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Protein

Nuclear RNA export factor 2

Gene

nxf-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the export of cellular mRNA to the cytoplasm.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear RNA export factor 2
Gene namesi
Name:nxf-2
ORF Names:C15H11.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC15H11.6; CE36102; WBGene00003835; nxf-2.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Not localized at the nuclear rim.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205371 – 421Nuclear RNA export factor 2Add BLAST421

Proteomic databases

EPDiQ9XVS8.
PaxDbiQ9XVS8.
PeptideAtlasiQ9XVS8.
PRIDEiQ9XVS8.

Expressioni

Gene expression databases

BgeeiWBGene00003835.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
nxt-1Q9U7575EBI-2007577,EBI-2006451

Protein-protein interaction databases

BioGridi44942. 1 interactor.
IntActiQ9XVS8. 2 interactors.
MINTiMINT-6670375.
STRINGi6239.C15H11.6.1.

Structurei

Secondary structure

1421
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi226 – 243Combined sources18
Helixi248 – 251Combined sources4
Helixi252 – 258Combined sources7
Beta strandi261 – 263Combined sources3
Beta strandi265 – 271Combined sources7
Beta strandi276 – 278Combined sources3
Helixi285 – 293Combined sources9
Helixi298 – 300Combined sources3
Turni303 – 306Combined sources4
Helixi315 – 325Combined sources11
Beta strandi329 – 331Combined sources3
Helixi333 – 335Combined sources3
Beta strandi337 – 343Combined sources7
Beta strandi348 – 358Combined sources11
Helixi360 – 363Combined sources4
Beta strandi373 – 383Combined sources11
Beta strandi389 – 399Combined sources11
Helixi403 – 411Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NV0X-ray1.84A218-421[»]
ProteinModelPortaliQ9XVS8.
SMRiQ9XVS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 94RRMAdd BLAST69
Repeati95 – 119LRR 1Add BLAST25
Repeati121 – 145LRR 2Add BLAST25
Domaini231 – 398NTF2PROSITE-ProRule annotationAdd BLAST168

Domaini

The RNA-binding domain is a non-canonical RNP-type domain.

Sequence similaritiesi

Belongs to the NXF family.Curated
Contains 2 LRR (leucine-rich) repeats.Curated
Contains 1 NTF2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG3763. Eukaryota.
ENOG410XR55. LUCA.
HOGENOMiHOG000017553.
InParanoidiQ9XVS8.
KOiK14284.
OrthoDBiEOG091G04QA.
PhylomeDBiQ9XVS8.

Family and domain databases

Gene3Di3.10.450.50. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
IPR030217. NXF_fam.
[Graphical view]
PANTHERiPTHR10662. PTHR10662. 2 hits.
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF54427. SSF54427. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XVS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGQNRRGYR NIEGRLSLSS HSSHSSPRQT HVTNLRPAEI KVVQDVVDGC
60 70 80 90 100
YVATDDVLNL SNFSKNTEFV ERDMLMCLTK TRVMSVVLQH IGYKYPRISG
110 120 130 140 150
ISFSNNRLCH LDHLSSLSSI SKFLKFLDLS HNQVLKVFVF LNFITFFSKI
160 170 180 190 200
SSGEELKKLG TIPVETVFFE GNPVCEKFVQ CAEYANFIQK TFPKCSNLDG
210 220 230 240 250
MEVEPKPDHN RIEQIIPFRN GYYGSDEVRT LVEEFIITYY KIYDGADGQQ
260 270 280 290 300
TRKQLLDAYD TNNSTFTHTV VCLWDPIKFV MYPDSESYRM YLRTSHNVLN
310 320 330 340 350
QEYFAANRAS RISHGAMDIV VALSRLPATI HLMDTFVVDV FLVSATLLGF
360 370 380 390 400
TLHGTFRDGP SAIKPENTEE HDNYFTRTFM VAPRGEGKVA IVSDQLFISS
410 420
MSKRRGDQYR MLVETATDID Q
Length:421
Mass (Da):48,134
Last modified:November 1, 1999 - v1
Checksum:i3B0A8CCAD0FFD918
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81035 Genomic DNA. Translation: CAB02733.2.
PIRiT19315.
RefSeqiNP_506568.2. NM_074167.6.
UniGeneiCel.2933.

Genome annotation databases

GeneIDi179938.
KEGGicel:CELE_C15H11.6.
UCSCiC15H11.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81035 Genomic DNA. Translation: CAB02733.2.
PIRiT19315.
RefSeqiNP_506568.2. NM_074167.6.
UniGeneiCel.2933.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NV0X-ray1.84A218-421[»]
ProteinModelPortaliQ9XVS8.
SMRiQ9XVS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44942. 1 interactor.
IntActiQ9XVS8. 2 interactors.
MINTiMINT-6670375.
STRINGi6239.C15H11.6.1.

Proteomic databases

EPDiQ9XVS8.
PaxDbiQ9XVS8.
PeptideAtlasiQ9XVS8.
PRIDEiQ9XVS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi179938.
KEGGicel:CELE_C15H11.6.
UCSCiC15H11.6.1. c. elegans.

Organism-specific databases

CTDi179938.
WormBaseiC15H11.6; CE36102; WBGene00003835; nxf-2.

Phylogenomic databases

eggNOGiKOG3763. Eukaryota.
ENOG410XR55. LUCA.
HOGENOMiHOG000017553.
InParanoidiQ9XVS8.
KOiK14284.
OrthoDBiEOG091G04QA.
PhylomeDBiQ9XVS8.

Enzyme and pathway databases

ReactomeiR-CEL-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.

Miscellaneous databases

PROiQ9XVS8.

Gene expression databases

BgeeiWBGene00003835.

Family and domain databases

Gene3Di3.10.450.50. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
IPR030217. NXF_fam.
[Graphical view]
PANTHERiPTHR10662. PTHR10662. 2 hits.
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF54427. SSF54427. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNXF2_CAEEL
AccessioniPrimary (citable) accession number: Q9XVS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.