SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9XTT8

- PP4C2_CAEEL

UniProt

Q9XTT8 - PP4C2_CAEEL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Serine/threonine-protein phosphatase 4 catalytic subunit 2
Gene
pph-4.2, Y49E10.3
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Protein phosphatase which seems to be involved in larval development but not essential for embryogenesis.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Manganese 1 By similarity
Metal bindingi66 – 661Manganese 1 By similarity
Metal bindingi92 – 921Manganese 1 By similarity
Metal bindingi92 – 921Manganese 2 By similarity
Metal bindingi124 – 1241Manganese 2 By similarity
Active sitei125 – 1251Proton donor By similarity
Metal bindingi174 – 1741Manganese 2 By similarity
Metal bindingi249 – 2491Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit 2 (EC:3.1.3.16)
Short name:
PP4C-2
Gene namesi
Name:pph-4.2
ORF Names:Y49E10.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiY49E10.3a; CE22221; WBGene00004086; pph-4.2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Serine/threonine-protein phosphatase 4 catalytic subunit 2
PRO_0000353211Add
BLAST

Proteomic databases

PaxDbiQ9XTT8.
PRIDEiQ9XTT8.

Interactioni

Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9XTT8.
SMRiQ9XTT8. Positions 16-311.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
GeneTreeiENSGT00550000074618.
HOGENOMiHOG000172696.
InParanoidiQ9XTT8.
KOiK15423.
OMAiCELICET.
OrthoDBiEOG74N5H2.
PhylomeDBiQ9XTT8.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XTT8-1 [UniParc]FASTAAdd to Basket

« Hide

MLEEDAAGPD QLGPNDLDRQ IEIAMRCELI CETQVKSICA KVREILIEEA    50
NVQVIDTPVT ICGDIHGQFH DLMELFRVGG SPPNTNYLFL GDYVDRGYNS 100
VETFILLMLL KCRYPDRITL IRGNHESRQI TQVYGFYDEC VRKYGSGQVW 150
KHCTEIFDYL SLAAVIDGKL FCVHGGLSPS IATLDQIRVL DRKIEVPHEG 200
PMCDLLWSDP EEGCSGWGIS PRGAGYLFGG DAAELFCENN DFLRICRAHQ 250
LVMEGYKLHF RKRVVTVWSA PNYCYRCGNV AAIMEVTEEN IDSDPVFEVF 300
EAATVENRGE PKKQPIAQYF L 321
Length:321
Mass (Da):36,306
Last modified:November 1, 1999 - v1
Checksum:iFB599CACFF3B1D05
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti303 – 3031A → G in BAB63948. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB070574 mRNA. Translation: BAB63948.1.
Z98866 Genomic DNA. Translation: CAB11559.1.
PIRiT27049.
RefSeqiNP_001022898.1. NM_001027727.3.
UniGeneiCel.22824.

Genome annotation databases

EnsemblMetazoaiY49E10.3a; Y49E10.3a; WBGene00004086.
GeneIDi176663.
KEGGicel:CELE_Y49E10.3.
UCSCiY49E10.3b. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB070574 mRNA. Translation: BAB63948.1 .
Z98866 Genomic DNA. Translation: CAB11559.1 .
PIRi T27049.
RefSeqi NP_001022898.1. NM_001027727.3.
UniGenei Cel.22824.

3D structure databases

ProteinModelPortali Q9XTT8.
SMRi Q9XTT8. Positions 16-311.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9XTT8.
PRIDEi Q9XTT8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai Y49E10.3a ; Y49E10.3a ; WBGene00004086 .
GeneIDi 176663.
KEGGi cel:CELE_Y49E10.3.
UCSCi Y49E10.3b. c. elegans.

Organism-specific databases

CTDi 176663.
WormBasei Y49E10.3a ; CE22221 ; WBGene00004086 ; pph-4.2.

Phylogenomic databases

eggNOGi COG0639.
GeneTreei ENSGT00550000074618.
HOGENOMi HOG000172696.
InParanoidi Q9XTT8.
KOi K15423.
OMAi CELICET.
OrthoDBi EOG74N5H2.
PhylomeDBi Q9XTT8.

Miscellaneous databases

NextBioi 893512.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans."
    Sumiyoshi E., Sugimoto A., Yamamoto M.
    J. Cell Sci. 115:1403-1410(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiPP4C2_CAEEL
AccessioniPrimary (citable) accession number: Q9XTT8
Secondary accession number(s): Q966Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi