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Q9XXC8

- MECR2_CAEEL

UniProt

Q9XXC8 - MECR2_CAEEL

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Protein

Probable trans-2-enoyl-CoA reductase 2, mitochondrial

Gene
Y48A6B.9
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei131 – 1311NADP By similarity
Binding sitei332 – 3321NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi157 – 1604NADP By similarity
Nucleotide bindingi180 – 1823NADP By similarity
Nucleotide bindingi249 – 2524NADP By similarity

GO - Molecular functioni

  1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Probable trans-2-enoyl-CoA reductase 2, mitochondrial (EC:1.3.1.38)
Gene namesi
ORF Names:Y48A6B.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiY48A6B.9a; CE19192; WBGene00012970.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222Mitochondrion Reviewed predictionAdd
BLAST
Chaini23 – 346324Probable trans-2-enoyl-CoA reductase 2, mitochondrialPRO_0000000893Add
BLAST

Proteomic databases

PaxDbiQ9XXC8.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

BioGridi41720. 1 interaction.
DIPiDIP-24981N.
IntActiQ9XXC8. 2 interactions.
MINTiMINT-1059728.
STRINGi6239.Y48A6B.9.

Structurei

3D structure databases

ProteinModelPortaliQ9XXC8.
SMRiQ9XXC8. Positions 6-329.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0604.
GeneTreeiENSGT00740000115589.
HOGENOMiHOG000294683.
InParanoidiQ9XXC8.
KOiK07512.
OMAiSANTPIW.
PhylomeDBiQ9XXC8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XXC8-1 [UniParc]FASTAAdd to Basket

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MQKTIRSQAL IYRKFGDPLK VLQLETVEVP AEPGSGECLV EWLASPINPL    50
DINRIQGNYA VRAELPVIGG SEGVGRVVKA GSGSRFKSGD HVTIFSANTP 100
IWTEFGVVDD DELVKLDNRI PLDLAATLMI NPPTAWIMLK KYVNLQKGDY 150
IIQNSANSGV GRSVIEMCKA LGYKSINIVR NRQNIEALKT DLWRIGADHV 200
FTEEEFKGTS RQFLKSINVR PKLALNGVGG KSALQISSVL ERGGTCVTYG 250
GMSKKAHEFT TSALVFNDIC VRGVAVGMWA RQEEHLDEWN LCVDEVQKLA 300
VAGKITAIPM EKVVLADHKT AIQKSLEGRS IKQLFVINSK ASASHI 346
Length:346
Mass (Da):37,944
Last modified:November 1, 1999 - v1
Checksum:iE14426AADA5FB4A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL023844 Genomic DNA. Translation: CAA19533.1.
PIRiT26986.
RefSeqiNP_001255097.1. NM_001268168.1.
UniGeneiCel.9759.

Genome annotation databases

EnsemblMetazoaiY48A6B.9a; Y48A6B.9a; WBGene00012970.
GeneIDi176534.
KEGGicel:CELE_Y48A6B.9.
UCSCiY48A6B.9. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL023844 Genomic DNA. Translation: CAA19533.1 .
PIRi T26986.
RefSeqi NP_001255097.1. NM_001268168.1.
UniGenei Cel.9759.

3D structure databases

ProteinModelPortali Q9XXC8.
SMRi Q9XXC8. Positions 6-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 41720. 1 interaction.
DIPi DIP-24981N.
IntActi Q9XXC8. 2 interactions.
MINTi MINT-1059728.
STRINGi 6239.Y48A6B.9.

Proteomic databases

PaxDbi Q9XXC8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y48A6B.9a ; Y48A6B.9a ; WBGene00012970 .
GeneIDi 176534.
KEGGi cel:CELE_Y48A6B.9.
UCSCi Y48A6B.9. c. elegans.

Organism-specific databases

CTDi 176534.
WormBasei Y48A6B.9a ; CE19192 ; WBGene00012970 .

Phylogenomic databases

eggNOGi COG0604.
GeneTreei ENSGT00740000115589.
HOGENOMi HOG000294683.
InParanoidi Q9XXC8.
KOi K07512.
OMAi SANTPIW.
PhylomeDBi Q9XXC8.

Miscellaneous databases

NextBioi 892980.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiMECR2_CAEEL
AccessioniPrimary (citable) accession number: Q9XXC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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