Reviewed, UniProtKB/Swiss-Prot Q9XTA2 (PPCE_BOVIN)

Names and origin

Protein names

Recommended name:
    Prolyl endopeptidase
      Short name=PE
    EC=3.4.21.26
Alternative name(s):
    Post-proline cleaving enzyme

Gene names

Name:

PREP

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	710 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
Catalytic activity	Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the peptidase S9A family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protease Serine protease
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 710	710	Prolyl endopeptidase		PRO_0000122400
Sites
	Active site	554	1	Charge relay system By similarity
	Active site	641	1	Charge relay system By similarity
	Active site	680	1	Charge relay system By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9XTA2-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: CB2E7F0DAE2CFE9C	FASTA	710	80,641
	10 20 30 40 50 60 MLSFQYPDVY RDETAVQDYH GHKICDPYAW LEDPDSEQTK AFVEAQNKIT VPFLEQCPIR 70 80 90 100 110 120 GLYKERMTEL YDYPKYSCNF KKGKRYFYFY NTGLQNQRVL YVQDSLEGEA RVCLDPNTLS 130 140 150 160 170 180 DDGTVALRGY AFSEDGEYVA YGLSASGSDW VTIKFMKVDG AKELADVLER VKFSCMAWTH 190 200 210 220 230 240 DGKGMFYNAY PQQDGKSDGT ETSTNLHQKL CYHVLGTDQS EDILCAEFPD EPKWMGGAEL 250 260 270 280 290 300 SDDGRYVLLS IREGCDPVNR LWYCDLHQEP NGITGILKWV KLIDNFEGEY DYVTNEGTVF 310 320 330 340 350 360 TFKTNRHSPN YRLINIDFTD PEESRWKVLV PEHEKDVLEW VACVRSNFLV LCYLHDVKNT 370 380 390 400 410 420 LQLHDMATGA LLKTFPLEVG SVVGYSGQKK DTEIFYQFTS FLSPGIIYHC DLTKEELEPR 430 440 450 460 470 480 VFREVTVKGI DASDYQTVQI FYPSKDGTKI PMFIVHKKGI KLDGSHPAFL YGYGGFNISI 490 500 510 520 530 540 TPNYSVCRLI FVRHMGGVLA VANIRGGGEY GETWHKGGIL ANKQNCFDDF QCAAEYLIKE 550 560 570 580 590 600 GYTSPKRLTI NGGSNGGLLV ATCANQRPDL FGCVIAQVGV MDMLKFHKYT IGHAWTTDYG 610 620 630 640 650 660 CSDNKQHFEW LIKYSPLHNV KLPEADDIQY PSMLLLTADH DDRVVPLHSP KFIATLQHLV 670 680 690 700 710 GRSRKQNNPL LIHVDTKAGH GAGKPTAKVI EEVSDMFAFI ARCLNIDWIQ

References

[1]

"Cloning and expression of the cDNA encoding prolyl oligopeptidase (prolyl endopeptidase) from bovine brain." Yoshimoto T., Miyazaki K., Haraguchi N., Kitazono A., Kabashima T., Ito K. Biol. Pharm. Bull. 20:1047-1050(1997) [PubMed: 9353562] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB028866 mRNA. Translation: BAA78907.1.
IPI	IPI00691552.
PIR	JC5877.
RefSeq	NP_777197.1.
UniGene	Bt.4796
3D structure databases
HSSP	HSSP built from PDB template 1O6G based on UniProtKB P23687.
SMR	Q9XTA2. Positions 1-709.
ModBase	Search...
Protein family/group databases
MEROPS	S09.001.
Genome annotation databases
Ensembl	ENSBTAG00000016281. Bos taurus. [Contig view]
GeneID	286818.
KEGG	bta:286818.
Phylogenomic databases
HOVERGEN	Q9XTA2.
Enzyme and pathway databases
BRENDA	3.4.21.26. 251.
Family and domain databases
InterPro	IPR002471. Pept_S9_AS. IPR001375. Peptidase_S9. IPR002470. Peptidase_S9A. IPR004106. Peptidase_S9A_N. [Graphical view]
PANTHER	PTHR11757. Peptidase_S9A. 1 hit.
Pfam	PF00326. Peptidase_S9. 1 hit. PF02897. Peptidase_S9_N. 1 hit. [Graphical view]
PRINTS	PR00862. PROLIGOPTASE.
PROSITE	PS00708. PRO_ENDOPEP_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPCE_BOVIN

Accession

Primary (citable) accession number: Q9XTA2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)