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Protein

Probable trans-2-enoyl-CoA reductase 2, mitochondrial

Gene

Y48A6B.9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis (By similarity).By similarity

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei131 – 1311NADPBy similarity
Binding sitei332 – 3321NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi157 – 1604NADPBy similarity
Nucleotide bindingi180 – 1823NADPBy similarity
Nucleotide bindingi249 – 2524NADPBy similarity

GO - Molecular functioni

  1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BRENDAi1.3.1.38. 1045.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable trans-2-enoyl-CoA reductase 2, mitochondrial (EC:1.3.1.38)
Gene namesi
ORF Names:Y48A6B.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiY48A6B.9a; CE19192; WBGene00012970.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222MitochondrionSequence AnalysisAdd
BLAST
Chaini23 – 346324Probable trans-2-enoyl-CoA reductase 2, mitochondrialPRO_0000000893Add
BLAST

Proteomic databases

PaxDbiQ9XXC8.

Expressioni

Gene expression databases

ExpressionAtlasiQ9XXC8. baseline and differential.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi41720. 1 interaction.
DIPiDIP-24981N.
IntActiQ9XXC8. 2 interactions.
MINTiMINT-1059728.
STRINGi6239.Y48A6B.9.

Structurei

3D structure databases

ProteinModelPortaliQ9XXC8.
SMRiQ9XXC8. Positions 6-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0604.
GeneTreeiENSGT00740000115589.
HOGENOMiHOG000294683.
InParanoidiQ9XXC8.
KOiK07512.
OMAiAATLMIN.
PhylomeDBiQ9XXC8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XXC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKTIRSQAL IYRKFGDPLK VLQLETVEVP AEPGSGECLV EWLASPINPL
60 70 80 90 100
DINRIQGNYA VRAELPVIGG SEGVGRVVKA GSGSRFKSGD HVTIFSANTP
110 120 130 140 150
IWTEFGVVDD DELVKLDNRI PLDLAATLMI NPPTAWIMLK KYVNLQKGDY
160 170 180 190 200
IIQNSANSGV GRSVIEMCKA LGYKSINIVR NRQNIEALKT DLWRIGADHV
210 220 230 240 250
FTEEEFKGTS RQFLKSINVR PKLALNGVGG KSALQISSVL ERGGTCVTYG
260 270 280 290 300
GMSKKAHEFT TSALVFNDIC VRGVAVGMWA RQEEHLDEWN LCVDEVQKLA
310 320 330 340
VAGKITAIPM EKVVLADHKT AIQKSLEGRS IKQLFVINSK ASASHI
Length:346
Mass (Da):37,944
Last modified:November 1, 1999 - v1
Checksum:iE14426AADA5FB4A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023844 Genomic DNA. Translation: CAA19533.1.
PIRiT26986.
RefSeqiNP_001255097.1. NM_001268168.1.
UniGeneiCel.9759.

Genome annotation databases

EnsemblMetazoaiY48A6B.9a; Y48A6B.9a; WBGene00012970.
GeneIDi176534.
KEGGicel:CELE_Y48A6B.9.
UCSCiY48A6B.9. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023844 Genomic DNA. Translation: CAA19533.1.
PIRiT26986.
RefSeqiNP_001255097.1. NM_001268168.1.
UniGeneiCel.9759.

3D structure databases

ProteinModelPortaliQ9XXC8.
SMRiQ9XXC8. Positions 6-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41720. 1 interaction.
DIPiDIP-24981N.
IntActiQ9XXC8. 2 interactions.
MINTiMINT-1059728.
STRINGi6239.Y48A6B.9.

Proteomic databases

PaxDbiQ9XXC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY48A6B.9a; Y48A6B.9a; WBGene00012970.
GeneIDi176534.
KEGGicel:CELE_Y48A6B.9.
UCSCiY48A6B.9. c. elegans.

Organism-specific databases

CTDi176534.
WormBaseiY48A6B.9a; CE19192; WBGene00012970.

Phylogenomic databases

eggNOGiCOG0604.
GeneTreeiENSGT00740000115589.
HOGENOMiHOG000294683.
InParanoidiQ9XXC8.
KOiK07512.
OMAiAATLMIN.
PhylomeDBiQ9XXC8.

Enzyme and pathway databases

BRENDAi1.3.1.38. 1045.

Miscellaneous databases

NextBioi892980.

Gene expression databases

ExpressionAtlasiQ9XXC8. baseline and differential.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiMECR2_CAEEL
AccessioniPrimary (citable) accession number: Q9XXC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: April 1, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.