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Protein
Submitted name:

AQuaPorin or aquaglyceroporin related

Gene

aqp-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • glycerol channel activity Source: GO_Central
  • substrate-specific channel activity Source: WormBase
  • urea transmembrane transporter activity Source: GO_Central
  • water channel activity Source: WormBase

GO - Biological processi

  • cellular water homeostasis Source: GO_Central
  • glycerol transport Source: WormBase
  • ion transmembrane transport Source: GO_Central
  • urea transmembrane transport Source: GO_Central
  • water transport Source: WormBase
Complete GO annotation...

Keywords - Biological processi

TransportUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-CEL-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-CEL-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Submitted name:
AQuaPorin or aquaglyceroporin relatedImported
Gene namesi
Name:aqp-3Imported
ORF Names:CELE_Y69E1A.7Imported, Y69E1A.7Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiY69E1A.7a; CE22814; WBGene00000171; aqp-3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei118 – 135HelicalSequence analysisAdd BLAST18
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei196 – 224HelicalSequence analysisAdd BLAST29
Transmembranei258 – 277HelicalSequence analysisAdd BLAST20
Transmembranei289 – 311HelicalSequence analysisAdd BLAST23
Transmembranei340 – 359HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9XW36.
PeptideAtlasiQ9XW36.

Expressioni

Gene expression databases

BgeeiWBGene00000171.
ExpressionAtlasiQ9XW36. differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.Y69E1A.7.

Structurei

3D structure databases

ProteinModelPortaliQ9XW36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
InParanoidiQ9XW36.
OMAiFGQYISI.
OrthoDBiEOG091G0FMS.
PhylomeDBiQ9XW36.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XW36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSDSSCSSS DRSFKFPFDT TDALSIHELA VKDLPKPDAE NPFSVAMHSP
60 70 80 90 100
PGSPPFAVDR KSVDNSVVAV TDTPFEFAPS QKSSQHTNRP PPFVKPEEEM
110 120 130 140 150
MYINHVERLK PKFAIGNELI RAFLAELFCT GFLVFGGECV NAQYVLSQGK
160 170 180 190 200
NNEWIGISVG WGLVLMLAVL MGSKISGAHL NPAVSFFQLT QGKINLIRFL
210 220 230 240 250
VYAVAQNIGA FLGAFGVFCV YYDAINVFEG GNRTVTGPTA TASIFATYPG
260 270 280 290 300
PFLGTFNAIV DQIAGTLVLC LGVAAITDRR NGIPAFLQPA WIGALLAFLG
310 320 330 340 350
MSLALNAGYA INPARDFAPR LFNLCAGYGW EVFSYRNYKW FWIPIICPMI
360 370 380 390 400
GGVLGAWLYE FFIGFHIQDE DAVSLDSESD KQLKTMIDNM VDIENQLPEY
410 420
TDKKQLSDIA SIHQNPSLRN I
Length:421
Mass (Da):46,231
Last modified:November 1, 1999 - v1
Checksum:i4AE77212C5F44FAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAA22259.1.
PIRiT27311.
RefSeqiNP_502044.1. NM_069643.1.
UniGeneiCel.28392.

Genome annotation databases

EnsemblMetazoaiY69E1A.7a; Y69E1A.7a; WBGene00000171.
GeneIDi190553.
UCSCiY69E1A.7. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA. Translation: CAA22259.1.
PIRiT27311.
RefSeqiNP_502044.1. NM_069643.1.
UniGeneiCel.28392.

3D structure databases

ProteinModelPortaliQ9XW36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y69E1A.7.

Proteomic databases

PaxDbiQ9XW36.
PeptideAtlasiQ9XW36.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY69E1A.7a; Y69E1A.7a; WBGene00000171.
GeneIDi190553.
UCSCiY69E1A.7. c. elegans.

Organism-specific databases

CTDi190553.
WormBaseiY69E1A.7a; CE22814; WBGene00000171; aqp-3.

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00510000046311.
HOGENOMiHOG000288287.
InParanoidiQ9XW36.
OMAiFGQYISI.
OrthoDBiEOG091G0FMS.
PhylomeDBiQ9XW36.

Enzyme and pathway databases

ReactomeiR-CEL-432030. Transport of glycerol from adipocytes to the liver by Aquaporins.
R-CEL-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-CEL-432047. Passive transport by Aquaporins.

Gene expression databases

BgeeiWBGene00000171.
ExpressionAtlasiQ9XW36. differential.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9XW36_CAEEL
AccessioniPrimary (citable) accession number: Q9XW36
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.