ID PE2R2_CANLF Reviewed; 361 AA. AC Q9XT82; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1999, sequence version 1. DT 27-MAR-2024, entry version 125. DE RecName: Full=Prostaglandin E2 receptor EP2 subtype; DE Short=PGE receptor EP2 subtype; DE Short=PGE2 receptor EP2 subtype; DE AltName: Full=Prostanoid EP2 receptor; GN Name=PTGER2; OS Canis lupus familiaris (Dog) (Canis familiaris). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis. OX NCBI_TaxID=9615; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Kidney; RX PubMed=10410384; DOI=10.1016/s0090-6980(98)00081-1; RA Hibbs T.A., Lu B., Smock S.L., Vestergaard P., Pan L.C., Owen T.A.; RT "Molecular cloning and characterization of the canine prostaglandin E RT receptor EP2 subtype."; RL Prostaglandins Other Lipid Mediat. 57:133-147(1999). CC -!- FUNCTION: Receptor for prostaglandin E2 (PGE2). The activity of this CC receptor is mediated by G(s) proteins that stimulate adenylate cyclase. CC The subsequent raise in intracellular cAMP is responsible for the CC relaxing effect of this receptor on smooth muscle (By similarity). CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF075602; AAD43140.1; -; mRNA. DR RefSeq; NP_001003170.1; NM_001003170.1. DR AlphaFoldDB; Q9XT82; -. DR SMR; Q9XT82; -. DR STRING; 9615.ENSCAFP00000021671; -. DR BindingDB; Q9XT82; -. DR GlyCosmos; Q9XT82; 3 sites, No reported glycans. DR PaxDb; 9612-ENSCAFP00000021671; -. DR Ensembl; ENSCAFT00000023338.5; ENSCAFP00000021671.5; ENSCAFG00000014701.5. DR Ensembl; ENSCAFT00030007739.1; ENSCAFP00030006785.1; ENSCAFG00030004194.1. DR Ensembl; ENSCAFT00040008881.1; ENSCAFP00040007709.1; ENSCAFG00040004719.1. DR Ensembl; ENSCAFT00805002545; ENSCAFP00805001978; ENSCAFG00805001406. DR Ensembl; ENSCAFT00845006662.1; ENSCAFP00845005301.1; ENSCAFG00845003728.1. DR GeneID; 403797; -. DR KEGG; cfa:403797; -. DR CTD; 5732; -. DR VEuPathDB; HostDB:ENSCAFG00845003728; -. DR VGNC; VGNC:45143; PTGER2. DR eggNOG; KOG3656; Eukaryota. DR GeneTree; ENSGT01050000244902; -. DR InParanoid; Q9XT82; -. DR OrthoDB; 5355693at2759; -. DR Reactome; R-CFA-391908; Prostanoid ligand receptors. DR Reactome; R-CFA-418555; G alpha (s) signalling events. DR Proteomes; UP000002254; Chromosome 8. DR Proteomes; UP000694429; Chromosome 8. DR Proteomes; UP000694542; Chromosome 8. DR Proteomes; UP000805418; Chromosome 8. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0004957; F:prostaglandin E receptor activity; IBA:GO_Central. DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central. DR GO; GO:0071380; P:cellular response to prostaglandin E stimulus; IBA:GO_Central. DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central. DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:CAFA. DR GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:CAFA. DR GO; GO:1902219; P:negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; IMP:CAFA. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:CAFA. DR CDD; cd15139; 7tmA_PGE2_EP2; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR008365; Prostanoid_rcpt. DR InterPro; IPR001923; Prostglndn_EP2_rcpt. DR PANTHER; PTHR11866; G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER; 1. DR PANTHER; PTHR11866:SF8; PROSTAGLANDIN E2 RECEPTOR EP2 SUBTYPE; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR01788; PROSTANOIDR. DR PRINTS; PR00581; PRSTNOIDEP2R. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..361 FT /note="Prostaglandin E2 receptor EP2 subtype" FT /id="PRO_0000070053" FT TOPO_DOM 1..23 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 24..47 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 48..65 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 66..91 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 92..111 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 112..132 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 133..151 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 152..176 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 177..198 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 199..223 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 224..262 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 263..286 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 287..299 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 300..323 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 324..361 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT REGION 1..21 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 230..253 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CARBOHYD 6 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 96 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 287 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 109..187 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" SQ SEQUENCE 361 AA; 40275 MW; BC997FC8DD4FBDCB CRC64; MGSISNNSGS EDCESREWLP SGESPAISSA MFSAGVLGNL IALALLARRW RGDAGRRAGR GNSISLFHVL VTELVFTDLL GTCLISPVVL ASYARNQTLM ALEPERRACT YFAFAMTFFS LATMLMLFAM ALERYLSIGR PYFYQRHVTR RGGLAVLPTI YTVSLLFCSL PLLGYGQYVQ YCPGTWCFIR HGRTAYLQLY ATLLLLLIVA VLACNFSVIL NLIRMHRRSG RSRCGPSLGS CRDGSGTRRR GERVSVAEET DHLILLAIMT ITFAICSLPF TIFAYMNETS SRREKWDLQA LRFLSINSII DPWVFAIFRP PVLRLMRSVL CCRVSLRAQD ATQTSCSIQS NASRLTFVDT S //