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Protein
Submitted name:

Brinker

Gene

brk

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • enhancer sequence-specific DNA binding Source: FlyBase
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: FlyBase
  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • cell competition in a multicellular organism Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • negative regulation of gene expression Source: FlyBase
  • negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: FlyBase
  • nervous system development Source: FlyBase
  • posterior Malpighian tubule development Source: FlyBase
  • regulation of BMP signaling pathway Source: FlyBase
  • regulation of gene expression Source: FlyBase
  • salivary gland boundary specification Source: FlyBase
  • transforming growth factor beta receptor signaling pathway Source: FlyBase
  • wing disc morphogenesis Source: FlyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
BrinkerImported
Submitted name:
BrkImported
Submitted name:
Putative transcription factorImported
Submitted name:
RE18244pImported
Gene namesi
Name:brkImported
Synonyms:brinkerImported, brk-RAImported
ORF Names:CG9653Imported, Dmel_CG9653Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0024250. brk.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: FlyBase
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiFBgn0024250.

Interactioni

Protein-protein interaction databases

MINTiMINT-853742.
STRINGi7227.FBpp0071007.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GLONMR-A43-101[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 10058BrkDBDInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili98 – 12124Sequence analysisAdd
BLAST
Coiled coili223 – 25028Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410J3SM. Eukaryota.
ENOG41125J6. LUCA.
OMAiCCPKGSP.
OrthoDBiEOG091G02C7.

Family and domain databases

InterProiIPR018586. Brinker_DNA-bd.
[Graphical view]
PfamiPF09607. BrkDBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XTN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSSEQLNG SGALNFKRPK DSSENATNSH TNNGNSSGSP KMGSRRIFTP
60 70 80 90 100
HFKLQVLESY RNDNDCKGNQ RATARKYNIH RRQIQKWLQC ESNLRSSVAN
110 120 130 140 150
NQQQQQQQQQ QQQQQQQQQQ LLPQQSVSPT PAVKVFHQLS HPLVHQLHHH
160 170 180 190 200
HAAAVGHHHH HAAHHHAAHH HHAAAAAAAA AAAAAAAAAH HHAAHHLLAA
210 220 230 240 250
NGMVPHPLAA HPHLHVPVAM HPQMQHQKEQ QQQQQQLQQE QQQQDQQQSQ
260 270 280 290 300
QETPATIATN GSNQGSSNVL SAAKIAAVVA AAMATSNGNP TPTATIPASS
310 320 330 340 350
SSSSNTLPSS NNSSCHNSSS SSNSCNSNQV PIQVPILSGS PGSTSSASHI
360 370 380 390 400
PHVPFAYHHN LHGYLENRLE AVATPAPMDL SLGSSARRQM QLHEKDPSGV
410 420 430 440 450
DLTFRKRKVI TSPMQPDKIS KLEEVIKKEP ETETENEDVE VDVETEQPEE
460 470 480 490 500
HKLPSKQVKL FKPYLLDDDE EQDHHHHHHH HRQEDLDEGA AEEEQDDEEE
510 520 530 540 550
SRYADDDEVD SKEAADKKQR RLKKKPSAIN EQREPIIWSN HPYPGGCVSP
560 570 580 590 600
GSSITSSFQC PTSMQQQQTF PVAGGSPNQQ FQDNCSSSKA TTPLSPFSAP
610 620 630 640 650
ALSPTGFCCP KGSPVSGYES SSSTYSDSGS NYSLNLQLHA VYNDNLMYMQ
660 670 680 690 700
QQQQQQQQQH HLQHQQHLQR WLDQESLATA RTSSVNRPLI LVADTAPTNL

TLVA
Length:704
Mass (Da):77,514
Last modified:November 1, 1999 - v1
Checksum:iECF542995CD98B11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125986 mRNA. Translation: AAD22080.1.
AE014298 Genomic DNA. Translation: AAF46251.3.
BT053738 mRNA. Translation: ACK77656.1.
AB023583 mRNA. Translation: BAA76710.1.
RefSeqiNP_511069.3. NM_078514.4.
UniGeneiDm.4389.

Genome annotation databases

EnsemblMetazoaiFBtr0071048; FBpp0071007; FBgn0024250.
GeneIDi31665.
KEGGidme:Dmel_CG9653.
UCSCiCG9653-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125986 mRNA. Translation: AAD22080.1.
AE014298 Genomic DNA. Translation: AAF46251.3.
BT053738 mRNA. Translation: ACK77656.1.
AB023583 mRNA. Translation: BAA76710.1.
RefSeqiNP_511069.3. NM_078514.4.
UniGeneiDm.4389.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GLONMR-A43-101[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-853742.
STRINGi7227.FBpp0071007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0071048; FBpp0071007; FBgn0024250.
GeneIDi31665.
KEGGidme:Dmel_CG9653.
UCSCiCG9653-RA. d. melanogaster.

Organism-specific databases

CTDi31665.
FlyBaseiFBgn0024250. brk.

Phylogenomic databases

eggNOGiENOG410J3SM. Eukaryota.
ENOG41125J6. LUCA.
OMAiCCPKGSP.
OrthoDBiEOG091G02C7.

Miscellaneous databases

ChiTaRSibrk. fly.
GenomeRNAii31665.

Gene expression databases

BgeeiFBgn0024250.

Family and domain databases

InterProiIPR018586. Brinker_DNA-bd.
[Graphical view]
PfamiPF09607. BrkDBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9XTN4_DROME
AccessioniPrimary (citable) accession number: Q9XTN4
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.