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Q9XTA2

- PPCE_BOVIN

UniProt

Q9XTA2 - PPCE_BOVIN

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Protein

Prolyl endopeptidase

Gene
PREP
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.

Catalytic activityi

Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei554 – 5541Charge relay system By similarity
Active sitei641 – 6411Charge relay system By similarity
Active sitei680 – 6801Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. serine-type exopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolyl endopeptidase (EC:3.4.21.26)
Short name:
PE
Alternative name(s):
Post-proline cleaving enzyme
Gene namesi
Name:PREP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710Prolyl endopeptidasePRO_0000122400Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei157 – 1571N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ9XTA2.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9XTA2.
SMRiQ9XTA2. Positions 1-709.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9A family.

Phylogenomic databases

eggNOGiCOG1505.
HOGENOMiHOG000238967.
HOVERGENiHBG007251.
InParanoidiQ9XTA2.
KOiK01322.

Family and domain databases

Gene3Di2.130.10.120. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR023302. Pept_S9A_N.
IPR001375. Peptidase_S9.
IPR002470. Peptidase_S9A.
[Graphical view]
PANTHERiPTHR11757. PTHR11757. 1 hit.
PfamiPF00326. Peptidase_S9. 1 hit.
PF02897. Peptidase_S9_N. 1 hit.
[Graphical view]
PRINTSiPR00862. PROLIGOPTASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XTA2-1 [UniParc]FASTAAdd to Basket

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MLSFQYPDVY RDETAVQDYH GHKICDPYAW LEDPDSEQTK AFVEAQNKIT    50
VPFLEQCPIR GLYKERMTEL YDYPKYSCNF KKGKRYFYFY NTGLQNQRVL 100
YVQDSLEGEA RVCLDPNTLS DDGTVALRGY AFSEDGEYVA YGLSASGSDW 150
VTIKFMKVDG AKELADVLER VKFSCMAWTH DGKGMFYNAY PQQDGKSDGT 200
ETSTNLHQKL CYHVLGTDQS EDILCAEFPD EPKWMGGAEL SDDGRYVLLS 250
IREGCDPVNR LWYCDLHQEP NGITGILKWV KLIDNFEGEY DYVTNEGTVF 300
TFKTNRHSPN YRLINIDFTD PEESRWKVLV PEHEKDVLEW VACVRSNFLV 350
LCYLHDVKNT LQLHDMATGA LLKTFPLEVG SVVGYSGQKK DTEIFYQFTS 400
FLSPGIIYHC DLTKEELEPR VFREVTVKGI DASDYQTVQI FYPSKDGTKI 450
PMFIVHKKGI KLDGSHPAFL YGYGGFNISI TPNYSVCRLI FVRHMGGVLA 500
VANIRGGGEY GETWHKGGIL ANKQNCFDDF QCAAEYLIKE GYTSPKRLTI 550
NGGSNGGLLV ATCANQRPDL FGCVIAQVGV MDMLKFHKYT IGHAWTTDYG 600
CSDNKQHFEW LIKYSPLHNV KLPEADDIQY PSMLLLTADH DDRVVPLHSP 650
KFIATLQHLV GRSRKQNNPL LIHVDTKAGH GAGKPTAKVI EEVSDMFAFI 700
ARCLNIDWIQ 710
Length:710
Mass (Da):80,641
Last modified:November 1, 1999 - v1
Checksum:iCB2E7F0DAE2CFE9C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028866 mRNA. Translation: BAA78907.1.
PIRiJC5877.
RefSeqiNP_777197.1. NM_174772.1.
UniGeneiBt.4796.

Genome annotation databases

GeneIDi286818.
KEGGibta:286818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028866 mRNA. Translation: BAA78907.1 .
PIRi JC5877.
RefSeqi NP_777197.1. NM_174772.1.
UniGenei Bt.4796.

3D structure databases

ProteinModelPortali Q9XTA2.
SMRi Q9XTA2. Positions 1-709.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9XTA2.
ChEMBLi CHEMBL2460.

Protein family/group databases

MEROPSi S09.001.

Proteomic databases

PRIDEi Q9XTA2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 286818.
KEGGi bta:286818.

Organism-specific databases

CTDi 5550.

Phylogenomic databases

eggNOGi COG1505.
HOGENOMi HOG000238967.
HOVERGENi HBG007251.
InParanoidi Q9XTA2.
KOi K01322.

Miscellaneous databases

NextBioi 20806472.

Family and domain databases

Gene3Di 2.130.10.120. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR023302. Pept_S9A_N.
IPR001375. Peptidase_S9.
IPR002470. Peptidase_S9A.
[Graphical view ]
PANTHERi PTHR11757. PTHR11757. 1 hit.
Pfami PF00326. Peptidase_S9. 1 hit.
PF02897. Peptidase_S9_N. 1 hit.
[Graphical view ]
PRINTSi PR00862. PROLIGOPTASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of the cDNA encoding prolyl oligopeptidase (prolyl endopeptidase) from bovine brain."
    Yoshimoto T., Miyazaki K., Haraguchi N., Kitazono A., Kabashima T., Ito K.
    Biol. Pharm. Bull. 20:1047-1050(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPPCE_BOVIN
AccessioniPrimary (citable) accession number: Q9XTA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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