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Q9XWE6

- MTHFS_CAEEL

UniProt

Q9XWE6 - MTHFS_CAEEL

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Protein
Probable 5-formyltetrahydrofolate cyclo-ligase
Gene
Y106G6E.4
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei59 – 591Substrate By similarity
Binding sitei107 – 1071Substrate By similarity
Binding sitei188 – 1881ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 125ATP By similarity
Nucleotide bindingi145 – 1528ATP By similarity

GO - Molecular functioni

  1. 5-formyltetrahydrofolate cyclo-ligase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 5-formyltetrahydrofolate cyclo-ligase (EC:6.3.3.2)
Alternative name(s):
5,10-methenyl-tetrahydrofolate synthetase
Short name:
MTHFS
Short name:
Methenyl-THF synthetase
Gene namesi
ORF Names:Y106G6E.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome I

Organism-specific databases

WormBaseiY106G6E.4; CE20408; WBGene00013708.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 206206Probable 5-formyltetrahydrofolate cyclo-ligase
PRO_0000200278Add
BLAST

Proteomic databases

PaxDbiQ9XWE6.
PRIDEiQ9XWE6.

Interactioni

Protein-protein interaction databases

STRINGi6239.Y106G6E.4.

Structurei

3D structure databases

ProteinModelPortaliQ9XWE6.
SMRiQ9XWE6. Positions 2-197.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni146 – 1505Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0212.
GeneTreeiENSGT00390000017791.
HOGENOMiHOG000007299.
InParanoidiQ9XWE6.
KOiK01934.
OMAiSCYLSMP.
OrthoDBiEOG73806H.
PhylomeDBiQ9XWE6.

Family and domain databases

Gene3Di3.40.50.10420. 1 hit.
InterProiIPR002698. FTHF_cligase.
IPR024185. FTHF_cligase-like.
[Graphical view]
PANTHERiPTHR23407:SF1. PTHR23407:SF1. 1 hit.
PfamiPF01812. 5-FTHF_cyc-lig. 1 hit.
[Graphical view]
PIRSFiPIRSF006806. FTHF_cligase. 1 hit.
TIGRFAMsiTIGR02727. MTHFS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9XWE6-1 [UniParc]FASTAAdd to Basket

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MSAIKEVKSE LRQFMKTLLG KISKEETQRQ TEAVFEKIIE SKWFQESKRL    50
SVYVSTSGEI QTDSIIQKAL EMGKEVFIPQ FTKGSTAMDM VRVPDQTAFD 100
NLPSTLWGIR QPEPKWKWQS YHETGPLDLI LAPGVAFSPY GLRCGHGKGY 150
YDRFFSTHHK HFPENSPKKI GLALREQIIG TIPISETDVE LDEVIYEGET 200
IIFDTI 206
Length:206
Mass (Da):23,561
Last modified:November 1, 1999 - v1
Checksum:iCAA2EF7A31F13039
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL032656 Genomic DNA. Translation: CAA21728.1.
PIRiT26418.
RefSeqiNP_492692.1. NM_060291.5.
UniGeneiCel.8713.

Genome annotation databases

EnsemblMetazoaiY106G6E.4; Y106G6E.4; WBGene00013708.
GeneIDi190922.
KEGGicel:CELE_Y106G6E.4.
UCSCiY106G6E.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL032656 Genomic DNA. Translation: CAA21728.1 .
PIRi T26418.
RefSeqi NP_492692.1. NM_060291.5.
UniGenei Cel.8713.

3D structure databases

ProteinModelPortali Q9XWE6.
SMRi Q9XWE6. Positions 2-197.
ModBasei Search...

Protein-protein interaction databases

STRINGi 6239.Y106G6E.4.

Proteomic databases

PaxDbi Q9XWE6.
PRIDEi Q9XWE6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y106G6E.4 ; Y106G6E.4 ; WBGene00013708 .
GeneIDi 190922.
KEGGi cel:CELE_Y106G6E.4.
UCSCi Y106G6E.4. c. elegans.

Organism-specific databases

CTDi 190922.
WormBasei Y106G6E.4 ; CE20408 ; WBGene00013708 .

Phylogenomic databases

eggNOGi COG0212.
GeneTreei ENSGT00390000017791.
HOGENOMi HOG000007299.
InParanoidi Q9XWE6.
KOi K01934.
OMAi SCYLSMP.
OrthoDBi EOG73806H.
PhylomeDBi Q9XWE6.

Miscellaneous databases

NextBioi 947390.
PROi Q9XWE6.

Family and domain databases

Gene3Di 3.40.50.10420. 1 hit.
InterProi IPR002698. FTHF_cligase.
IPR024185. FTHF_cligase-like.
[Graphical view ]
PANTHERi PTHR23407:SF1. PTHR23407:SF1. 1 hit.
Pfami PF01812. 5-FTHF_cyc-lig. 1 hit.
[Graphical view ]
PIRSFi PIRSF006806. FTHF_cligase. 1 hit.
TIGRFAMsi TIGR02727. MTHFS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiMTHFS_CAEEL
AccessioniPrimary (citable) accession number: Q9XWE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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