Reviewed, UniProtKB/Swiss-Prot Q9XVN3 (IASPP_CAEEL)

Names and origin

Protein names

Recommended name:
    Apoptotic enhancer 1 protein
Alternative name(s):
    Inhibitor member of the ASPP family
      Short name=Protein iASPP
    Ce-iASPP

Gene names

Name:	ape-1
ORF Names:	F46F3.4

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	769 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Inhibitor of cep-1, which prevents the activation of apoptosis. Ref.2
Subunit structure	Interacts with cep-1/p53. Ref.2
Subcellular location	Nucleus.
Sequence similarities	Belongs to the ASPP family. Contains 2 ANK repeats. Contains 1 SH3 domain.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Nucleus
Disease	Proto-oncogene
Domain	ANK repeat Repeat SH3 domain
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 769	769	Apoptotic enhancer 1 protein		PRO_0000066968
Regions
	Repeat	585 – 617	33	ANK 1
	Repeat	618 – 652	35	ANK 2
	Domain	684 – 746	63	SH3
	Compositional bias	76 – 81	6	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	Q9XVN3-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: B3CBE638180762AB	FASTA	769	85,436
	10 20 30 40 50 60 MVTTSSGGGI GYPANNGVTQ VSLIHSSDSV RTVSTAPIYR PTSSMASTMA HKSSTAPFIS 70 80 90 100 110 120 ANQRMSKPPV RVVAQPPPPH PQALSQQYHQ QNPMMMYSAP NTRPHVIPTM QVQPTMAAQI 130 140 150 160 170 180 KRNNPVNAQF QNPSEMIADY GVKPQSVEMV QRVRAVRRQV ADEETELRRL RELEHETAQL 190 200 210 220 230 240 QNKNYGRERE LNVQGSMLKE AQLELRNASM RAQSLNKHLE EMYRRRQTAA AAALVEQRKM 250 260 270 280 290 300 QQHQILLARA ANQVSTQEVI RPRASVEPFQ VNNTQQQQPS PQMMKSEEFS EKRDLNGQTG 310 320 330 340 350 360 SYDAIDGSGD HQKIPTEPSY LAPCKENQQK YSELSKMAST DPHSNHSSPS TSSQKAPTLI 370 380 390 400 410 420 TFSPPSFEQK INSSTMTRDS PFVERPTSFG DSLDESRLRS GKTDLVSLRS DSLKATKRRS 430 440 450 460 470 480 WAASEGTSMS EAEMIHRLLD EQRRGRSHFI PQLPTSQEEP SAITSETYAE EVVNSESKQV 490 500 510 520 530 540 ATSSDSTNNL ELPTEQMVLG SDTTTEEDAS SCSTRSDDGQ NLEMEVAIER RTVKGILRRP 550 560 570 580 590 600 NEKMNKGRIE FDPLALLLDA ALEGELDLVR SSASKLTDVS QANDEGITAL HNAICAGHYE 610 620 630 640 650 660 IVRFLIENDA DVNAQDSDGW TPLHCAASCN NLPMVRQLVE GGGCVLASTL SDMETPVEKC 670 680 690 700 710 720 EEDEDGYDGC LKYLSAAHNS TGSINTGKVY AAYGYEAAFE DELSFDAGDE LTVIEKDKVD 730 740 750 760 KNWWTCEKNN GEKGQVPRTY LALYPSLKYR KKLNFVMFDL PLESNNNVE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human." Bergamaschi D., Samuels Y., O'Neil N.J., Trigiante G., Crook T., Hsieh J.-K., O'Connor D.J., Zhong S., Campargue I., Tomlinson M.L., Kuwabara P.E., Lu X. Nat. Genet. 33:162-167(2003) [PubMed: 12524540] [Abstract] Cited for: FUNCTION, INTERACTION WITH P53.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z81085 Genomic DNA. Translation: CAB03115.1.
PIR	T22316.
RefSeq	NP_505955.1.
UniGene	Cel.17416
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	F46F3.4; F46F3.4; F46F3.4; Caenorhabditis elegans. [Genome view]
GeneID	179601.
KEGG	cel:F46F3.4.
NMPDR	fig|6239.3.peg.19800.
UCSC	F46F3.4. c. elegans.
Organism-specific databases
CTD	179601.
WormBase	WBGene00000146. ape-1.
WormPep	F46F3.4. CE19874. [WorfDB]
Phylogenomic databases
HOGENOM	HBG385538.
InParanoid	Q9XVN3.
OMA	RELEHET.
Gene expression databases
ArrayExpress	Q9XVN3.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001452. SH3_domain. IPR020473. SH3_region. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 1 hit.
Pfam	PF00023. Ank. 2 hits. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00452. SH3DOMAIN.
SMART	SM00248. ANK. 2 hits. SM00326. SH3. 1 hit. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 2 hits. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	906106.

Entry information

Entry name

IASPP_CAEEL

Accession

Primary (citable) accession number: Q9XVN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
Last sequence update:	November 1, 1999
Last modified:	December 15, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project