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Protein

Nuclear RNA export factor 2

Gene

nxf-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the export of cellular mRNA to the cytoplasm.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear RNA export factor 2
Gene namesi
Name:nxf-2
ORF Names:C15H11.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC15H11.6; CE36102; WBGene00003835; nxf-2.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Not localized at the nuclear rim.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Nuclear RNA export factor 2PRO_0000220537Add
BLAST

Proteomic databases

EPDiQ9XVS8.
PaxDbiQ9XVS8.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
nxt-1Q9U7575EBI-2007577,EBI-2006451

Protein-protein interaction databases

BioGridi44942. 1 interaction.
IntActiQ9XVS8. 2 interactions.
MINTiMINT-6670375.
STRINGi6239.C15H11.6.1.

Structurei

Secondary structure

1
421
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi226 – 24318Combined sources
Helixi248 – 2514Combined sources
Helixi252 – 2587Combined sources
Beta strandi261 – 2633Combined sources
Beta strandi265 – 2717Combined sources
Beta strandi276 – 2783Combined sources
Helixi285 – 2939Combined sources
Helixi298 – 3003Combined sources
Turni303 – 3064Combined sources
Helixi315 – 32511Combined sources
Beta strandi329 – 3313Combined sources
Helixi333 – 3353Combined sources
Beta strandi337 – 3437Combined sources
Beta strandi348 – 35811Combined sources
Helixi360 – 3634Combined sources
Beta strandi373 – 38311Combined sources
Beta strandi389 – 39911Combined sources
Helixi403 – 4119Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NV0X-ray1.84A218-421[»]
ProteinModelPortaliQ9XVS8.
SMRiQ9XVS8. Positions 35-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 9469RRMAdd
BLAST
Repeati95 – 11925LRR 1Add
BLAST
Repeati121 – 14525LRR 2Add
BLAST
Domaini231 – 398168NTF2PROSITE-ProRule annotationAdd
BLAST

Domaini

The RNA-binding domain is a non-canonical RNP-type domain.

Sequence similaritiesi

Belongs to the NXF family.Curated
Contains 2 LRR (leucine-rich) repeats.Curated
Contains 1 NTF2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG3763. Eukaryota.
ENOG410XR55. LUCA.
HOGENOMiHOG000017553.
InParanoidiQ9XVS8.
KOiK14284.
OrthoDBiEOG7QZGB9.
PhylomeDBiQ9XVS8.

Family and domain databases

Gene3Di3.10.450.50. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
IPR030217. NXF_fam.
[Graphical view]
PANTHERiPTHR10662. PTHR10662. 2 hits.
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF54427. SSF54427. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XVS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGQNRRGYR NIEGRLSLSS HSSHSSPRQT HVTNLRPAEI KVVQDVVDGC
60 70 80 90 100
YVATDDVLNL SNFSKNTEFV ERDMLMCLTK TRVMSVVLQH IGYKYPRISG
110 120 130 140 150
ISFSNNRLCH LDHLSSLSSI SKFLKFLDLS HNQVLKVFVF LNFITFFSKI
160 170 180 190 200
SSGEELKKLG TIPVETVFFE GNPVCEKFVQ CAEYANFIQK TFPKCSNLDG
210 220 230 240 250
MEVEPKPDHN RIEQIIPFRN GYYGSDEVRT LVEEFIITYY KIYDGADGQQ
260 270 280 290 300
TRKQLLDAYD TNNSTFTHTV VCLWDPIKFV MYPDSESYRM YLRTSHNVLN
310 320 330 340 350
QEYFAANRAS RISHGAMDIV VALSRLPATI HLMDTFVVDV FLVSATLLGF
360 370 380 390 400
TLHGTFRDGP SAIKPENTEE HDNYFTRTFM VAPRGEGKVA IVSDQLFISS
410 420
MSKRRGDQYR MLVETATDID Q
Length:421
Mass (Da):48,134
Last modified:November 1, 1999 - v1
Checksum:i3B0A8CCAD0FFD918
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81035 Genomic DNA. Translation: CAB02733.2.
PIRiT19315.
RefSeqiNP_506568.2. NM_074167.6.
UniGeneiCel.2933.

Genome annotation databases

GeneIDi179938.
KEGGicel:CELE_C15H11.6.
UCSCiC15H11.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81035 Genomic DNA. Translation: CAB02733.2.
PIRiT19315.
RefSeqiNP_506568.2. NM_074167.6.
UniGeneiCel.2933.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NV0X-ray1.84A218-421[»]
ProteinModelPortaliQ9XVS8.
SMRiQ9XVS8. Positions 35-412.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44942. 1 interaction.
IntActiQ9XVS8. 2 interactions.
MINTiMINT-6670375.
STRINGi6239.C15H11.6.1.

Proteomic databases

EPDiQ9XVS8.
PaxDbiQ9XVS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi179938.
KEGGicel:CELE_C15H11.6.
UCSCiC15H11.6.1. c. elegans.

Organism-specific databases

CTDi179938.
WormBaseiC15H11.6; CE36102; WBGene00003835; nxf-2.

Phylogenomic databases

eggNOGiKOG3763. Eukaryota.
ENOG410XR55. LUCA.
HOGENOMiHOG000017553.
InParanoidiQ9XVS8.
KOiK14284.
OrthoDBiEOG7QZGB9.
PhylomeDBiQ9XVS8.

Enzyme and pathway databases

ReactomeiR-CEL-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.

Miscellaneous databases

NextBioi907470.
PROiQ9XVS8.

Family and domain databases

Gene3Di3.10.450.50. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
IPR030217. NXF_fam.
[Graphical view]
PANTHERiPTHR10662. PTHR10662. 2 hits.
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF54427. SSF54427. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "A conserved family of nuclear export receptors mediates the exit of messenger RNA to the cytoplasm."
    Izaurralde E.
    Cell. Mol. Life Sci. 58:1105-1112(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiNXF2_CAEEL
AccessioniPrimary (citable) accession number: Q9XVS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.