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Q9XTT8

- PP4C2_CAEEL

UniProt

Q9XTT8 - PP4C2_CAEEL

Protein

Serine/threonine-protein phosphatase 4 catalytic subunit 2

Gene

pph-4.2

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Protein phosphatase which seems to be involved in larval development but not essential for embryogenesis.1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi64 – 641Manganese 1By similarity
    Metal bindingi66 – 661Manganese 1By similarity
    Metal bindingi92 – 921Manganese 1By similarity
    Metal bindingi92 – 921Manganese 2By similarity
    Metal bindingi124 – 1241Manganese 2By similarity
    Active sitei125 – 1251Proton donorBy similarity
    Metal bindingi174 – 1741Manganese 2By similarity
    Metal bindingi249 – 2491Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 4 catalytic subunit 2 (EC:3.1.3.16)
    Short name:
    PP4C-2
    Gene namesi
    Name:pph-4.2
    ORF Names:Y49E10.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiY49E10.3a; CE22221; WBGene00004086; pph-4.2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321Serine/threonine-protein phosphatase 4 catalytic subunit 2PRO_0000353211Add
    BLAST

    Proteomic databases

    PaxDbiQ9XTT8.
    PRIDEiQ9XTT8.

    Interactioni

    Subunit structurei

    Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XTT8.
    SMRiQ9XTT8. Positions 16-311.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0639.
    GeneTreeiENSGT00550000074618.
    HOGENOMiHOG000172696.
    InParanoidiQ9XTT8.
    KOiK15423.
    OMAiCELICET.
    OrthoDBiEOG74N5H2.
    PhylomeDBiQ9XTT8.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9XTT8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLEEDAAGPD QLGPNDLDRQ IEIAMRCELI CETQVKSICA KVREILIEEA    50
    NVQVIDTPVT ICGDIHGQFH DLMELFRVGG SPPNTNYLFL GDYVDRGYNS 100
    VETFILLMLL KCRYPDRITL IRGNHESRQI TQVYGFYDEC VRKYGSGQVW 150
    KHCTEIFDYL SLAAVIDGKL FCVHGGLSPS IATLDQIRVL DRKIEVPHEG 200
    PMCDLLWSDP EEGCSGWGIS PRGAGYLFGG DAAELFCENN DFLRICRAHQ 250
    LVMEGYKLHF RKRVVTVWSA PNYCYRCGNV AAIMEVTEEN IDSDPVFEVF 300
    EAATVENRGE PKKQPIAQYF L 321
    Length:321
    Mass (Da):36,306
    Last modified:November 1, 1999 - v1
    Checksum:iFB599CACFF3B1D05
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti303 – 3031A → G in BAB63948. (PubMed:11896188)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070574 mRNA. Translation: BAB63948.1.
    Z98866 Genomic DNA. Translation: CAB11559.1.
    PIRiT27049.
    RefSeqiNP_001022898.1. NM_001027727.3.
    UniGeneiCel.22824.

    Genome annotation databases

    EnsemblMetazoaiY49E10.3a; Y49E10.3a; WBGene00004086.
    GeneIDi176663.
    KEGGicel:CELE_Y49E10.3.
    UCSCiY49E10.3b. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB070574 mRNA. Translation: BAB63948.1 .
    Z98866 Genomic DNA. Translation: CAB11559.1 .
    PIRi T27049.
    RefSeqi NP_001022898.1. NM_001027727.3.
    UniGenei Cel.22824.

    3D structure databases

    ProteinModelPortali Q9XTT8.
    SMRi Q9XTT8. Positions 16-311.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9XTT8.
    PRIDEi Q9XTT8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai Y49E10.3a ; Y49E10.3a ; WBGene00004086 .
    GeneIDi 176663.
    KEGGi cel:CELE_Y49E10.3.
    UCSCi Y49E10.3b. c. elegans.

    Organism-specific databases

    CTDi 176663.
    WormBasei Y49E10.3a ; CE22221 ; WBGene00004086 ; pph-4.2.

    Phylogenomic databases

    eggNOGi COG0639.
    GeneTreei ENSGT00550000074618.
    HOGENOMi HOG000172696.
    InParanoidi Q9XTT8.
    KOi K15423.
    OMAi CELICET.
    OrthoDBi EOG74N5H2.
    PhylomeDBi Q9XTT8.

    Miscellaneous databases

    NextBioi 893512.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans."
      Sumiyoshi E., Sugimoto A., Yamamoto M.
      J. Cell Sci. 115:1403-1410(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: Bristol N2.
    2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiPP4C2_CAEEL
    AccessioniPrimary (citable) accession number: Q9XTT8
    Secondary accession number(s): Q966Q3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 4, 2008
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3