Reviewed, UniProtKB/Swiss-Prot Q9XVV3 (NHR67_CAEEL)

Names and origin

Protein names

Recommended name:
    Nuclear hormone receptor family member nhr-67

Gene names

Name:	nhr-67
ORF Names:	C08F8.8

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Orphan nuclear receptor.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the nuclear hormone receptor family. Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Receptor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	determination of adult life span Inferred from mutant phenotype. Source: WormBase hermaphrodite genitalia development Inferred from mutant phenotype. Source: WormBase locomotion Inferred from mutant phenotype. Source: WormBase positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase positive regulation of multicellular organism growth Inferred from mutant phenotype. Source: WormBase regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	O45622	1	EBI-314697,EBI-314704
	Q9N5S5	1	EBI-314697,EBI-314326
daf-21	Q18688	1	EBI-314697,EBI-313329
nhr-2	Q10902	1	EBI-314697,EBI-312197
pal-1	P34766	1	EBI-314697,EBI-311911
unc-37	O02482	1	EBI-314697,EBI-314716

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Nuclear hormone receptor family member nhr-67		PRO_0000053794
Regions
	DNA binding	18 – 98	81	Nuclear receptor
	Zinc finger	21 – 41	21	NR C4-type
	Zinc finger	57 – 86	30	NR C4-type

Sequences

	Sequence		Length	Mass (Da)
	Q9XVV3-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 4BC549E9C26BEA28	FASTA	416	46,771
	10 20 30 40 50 60 MMTAVSQMSV PSSRILLDVD CRVCEDHSSG KHYSIFSCDG CAGFFKRSIR RHRQYVCKNK 70 80 90 100 110 120 GSPSEGQCKV DKTHRNQCRA CRLRKCLEIG MNKDAVQHER GPRNSSLRRQ QMMFDHGSSP 130 140 150 160 170 180 NSPEMGSESD AIILPTSSMN RDTVAGTAAR IFFALVGFCQ NPLNGVPKER QMTMFQQNWA 190 200 210 220 230 240 ALLVLHATET RAITSKQIRT ETISGSSEQR NAVANAFEII ERLQLDNREY MMLKHFTMWR 250 260 270 280 290 300 DTPSAIQIVF QLASIQNFTH RTEPTRYIQC INAIAAIPTT SIIDVLFRPS IGSASMPRLI 310 320 330 340 350 360 QDMFKPPQQP TPTSLFPMAN FNLNFLLKQE KTETEEGEDI EEEDDATSSN QFDENSSTDD 370 380 390 400 410 RSVGELDPVQ LFLALNSSTQ PSSASSPSSS RPRHSIRSIT ELLSIQEEES VNVEEV

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z73103 Genomic DNA. Translation: CAA97428.1.
PIR	T19102.
RefSeq	NP_502094.1.
UniGene	Cel.12545
3D structure databases
HSSP	HSSP built from PDB template 1HCQ based on UniProtKB P03372.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:25535N.
IntAct	Q9XVV3. 7 interactions.
Genome annotation databases
Ensembl	C08F8.8. Caenorhabditis elegans. [Contig view]
GeneID	178024.
KEGG	cel:C08F8.8.
NMPDR	fig|6239.3.peg.15131.
Organism-specific databases
WormBase	WBGene00003657. nhr-67.
WormPep	C08F8.8. CE18491. [WorfDB]
Phylogenomic databases
OMA	Q9XVV3. RHSIRSI.
Gene expression databases
ArrayExpress	Q9XVV3.
Family and domain databases
InterPro	IPR000324. VitD_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
Pfam	PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00047. STROIDFINGER. PR00350. VITAMINDR.
ProDom	PD000035. Znf_C4steroid. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00399. ZnF_C4. 1 hit. [Graphical view]
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	899406.

Entry information

Entry name

NHR67_CAEEL

Accession

Primary (citable) accession number: Q9XVV3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project