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Protein

Probable phosphomannomutase

Gene

F52B11.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei14 – 141NucleophileBy similarity
Active sitei16 – 161Proton donor/acceptorSequence Analysis
Binding sitei129 – 1291SubstrateBy similarity
Binding sitei140 – 1401SubstrateBy similarity
Binding sitei147 – 1471SubstrateBy similarity
Binding sitei185 – 1851SubstrateBy similarity
Binding sitei187 – 1871SubstrateBy similarity

GO - Molecular functioni

  1. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. mannose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiREACT_284408. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
ORF Names:F52B11.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF52B11.2a; CE44567; WBGene00009925.
F52B11.2b; CE36163; WBGene00009925.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Probable phosphomannomutasePRO_0000199698Add
BLAST

Proteomic databases

PaxDbiQ9XUE6.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ9XUE6. 1 interaction.
STRINGi6239.F52B11.2.

Structurei

3D structure databases

ProteinModelPortaliQ9XUE6.
SMRiQ9XUE6. Positions 8-250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiCOG0561.
GeneTreeiENSGT00390000002918.
HOGENOMiHOG000181843.
InParanoidiQ9XUE6.
KOiK17497.
OMAiQEERLEF.
OrthoDBiEOG773XH0.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b (identifier: Q9XUE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSPASSRTI LVFDVDGTLT AARQTITPEM REFLIEARKR VPLAIVGGSD
60 70 80 90 100
FKKITEQLAD HDKDLLLSLF DYTFSENGLY GFKGTEPYPV QSIQKAIGDA
110 120 130 140 150
KLQELINFAL RYMSDIQLPV KRGNFVEFRN GMINLSPIGR SCSQEERMQF
160 170 180 190 200
VEFDKKHGIR QKFTEQLREK FGQYGLQFAI GGQISVDVFP TGWDKTFCLQ
210 220 230 240 250
YLVPDFDTIH FFGDKTAPGG NDHEIFADER TVGHTVEGPE DTRKHVENVL

KELD

Note: No experimental confirmation available.

Length:254
Mass (Da):28,839
Last modified:July 26, 2011 - v2
Checksum:iF4E0339B8C7DD8A8
GO
Isoform a (identifier: Q9XUE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Note: No experimental confirmation available.

Show »
Length:225
Mass (Da):25,777
Checksum:iA0F807E15A4DCD45
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2929Missing in isoform a. CuratedVSP_041635Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82268 Genomic DNA. Translation: CAB05198.3.
Z82268 Genomic DNA. Translation: CBX53327.1.
PIRiT22485.
RefSeqiNP_001255786.1. NM_001268857.1. [Q9XUE6-1]
NP_001255787.1. NM_001268858.1. [Q9XUE6-2]
UniGeneiCel.24635.

Genome annotation databases

EnsemblMetazoaiF52B11.2a; F52B11.2a; WBGene00009925. [Q9XUE6-1]
GeneIDi178364.
KEGGicel:CELE_F52B11.2.
UCSCiF52B11.2. c. elegans. [Q9XUE6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82268 Genomic DNA. Translation: CAB05198.3.
Z82268 Genomic DNA. Translation: CBX53327.1.
PIRiT22485.
RefSeqiNP_001255786.1. NM_001268857.1. [Q9XUE6-1]
NP_001255787.1. NM_001268858.1. [Q9XUE6-2]
UniGeneiCel.24635.

3D structure databases

ProteinModelPortaliQ9XUE6.
SMRiQ9XUE6. Positions 8-250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9XUE6. 1 interaction.
STRINGi6239.F52B11.2.

Proteomic databases

PaxDbiQ9XUE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF52B11.2a; F52B11.2a; WBGene00009925. [Q9XUE6-1]
GeneIDi178364.
KEGGicel:CELE_F52B11.2.
UCSCiF52B11.2. c. elegans. [Q9XUE6-1]

Organism-specific databases

CTDi178364.
WormBaseiF52B11.2a; CE44567; WBGene00009925.
F52B11.2b; CE36163; WBGene00009925.

Phylogenomic databases

eggNOGiCOG0561.
GeneTreeiENSGT00390000002918.
HOGENOMiHOG000181843.
InParanoidiQ9XUE6.
KOiK17497.
OMAiQEERLEF.
OrthoDBiEOG773XH0.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.
ReactomeiREACT_284408. Synthesis of GDP-mannose.

Miscellaneous databases

NextBioi900832.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: Bristol N2.

Entry informationi

Entry nameiPMM_CAEEL
AccessioniPrimary (citable) accession number: Q9XUE6
Secondary accession number(s): E3W758
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2001
Last sequence update: July 26, 2011
Last modified: March 31, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.