Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Eukaryotic translation initiation factor 3 subunit B

Gene

eif-3.B

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-CEL-72702. Ribosomal scanning and start codon recognition.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit BUniRule annotation
Short name:
eIF3bUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 9UniRule annotation
Gene namesi
Name:eif-3.BUniRule annotation
ORF Names:Y54E2A.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiY54E2A.11a; CE47851; WBGene00001225; eif-3.B.
Y54E2A.11b; CE47908; WBGene00001225; eif-3.B.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Extended lifespan in adults.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 725725Eukaryotic translation initiation factor 3 subunit BPRO_0000363789Add
BLAST

Proteomic databases

EPDiQ9XWI6.
PaxDbiQ9XWI6.
PRIDEiQ9XWI6.

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.UniRule annotation

Protein-protein interaction databases

BioGridi40419. 3 interactions.
DIPiDIP-26989N.
IntActiQ9XWI6. 3 interactions.
MINTiMINT-1097629.
STRINGi6239.Y54E2A.11a.1.

Structurei

3D structure databases

ProteinModelPortaliQ9XWI6.
SMRiQ9XWI6. Positions 45-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 13085RRMUniRule annotationAdd
BLAST
Repeati202 – 24039WD 1Add
BLAST
Repeati242 – 28039WD 2Add
BLAST
Repeati354 – 39542WD 3Add
BLAST
Repeati462 – 50443WD 4Add
BLAST
Repeati510 – 55243WD 5Add
BLAST
Repeati554 – 59441WD 6Add
BLAST

Sequence similaritiesi

Belongs to the eIF-3 subunit B family.UniRule annotation
Contains 1 RRM (RNA recognition motif) domain.UniRule annotation
Contains 6 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2314. Eukaryota.
COG5354. LUCA.
GeneTreeiENSGT00550000074913.
HOGENOMiHOG000265546.
InParanoidiQ9XWI6.
KOiK03253.
OMAiDYQEEPN.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
HAMAPiMF_03001. eIF3b.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR011400. EIF3B.
IPR013979. TIF_beta_prop-like.
[Graphical view]
PANTHERiPTHR14068. PTHR14068. 1 hit.
PfamiPF08662. eIF2A. 1 hit.
[Graphical view]
PIRSFiPIRSF036424. eIF3b. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q9XWI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEIDFNKEN EEDFSDPPGF VDDVTDDVLV PDVLHKKPTI DEFEDNCVFI
60 70 80 90 100
AGIPVVGADR LGKLQSVLKK VLERLDPAVK LYIPPSPEGG CLGVLLTEWA
110 120 130 140 150
DQRSAQFAVK SLNGYAFDKN HTFTARSFKD MKQLEAPSDH WTTPEKQAYN
160 170 180 190 200
DVGDLWWWLQ NERCRDQFAI SHDKLGVPTV GVFTNMKGND PELAGDADKA
210 220 230 240 250
ERANWTETVF TWSPHGSYLS TIHKQGIILW GGKDYARAHR FAHTNVQYID
260 270 280 290 300
FSPCETYLVT YAAPEESNSW GDCEKDSLRI WDVRTGELKK AFSTFELTGR
310 320 330 340 350
TQLPTWPFFR WSFDEKYFAC LKAPEKDKLE REQKINGISI FESEKFELYE
360 370 380 390 400
GRPVNIENIK QFEWSPTSTV LAYYSECTDA VPAEFGLLQV PSMQRLRSAR
410 420 430 440 450
VHNVADAQMF WQKSGKRLAF YTMRFKKKEY RETGEVKYVG GCQYHVDIFE
460 470 480 490 500
IDKKDVSLMN LPLSEPFIHF DWDPEGDKFC VLVGNTAKAT PQVYKIEANS
510 520 530 540 550
HAPKLVSKLD AGVHFNEVQF APKGGWLAVL AKVSAGGNVY FIDTSLSEAK
560 570 580 590 600
RTNVIEHPLF NKGYWDPTGR YFVTCSTLGG RAGADLGYRI FTFQGRELCR
610 620 630 640 650
KNLDRLAQFK WRPRPPVKLS EQKQREIKKN LKKTAAKFIK QDDDEKCRAS
660 670 680 690 700
QEVVEKRRKI MAAFDIIRSR NREQLDATRD ERISLRNGVD TEAQLDEDEF
710 720
VDEEITIALS TSKTQAPLTE EEMRD
Note: No experimental confirmation available.
Length:725
Mass (Da):83,065
Last modified:July 24, 2013 - v2
Checksum:iC73A8E862A32F887
GO
Isoform b (identifier: Q9XWI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-193: YNDVGDLWWW...TNMKGNDPEL → KTTLVPTVSL...TAGETVRRIV
     194-725: Missing.

Note: No experimental confirmation available.
Show »
Length:193
Mass (Da):21,574
Checksum:i17087D08F4F79715
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei149 – 19345YNDVG…NDPEL → KTTLVPTVSLIPTFNTLISR RVRPTLLPTPLRKSRTAGET VRRIV in isoform b. CuratedVSP_047618Add
BLAST
Alternative sequencei194 – 725532Missing in isoform b. CuratedVSP_047619Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL032646 Genomic DNA. Translation: CAA21681.2.
AL032646 Genomic DNA. Translation: CAE46682.2.
PIRiT27148.
RefSeqiNP_001022469.2. NM_001027298.5. [Q9XWI6-1]
NP_001022470.2. NM_001027299.5. [Q9XWI6-2]

Genome annotation databases

EnsemblMetazoaiY54E2A.11a.1; Y54E2A.11a.1; WBGene00001225. [Q9XWI6-1]
Y54E2A.11a.2; Y54E2A.11a.2; WBGene00001225. [Q9XWI6-1]
Y54E2A.11a.3; Y54E2A.11a.3; WBGene00001225.
GeneIDi175138.
KEGGicel:CELE_Y54E2A.11.
UCSCiY54E2A.11a.2. c. elegans. [Q9XWI6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL032646 Genomic DNA. Translation: CAA21681.2.
AL032646 Genomic DNA. Translation: CAE46682.2.
PIRiT27148.
RefSeqiNP_001022469.2. NM_001027298.5. [Q9XWI6-1]
NP_001022470.2. NM_001027299.5. [Q9XWI6-2]

3D structure databases

ProteinModelPortaliQ9XWI6.
SMRiQ9XWI6. Positions 45-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40419. 3 interactions.
DIPiDIP-26989N.
IntActiQ9XWI6. 3 interactions.
MINTiMINT-1097629.
STRINGi6239.Y54E2A.11a.1.

Proteomic databases

EPDiQ9XWI6.
PaxDbiQ9XWI6.
PRIDEiQ9XWI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY54E2A.11a.1; Y54E2A.11a.1; WBGene00001225. [Q9XWI6-1]
Y54E2A.11a.2; Y54E2A.11a.2; WBGene00001225. [Q9XWI6-1]
Y54E2A.11a.3; Y54E2A.11a.3; WBGene00001225.
GeneIDi175138.
KEGGicel:CELE_Y54E2A.11.
UCSCiY54E2A.11a.2. c. elegans. [Q9XWI6-1]

Organism-specific databases

CTDi175138.
WormBaseiY54E2A.11a; CE47851; WBGene00001225; eif-3.B.
Y54E2A.11b; CE47908; WBGene00001225; eif-3.B.

Phylogenomic databases

eggNOGiKOG2314. Eukaryota.
COG5354. LUCA.
GeneTreeiENSGT00550000074913.
HOGENOMiHOG000265546.
InParanoidiQ9XWI6.
KOiK03253.
OMAiDYQEEPN.

Enzyme and pathway databases

ReactomeiR-CEL-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-CEL-72689. Formation of a pool of free 40S subunits.
R-CEL-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-CEL-72702. Ribosomal scanning and start codon recognition.

Miscellaneous databases

NextBioi886926.
PROiQ9XWI6.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
HAMAPiMF_03001. eIF3b.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR011400. EIF3B.
IPR013979. TIF_beta_prop-like.
[Graphical view]
PANTHERiPTHR14068. PTHR14068. 1 hit.
PfamiPF08662. eIF2A. 1 hit.
[Graphical view]
PIRSFiPIRSF036424. eIF3b. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  2. "Lifespan regulation by evolutionarily conserved genes essential for viability."
    Curran S.P., Ruvkun G.
    PLoS Genet. 3:E56-E56(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiEIF3B_CAEEL
AccessioniPrimary (citable) accession number: Q9XWI6
Secondary accession number(s): Q7K785
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 24, 2013
Last modified: May 11, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Translation initiation factors
    List of translation initiation factor entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.