Reviewed, UniProtKB/Swiss-Prot Q9XVJ2 (GNPI_CAEEL)

Names and origin

Protein names

Recommended name:
    Probable glucosamine-6-phosphate isomerase
    EC=3.5.99.6
Alternative name(s):
    Glucosamine-6-phosphate deaminase
      Short name=GlcN6P deaminase
      Short name=GNPDA

Gene names

ORF Names:

T03F6.3

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3.
Subunit structure	Homohexamer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	N-acetylglucosamine metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucosamine-6-phosphate deaminase activity Inferred from electronic annotation. Source: EC hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
F59B2.3	P34480	1	EBI-323536,EBI-323530

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Probable glucosamine-6-phosphate isomerase		PRO_0000160126
Sites
	Active site	71	1	Proton acceptor; for enolization step By similarity
	Active site	140	1	For ring-opening step By similarity
	Active site	142	1	Proton acceptor; for ring-opening step By similarity
	Active site	147	1	For ring-opening step By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9XVJ2-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: A0A30B74D7B253CB	FASTA	267	29,913
	10 20 30 40 50 60 MKLIIEENAD KVAEFAARYV VTKINEATEN GKYLVLGLPT GSTPLGMYKK LIEFYNAGVI 70 80 90 100 110 120 SFEKVKTFNM DEYVDLPRDH TESYHSFMFD NFFRHIDINP ANIHILDGNT SDHEKECEEY 130 140 150 160 170 180 ERKIKESGGI DLFVGGIGPD GHIAFNEPGS SLASRTRIKT LNEDTIQANA RFFGGDITKV 190 200 210 220 230 240 PTQALTVGVQ TVMDAREVMI LITGSHKALA LHQAIECGIS HMCTVSAMQM HRCATFIADE 250 260 DATLELKVKT VKYFKGLMNH HRSLVMF

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z81113 Genomic DNA. Translation: CAB03280.1.
PIR	T24397.
RefSeq	NP_499758.1.
UniGene	Cel.10108
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:25269N.
IntAct	Q9XVJ2. 1 interaction.
STRING	Q9XVJ2.
Genome annotation databases
Ensembl	T03F6.3; T03F6.3; T03F6.3; Caenorhabditis elegans. [Genome view]
GeneID	176760.
KEGG	cel:T03F6.3.
NMPDR	fig|6239.3.peg.12055.
UCSC	T03F6.3. c. elegans.
Organism-specific databases
CTD	176760.
WormBase	WBGene00011399. T03F6.3.
WormPep	T03F6.3. CE16337. [WorfDB]
Phylogenomic databases
OMA	DYSQASE
Enzyme and pathway databases
BRENDA	3.5.99.6. 672.
Gene expression databases
ArrayExpress	Q9XVJ2.
Family and domain databases
InterPro	IPR006148. Glc/Gal-6P_isomerase. IPR004547. Glucosamine6P_isomerase. IPR018321. Glucosamine6P_isomerase_CS. IPR018322. Glucosamine6P_isomerase_subgr. [Graphical view]
PANTHER	PTHR11280. NagB. 1 hit.
Pfam	PF01182. Glucosamine_iso. 1 hit. [Graphical view]
TIGRFAMs	TIGR00502. nagB. 1 hit.
PROSITE	PS01161. GLC_GALNAC_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	893892.

Entry information

Entry name

GNPI_CAEEL

Accession

Primary (citable) accession number: Q9XVJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	November 24, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project