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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit 2

Gene

pph-4.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protein phosphatase which seems to be involved in larval development but not essential for embryogenesis.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Manganese 1By similarity1
Metal bindingi66Manganese 1By similarity1
Metal bindingi92Manganese 1By similarity1
Metal bindingi92Manganese 2By similarity1
Metal bindingi124Manganese 2By similarity1
Active sitei125Proton donorBy similarity1
Metal bindingi174Manganese 2By similarity1
Metal bindingi249Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit 2 (EC:3.1.3.16)
Short name:
PP4C-2
Gene namesi
Name:pph-4.2
ORF Names:Y49E10.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiY49E10.3a; CE22221; WBGene00004086; pph-4.2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003532111 – 321Serine/threonine-protein phosphatase 4 catalytic subunit 2Add BLAST321

Proteomic databases

PaxDbiQ9XTT8.
PeptideAtlasiQ9XTT8.
PRIDEiQ9XTT8.

Expressioni

Gene expression databases

BgeeiWBGene00004086.
ExpressionAtlasiQ9XTT8. differential.

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.By similarity

Protein-protein interaction databases

STRINGi6239.Y49E10.3a.

Structurei

3D structure databases

ProteinModelPortaliQ9XTT8.
SMRiQ9XTT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0372. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00550000074618.
HOGENOMiHOG000172696.
InParanoidiQ9XTT8.
KOiK15423.
OMAiCELICET.
OrthoDBiEOG091G0B6S.
PhylomeDBiQ9XTT8.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XTT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEEDAAGPD QLGPNDLDRQ IEIAMRCELI CETQVKSICA KVREILIEEA
60 70 80 90 100
NVQVIDTPVT ICGDIHGQFH DLMELFRVGG SPPNTNYLFL GDYVDRGYNS
110 120 130 140 150
VETFILLMLL KCRYPDRITL IRGNHESRQI TQVYGFYDEC VRKYGSGQVW
160 170 180 190 200
KHCTEIFDYL SLAAVIDGKL FCVHGGLSPS IATLDQIRVL DRKIEVPHEG
210 220 230 240 250
PMCDLLWSDP EEGCSGWGIS PRGAGYLFGG DAAELFCENN DFLRICRAHQ
260 270 280 290 300
LVMEGYKLHF RKRVVTVWSA PNYCYRCGNV AAIMEVTEEN IDSDPVFEVF
310 320
EAATVENRGE PKKQPIAQYF L
Length:321
Mass (Da):36,306
Last modified:November 1, 1999 - v1
Checksum:iFB599CACFF3B1D05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti303A → G in BAB63948 (PubMed:11896188).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070574 mRNA. Translation: BAB63948.1.
Z98866 Genomic DNA. Translation: CAB11559.1.
PIRiT27049.
RefSeqiNP_001022898.1. NM_001027727.3.
UniGeneiCel.22824.

Genome annotation databases

EnsemblMetazoaiY49E10.3a; Y49E10.3a; WBGene00004086.
GeneIDi176663.
KEGGicel:CELE_Y49E10.3.
UCSCiY49E10.3b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB070574 mRNA. Translation: BAB63948.1.
Z98866 Genomic DNA. Translation: CAB11559.1.
PIRiT27049.
RefSeqiNP_001022898.1. NM_001027727.3.
UniGeneiCel.22824.

3D structure databases

ProteinModelPortaliQ9XTT8.
SMRiQ9XTT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y49E10.3a.

Proteomic databases

PaxDbiQ9XTT8.
PeptideAtlasiQ9XTT8.
PRIDEiQ9XTT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY49E10.3a; Y49E10.3a; WBGene00004086.
GeneIDi176663.
KEGGicel:CELE_Y49E10.3.
UCSCiY49E10.3b. c. elegans.

Organism-specific databases

CTDi176663.
WormBaseiY49E10.3a; CE22221; WBGene00004086; pph-4.2.

Phylogenomic databases

eggNOGiKOG0372. Eukaryota.
COG0639. LUCA.
GeneTreeiENSGT00550000074618.
HOGENOMiHOG000172696.
InParanoidiQ9XTT8.
KOiK15423.
OMAiCELICET.
OrthoDBiEOG091G0B6S.
PhylomeDBiQ9XTT8.

Miscellaneous databases

PROiQ9XTT8.

Gene expression databases

BgeeiWBGene00004086.
ExpressionAtlasiQ9XTT8. differential.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP4C2_CAEEL
AccessioniPrimary (citable) accession number: Q9XTT8
Secondary accession number(s): Q966Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.