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Q9XXC8

- MECR2_CAEEL

UniProt

Q9XXC8 - MECR2_CAEEL

Protein

Probable trans-2-enoyl-CoA reductase 2, mitochondrial

Gene

Y48A6B.9

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.By similarity

    Catalytic activityi

    Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei131 – 1311NADPBy similarity
    Binding sitei332 – 3321NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi157 – 1604NADPBy similarity
    Nucleotide bindingi180 – 1823NADPBy similarity
    Nucleotide bindingi249 – 2524NADPBy similarity

    GO - Molecular functioni

    1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable trans-2-enoyl-CoA reductase 2, mitochondrial (EC:1.3.1.38)
    Gene namesi
    ORF Names:Y48A6B.9
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiY48A6B.9a; CE19192; WBGene00012970.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2222MitochondrionSequence AnalysisAdd
    BLAST
    Chaini23 – 346324Probable trans-2-enoyl-CoA reductase 2, mitochondrialPRO_0000000893Add
    BLAST

    Proteomic databases

    PaxDbiQ9XXC8.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi41720. 1 interaction.
    DIPiDIP-24981N.
    IntActiQ9XXC8. 2 interactions.
    MINTiMINT-1059728.
    STRINGi6239.Y48A6B.9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XXC8.
    SMRiQ9XXC8. Positions 6-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0604.
    GeneTreeiENSGT00740000115589.
    HOGENOMiHOG000294683.
    InParanoidiQ9XXC8.
    KOiK07512.
    OMAiSANTPIW.
    PhylomeDBiQ9XXC8.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9XXC8-1 [UniParc]FASTAAdd to Basket

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    MQKTIRSQAL IYRKFGDPLK VLQLETVEVP AEPGSGECLV EWLASPINPL    50
    DINRIQGNYA VRAELPVIGG SEGVGRVVKA GSGSRFKSGD HVTIFSANTP 100
    IWTEFGVVDD DELVKLDNRI PLDLAATLMI NPPTAWIMLK KYVNLQKGDY 150
    IIQNSANSGV GRSVIEMCKA LGYKSINIVR NRQNIEALKT DLWRIGADHV 200
    FTEEEFKGTS RQFLKSINVR PKLALNGVGG KSALQISSVL ERGGTCVTYG 250
    GMSKKAHEFT TSALVFNDIC VRGVAVGMWA RQEEHLDEWN LCVDEVQKLA 300
    VAGKITAIPM EKVVLADHKT AIQKSLEGRS IKQLFVINSK ASASHI 346
    Length:346
    Mass (Da):37,944
    Last modified:November 1, 1999 - v1
    Checksum:iE14426AADA5FB4A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL023844 Genomic DNA. Translation: CAA19533.1.
    PIRiT26986.
    RefSeqiNP_001255097.1. NM_001268168.1.
    UniGeneiCel.9759.

    Genome annotation databases

    EnsemblMetazoaiY48A6B.9a; Y48A6B.9a; WBGene00012970.
    GeneIDi176534.
    KEGGicel:CELE_Y48A6B.9.
    UCSCiY48A6B.9. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL023844 Genomic DNA. Translation: CAA19533.1 .
    PIRi T26986.
    RefSeqi NP_001255097.1. NM_001268168.1.
    UniGenei Cel.9759.

    3D structure databases

    ProteinModelPortali Q9XXC8.
    SMRi Q9XXC8. Positions 6-329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 41720. 1 interaction.
    DIPi DIP-24981N.
    IntActi Q9XXC8. 2 interactions.
    MINTi MINT-1059728.
    STRINGi 6239.Y48A6B.9.

    Proteomic databases

    PaxDbi Q9XXC8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y48A6B.9a ; Y48A6B.9a ; WBGene00012970 .
    GeneIDi 176534.
    KEGGi cel:CELE_Y48A6B.9.
    UCSCi Y48A6B.9. c. elegans.

    Organism-specific databases

    CTDi 176534.
    WormBasei Y48A6B.9a ; CE19192 ; WBGene00012970 .

    Phylogenomic databases

    eggNOGi COG0604.
    GeneTreei ENSGT00740000115589.
    HOGENOMi HOG000294683.
    InParanoidi Q9XXC8.
    KOi K07512.
    OMAi SANTPIW.
    PhylomeDBi Q9XXC8.

    Miscellaneous databases

    NextBioi 892980.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiMECR2_CAEEL
    AccessioniPrimary (citable) accession number: Q9XXC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3