRD SVDSVEDERL
660 670 680 690 700
AKFVVGNHRT HHPDAKKIVK EGDELEEDQM DERTGVRLIP QDLLRKYIIY
710 720 730 740 750
AREKCHPTLP EQHSEKFSNI FAQMRKESMA TGSVAITVRH VESMIRLSEA
760 770 780 790 800
HAKLHLRSYV NDEDCAAAIR VMLESFVNTQ KASIMRMMKK TFSRHLTENR
810 820 830 840 850
SANELLLFIL KQLIRQQMHY ATARAAAGTI LQSVTIPESE FIEKAQQLRI
860 870 880
ENVKPFYTSE IFASNNFLYD PSKKTIVQEI F
Length:881
Mass (Da):99,323
Last modified:November 1, 1999 - v1
Checksum:i859E85B2838D5618
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA19452.1.
PIRiT26498.
RefSeqiNP_001022416.1. NM_001027245.5.
UniGeneiCel.16967.

Genome annotation databases

EnsemblMetazoaiY17G7B.5a.1; Y17G7B.5a.1; WBGene00003154.
Y17G7B.5a.2; Y17G7B.5a.2; WBGene00003154.
GeneIDi174841.
KEGGicel:CELE_Y17G7B.5.
UCSCiY17G7B.5b. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiQ9XXI9_CAEEL
AccessioniPrimary (citable) accession number: Q9XXI9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: September 27, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported