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Q9XUE6

- PMM_CAEEL

UniProt

Q9XUE6 - PMM_CAEEL

Protein

Probable phosphomannomutase

Gene

F52B11.2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei14 – 141NucleophileBy similarity
    Active sitei16 – 161Proton donor/acceptorSequence Analysis
    Binding sitei129 – 1291SubstrateBy similarity
    Binding sitei140 – 1401SubstrateBy similarity
    Binding sitei147 – 1471SubstrateBy similarity
    Binding sitei185 – 1851SubstrateBy similarity
    Binding sitei187 – 1871SubstrateBy similarity

    GO - Molecular functioni

    1. phosphomannomutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    2. mannose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    ReactomeiREACT_183021. Synthesis of GDP-mannose.
    UniPathwayiUPA00126; UER00424.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable phosphomannomutase (EC:5.4.2.8)
    Short name:
    PMM
    Gene namesi
    ORF Names:F52B11.2
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiF52B11.2a; CE44567; WBGene00009925.
    F52B11.2b; CE36163; WBGene00009925.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254Probable phosphomannomutasePRO_0000199698Add
    BLAST

    Proteomic databases

    PaxDbiQ9XUE6.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ9XUE6. 1 interaction.
    STRINGi6239.F52B11.2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XUE6.
    SMRiQ9XUE6. Positions 8-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic PMM family.Curated

    Phylogenomic databases

    eggNOGiCOG0561.
    GeneTreeiENSGT00390000002918.
    HOGENOMiHOG000181843.
    InParanoidiQ9XUE6.
    KOiK17497.
    OMAiTYCLQHV.
    OrthoDBiEOG773XH0.

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    InterProiIPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view]
    PANTHERiPTHR10466. PTHR10466. 1 hit.
    PfamiPF03332. PMM. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform b (identifier: Q9XUE6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTSPASSRTI LVFDVDGTLT AARQTITPEM REFLIEARKR VPLAIVGGSD    50
    FKKITEQLAD HDKDLLLSLF DYTFSENGLY GFKGTEPYPV QSIQKAIGDA 100
    KLQELINFAL RYMSDIQLPV KRGNFVEFRN GMINLSPIGR SCSQEERMQF 150
    VEFDKKHGIR QKFTEQLREK FGQYGLQFAI GGQISVDVFP TGWDKTFCLQ 200
    YLVPDFDTIH FFGDKTAPGG NDHEIFADER TVGHTVEGPE DTRKHVENVL 250
    KELD 254

    Note: No experimental confirmation available.

    Length:254
    Mass (Da):28,839
    Last modified:July 27, 2011 - v2
    Checksum:iF4E0339B8C7DD8A8
    GO
    Isoform a (identifier: Q9XUE6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-29: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:225
    Mass (Da):25,777
    Checksum:iA0F807E15A4DCD45
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2929Missing in isoform a. CuratedVSP_041635Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z82268 Genomic DNA. Translation: CAB05198.3.
    Z82268 Genomic DNA. Translation: CBX53327.1.
    PIRiT22485.
    RefSeqiNP_001255786.1. NM_001268857.1. [Q9XUE6-1]
    NP_001255787.1. NM_001268858.1. [Q9XUE6-2]
    UniGeneiCel.24635.

    Genome annotation databases

    EnsemblMetazoaiF52B11.2a; F52B11.2a; WBGene00009925. [Q9XUE6-1]
    GeneIDi178364.
    KEGGicel:CELE_F52B11.2.
    UCSCiF52B11.2. c. elegans. [Q9XUE6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z82268 Genomic DNA. Translation: CAB05198.3 .
    Z82268 Genomic DNA. Translation: CBX53327.1 .
    PIRi T22485.
    RefSeqi NP_001255786.1. NM_001268857.1. [Q9XUE6-1 ]
    NP_001255787.1. NM_001268858.1. [Q9XUE6-2 ]
    UniGenei Cel.24635.

    3D structure databases

    ProteinModelPortali Q9XUE6.
    SMRi Q9XUE6. Positions 8-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9XUE6. 1 interaction.
    STRINGi 6239.F52B11.2.

    Proteomic databases

    PaxDbi Q9XUE6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai F52B11.2a ; F52B11.2a ; WBGene00009925 . [Q9XUE6-1 ]
    GeneIDi 178364.
    KEGGi cel:CELE_F52B11.2.
    UCSCi F52B11.2. c. elegans. [Q9XUE6-1 ]

    Organism-specific databases

    CTDi 178364.
    WormBasei F52B11.2a ; CE44567 ; WBGene00009925 .
    F52B11.2b ; CE36163 ; WBGene00009925 .

    Phylogenomic databases

    eggNOGi COG0561.
    GeneTreei ENSGT00390000002918.
    HOGENOMi HOG000181843.
    InParanoidi Q9XUE6.
    KOi K17497.
    OMAi TYCLQHV.
    OrthoDBi EOG773XH0.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00424 .
    Reactomei REACT_183021. Synthesis of GDP-mannose.

    Miscellaneous databases

    NextBioi 900832.

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    InterProi IPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view ]
    PANTHERi PTHR10466. PTHR10466. 1 hit.
    Pfami PF03332. PMM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPMM_CAEEL
    AccessioniPrimary (citable) accession number: Q9XUE6
    Secondary accession number(s): E3W758
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3