Reviewed, UniProtKB/Swiss-Prot Q9XXC8 (MECR2_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable trans-2-enoyl-CoA reductase 2, mitochondrial
    EC=1.3.1.38

Gene names

ORF Names:

Y48A6B.9

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA. May have a role in the mitochondrial synthesis of fatty acids By similarity.
Catalytic activity	Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct trans-2-enoyl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9XWG3	1	EBI-331545,EBI-331496

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 22	22	Mitochondrion Potential
	Chain	23 – 346	324	Probable trans-2-enoyl-CoA reductase 2, mitochondrial		PRO_0000000893

Sequences

	Sequence		Length	Mass (Da)
	Q9XXC8-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: E14426AADA5FB4A6	FASTA	346	37,944
	10 20 30 40 50 60 MQKTIRSQAL IYRKFGDPLK VLQLETVEVP AEPGSGECLV EWLASPINPL DINRIQGNYA 70 80 90 100 110 120 VRAELPVIGG SEGVGRVVKA GSGSRFKSGD HVTIFSANTP IWTEFGVVDD DELVKLDNRI 130 140 150 160 170 180 PLDLAATLMI NPPTAWIMLK KYVNLQKGDY IIQNSANSGV GRSVIEMCKA LGYKSINIVR 190 200 210 220 230 240 NRQNIEALKT DLWRIGADHV FTEEEFKGTS RQFLKSINVR PKLALNGVGG KSALQISSVL 250 260 270 280 290 300 ERGGTCVTYG GMSKKAHEFT TSALVFNDIC VRGVAVGMWA RQEEHLDEWN LCVDEVQKLA 310 320 330 340 VAGKITAIPM EKVVLADHKT AIQKSLEGRS IKQLFVINSK ASASHI

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL023844 Genomic DNA. Translation: CAA19533.1.
PIR	T26986.
RefSeq	NP_499420.1.
UniGene	Cel.9759
3D structure databases
SMR	Q9XXC8. Positions 7-331.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-24981N.
IntAct	Q9XXC8. 1 interaction.
STRING	Q9XXC8.
Genome annotation databases
Ensembl	Y48A6B.9; Y48A6B.9; Y48A6B.9; Caenorhabditis elegans. [Genome view]
GeneID	176534.
KEGG	cel:Y48A6B.9.
UCSC	Y48A6B.9. c. elegans.
Organism-specific databases
CTD	176534.
WormBase	WBGene00012970. Y48A6B.9.
WormPep	Y48A6B.9. CE19192. [WorfDB]
Phylogenomic databases
eggNOG	meNOG05399.
HOGENOM	HBG753318.
InParanoid	Q9XXC8.
OMA	AATLMIN.
PhylomeDB	Q9XXC8.
Enzyme and pathway databases
BRENDA	1.3.1.38. 672.
Gene expression databases
ArrayExpress	Q9XXC8.
Family and domain databases
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	892980.

Entry information

Entry name

MECR2_CAEEL

Accession

Primary (citable) accession number: Q9XXC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	November 1, 1999
Last modified:	January 19, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project