Q9XTT8 (PP4C2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit 2
Short name=PP4C-2
EC=3.1.3.16

Gene names

Name:	pph-4.2
ORF Names:	Y49E10.3

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein phosphatase which seems to be involved in larval development but not essential for embryogenesis. Ref.1
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Binds 1 iron ion per subunit By similarity. Binds 1 manganese ion per subunit By similarity.
Subunit structure	Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits By similarity.
Sequence similarities	Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

Ontologies

Keywords
Ligand	Iron Manganese Metal-binding
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Serine/threonine-protein phosphatase 4 catalytic subunit 2		PRO_0000353211
Sites
	Active site	125	1	Proton donor By similarity
	Metal binding	64	1	Iron By similarity
	Metal binding	66	1	Iron By similarity
	Metal binding	92	1	Iron By similarity
	Metal binding	92	1	Manganese By similarity
	Metal binding	124	1	Manganese By similarity
	Metal binding	174	1	Manganese By similarity
	Metal binding	249	1	Manganese By similarity
Experimental info
	Sequence conflict	303	1	A → G in BAB63948. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9XTT8 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: FB599CACFF3B1D05	FASTA	321	36,306
	10 20 30 40 50 60 MLEEDAAGPD QLGPNDLDRQ IEIAMRCELI CETQVKSICA KVREILIEEA NVQVIDTPVT 70 80 90 100 110 120 ICGDIHGQFH DLMELFRVGG SPPNTNYLFL GDYVDRGYNS VETFILLMLL KCRYPDRITL 130 140 150 160 170 180 IRGNHESRQI TQVYGFYDEC VRKYGSGQVW KHCTEIFDYL SLAAVIDGKL FCVHGGLSPS 190 200 210 220 230 240 IATLDQIRVL DRKIEVPHEG PMCDLLWSDP EEGCSGWGIS PRGAGYLFGG DAAELFCENN 250 260 270 280 290 300 DFLRICRAHQ LVMEGYKLHF RKRVVTVWSA PNYCYRCGNV AAIMEVTEEN IDSDPVFEVF 310 320 EAATVENRGE PKKQPIAQYF L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans." Sumiyoshi E., Sugimoto A., Yamamoto M. J. Cell Sci. 115:1403-1410(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Strain: Bristol N2.
[2]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB070574 mRNA. Translation: BAB63948.1. Z98866 Genomic DNA. Translation: CAB11559.1.
PIR	T27049.
RefSeq	NP_001022898.1. NM_001027727.3.
3D structure databases
HSSP	HSSP built from PDB template 1FJM based on UniProtKB P62139.
ProteinModelPortal	Q9XTT8.
SMR	Q9XTT8. Positions 16-311.
ModBase	Search...
Proteomic databases
PaxDb	Q9XTT8.
PRIDE	Q9XTT8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	Y49E10.3a; Y49E10.3a; Y49E10.3.
GeneID	176663.
KEGG	cel:CELE_Y49E10.3.
UCSC	Y49E10.3b. c. elegans.
Organism-specific databases
CTD	176663.
WormBase	Y49E10.3a; CE22221; WBGene00004086; pph-4.2.
Phylogenomic databases
eggNOG	COG0639.
GeneTree	ENSGT00550000074618.
HOGENOM	HOG000172696.
InParanoid	Q9XTT8.
OMA	RVVTVWS.
Gene expression databases
ArrayExpress	Q9XTT8.
Family and domain databases
InterPro	IPR004843. Metallo_PEstase_dom. IPR006186. Ser/Thr-sp_prot-phosphatase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PRINTS	PR00114. STPHPHTASE.
SMART	SM00156. PP2Ac. 1 hit. [Graphical view]
PROSITE	PS00125. SER_THR_PHOSPHATASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	893512.

Entry information

Entry name

PP4C2_CAEEL

Accession

Primary (citable) accession number: Q9XTT8
Secondary accession number(s): Q966Q3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 4, 2008
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project