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Q9XW79

- PP4C1_CAEEL

UniProt

Q9XW79 - PP4C1_CAEEL

Protein

Serine/threonine-protein phosphatase 4 catalytic subunit 1

Gene

pph-4.1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Protein phosphatase which is essential for embryogenesis. Is required for centrosome maturation and is involved in gametogenesis. Required for meiotic spindle formation during spermatogenesis and for chiasmata formation during oogenesis. However, is apparently dispensable for female meiotic divisions, which do not depend on centrosomes.1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi79 – 791Manganese 1By similarity
    Metal bindingi81 – 811Manganese 1By similarity
    Metal bindingi107 – 1071Manganese 1By similarity
    Metal bindingi107 – 1071Manganese 2By similarity
    Metal bindingi139 – 1391Manganese 2By similarity
    Active sitei140 – 1401Proton donorBy similarity
    Metal bindingi189 – 1891Manganese 2By similarity
    Metal bindingi264 – 2641Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW
    3. protein binding Source: IntAct

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    SignaLinkiQ9XW79.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 4 catalytic subunit 1 (EC:3.1.3.16)
    Short name:
    PP4C-1
    Gene namesi
    Name:pph-4.1
    ORF Names:Y75B8A.30
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiY75B8A.30; CE23041; WBGene00004085; pph-4.1.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication
    Note: Localizes at centrosomes from prophase to telophase but dot during interphase. Locolaized to cytoplasm throughout the cell cycle.

    GO - Cellular componenti

    1. centrosome Source: WormBase
    2. cytoplasm Source: WormBase

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333Serine/threonine-protein phosphatase 4 catalytic subunit 1PRO_0000353210Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei333 – 3331Leucine methyl esterBy similarity

    Post-translational modificationi

    Reversibly methyl esterified on Leu-333 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization By similarity.By similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    PaxDbiQ9XW79.
    PRIDEiQ9XW79.

    Interactioni

    Subunit structurei

    Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ppfr-4Q9N4E93EBI-331742,EBI-331766

    Protein-protein interaction databases

    BioGridi41836. 8 interactions.
    DIPiDIP-24807N.
    IntActiQ9XW79. 7 interactions.
    MINTiMINT-1045242.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XW79.
    SMRiQ9XW79. Positions 29-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0639.
    GeneTreeiENSGT00550000074618.
    HOGENOMiHOG000172696.
    InParanoidiQ9XW79.
    KOiK15423.
    OMAiVFNHRND.
    OrthoDBiEOG74N5H2.
    PhylomeDBiQ9XW79.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9XW79-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALACTDSAN STFSRVDSPT SGPSDQLTTH DLDRHIEKLM RCELIAEQDV    50
    KTLCAKAREI LAEEGNVQVI DSPVTICGDI HGQFYDLMEL FKVGGPVPNT 100
    NYLFLGDFVD RGFYSVETFL LLLALKARYP DRMMLIRGNH ESRQITQVYG 150
    FYDECLRKYG NASVWKHCTE VFDYLSLAAV IDGKVFCVHG GLSPSISTMD 200
    QIRVIDRKQE VPHDGPMCDL LWSDPEEGNV GWGLSPRGAG YLFGADASKT 250
    FCETNGVDLI CRAHQLVMEG YKWHFNEKVL TVWSAPNYCY RCGNVAAILE 300
    LDENLNKEFT IFEAAPQENR GAPAKKPHAD YFL 333
    Length:333
    Mass (Da):37,359
    Last modified:November 1, 1999 - v1
    Checksum:i7C7EA2177E45AA52
    GO

    Sequence cautioni

    The sequence BAB63947.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070573 mRNA. Translation: BAB63947.1. Different initiation.
    AL033514 Genomic DNA. Translation: CAA22090.1.
    PIRiT27390.
    RefSeqiNP_499603.1. NM_067202.5.
    UniGeneiCel.19352.

    Genome annotation databases

    EnsemblMetazoaiY75B8A.30; Y75B8A.30; WBGene00004085.
    GeneIDi176657.
    KEGGicel:CELE_Y75B8A.30.
    UCSCiY75B8A.30. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070573 mRNA. Translation: BAB63947.1 . Different initiation.
    AL033514 Genomic DNA. Translation: CAA22090.1 .
    PIRi T27390.
    RefSeqi NP_499603.1. NM_067202.5.
    UniGenei Cel.19352.

    3D structure databases

    ProteinModelPortali Q9XW79.
    SMRi Q9XW79. Positions 29-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 41836. 8 interactions.
    DIPi DIP-24807N.
    IntActi Q9XW79. 7 interactions.
    MINTi MINT-1045242.

    Proteomic databases

    PaxDbi Q9XW79.
    PRIDEi Q9XW79.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y75B8A.30 ; Y75B8A.30 ; WBGene00004085 .
    GeneIDi 176657.
    KEGGi cel:CELE_Y75B8A.30.
    UCSCi Y75B8A.30. c. elegans.

    Organism-specific databases

    CTDi 176657.
    WormBasei Y75B8A.30 ; CE23041 ; WBGene00004085 ; pph-4.1.

    Phylogenomic databases

    eggNOGi COG0639.
    GeneTreei ENSGT00550000074618.
    HOGENOMi HOG000172696.
    InParanoidi Q9XW79.
    KOi K15423.
    OMAi VFNHRND.
    OrthoDBi EOG74N5H2.
    PhylomeDBi Q9XW79.

    Enzyme and pathway databases

    SignaLinki Q9XW79.

    Miscellaneous databases

    NextBioi 893488.
    PROi Q9XW79.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans."
      Sumiyoshi E., Sugimoto A., Yamamoto M.
      J. Cell Sci. 115:1403-1410(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPP4C1_CAEEL
    AccessioniPrimary (citable) accession number: Q9XW79
    Secondary accession number(s): Q966Q4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 4, 2008
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3