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Q9XUE6

- PMM_CAEEL

UniProt

Q9XUE6 - PMM_CAEEL

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Protein

Probable phosphomannomutase

Gene
F52B11.2
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei14 – 141Nucleophile By similarity
Active sitei16 – 161Proton donor/acceptor Reviewed prediction
Binding sitei129 – 1291Substrate By similarity
Binding sitei140 – 1401Substrate By similarity
Binding sitei147 – 1471Substrate By similarity
Binding sitei185 – 1851Substrate By similarity
Binding sitei187 – 1871Substrate By similarity

GO - Molecular functioni

  1. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. mannose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiREACT_183021. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
ORF Names:F52B11.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiF52B11.2a; CE44567; WBGene00009925.
F52B11.2b; CE36163; WBGene00009925.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Probable phosphomannomutasePRO_0000199698Add
BLAST

Proteomic databases

PaxDbiQ9XUE6.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

IntActiQ9XUE6. 1 interaction.
STRINGi6239.F52B11.2.

Structurei

3D structure databases

ProteinModelPortaliQ9XUE6.
SMRiQ9XUE6. Positions 8-250.

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.

Phylogenomic databases

eggNOGiCOG0561.
GeneTreeiENSGT00390000002918.
HOGENOMiHOG000181843.
InParanoidiQ9XUE6.
KOiK17497.
OMAiTYCLQHV.
OrthoDBiEOG773XH0.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform b (identifier: Q9XUE6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTSPASSRTI LVFDVDGTLT AARQTITPEM REFLIEARKR VPLAIVGGSD    50
FKKITEQLAD HDKDLLLSLF DYTFSENGLY GFKGTEPYPV QSIQKAIGDA 100
KLQELINFAL RYMSDIQLPV KRGNFVEFRN GMINLSPIGR SCSQEERMQF 150
VEFDKKHGIR QKFTEQLREK FGQYGLQFAI GGQISVDVFP TGWDKTFCLQ 200
YLVPDFDTIH FFGDKTAPGG NDHEIFADER TVGHTVEGPE DTRKHVENVL 250
KELD 254

Note: No experimental confirmation available.

Length:254
Mass (Da):28,839
Last modified:July 27, 2011 - v2
Checksum:iF4E0339B8C7DD8A8
GO
Isoform a (identifier: Q9XUE6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Note: No experimental confirmation available.

Show »
Length:225
Mass (Da):25,777
Checksum:iA0F807E15A4DCD45
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2929Missing in isoform a. VSP_041635Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z82268 Genomic DNA. Translation: CAB05198.3.
Z82268 Genomic DNA. Translation: CBX53327.1.
PIRiT22485.
RefSeqiNP_001255786.1. NM_001268857.1. [Q9XUE6-1]
NP_001255787.1. NM_001268858.1. [Q9XUE6-2]
UniGeneiCel.24635.

Genome annotation databases

EnsemblMetazoaiF52B11.2a; F52B11.2a; WBGene00009925. [Q9XUE6-1]
GeneIDi178364.
KEGGicel:CELE_F52B11.2.
UCSCiF52B11.2. c. elegans. [Q9XUE6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z82268 Genomic DNA. Translation: CAB05198.3 .
Z82268 Genomic DNA. Translation: CBX53327.1 .
PIRi T22485.
RefSeqi NP_001255786.1. NM_001268857.1. [Q9XUE6-1 ]
NP_001255787.1. NM_001268858.1. [Q9XUE6-2 ]
UniGenei Cel.24635.

3D structure databases

ProteinModelPortali Q9XUE6.
SMRi Q9XUE6. Positions 8-250.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9XUE6. 1 interaction.
STRINGi 6239.F52B11.2.

Proteomic databases

PaxDbi Q9XUE6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F52B11.2a ; F52B11.2a ; WBGene00009925 . [Q9XUE6-1 ]
GeneIDi 178364.
KEGGi cel:CELE_F52B11.2.
UCSCi F52B11.2. c. elegans. [Q9XUE6-1 ]

Organism-specific databases

CTDi 178364.
WormBasei F52B11.2a ; CE44567 ; WBGene00009925 .
F52B11.2b ; CE36163 ; WBGene00009925 .

Phylogenomic databases

eggNOGi COG0561.
GeneTreei ENSGT00390000002918.
HOGENOMi HOG000181843.
InParanoidi Q9XUE6.
KOi K17497.
OMAi TYCLQHV.
OrthoDBi EOG773XH0.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00424 .
Reactomei REACT_183021. Synthesis of GDP-mannose.

Miscellaneous databases

NextBioi 900832.

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view ]
PANTHERi PTHR10466. PTHR10466. 1 hit.
Pfami PF03332. PMM. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiPMM_CAEEL
AccessioniPrimary (citable) accession number: Q9XUE6
Secondary accession number(s): E3W758
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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