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Q9XW79

- PP4C1_CAEEL

UniProt

Q9XW79 - PP4C1_CAEEL

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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit 1

Gene
pph-4.1, Y75B8A.30
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Protein phosphatase which is essential for embryogenesis. Is required for centrosome maturation and is involved in gametogenesis. Required for meiotic spindle formation during spermatogenesis and for chiasmata formation during oogenesis. However, is apparently dispensable for female meiotic divisions, which do not depend on centrosomes.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Manganese 1 By similarity
Metal bindingi81 – 811Manganese 1 By similarity
Metal bindingi107 – 1071Manganese 1 By similarity
Metal bindingi107 – 1071Manganese 2 By similarity
Metal bindingi139 – 1391Manganese 2 By similarity
Active sitei140 – 1401Proton donor By similarity
Metal bindingi189 – 1891Manganese 2 By similarity
Metal bindingi264 – 2641Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
  3. protein binding Source: IntAct
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

SignaLinkiQ9XW79.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit 1 (EC:3.1.3.16)
Short name:
PP4C-1
Gene namesi
Name:pph-4.1
ORF Names:Y75B8A.30
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiY75B8A.30; CE23041; WBGene00004085; pph-4.1.

Subcellular locationi

Cytoplasm. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome
Note: Localizes at centrosomes from prophase to telophase but dot during interphase. Locolaized to cytoplasm throughout the cell cycle.1 Publication

GO - Cellular componenti

  1. centrosome Source: WormBase
  2. cytoplasm Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Serine/threonine-protein phosphatase 4 catalytic subunit 1PRO_0000353210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei333 – 3331Leucine methyl ester By similarity

Post-translational modificationi

Reversibly methyl esterified on Leu-333 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization By similarity.

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ9XW79.
PRIDEiQ9XW79.

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
ppfr-4Q9N4E93EBI-331742,EBI-331766

Protein-protein interaction databases

BioGridi41836. 8 interactions.
DIPiDIP-24807N.
IntActiQ9XW79. 7 interactions.
MINTiMINT-1045242.

Structurei

3D structure databases

ProteinModelPortaliQ9XW79.
SMRiQ9XW79. Positions 29-316.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00550000074618.
HOGENOMiHOG000172696.
InParanoidiQ9XW79.
KOiK15423.
OMAiVFNHRND.
OrthoDBiEOG74N5H2.
PhylomeDBiQ9XW79.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XW79-1 [UniParc]FASTAAdd to Basket

« Hide

MALACTDSAN STFSRVDSPT SGPSDQLTTH DLDRHIEKLM RCELIAEQDV    50
KTLCAKAREI LAEEGNVQVI DSPVTICGDI HGQFYDLMEL FKVGGPVPNT 100
NYLFLGDFVD RGFYSVETFL LLLALKARYP DRMMLIRGNH ESRQITQVYG 150
FYDECLRKYG NASVWKHCTE VFDYLSLAAV IDGKVFCVHG GLSPSISTMD 200
QIRVIDRKQE VPHDGPMCDL LWSDPEEGNV GWGLSPRGAG YLFGADASKT 250
FCETNGVDLI CRAHQLVMEG YKWHFNEKVL TVWSAPNYCY RCGNVAAILE 300
LDENLNKEFT IFEAAPQENR GAPAKKPHAD YFL 333
Length:333
Mass (Da):37,359
Last modified:November 1, 1999 - v1
Checksum:i7C7EA2177E45AA52
GO

Sequence cautioni

The sequence BAB63947.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB070573 mRNA. Translation: BAB63947.1. Different initiation.
AL033514 Genomic DNA. Translation: CAA22090.1.
PIRiT27390.
RefSeqiNP_499603.1. NM_067202.5.
UniGeneiCel.19352.

Genome annotation databases

EnsemblMetazoaiY75B8A.30; Y75B8A.30; WBGene00004085.
GeneIDi176657.
KEGGicel:CELE_Y75B8A.30.
UCSCiY75B8A.30. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB070573 mRNA. Translation: BAB63947.1 . Different initiation.
AL033514 Genomic DNA. Translation: CAA22090.1 .
PIRi T27390.
RefSeqi NP_499603.1. NM_067202.5.
UniGenei Cel.19352.

3D structure databases

ProteinModelPortali Q9XW79.
SMRi Q9XW79. Positions 29-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 41836. 8 interactions.
DIPi DIP-24807N.
IntActi Q9XW79. 7 interactions.
MINTi MINT-1045242.

Proteomic databases

PaxDbi Q9XW79.
PRIDEi Q9XW79.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y75B8A.30 ; Y75B8A.30 ; WBGene00004085 .
GeneIDi 176657.
KEGGi cel:CELE_Y75B8A.30.
UCSCi Y75B8A.30. c. elegans.

Organism-specific databases

CTDi 176657.
WormBasei Y75B8A.30 ; CE23041 ; WBGene00004085 ; pph-4.1.

Phylogenomic databases

eggNOGi COG0639.
GeneTreei ENSGT00550000074618.
HOGENOMi HOG000172696.
InParanoidi Q9XW79.
KOi K15423.
OMAi VFNHRND.
OrthoDBi EOG74N5H2.
PhylomeDBi Q9XW79.

Enzyme and pathway databases

SignaLinki Q9XW79.

Miscellaneous databases

NextBioi 893488.
PROi Q9XW79.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans."
    Sumiyoshi E., Sugimoto A., Yamamoto M.
    J. Cell Sci. 115:1403-1410(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPP4C1_CAEEL
AccessioniPrimary (citable) accession number: Q9XW79
Secondary accession number(s): Q966Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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