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Q9XWE6

- MTHFS_CAEEL

UniProt

Q9XWE6 - MTHFS_CAEEL

Protein

Probable 5-formyltetrahydrofolate cyclo-ligase

Gene

Y106G6E.4

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-CHO-H4PteGlu) to yield 5,10-methenyltetrahydrofolate By similarity.By similarity

    Catalytic activityi

    ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate.

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei12 – 121ATPBy similarity
    Binding sitei54 – 541Substrate; via carbonyl oxygenBy similarity
    Binding sitei59 – 591SubstrateBy similarity
    Metal bindingi152 – 1521MagnesiumBy similarity
    Metal bindingi188 – 1881MagnesiumBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 125ATPBy similarity
    Nucleotide bindingi143 – 1519ATPBy similarity

    GO - Molecular functioni

    1. 5-formyltetrahydrofolate cyclo-ligase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 5-formyltetrahydrofolate cyclo-ligase (EC:6.3.3.2)
    Alternative name(s):
    5,10-methenyl-tetrahydrofolate synthetase
    Short name:
    MTHFS
    Short name:
    Methenyl-THF synthetase
    Gene namesi
    ORF Names:Y106G6E.4
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome I

    Organism-specific databases

    WormBaseiY106G6E.4; CE20408; WBGene00013708.

    Subcellular locationi

    Cytoplasm By similarity

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 206206Probable 5-formyltetrahydrofolate cyclo-ligasePRO_0000200278Add
    BLAST

    Proteomic databases

    PaxDbiQ9XWE6.
    PRIDEiQ9XWE6.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi6239.Y106G6E.4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XWE6.
    SMRiQ9XWE6. Positions 2-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni146 – 1505Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0212.
    GeneTreeiENSGT00390000017791.
    HOGENOMiHOG000007299.
    InParanoidiQ9XWE6.
    KOiK01934.
    OMAiSCYLSMP.
    OrthoDBiEOG73806H.
    PhylomeDBiQ9XWE6.

    Family and domain databases

    Gene3Di3.40.50.10420. 1 hit.
    InterProiIPR002698. FTHF_cligase.
    IPR024185. FTHF_cligase-like.
    [Graphical view]
    PANTHERiPTHR23407:SF1. PTHR23407:SF1. 1 hit.
    PfamiPF01812. 5-FTHF_cyc-lig. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006806. FTHF_cligase. 1 hit.
    TIGRFAMsiTIGR02727. MTHFS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9XWE6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAIKEVKSE LRQFMKTLLG KISKEETQRQ TEAVFEKIIE SKWFQESKRL    50
    SVYVSTSGEI QTDSIIQKAL EMGKEVFIPQ FTKGSTAMDM VRVPDQTAFD 100
    NLPSTLWGIR QPEPKWKWQS YHETGPLDLI LAPGVAFSPY GLRCGHGKGY 150
    YDRFFSTHHK HFPENSPKKI GLALREQIIG TIPISETDVE LDEVIYEGET 200
    IIFDTI 206
    Length:206
    Mass (Da):23,561
    Last modified:November 1, 1999 - v1
    Checksum:iCAA2EF7A31F13039
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL032656 Genomic DNA. Translation: CAA21728.1.
    PIRiT26418.
    RefSeqiNP_492692.1. NM_060291.5.
    UniGeneiCel.8713.

    Genome annotation databases

    EnsemblMetazoaiY106G6E.4; Y106G6E.4; WBGene00013708.
    GeneIDi190922.
    KEGGicel:CELE_Y106G6E.4.
    UCSCiY106G6E.4. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL032656 Genomic DNA. Translation: CAA21728.1 .
    PIRi T26418.
    RefSeqi NP_492692.1. NM_060291.5.
    UniGenei Cel.8713.

    3D structure databases

    ProteinModelPortali Q9XWE6.
    SMRi Q9XWE6. Positions 2-197.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.Y106G6E.4.

    Proteomic databases

    PaxDbi Q9XWE6.
    PRIDEi Q9XWE6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y106G6E.4 ; Y106G6E.4 ; WBGene00013708 .
    GeneIDi 190922.
    KEGGi cel:CELE_Y106G6E.4.
    UCSCi Y106G6E.4. c. elegans.

    Organism-specific databases

    CTDi 190922.
    WormBasei Y106G6E.4 ; CE20408 ; WBGene00013708 .

    Phylogenomic databases

    eggNOGi COG0212.
    GeneTreei ENSGT00390000017791.
    HOGENOMi HOG000007299.
    InParanoidi Q9XWE6.
    KOi K01934.
    OMAi SCYLSMP.
    OrthoDBi EOG73806H.
    PhylomeDBi Q9XWE6.

    Miscellaneous databases

    NextBioi 947390.
    PROi Q9XWE6.

    Family and domain databases

    Gene3Di 3.40.50.10420. 1 hit.
    InterProi IPR002698. FTHF_cligase.
    IPR024185. FTHF_cligase-like.
    [Graphical view ]
    PANTHERi PTHR23407:SF1. PTHR23407:SF1. 1 hit.
    Pfami PF01812. 5-FTHF_cyc-lig. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006806. FTHF_cligase. 1 hit.
    TIGRFAMsi TIGR02727. MTHFS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiMTHFS_CAEEL
    AccessioniPrimary (citable) accession number: Q9XWE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3