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Q9XWE6

- MTHFS_CAEEL

UniProt

Q9XWE6 - MTHFS_CAEEL

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Protein

Probable 5-formyltetrahydrofolate cyclo-ligase

Gene

Y106G6E.4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-CHO-H4PteGlu) to yield 5,10-methenyltetrahydrofolate (By similarity).By similarity

Catalytic activityi

ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate.

Cofactori

Magnesium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei12 – 121ATPBy similarity
Binding sitei54 – 541Substrate; via carbonyl oxygenBy similarity
Binding sitei59 – 591SubstrateBy similarity
Metal bindingi152 – 1521MagnesiumBy similarity
Metal bindingi188 – 1881MagnesiumBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 125ATPBy similarity
Nucleotide bindingi143 – 1519ATPBy similarity

GO - Molecular functioni

  1. 5-formyltetrahydrofolate cyclo-ligase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-formyltetrahydrofolate cyclo-ligase (EC:6.3.3.2)
Alternative name(s):
5,10-methenyl-tetrahydrofolate synthetase
Short name:
MTHFS
Short name:
Methenyl-THF synthetase
Gene namesi
ORF Names:Y106G6E.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiY106G6E.4; CE20408; WBGene00013708.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Probable 5-formyltetrahydrofolate cyclo-ligasePRO_0000200278Add
BLAST

Proteomic databases

PaxDbiQ9XWE6.
PRIDEiQ9XWE6.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi6239.Y106G6E.4.

Structurei

3D structure databases

ProteinModelPortaliQ9XWE6.
SMRiQ9XWE6. Positions 2-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni146 – 1505Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0212.
GeneTreeiENSGT00390000017791.
HOGENOMiHOG000007299.
InParanoidiQ9XWE6.
KOiK01934.
OMAiSCYLSMP.
OrthoDBiEOG73806H.
PhylomeDBiQ9XWE6.

Family and domain databases

Gene3Di3.40.50.10420. 1 hit.
InterProiIPR002698. FTHF_cligase.
IPR024185. FTHF_cligase-like.
[Graphical view]
PANTHERiPTHR23407:SF1. PTHR23407:SF1. 1 hit.
PfamiPF01812. 5-FTHF_cyc-lig. 1 hit.
[Graphical view]
PIRSFiPIRSF006806. FTHF_cligase. 1 hit.
TIGRFAMsiTIGR02727. MTHFS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9XWE6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAIKEVKSE LRQFMKTLLG KISKEETQRQ TEAVFEKIIE SKWFQESKRL
60 70 80 90 100
SVYVSTSGEI QTDSIIQKAL EMGKEVFIPQ FTKGSTAMDM VRVPDQTAFD
110 120 130 140 150
NLPSTLWGIR QPEPKWKWQS YHETGPLDLI LAPGVAFSPY GLRCGHGKGY
160 170 180 190 200
YDRFFSTHHK HFPENSPKKI GLALREQIIG TIPISETDVE LDEVIYEGET

IIFDTI
Length:206
Mass (Da):23,561
Last modified:November 1, 1999 - v1
Checksum:iCAA2EF7A31F13039
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL032656 Genomic DNA. Translation: CAA21728.1.
PIRiT26418.
RefSeqiNP_492692.1. NM_060291.5.
UniGeneiCel.8713.

Genome annotation databases

EnsemblMetazoaiY106G6E.4; Y106G6E.4; WBGene00013708.
GeneIDi190922.
KEGGicel:CELE_Y106G6E.4.
UCSCiY106G6E.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL032656 Genomic DNA. Translation: CAA21728.1 .
PIRi T26418.
RefSeqi NP_492692.1. NM_060291.5.
UniGenei Cel.8713.

3D structure databases

ProteinModelPortali Q9XWE6.
SMRi Q9XWE6. Positions 2-197.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.Y106G6E.4.

Proteomic databases

PaxDbi Q9XWE6.
PRIDEi Q9XWE6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y106G6E.4 ; Y106G6E.4 ; WBGene00013708 .
GeneIDi 190922.
KEGGi cel:CELE_Y106G6E.4.
UCSCi Y106G6E.4. c. elegans.

Organism-specific databases

CTDi 190922.
WormBasei Y106G6E.4 ; CE20408 ; WBGene00013708 .

Phylogenomic databases

eggNOGi COG0212.
GeneTreei ENSGT00390000017791.
HOGENOMi HOG000007299.
InParanoidi Q9XWE6.
KOi K01934.
OMAi SCYLSMP.
OrthoDBi EOG73806H.
PhylomeDBi Q9XWE6.

Miscellaneous databases

NextBioi 947390.
PROi Q9XWE6.

Family and domain databases

Gene3Di 3.40.50.10420. 1 hit.
InterProi IPR002698. FTHF_cligase.
IPR024185. FTHF_cligase-like.
[Graphical view ]
PANTHERi PTHR23407:SF1. PTHR23407:SF1. 1 hit.
Pfami PF01812. 5-FTHF_cyc-lig. 1 hit.
[Graphical view ]
PIRSFi PIRSF006806. FTHF_cligase. 1 hit.
TIGRFAMsi TIGR02727. MTHFS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiMTHFS_CAEEL
AccessioniPrimary (citable) accession number: Q9XWE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3