Q9XUE6 (PMM_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable phosphomannomutase
Short name=PMM
EC=5.4.2.8

Gene names

ORF Names:

F52B11.2

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions By similarity.
Catalytic activity	Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the eukaryotic PMM family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	GDP-mannose biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway mannose biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphomannomutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform b (identifier: Q9XUE6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform a (identifier: Q9XUE6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Probable phosphomannomutase		PRO_0000199698
Sites
	Active site	49	1	By similarity
	Active site	195	1	By similarity
	Binding site	129	1	Substrate By similarity
	Binding site	140	1	Substrate By similarity
	Binding site	147	1	Substrate By similarity
	Binding site	185	1	Substrate By similarity
	Binding site	187	1	Substrate By similarity
Natural variations
	Alternative sequence	1 – 29	29	Missing in isoform a.		VSP_041635

Sequences

	Sequence		Length	Mass (Da)
	Isoform b [UniParc]. Last modified July 27, 2011. Version 2. Checksum: F4E0339B8C7DD8A8	FASTA	254	28,839
	10 20 30 40 50 60 MTSPASSRTI LVFDVDGTLT AARQTITPEM REFLIEARKR VPLAIVGGSD FKKITEQLAD 70 80 90 100 110 120 HDKDLLLSLF DYTFSENGLY GFKGTEPYPV QSIQKAIGDA KLQELINFAL RYMSDIQLPV 130 140 150 160 170 180 KRGNFVEFRN GMINLSPIGR SCSQEERMQF VEFDKKHGIR QKFTEQLREK FGQYGLQFAI 190 200 210 220 230 240 GGQISVDVFP TGWDKTFCLQ YLVPDFDTIH FFGDKTAPGG NDHEIFADER TVGHTVEGPE 250 DTRKHVENVL KELD
	Isoform a [UniParc]. Checksum: A0F807E15A4DCD45	FASTA	225	25,777
	10 20 30 40 50 60 MREFLIEARK RVPLAIVGGS DFKKITEQLA DHDKDLLLSL FDYTFSENGL YGFKGTEPYP 70 80 90 100 110 120 VQSIQKAIGD AKLQELINFA LRYMSDIQLP VKRGNFVEFR NGMINLSPIG RSCSQEERMQ 130 140 150 160 170 180 FVEFDKKHGI RQKFTEQLRE KFGQYGLQFA IGGQISVDVF PTGWDKTFCL QYLVPDFDTI 190 200 210 220 HFFGDKTAPG GNDHEIFADE RTVGHTVEGP EDTRKHVENV LKELD

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z82268 Genomic DNA. Translation: CAB05198.3. Z82268 Genomic DNA. Translation: CBX53327.1.
PIR	T22485.
RefSeq	NP_001255786.1. NM_001268857.1. NP_001255787.1. NM_001268858.1.
3D structure databases
ProteinModelPortal	Q9XUE6.
SMR	Q9XUE6. Positions 8-250.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9XUE6. 1 interaction.
STRING	6239.F52B11.2.
Proteomic databases
PaxDb	Q9XUE6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F52B11.2a; F52B11.2a; F52B11.2.
GeneID	178364.
KEGG	cel:CELE_F52B11.2.
UCSC	F52B11.2. c. elegans.
Organism-specific databases
CTD	178364.
WormBase	F52B11.2a; CE44567; WBGene00009925. F52B11.2b; CE36163; WBGene00009925.
Phylogenomic databases
eggNOG	COG0561.
GeneTree	ENSGT00390000002918.
HOGENOM	HOG000181843.
InParanoid	Q9XUE6.
OMA	EFERYDK.
Enzyme and pathway databases
UniPathway	UPA00126; UER00424.
Family and domain databases
Gene3D	3.40.50.1000. 2 hits.
InterPro	IPR023214. HAD-like_dom. IPR006379. HAD-SF_hydro_IIB. IPR005002. PMM. [Graphical view]
PANTHER	PTHR10466. PTHR10466. 1 hit.
Pfam	PF03332. PMM. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01484. HAD-SF-IIB. 1 hit.
ProtoNet	Search...
Other
NextBio	900832.

Entry information

Entry name

PMM_CAEEL

Accession

Primary (citable) accession number: Q9XUE6
Secondary accession number(s): E3W758

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project