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Protein

Serine palmitoyltransferase 3

Gene

sptl-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen.By similarity1 Publication

Catalytic activityi

Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

Cofactori

Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid metabolism, Sphingolipid metabolism
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00222

Names & Taxonomyi

Protein namesi
Recommended name:
Serine palmitoyltransferase 3 (EC:2.3.1.50)
Alternative name(s):
Long chain base biosynthesis protein 3
Short name:
LCB 3
Serine-palmitoyl-CoA transferase 3
Short name:
SPT 3
Short name:
SPT3
Gene namesi
Name:sptl-3
ORF Names:T22G5.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT22G5.5a ; CE31996 ; WBGene00011932 ; sptl-3
T22G5.5b ; CE47328 ; WBGene00011932 ; sptl-3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004212731 – 512Serine palmitoyltransferase 3Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei345N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

EPDiQ9XVI6
PaxDbiQ9XVI6
PeptideAtlasiQ9XVI6
PRIDEiQ9XVI6

Expressioni

Gene expression databases

BgeeiWBGene00011932

Interactioni

Subunit structurei

Heterodimer of sptl-1/sptl-3.By similarity

Protein-protein interaction databases

BioGridi44898, 1 interactor
DIPiDIP-26788N
IntActiQ9XVI6, 2 interactors
STRINGi6239.T22G5.5.1

Structurei

3D structure databases

ProteinModelPortaliQ9XVI6
SMRiQ9XVI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1357 Eukaryota
COG0156 LUCA
GeneTreeiENSGT00550000074678
HOGENOMiHOG000206826
InParanoidiQ9XVI6
KOiK00654
OMAiRYFRKEL
OrthoDBiEOG091G0558
PhylomeDBiQ9XVI6

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: Q9XVI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGTQNGKAV ANGKAKNGNI TEKVIKLDPC PKPAFYVFWL VQLNITMMLV
60 70 80 90 100
GAMVATLFDK WGIVKTKRSK GDPRMESFQP LGNSFDATYT DHIYRQSTDV
110 120 130 140 150
VNRPISGVPG AIVRLKDRYT DDHGWTQKYT GTESEVINLG SYNYLGFSHR
160 170 180 190 200
SGVCAEAAAA HIDKYGINCG GSRQEIGNHV AHKSVESTIA QYLNVEDAIV
210 220 230 240 250
FPMGFATNSM NIPSLVDKGS LILSDRLNHA SLVTGCRLSG AHTVVFRHND
260 270 280 290 300
ASDCERKLRD ALCGVSPKTG EKYNKVLIII EGIYSMEGTI VNLPAFIAVK
310 320 330 340 350
KKYNCYLFLD EAHSIGAVGP SGRGVAEYWG CNPRDIDIMM GTLTKSFASA
360 370 380 390 400
GGYMGGSKKV IDHIRRYSAG TCYGVTMSPP LIAQVERAVL IMSGKDGTDI
410 420 430 440 450
GRQKAIQLLE NSRYFRKELR KRGFLVYGNN DSPVVPLMTF YITKVVEFSR
460 470 480 490 500
RMLKHNIGIV AVGYPATPLL EARVRFCLSA DHTKEHLDYI LEAVEQVGME
510
TGTFYGTKIV DE
Length:512
Mass (Da):56,334
Last modified:March 1, 2003 - v2
Checksum:i3F68835D2961C4D0
GO
Isoform b (identifier: Q9XVI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSSCFVFYNM

Show »
Length:521
Mass (Da):57,413
Checksum:i0D69BF15189AF627
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0453801M → MSSCFVFYNM in isoform b. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81127 Genomic DNA Translation: CAB03390.2
Z81127 Genomic DNA Translation: CCG28222.1
PIRiT25126
RefSeqiNP_001256547.1, NM_001269618.1 [Q9XVI6-2]
NP_001256548.1, NM_001269619.1 [Q9XVI6-1]
UniGeneiCel.17398

Genome annotation databases

EnsemblMetazoaiT22G5.5a.1; T22G5.5a.1; WBGene00011932 [Q9XVI6-1]
T22G5.5a.2; T22G5.5a.2; WBGene00011932 [Q9XVI6-1]
GeneIDi179884
KEGGicel:CELE_T22G5.5
UCSCiT22G5.5.1 c. elegans [Q9XVI6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSPTC3_CAEEL
AccessioniPrimary (citable) accession number: Q9XVI6
Secondary accession number(s): H9G307
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health