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Protein

Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial

Gene

B0250.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH.

Pathwayi: L-valine degradation

This protein is involved in the pathway L-valine degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway L-valine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96NADBy similarity1
Active sitei172By similarity1
Binding sitei247NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi2 – 30NADBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Branched-chain amino acid catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-CEL-70895. Branched-chain amino acid catabolism.
UniPathwayiUPA00362.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial (EC:1.1.1.31)
Short name:
HIBADH
Gene namesi
ORF Names:B0250.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiB0250.5; CE18481; WBGene00007122.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001730551 – 299Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrialAdd BLAST299

Proteomic databases

EPDiQ9XTI0.
PaxDbiQ9XTI0.
PeptideAtlasiQ9XTI0.
PRIDEiQ9XTI0.

PTM databases

iPTMnetiQ9XTI0.

Expressioni

Gene expression databases

BgeeiWBGene00007122.

Interactioni

Protein-protein interaction databases

STRINGi6239.B0250.5.

Structurei

3D structure databases

ProteinModelPortaliQ9XTI0.
SMRiQ9XTI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0409. Eukaryota.
COG2084. LUCA.
GeneTreeiENSGT00530000063270.
HOGENOMiHOG000219610.
InParanoidiQ9XTI0.
KOiK00020.
OMAiNIVHCGE.
OrthoDBiEOG091G0CUJ.
PhylomeDBiQ9XTI0.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR002204. 3-OH-isobutyrate_DH-rel_CS.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006115. 6PGDH_NADP-bd.
IPR011548. HIBADH.
IPR015815. HIBADH-related.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
[Graphical view]
PfamiPF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000103. HIBADH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01692. HIBADH. 1 hit.
PROSITEiPS00895. 3_HYDROXYISOBUT_DH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XTI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTGFIGLG NMGGHMARNL IKNGKKLIVY DVNKAVVQEF KAEGCEVAAH
60 70 80 90 100
PADIAAASKE IITVLPSSPH VKAVYQGEAG IFKTIQPGTL CMDSSTIDQI
110 120 130 140 150
VSLEVAQAAA LLKAEYIDAP ISGGVTGAQQ ATLTFMVGAG NDATFKRAEA
160 170 180 190 200
VLSLMGKNIV NLGAVGNGTA AKICNNMLLG IQMVAVAETM NLGISMGLDA
210 220 230 240 250
KALAGIVNTS SGRCWSSDTY NPVPGVIENI PSCRGYAGGF GTTLMAKDLS
260 270 280 290
LAQNASTNTQ APTPMGSLAH QIYRILARDP QYQAKDFGVV YQFLKKQNS
Length:299
Mass (Da):31,217
Last modified:November 1, 1999 - v1
Checksum:iF30B423A597CABF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81453, AL031630 Genomic DNA. Translation: CAB03798.1.
PIRiT18682.
RefSeqiNP_507943.1. NM_075542.6.
UniGeneiCel.9442.

Genome annotation databases

EnsemblMetazoaiB0250.5; B0250.5; WBGene00007122.
GeneIDi180344.
KEGGicel:CELE_B0250.5.
UCSCiB0250.5. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81453, AL031630 Genomic DNA. Translation: CAB03798.1.
PIRiT18682.
RefSeqiNP_507943.1. NM_075542.6.
UniGeneiCel.9442.

3D structure databases

ProteinModelPortaliQ9XTI0.
SMRiQ9XTI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.B0250.5.

PTM databases

iPTMnetiQ9XTI0.

Proteomic databases

EPDiQ9XTI0.
PaxDbiQ9XTI0.
PeptideAtlasiQ9XTI0.
PRIDEiQ9XTI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0250.5; B0250.5; WBGene00007122.
GeneIDi180344.
KEGGicel:CELE_B0250.5.
UCSCiB0250.5. c. elegans.

Organism-specific databases

CTDi180344.
WormBaseiB0250.5; CE18481; WBGene00007122.

Phylogenomic databases

eggNOGiKOG0409. Eukaryota.
COG2084. LUCA.
GeneTreeiENSGT00530000063270.
HOGENOMiHOG000219610.
InParanoidiQ9XTI0.
KOiK00020.
OMAiNIVHCGE.
OrthoDBiEOG091G0CUJ.
PhylomeDBiQ9XTI0.

Enzyme and pathway databases

UniPathwayiUPA00362.
ReactomeiR-CEL-70895. Branched-chain amino acid catabolism.

Miscellaneous databases

PROiQ9XTI0.

Gene expression databases

BgeeiWBGene00007122.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR002204. 3-OH-isobutyrate_DH-rel_CS.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006115. 6PGDH_NADP-bd.
IPR011548. HIBADH.
IPR015815. HIBADH-related.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
[Graphical view]
PfamiPF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000103. HIBADH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01692. HIBADH. 1 hit.
PROSITEiPS00895. 3_HYDROXYISOBUT_DH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei3HIDH_CAEEL
AccessioniPrimary (citable) accession number: Q9XTI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.