Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9XUE6 (PMM_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable phosphomannomutase

Short name=PMM
EC=5.4.2.8
Gene names
ORF Names:F52B11.2
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.

Catalytic activity

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the eukaryotic PMM family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGDP-mannose biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

mannose biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphomannomutase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform b (identifier: Q9XUE6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform a (identifier: Q9XUE6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Probable phosphomannomutase
PRO_0000199698

Sites

Active site141Nucleophile By similarity
Active site161Proton donor/acceptor Potential
Binding site1291Substrate By similarity
Binding site1401Substrate By similarity
Binding site1471Substrate By similarity
Binding site1851Substrate By similarity
Binding site1871Substrate By similarity

Natural variations

Alternative sequence1 – 2929Missing in isoform a.
VSP_041635

Sequences

Sequence LengthMass (Da)Tools
Isoform b [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: F4E0339B8C7DD8A8

FASTA25428,839
        10         20         30         40         50         60 
MTSPASSRTI LVFDVDGTLT AARQTITPEM REFLIEARKR VPLAIVGGSD FKKITEQLAD 

        70         80         90        100        110        120 
HDKDLLLSLF DYTFSENGLY GFKGTEPYPV QSIQKAIGDA KLQELINFAL RYMSDIQLPV 

       130        140        150        160        170        180 
KRGNFVEFRN GMINLSPIGR SCSQEERMQF VEFDKKHGIR QKFTEQLREK FGQYGLQFAI 

       190        200        210        220        230        240 
GGQISVDVFP TGWDKTFCLQ YLVPDFDTIH FFGDKTAPGG NDHEIFADER TVGHTVEGPE 

       250 
DTRKHVENVL KELD 

« Hide

Isoform a [UniParc].

Checksum: A0F807E15A4DCD45
Show »

FASTA22525,777

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z82268 Genomic DNA. Translation: CAB05198.3.
Z82268 Genomic DNA. Translation: CBX53327.1.
PIRT22485.
RefSeqNP_001255786.1. NM_001268857.1. [Q9XUE6-1]
NP_001255787.1. NM_001268858.1. [Q9XUE6-2]
UniGeneCel.24635.

3D structure databases

ProteinModelPortalQ9XUE6.
SMRQ9XUE6. Positions 8-250.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9XUE6. 1 interaction.
STRING6239.F52B11.2.

Proteomic databases

PaxDbQ9XUE6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF52B11.2a; F52B11.2a; WBGene00009925. [Q9XUE6-1]
GeneID178364.
KEGGcel:CELE_F52B11.2.
UCSCF52B11.2. c. elegans. [Q9XUE6-1]

Organism-specific databases

CTD178364.
WormBaseF52B11.2a; CE44567; WBGene00009925.
F52B11.2b; CE36163; WBGene00009925.

Phylogenomic databases

eggNOGCOG0561.
GeneTreeENSGT00390000002918.
HOGENOMHOG000181843.
InParanoidQ9XUE6.
KOK17497.
OMATYCLQHV.
OrthoDBEOG773XH0.

Enzyme and pathway databases

UniPathwayUPA00126; UER00424.

Family and domain databases

Gene3D3.40.50.1000. 2 hits.
InterProIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERPTHR10466. PTHR10466. 1 hit.
PfamPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetSearch...

Other

NextBio900832.

Entry information

Entry namePMM_CAEEL
AccessionPrimary (citable) accession number: Q9XUE6
Secondary accession number(s): E3W758
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: June 11, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase