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Protein
Submitted name:

CTLA-4 protein

Gene

CTLA4

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
CTLA-4 proteinImported
Submitted name:
Costimulatory molecule B7 receptor CD152Imported
Submitted name:
Cytotoxic T-lymphocyte-associated 4Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:CTLA4Imported
Synonyms:CD152Imported, CTLA-4Imported
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome C1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei162 – 18625HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000013243.

Structurei

3D structure databases

SMRiQ9XTA1. Positions 37-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 152110IGInterPro annotationAdd
BLAST
Domaini53 – 13179IGvInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ05. Eukaryota.
ENOG410YUQR. LUCA.
GeneTreeiENSGT00530000063873.
HOVERGENiHBG057978.
KOiK06538.
OMAiFSKGMHV.
OrthoDBiEOG70GMGW.
TreeFamiTF335679.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR008096. CTLA4.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01720. CTLANTIGEN4.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9XTA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACFGFRRHG AQLDLASRTW PCTALFSLLF IPVFSKGMHV AQPAVVLASS
60 70 80 90 100
RGVASFVCEY GSSGNAAEVR VTVLRQTGSQ MTEVCAATYT VENELAFLDD
110 120 130 140 150
STCTGISSGN KVNLTIQGLR AMDTGLYICK VELMYPPPYY AGMGNGTQIY
160 170 180 190 200
VIDPEPCPDS DFLLWILAAV SSGLFFYSFL ITAVSLSKML KKRSPLTTGV
210 220
YVKMPPTEPE CEKQFQPYFI PIN
Length:223
Mass (Da):24,379
Last modified:November 1, 1999 - v1
Checksum:i125C2DF76CEE6E7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG02153407 Genomic DNA. No translation available.
AF170725 mRNA. Translation: AAD50988.1.
AF154844 mRNA. Translation: AAG43372.1.
AB029395 mRNA. Translation: BAA82273.1.
RefSeqiNP_001009236.1. NM_001009236.1.

Genome annotation databases

EnsembliENSFCAT00000014276; ENSFCAP00000013243; ENSFCAG00000014272.
GeneIDi493743.
KEGGifca:493743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AANG02153407 Genomic DNA. No translation available.
AF170725 mRNA. Translation: AAD50988.1.
AF154844 mRNA. Translation: AAG43372.1.
AB029395 mRNA. Translation: BAA82273.1.
RefSeqiNP_001009236.1. NM_001009236.1.

3D structure databases

SMRiQ9XTA1. Positions 37-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000013243.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFCAT00000014276; ENSFCAP00000013243; ENSFCAG00000014272.
GeneIDi493743.
KEGGifca:493743.

Organism-specific databases

CTDi1493.

Phylogenomic databases

eggNOGiENOG410IJ05. Eukaryota.
ENOG410YUQR. LUCA.
GeneTreeiENSGT00530000063873.
HOVERGENiHBG057978.
KOiK06538.
OMAiFSKGMHV.
OrthoDBiEOG70GMGW.
TreeFamiTF335679.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR008096. CTLA4.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01720. CTLANTIGEN4.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide and Predicted Amino Acid Sequences of Canine and Feline CD152 (CTLA4)."
    Yang S., Sim G.-K.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Molecular cloning and sequencing of a cDNA encoding the feline cytotoxic T-lymphocyte-associated 4 (CTLA4) homologue."
    Nishimura Y., Miyazawa T., Ikeda Y., Izumiya Y., Nakamura K., Sato E., Mikami T., Takahashi E.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Choi I.-S., Hash S., Collisson E.W.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Molecular cloning and expression of feline CD28 and CTLA-4 cDNA."
    Choi I.S., Hash S.M., Collisson E.W.
    Vet. Immunol. Immunopathol. 76:45-59(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AbyssinianImported.
  6. "Sequence assembly of the Felis catus genome version 6.2."
    Hillier L.W., Warren W., Obrien S., Wilson R.K.
    Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AbyssinianImported.
  7. Ensembl
    Submitted (MAR-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: breed AbyssinianImported.

Entry informationi

Entry nameiQ9XTA1_FELCA
AccessioniPrimary (citable) accession number: Q9XTA1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.