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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit 2

Gene

pph-4.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protein phosphatase which seems to be involved in larval development but not essential for embryogenesis.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Manganese 1By similarity
Metal bindingi66 – 661Manganese 1By similarity
Metal bindingi92 – 921Manganese 1By similarity
Metal bindingi92 – 921Manganese 2By similarity
Metal bindingi124 – 1241Manganese 2By similarity
Active sitei125 – 1251Proton donorBy similarity
Metal bindingi174 – 1741Manganese 2By similarity
Metal bindingi249 – 2491Manganese 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit 2 (EC:3.1.3.16)
Short name:
PP4C-2
Gene namesi
Name:pph-4.2
ORF Names:Y49E10.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiY49E10.3a; CE22221; WBGene00004086; pph-4.2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Serine/threonine-protein phosphatase 4 catalytic subunit 2PRO_0000353211Add
BLAST

Proteomic databases

PaxDbiQ9XTT8.
PRIDEiQ9XTT8.

Expressioni

Gene expression databases

ExpressionAtlasiQ9XTT8. baseline.

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.By similarity

Protein-protein interaction databases

STRINGi6239.Y49E10.3a.

Structurei

3D structure databases

ProteinModelPortaliQ9XTT8.
SMRiQ9XTT8. Positions 16-311.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00550000074618.
HOGENOMiHOG000172696.
InParanoidiQ9XTT8.
OMAiCELICET.
OrthoDBiEOG74N5H2.
PhylomeDBiQ9XTT8.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XTT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEEDAAGPD QLGPNDLDRQ IEIAMRCELI CETQVKSICA KVREILIEEA
60 70 80 90 100
NVQVIDTPVT ICGDIHGQFH DLMELFRVGG SPPNTNYLFL GDYVDRGYNS
110 120 130 140 150
VETFILLMLL KCRYPDRITL IRGNHESRQI TQVYGFYDEC VRKYGSGQVW
160 170 180 190 200
KHCTEIFDYL SLAAVIDGKL FCVHGGLSPS IATLDQIRVL DRKIEVPHEG
210 220 230 240 250
PMCDLLWSDP EEGCSGWGIS PRGAGYLFGG DAAELFCENN DFLRICRAHQ
260 270 280 290 300
LVMEGYKLHF RKRVVTVWSA PNYCYRCGNV AAIMEVTEEN IDSDPVFEVF
310 320
EAATVENRGE PKKQPIAQYF L
Length:321
Mass (Da):36,306
Last modified:November 1, 1999 - v1
Checksum:iFB599CACFF3B1D05
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti303 – 3031A → G in BAB63948 (PubMed:11896188).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070574 mRNA. Translation: BAB63948.1.
Z98866 Genomic DNA. Translation: CAB11559.1.
PIRiT27049.
RefSeqiNP_001022898.1. NM_001027727.3.
UniGeneiCel.22824.

Genome annotation databases

EnsemblMetazoaiY49E10.3a; Y49E10.3a; WBGene00004086.
GeneIDi176663.
UCSCiY49E10.3b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070574 mRNA. Translation: BAB63948.1.
Z98866 Genomic DNA. Translation: CAB11559.1.
PIRiT27049.
RefSeqiNP_001022898.1. NM_001027727.3.
UniGeneiCel.22824.

3D structure databases

ProteinModelPortaliQ9XTT8.
SMRiQ9XTT8. Positions 16-311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y49E10.3a.

Proteomic databases

PaxDbiQ9XTT8.
PRIDEiQ9XTT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY49E10.3a; Y49E10.3a; WBGene00004086.
GeneIDi176663.
UCSCiY49E10.3b. c. elegans.

Organism-specific databases

CTDi176663.
WormBaseiY49E10.3a; CE22221; WBGene00004086; pph-4.2.

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00550000074618.
HOGENOMiHOG000172696.
InParanoidiQ9XTT8.
OMAiCELICET.
OrthoDBiEOG74N5H2.
PhylomeDBiQ9XTT8.

Miscellaneous databases

NextBioi893512.
PROiQ9XTT8.

Gene expression databases

ExpressionAtlasiQ9XTT8. baseline.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans."
    Sumiyoshi E., Sugimoto A., Yamamoto M.
    J. Cell Sci. 115:1403-1410(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPP4C2_CAEEL
AccessioniPrimary (citable) accession number: Q9XTT8
Secondary accession number(s): Q966Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 1, 1999
Last modified: July 22, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.