Q9XUY5 (AT1B3_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable sodium/potassium-transporting ATPase subunit beta-3

Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-3

Gene names

Name:	nkb-3
ORF Names:	F55F3.3

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane By similarity. Implicated in genomic response to various soil bacteria that affects fitness, lifespan and brood size. Ref.2
Subunit structure	Composed of three subunits: alpha (catalytic), beta and gamma By similarity.
Subcellular location	Membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the X(+)/potassium ATPases subunit beta family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Sodium transport Sodium/potassium transport Transport
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Potassium Sodium
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sodium:potassium-exchanging ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Probable sodium/potassium-transporting ATPase subunit beta-3		PRO_0000250559
Regions
	Topological domain	1 – 50	50	Cytoplasmic Potential
	Transmembrane	51 – 71	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	72 – 317	246	Lumenal Potential
Amino acid modifications
	Glycosylation	138	1	N-linked (GlcNAc...) Potential
	Disulfide bond	173 ↔ 187		By similarity
	Disulfide bond	225 ↔ 282		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9XUY5 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 71189FBE7CA785C2	FASTA	317	35,750
	10 20 30 40 50 60 MTNGGRNGEE NKNLMNGEAK AEPETFAQFL YNKDKGTVLG RTGTSWCQIT VFYIIFYIFL 70 80 90 100 110 120 SAFFIGCLSI FLRTLDPKVP RFYGKGTIIG VNPGVGYQPW LKENPDSTLI KFNLQDSKSW 130 140 150 160 170 180 EPYVKQLDNY LSKYKNTNET RDCGASDNND ALETDTDTFP CRFDLGLFEK ANCGAKDQYG 190 200 210 220 230 240 YKSGKPCVAV SLNRLIGWRP VNYDDGSVPE EIKGRYKPGS ITINCEGATS FDKEHLGKVK 250 260 270 280 290 300 YIPETGIDGR YYPYVFVPSY QQPIAMVKFD TIPRNKLVIV ECRAYASNIE HDISTRLGMV 310 YFELFVEDKK PVAAPAA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Caenorhabditis elegans genomic response to soil bacteria predicts environment-specific genetic effects on life history traits." Coolon J.D., Jones K.L., Todd T.C., Carr B.C., Herman M.A. PLoS Genet. 5:E1000503-E1000503(2009) [PubMed: 19503598] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z81550 Genomic DNA. Translation: CAB04477.1.
PIR	T22736.
RefSeq	NP_510300.1. NM_077899.3.
UniGene	Cel.6414.
3D structure databases
ProteinModelPortal	Q9XUY5.
SMR	Q9XUY5. Positions 32-308.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-25820N.
MINT	MINT-1118414.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F55F3.3.1; F55F3.3.1; F55F3.3. F55F3.3.2; F55F3.3.2; F55F3.3.
GeneID	181494.
KEGG	cel:F55F3.3.
UCSC	F55F3.3.1. c. elegans.
Organism-specific databases
CTD	181494.
WormBase	F55F3.3; CE18746; WBGene00010117; nkb-3.
Phylogenomic databases
eggNOG	meNOG09411.
GeneTree	EMGT00050000007260.
HOGENOM	HBG379014.
InParanoid	Q9XUY5.
OMA	PWLKENP.
PhylomeDB	Q9XUY5.
Gene expression databases
ArrayExpress	Q9XUY5.
Family and domain databases
InterPro	IPR000402. ATPase_P-typ_cation-exchng_bsu. [Graphical view]
KO	K01540.
PANTHER	PTHR11523. ATPase_H_Na/K_b. 1 hit.
Pfam	PF00287. Na_K-ATPase. 1 hit. [Graphical view]
PROSITE	PS00390. ATPASE_NA_K_BETA_1. 1 hit. PS00391. ATPASE_NA_K_BETA_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	914182.

Entry information

Entry name

AT1B3_CAEEL

Accession

Primary (citable) accession number: Q9XUY5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	November 1, 1999
Last modified:	November 16, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project