Q9XVV3 (NHR67_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear hormone receptor family member nhr-67

Gene names

Name:	nhr-67
ORF Names:	C08F8.8

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Orphan nuclear receptor.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the nuclear hormone receptor family. Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell migration Inferred from mutant phenotype. Source: WormBase determination of adult lifespan Inferred from mutant phenotype. Source: WormBase gonad morphogenesis Inferred from mutant phenotype. Source: WormBase hermaphrodite genitalia development Inferred from mutant phenotype. Source: WormBase positive regulation of growth rate Inferred from mutant phenotype. Source: WormBase positive regulation of multicellular organism growth Inferred from mutant phenotype. Source: WormBase positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay. Source: WormBase transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding Inferred from direct assay. Source: WormBase sequence-specific DNA binding transcription factor activity Inferred from direct assay. Source: WormBase steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
unc-37	O02482	3	EBI-314697,EBI-314716

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Nuclear hormone receptor family member nhr-67		PRO_0000053794
Regions
	DNA binding	18 – 98	81	Nuclear receptor
	Zinc finger	21 – 41	21	NR C4-type
	Zinc finger	57 – 86	30	NR C4-type

Sequences

	Sequence		Length	Mass (Da)
	Q9XVV3 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 4BC549E9C26BEA28	FASTA	416	46,771
	10 20 30 40 50 60 MMTAVSQMSV PSSRILLDVD CRVCEDHSSG KHYSIFSCDG CAGFFKRSIR RHRQYVCKNK 70 80 90 100 110 120 GSPSEGQCKV DKTHRNQCRA CRLRKCLEIG MNKDAVQHER GPRNSSLRRQ QMMFDHGSSP 130 140 150 160 170 180 NSPEMGSESD AIILPTSSMN RDTVAGTAAR IFFALVGFCQ NPLNGVPKER QMTMFQQNWA 190 200 210 220 230 240 ALLVLHATET RAITSKQIRT ETISGSSEQR NAVANAFEII ERLQLDNREY MMLKHFTMWR 250 260 270 280 290 300 DTPSAIQIVF QLASIQNFTH RTEPTRYIQC INAIAAIPTT SIIDVLFRPS IGSASMPRLI 310 320 330 340 350 360 QDMFKPPQQP TPTSLFPMAN FNLNFLLKQE KTETEEGEDI EEEDDATSSN QFDENSSTDD 370 380 390 400 410 RSVGELDPVQ LFLALNSSTQ PSSASSPSSS RPRHSIRSIT ELLSIQEEES VNVEEV

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z73103 Genomic DNA. Translation: CAA97428.1.
PIR	T19102.
RefSeq	NP_502094.1. NM_069693.2.
UniGene	Cel.12545.
3D structure databases
ProteinModelPortal	Q9XVV3.
SMR	Q9XVV3. Positions 20-304.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-25535N.
IntAct	Q9XVV3. 6 interactions.
MINT	MINT-1049427.
STRING	Q9XVV3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	C08F8.8; C08F8.8; C08F8.8.
GeneID	178024.
KEGG	cel:C08F8.8.
NMPDR	fig|6239.3.peg.15131.
UCSC	C08F8.8. c. elegans.
Organism-specific databases
CTD	178024.
WormBase	C08F8.8; CE18491; WBGene00003657; nhr-67.
Phylogenomic databases
GeneTree	EMGT00050000002161.
HOGENOM	HBG713785.
InParanoid	Q9XVV3.
OMA	NSPEMGS.
PhylomeDB	Q9XVV3.
Gene expression databases
ArrayExpress	Q9XVV3.
Family and domain databases
InterPro	IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:1.10.565.10. Nucl_hrmn_rcpt_lig_bd. 1 hit. G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
KO	K08545.
Pfam	PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00047. STROIDFINGER.
SMART	SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	899406.

Entry information

Entry name

NHR67_CAEEL

Accession

Primary (citable) accession number: Q9XVV3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	November 1, 1999
Last modified:	December 14, 2011
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project