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Q9XVI6

- SPTC3_CAEEL

UniProt

Q9XVI6 - SPTC3_CAEEL

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Protein
Serine palmitoyltransferase 3
Gene
sptl-3, T22G5.5
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 By similarity. Required for the specification of abicobasal polarity and development of the gut lumen.1 Publication

Catalytic activityi

Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2.

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

GO - Molecular functioni

  1. pyridoxal phosphate binding Source: InterPro
  2. serine C-palmitoyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. biosynthetic process Source: InterPro
  2. sphingolipid metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiREACT_183003. Sphingolipid de novo biosynthesis.
UniPathwayiUPA00222.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine palmitoyltransferase 3 (EC:2.3.1.50)
Alternative name(s):
Long chain base biosynthesis protein 3
Short name:
LCB 3
Serine-palmitoyl-CoA transferase 3
Short name:
SPT 3
Short name:
SPT3
Gene namesi
Name:sptl-3
ORF Names:T22G5.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome V

Organism-specific databases

WormBaseiT22G5.5a; CE31996; WBGene00011932; sptl-3.
T22G5.5b; CE47328; WBGene00011932; sptl-3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Serine palmitoyltransferase 3
PRO_0000421273Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei345 – 3451N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PaxDbiQ9XVI6.

Interactioni

Subunit structurei

Heterodimer of sptl-1/sptl-3 By similarity.

Protein-protein interaction databases

DIPiDIP-26788N.
IntActiQ9XVI6. 1 interaction.
MINTiMINT-1127619.
STRINGi6239.T22G5.5.1.

Structurei

3D structure databases

ProteinModelPortaliQ9XVI6.
SMRiQ9XVI6. Positions 133-502.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0156.
GeneTreeiENSGT00550000074678.
HOGENOMiHOG000206826.
InParanoidiQ9XVI6.
OMAiGINCGGS.
PhylomeDBiQ9XVI6.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform a (identifier: Q9XVI6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGGTQNGKAV ANGKAKNGNI TEKVIKLDPC PKPAFYVFWL VQLNITMMLV    50
GAMVATLFDK WGIVKTKRSK GDPRMESFQP LGNSFDATYT DHIYRQSTDV 100
VNRPISGVPG AIVRLKDRYT DDHGWTQKYT GTESEVINLG SYNYLGFSHR 150
SGVCAEAAAA HIDKYGINCG GSRQEIGNHV AHKSVESTIA QYLNVEDAIV 200
FPMGFATNSM NIPSLVDKGS LILSDRLNHA SLVTGCRLSG AHTVVFRHND 250
ASDCERKLRD ALCGVSPKTG EKYNKVLIII EGIYSMEGTI VNLPAFIAVK 300
KKYNCYLFLD EAHSIGAVGP SGRGVAEYWG CNPRDIDIMM GTLTKSFASA 350
GGYMGGSKKV IDHIRRYSAG TCYGVTMSPP LIAQVERAVL IMSGKDGTDI 400
GRQKAIQLLE NSRYFRKELR KRGFLVYGNN DSPVVPLMTF YITKVVEFSR 450
RMLKHNIGIV AVGYPATPLL EARVRFCLSA DHTKEHLDYI LEAVEQVGME 500
TGTFYGTKIV DE 512
Length:512
Mass (Da):56,334
Last modified:March 1, 2003 - v2
Checksum:i3F68835D2961C4D0
GO
Isoform b (identifier: Q9XVI6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSSCFVFYNM

Show »
Length:521
Mass (Da):57,413
Checksum:i0D69BF15189AF627
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MSSCFVFYNM in isoform b.
VSP_045380

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z81127 Genomic DNA. Translation: CAB03390.2.
Z81127 Genomic DNA. Translation: CCG28222.1.
PIRiT25126.
RefSeqiNP_001256547.1. NM_001269618.1. [Q9XVI6-2]
NP_001256548.1. NM_001269619.1. [Q9XVI6-1]
UniGeneiCel.17398.

Genome annotation databases

EnsemblMetazoaiT22G5.5a.1; T22G5.5a.1; WBGene00011932. [Q9XVI6-1]
T22G5.5a.2; T22G5.5a.2; WBGene00011932. [Q9XVI6-1]
GeneIDi179884.
KEGGicel:CELE_T22G5.5.
UCSCiT22G5.5.1. c. elegans. [Q9XVI6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z81127 Genomic DNA. Translation: CAB03390.2 .
Z81127 Genomic DNA. Translation: CCG28222.1 .
PIRi T25126.
RefSeqi NP_001256547.1. NM_001269618.1. [Q9XVI6-2 ]
NP_001256548.1. NM_001269619.1. [Q9XVI6-1 ]
UniGenei Cel.17398.

3D structure databases

ProteinModelPortali Q9XVI6.
SMRi Q9XVI6. Positions 133-502.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-26788N.
IntActi Q9XVI6. 1 interaction.
MINTi MINT-1127619.
STRINGi 6239.T22G5.5.1.

Proteomic databases

PaxDbi Q9XVI6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai T22G5.5a.1 ; T22G5.5a.1 ; WBGene00011932 . [Q9XVI6-1 ]
T22G5.5a.2 ; T22G5.5a.2 ; WBGene00011932 . [Q9XVI6-1 ]
GeneIDi 179884.
KEGGi cel:CELE_T22G5.5.
UCSCi T22G5.5.1. c. elegans. [Q9XVI6-1 ]

Organism-specific databases

CTDi 179884.
WormBasei T22G5.5a ; CE31996 ; WBGene00011932 ; sptl-3.
T22G5.5b ; CE47328 ; WBGene00011932 ; sptl-3.

Phylogenomic databases

eggNOGi COG0156.
GeneTreei ENSGT00550000074678.
HOGENOMi HOG000206826.
InParanoidi Q9XVI6.
OMAi GINCGGS.
PhylomeDBi Q9XVI6.

Enzyme and pathway databases

UniPathwayi UPA00222 .
Reactomei REACT_183003. Sphingolipid de novo biosynthesis.

Miscellaneous databases

NextBioi 907264.
PROi Q9XVI6.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.
  2. "Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis."
    Zhang H., Abraham N., Khan L.A., Hall D.H., Fleming J.T., Gobel V.
    Nat. Cell Biol. 13:1189-1201(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSPTC3_CAEEL
AccessioniPrimary (citable) accession number: Q9XVI6
Secondary accession number(s): H9G307
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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