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Q9XTT8 (PP4C2_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit 2

Short name=PP4C-2
EC=3.1.3.16
Gene names
Name:pph-4.2
ORF Names:Y49E10.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein phosphatase which seems to be involved in larval development but not essential for embryogenesis. Ref.1

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Subunit structure

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Serine/threonine-protein phosphatase 4 catalytic subunit 2
PRO_0000353211

Sites

Active site1251Proton donor By similarity
Metal binding641Iron By similarity
Metal binding661Iron By similarity
Metal binding921Iron By similarity
Metal binding921Manganese By similarity
Metal binding1241Manganese By similarity
Metal binding1741Manganese By similarity
Metal binding2491Manganese By similarity

Experimental info

Sequence conflict3031A → G in BAB63948. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9XTT8 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: FB599CACFF3B1D05

FASTA32136,306
        10         20         30         40         50         60 
MLEEDAAGPD QLGPNDLDRQ IEIAMRCELI CETQVKSICA KVREILIEEA NVQVIDTPVT 

        70         80         90        100        110        120 
ICGDIHGQFH DLMELFRVGG SPPNTNYLFL GDYVDRGYNS VETFILLMLL KCRYPDRITL 

       130        140        150        160        170        180 
IRGNHESRQI TQVYGFYDEC VRKYGSGQVW KHCTEIFDYL SLAAVIDGKL FCVHGGLSPS 

       190        200        210        220        230        240 
IATLDQIRVL DRKIEVPHEG PMCDLLWSDP EEGCSGWGIS PRGAGYLFGG DAAELFCENN 

       250        260        270        280        290        300 
DFLRICRAHQ LVMEGYKLHF RKRVVTVWSA PNYCYRCGNV AAIMEVTEEN IDSDPVFEVF 

       310        320 
EAATVENRGE PKKQPIAQYF L 

« Hide

References

« Hide 'large scale' references
[1]"Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans."
Sumiyoshi E., Sugimoto A., Yamamoto M.
J. Cell Sci. 115:1403-1410(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: Bristol N2.
[2]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB070574 mRNA. Translation: BAB63948.1.
Z98866 Genomic DNA. Translation: CAB11559.1.
PIRT27049.
RefSeqNP_001022898.1. NM_001027727.3.
UniGeneCel.22824.

3D structure databases

ProteinModelPortalQ9XTT8.
SMRQ9XTT8. Positions 16-311.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9XTT8.
PRIDEQ9XTT8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaY49E10.3a; Y49E10.3a; Y49E10.3.
GeneID176663.
KEGGcel:CELE_Y49E10.3.
UCSCY49E10.3b. c. elegans.

Organism-specific databases

CTD176663.
WormBaseY49E10.3a; CE22221; WBGene00004086; pph-4.2.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000172696.
InParanoidQ9XTT8.
KOK15423.
OMACELICET.
OrthoDBEOG74N5H2.
PhylomeDBQ9XTT8.

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio893512.

Entry information

Entry namePP4C2_CAEEL
AccessionPrimary (citable) accession number: Q9XTT8
Secondary accession number(s): Q966Q3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase