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Q9XTA2 (PPCE_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prolyl endopeptidase

Short name=PE
EC=3.4.21.26
Alternative name(s):
Post-proline cleaving enzyme
Gene names
Name:PREP
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length710 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.

Catalytic activity

Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the peptidase S9A family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protease
Serine protease
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

serine-type exopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 710710Prolyl endopeptidase
PRO_0000122400

Sites

Active site5541Charge relay system By similarity
Active site6411Charge relay system By similarity
Active site6801Charge relay system By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue1571N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9XTA2 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: CB2E7F0DAE2CFE9C

FASTA71080,641
        10         20         30         40         50         60 
MLSFQYPDVY RDETAVQDYH GHKICDPYAW LEDPDSEQTK AFVEAQNKIT VPFLEQCPIR 

        70         80         90        100        110        120 
GLYKERMTEL YDYPKYSCNF KKGKRYFYFY NTGLQNQRVL YVQDSLEGEA RVCLDPNTLS 

       130        140        150        160        170        180 
DDGTVALRGY AFSEDGEYVA YGLSASGSDW VTIKFMKVDG AKELADVLER VKFSCMAWTH 

       190        200        210        220        230        240 
DGKGMFYNAY PQQDGKSDGT ETSTNLHQKL CYHVLGTDQS EDILCAEFPD EPKWMGGAEL 

       250        260        270        280        290        300 
SDDGRYVLLS IREGCDPVNR LWYCDLHQEP NGITGILKWV KLIDNFEGEY DYVTNEGTVF 

       310        320        330        340        350        360 
TFKTNRHSPN YRLINIDFTD PEESRWKVLV PEHEKDVLEW VACVRSNFLV LCYLHDVKNT 

       370        380        390        400        410        420 
LQLHDMATGA LLKTFPLEVG SVVGYSGQKK DTEIFYQFTS FLSPGIIYHC DLTKEELEPR 

       430        440        450        460        470        480 
VFREVTVKGI DASDYQTVQI FYPSKDGTKI PMFIVHKKGI KLDGSHPAFL YGYGGFNISI 

       490        500        510        520        530        540 
TPNYSVCRLI FVRHMGGVLA VANIRGGGEY GETWHKGGIL ANKQNCFDDF QCAAEYLIKE 

       550        560        570        580        590        600 
GYTSPKRLTI NGGSNGGLLV ATCANQRPDL FGCVIAQVGV MDMLKFHKYT IGHAWTTDYG 

       610        620        630        640        650        660 
CSDNKQHFEW LIKYSPLHNV KLPEADDIQY PSMLLLTADH DDRVVPLHSP KFIATLQHLV 

       670        680        690        700        710 
GRSRKQNNPL LIHVDTKAGH GAGKPTAKVI EEVSDMFAFI ARCLNIDWIQ 

« Hide

References

[1]"Cloning and expression of the cDNA encoding prolyl oligopeptidase (prolyl endopeptidase) from bovine brain."
Yoshimoto T., Miyazaki K., Haraguchi N., Kitazono A., Kabashima T., Ito K.
Biol. Pharm. Bull. 20:1047-1050(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB028866 mRNA. Translation: BAA78907.1.
PIRJC5877.
RefSeqNP_777197.1. NM_174772.1.
UniGeneBt.4796.

3D structure databases

ProteinModelPortalQ9XTA2.
SMRQ9XTA2. Positions 1-709.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ9XTA2.
ChEMBLCHEMBL2460.

Protein family/group databases

MEROPSS09.001.

Proteomic databases

PRIDEQ9XTA2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID286818.
KEGGbta:286818.

Organism-specific databases

CTD5550.

Phylogenomic databases

eggNOGCOG1505.
HOGENOMHOG000238967.
HOVERGENHBG007251.
InParanoidQ9XTA2.
KOK01322.

Family and domain databases

Gene3D2.130.10.120. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR023302. Pept_S9A_N.
IPR001375. Peptidase_S9.
IPR002470. Peptidase_S9A.
[Graphical view]
PANTHERPTHR11757. PTHR11757. 1 hit.
PfamPF00326. Peptidase_S9. 1 hit.
PF02897. Peptidase_S9_N. 1 hit.
[Graphical view]
PRINTSPR00862. PROLIGOPTASE.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806472.

Entry information

Entry namePPCE_BOVIN
AccessionPrimary (citable) accession number: Q9XTA2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries