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Protein

Proteasome subunit pbs-5

Gene

pbs-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins (PubMed:27528192). This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins (By similarity). The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity).By similarity1 Publication

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-CEL-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-CEL-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-CEL-382556. ABC-family proteins mediated transport.
R-CEL-4641258. Degradation of DVL.
R-CEL-5689603. UCH proteinases.
R-CEL-5689880. Ub-specific processing proteases.
R-CEL-68949. Orc1 removal from chromatin.
R-CEL-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-CEL-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-CEL-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-CEL-8941858. Regulation of RUNX3 expression and activity.
R-CEL-8948751. Regulation of PTEN stability and activity.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Protein family/group databases

MEROPSiT01.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit pbs-5Imported (EC:3.4.25.1By similarity)
Gene namesi
Name:pbs-5Imported
ORF Names:K05C4.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiK05C4.1; CE19969; WBGene00003951; pbs-5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Constitutive skn-1-dependent expression of the proteasomal subunit rpt-3. Double knockout with ddi-1, sel-1, sel-9, png-1 or skn-1a results in failed expression of the proteasomal subunit rpt-3.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004423371 – 284Proteasome subunit pbs-5CuratedAdd BLAST284
PropeptideiPRO_00004423361 – 64Removed in mature formBy similarityAdd BLAST64

Keywords - PTMi

Zymogen

Proteomic databases

EPDiQ9XUV0.
PaxDbiQ9XUV0.
PeptideAtlasiQ9XUV0.

Expressioni

Gene expression databases

BgeeiWBGene00003951.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.By similarity

Protein-protein interaction databases

DIPiDIP-25961N.
IntActiQ9XUV0. 5 interactors.
MINTiMINT-211978.
STRINGi6239.K05C4.1.2.

Structurei

3D structure databases

ProteinModelPortaliQ9XUV0.
SMRiQ9XUV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0175. Eukaryota.
ENOG410XQRP. LUCA.
GeneTreeiENSGT00510000046395.
HOGENOMiHOG000091082.
InParanoidiQ9XUV0.
KOiK02737.
OMAiTMCAGVT.
OrthoDBiEOG091G0BPS.
PhylomeDBiQ9XUV0.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR000243. Pept_T1A_subB.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS51476. PROTEASOME_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XUV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGETFDDFE NDEGEMAMAK QNLIAEPARA DFTFAKLPLG IQPVDFMKTH
60 70 80 90 100
FAETAGKSMQ FRKGTTTLAF VYEPATPADK GGIIVAVDSR ASSGEYISSK
110 120 130 140 150
SVMKILDIGD RMVATMAGGA ADCQFWTRIV AKYCTLYELR EKTSITVSAA
160 170 180 190 200
SKYFANTLYG YRGQGLSVGS MVAGYDKKGP QIFKVDSEGD RCQLKVCSVG
210 220 230 240 250
SGSLNAYGIL DNHYKPKMTD DEARKLGLRA IMHATYRDSG SGGVCNLCHI
260 270 280
TPTEKIRLPP MDVSKLWYEF ADELGRDITY NPVE
Length:284
Mass (Da):31,230
Last modified:November 1, 1999 - v1
Checksum:iA382E295F2C50604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAB04567.1.
PIRiT23336.
RefSeqiNP_493558.1. NM_061157.4.
UniGeneiCel.4934.

Genome annotation databases

EnsemblMetazoaiK05C4.1; K05C4.1; WBGene00003951.
GeneIDi173334.
KEGGicel:CELE_K05C4.1.
UCSCiK05C4.1.1. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiPBS5_CAEEL
AccessioniPrimary (citable) accession number: Q9XUV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: November 1, 1999
Last modified: November 22, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families