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Protein

Myosin-2 essential light chain

Gene

mlc-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for cytokinesis and embryo elongation. May regulate myosin II complex formation and/or the association of myosin with actin. May be involved in the organization of mlc-4 and nmy-2 into bundles.1 Publication

GO - Molecular functioni

GO - Biological processi

  • mitotic cytokinesis Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-2 essential light chain1 Publication
Gene namesi
Name:mlc-5Imported
ORF Names:T12D8.6Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT12D8.6; CE16403; WBGene00011734; mlc-5.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: WormBase
  • cytoplasm Source: UniProtKB-SubCell
  • myosin complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Arrest at the 1-cell stage embryo due to a cytokinesis defect characterized by a failure to form a contractile ring.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Myosin-2 essential light chainPRO_0000432386Add
BLAST

Proteomic databases

EPDiQ9XVI9.
PaxDbiQ9XVI9.

Expressioni

Developmental stagei

Expressed during embryogenesis in seam cells as well as in the dorsal and ventral hypodermal cells where it co-localizes with actin bundles.1 Publication

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains (two regulatory light chains and two essential light chains).1 Publication

Protein-protein interaction databases

IntActiQ9XVI9. 1 interaction.
STRINGi6239.T12D8.6.2.

Structurei

3D structure databases

ProteinModelPortaliQ9XVI9.
SMRiQ9XVI9. Positions 5-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 3736EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini75 – 11036EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
InParanoidiQ9XVI9.
KOiK12751.
OMAiRVSFEVF.
PhylomeDBiQ9XVI9.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XVI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLADCREV FAYFDSKGDE RISVQQVGDV LRALGQNPTE AEIHKCVGSF
60 70 80 90 100
DREARLSFED FVPIFQSVSK NREKHTVEEF VEGLSHFDKE GNGMINVAEL
110 120 130 140
RHLLTTLGER LSDEDVDQLL SGHNDSHGNV NISDFVRAVM NS
Length:142
Mass (Da):15,971
Last modified:November 1, 1999 - v1
Checksum:iF3C09D220C797F12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81120 Genomic DNA. Translation: CAB03346.1.
PIRiT24862.
RefSeqiNP_499813.1. NM_067412.6.
UniGeneiCel.20526.

Genome annotation databases

EnsemblMetazoaiT12D8.6.1; T12D8.6.1; WBGene00011734.
T12D8.6.2; T12D8.6.2; WBGene00011734.
GeneIDi176796.
KEGGicel:CELE_T12D8.6.
UCSCiT12D8.6.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81120 Genomic DNA. Translation: CAB03346.1.
PIRiT24862.
RefSeqiNP_499813.1. NM_067412.6.
UniGeneiCel.20526.

3D structure databases

ProteinModelPortaliQ9XVI9.
SMRiQ9XVI9. Positions 5-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9XVI9. 1 interaction.
STRINGi6239.T12D8.6.2.

Proteomic databases

EPDiQ9XVI9.
PaxDbiQ9XVI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT12D8.6.1; T12D8.6.1; WBGene00011734.
T12D8.6.2; T12D8.6.2; WBGene00011734.
GeneIDi176796.
KEGGicel:CELE_T12D8.6.
UCSCiT12D8.6.1. c. elegans.

Organism-specific databases

CTDi176796.
WormBaseiT12D8.6; CE16403; WBGene00011734; mlc-5.

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
InParanoidiQ9XVI9.
KOiK12751.
OMAiRVSFEVF.
PhylomeDBiQ9XVI9.

Miscellaneous databases

NextBioi894038.
PROiQ9XVI9.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.
  2. "Myosin II regulation during C. elegans embryonic elongation: LET-502/ROCK, MRCK-1 and PAK-1, three kinases with different roles."
    Gally C., Wissler F., Zahreddine H., Quintin S., Landmann F., Labouesse M.
    Development 136:3109-3119(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiMLC5_CAEEL
AccessioniPrimary (citable) accession number: Q9XVI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 4, 2015
Last sequence update: November 1, 1999
Last modified: March 16, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.