Reviewed, UniProtKB/Swiss-Prot Q9XTT4 (ANI1_CAEEL)

Names and origin

Protein names

Recommended name:
    Anillin-like protein 1

Gene names

Name:	ani-1
ORF Names:	Y49E10.19

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	1159 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Required for contractile events in embryos that occur prior to mitosis, such as cortical ruffling and pseudocleavage. May promote membrane ruffling by organizing cortical patches of septins and myosin II. Also required for the asymmetric cleavage events that extrude the two polar bodies during oocyte meiosis. Not generally required for cytokinesis in mitotic cells. Ref.2
Subcellular location	Cytoplasm › cell cortex. Cytoplasm › cytoskeleton.
Developmental stage	Enriched in embryos, where it localizes predominantly to cortical regions and the cytokinetic furrow in telophase. Ref.2
Sequence similarities	Contains 1 PH domain.

Ontologies

Keywords
Biological process	Meiosis
Cellular component	Cytoplasm Cytoskeleton
Molecular function	Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase growth Inferred from mutant phenotype. Source: WormBase meiosis Inferred from electronic annotation. Source: UniProtKB-KW nematode larval development Inferred from mutant phenotype. Source: WormBase
Cellular component	cell cortex Inferred from electronic annotation. Source: UniProtKB-SubCell cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1159	1159	Anillin-like protein 1		PRO_0000227969
Regions
	Domain	1029 – 1147	119	PH

Sequences

	Sequence		Length	Mass (Da)
	Q9XTT4-1 [UniParc]. Last modified June 1, 2003. Version 2. Checksum: A1667EFC6B1BD147	FASTA	1,159	126,803
	10 20 30 40 50 60 MGDQFDSLME RIRVRQAEMS GEGEVAKENG PVTSKITSVK QEVASPTKVF GSSSKCNDGP 70 80 90 100 110 120 STPVHFHPQE PKETTPNMKE NAENSLNSFK DATVNESSSK KTSRFSMLAQ EIDEYEYDYQ 130 140 150 160 170 180 SQYNKPKEAY MKGRSPRMSI GETRPAVLCT PAGAQAMKSP NVAVSSKSAP EIALGMSDFE 190 200 210 220 230 240 ARRIKFAQPI VNVNYLPNES SIFSGGSGSS VNDQSTVLGG SAEMMNVTTS SLSCGELSMN 250 260 270 280 290 300 QHITHENTII NAQSCDNREA ILRERQQVSN EEYGPHTFMR KKVPKEASSA TSSSSSTTTL 310 320 330 340 350 360 TTISGASGST TSGISNAPQD SASTKTTTNT FTSSYLLTKT SNNNINALVS SSPKPFSKDI 370 380 390 400 410 420 GRSMFSPVHF TPKSTSSPKT LSESIFSPSK SAAVEGSIAT TRRLQFEEKL KKSSSANVTA 430 440 450 460 470 480 PPAPTSAPVP TPRHVAPLAP TVAQQSHLTP NHRHAAQQKK HLFPVVGIVA TAPIPVQTQW 490 500 510 520 530 540 RGQSNTPVVQ GARADEKTAG NEPPVGAGVG KLKNLKSRWE FSSATGTPIH PDATEDSLIA 550 560 570 580 590 600 TAIKMKESAI PKQLGHRSER KGPSASSLYS QGARSNTASP ASKSTRYEQE EEDDVFEAPE 610 620 630 640 650 660 FNDGGDVISE DGILQEEEED TSKFIDNAFG FMEGSGAGTP SPYREPPLQR LEKNRPPAEV 670 680 690 700 710 720 IEEETENEDE SEPYEPEEEE DDDATTQFPV PERSRKSSSQ LAYSVSFYRK IQRDRNEESS 730 740 750 760 770 780 TVLAGPVISQ ISPSAPPMSS SLTSQQKLRQ LTTGPANGAR IVESAKDAHD RIKRAIQVEE 790 800 810 820 830 840 QLVAQSKRAM ILARDKPSFR GSREEFEAQW AMLRHVEKHR ALLTEYDRLK RDGPRIIDGP 850 860 870 880 890 900 RGTITVSQLS VNMARDYVSA NIASSKKSDE VFYFAAILRY GEQVDVSKMV TSDGGLNRRG 910 920 930 940 950 960 VLEFPVPLML TGIPPDFRAT VEIYGQRSMR ESTSHEDKYK LKNSTFKAKT RNTFLGGGST 970 980 990 1000 1010 1020 SSANQSLFVD PAASSSSTSS TTSNFNLLGT FSFDINCPGK HLYNMSHTVY PLEGITQMKV 1030 1040 1050 1060 1070 1080 RKQAIDGADI TYHGFLSMYQ RTGEGLGSWT RYWCALENGE MKFWKQPEDE GTKGYTALMD 1090 1100 1110 1120 1130 1140 LSTCCRSEGA SVVEDICPFP NSFHIDVWAP KMDTSDPRGI ERLRVMLAAD TAQDLQTWLS 1150 LINSTSKQLC TWRNPIVNQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Distinct roles for two C. elegans anillins in the gonad and early embryo." Maddox A.S., Habermann B., Desai A., Oegema K. Development 132:2837-2848(2005) [PubMed: 15930113] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z98866 Genomic DNA. Translation: CAB11565.2.
PIR	T27053.
RefSeq	NP_499624.2.
UniGene	Cel.34206
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	Y49E10.19; Y49E10.19; Y49E10.19; Caenorhabditis elegans. [Genome view]
GeneID	176672.
KEGG	cel:Y49E10.19.
NMPDR	fig|6239.3.peg.11873.
UCSC	Y49E10.19. c. elegans.
Organism-specific databases
CTD	176672.
WormBase	WBGene00013038. ani-1.
WormPep	Y49E10.19. CE33878. [WorfDB]
Phylogenomic databases
HOGENOM	HBG382590.
InParanoid	Q9XTT4.
OMA	NESSIFS.
Gene expression databases
ArrayExpress	Q9XTT4.
Family and domain databases
InterPro	IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
Pfam	PF00169. PH. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	893552.

Entry information

Entry name

ANI1_CAEEL

Accession

Primary (citable) accession number: Q9XTT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	June 1, 2003
Last modified:	December 15, 2009
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project