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Q9XT82

- PE2R2_CANFA

UniProt

Q9XT82 - PE2R2_CANFA

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Protein
Prostaglandin E2 receptor EP2 subtype
Gene
PTGER2
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle By similarity.

GO - Molecular functioni

  1. prostaglandin E receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostaglandin E2 receptor EP2 subtype
    Short name:
    PGE receptor EP2 subtype
    Short name:
    PGE2 receptor EP2 subtype
    Alternative name(s):
    Prostanoid EP2 receptor
    Gene namesi
    Name:PTGER2
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei24 – 4724Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini48 – 6518Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei66 – 9126Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini92 – 11120Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei112 – 13221Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini133 – 15119Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei152 – 17625Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini177 – 19822Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei199 – 22325Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini224 – 26239Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei263 – 28624Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini287 – 29913Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei300 – 32324Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini324 – 36138Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Prostaglandin E2 receptor EP2 subtype
    PRO_0000070053Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi96 – 961N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi109 ↔ 187 By similarity
    Glycosylationi287 – 2871N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000021671.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XT82.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG275624.
    HOGENOMiHOG000115475.
    HOVERGENiHBG003074.
    InParanoidiQ9XT82.
    KOiK04259.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001923. Prostglndn_EP2_rcpt.
    [Graphical view]
    PANTHERiPTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF8. PTHR11866:SF8. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01788. PROSTANOIDR.
    PR00581. PRSTNOIDEP2R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9XT82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSISNNSGS EDCESREWLP SGESPAISSA MFSAGVLGNL IALALLARRW    50
    RGDAGRRAGR GNSISLFHVL VTELVFTDLL GTCLISPVVL ASYARNQTLM 100
    ALEPERRACT YFAFAMTFFS LATMLMLFAM ALERYLSIGR PYFYQRHVTR 150
    RGGLAVLPTI YTVSLLFCSL PLLGYGQYVQ YCPGTWCFIR HGRTAYLQLY 200
    ATLLLLLIVA VLACNFSVIL NLIRMHRRSG RSRCGPSLGS CRDGSGTRRR 250
    GERVSVAEET DHLILLAIMT ITFAICSLPF TIFAYMNETS SRREKWDLQA 300
    LRFLSINSII DPWVFAIFRP PVLRLMRSVL CCRVSLRAQD ATQTSCSIQS 350
    NASRLTFVDT S 361
    Length:361
    Mass (Da):40,275
    Last modified:November 1, 1999 - v1
    Checksum:iBC997FC8DD4FBDCB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075602 mRNA. Translation: AAD43140.1.
    RefSeqiNP_001003170.1. NM_001003170.1.
    UniGeneiCfa.3657.

    Genome annotation databases

    GeneIDi403797.
    KEGGicfa:403797.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF075602 mRNA. Translation: AAD43140.1 .
    RefSeqi NP_001003170.1. NM_001003170.1.
    UniGenei Cfa.3657.

    3D structure databases

    ProteinModelPortali Q9XT82.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000021671.

    Chemistry

    BindingDBi Q9XT82.

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403797.
    KEGGi cfa:403797.

    Organism-specific databases

    CTDi 5732.

    Phylogenomic databases

    eggNOGi NOG275624.
    HOGENOMi HOG000115475.
    HOVERGENi HBG003074.
    InParanoidi Q9XT82.
    KOi K04259.

    Miscellaneous databases

    NextBioi 20817294.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001923. Prostglndn_EP2_rcpt.
    [Graphical view ]
    PANTHERi PTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF8. PTHR11866:SF8. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01788. PROSTANOIDR.
    PR00581. PRSTNOIDEP2R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the canine prostaglandin E receptor EP2 subtype."
      Hibbs T.A., Lu B., Smock S.L., Vestergaard P., Pan L.C., Owen T.A.
      Prostaglandins Other Lipid Mediat. 57:133-147(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiPE2R2_CANFA
    AccessioniPrimary (citable) accession number: Q9XT82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: April 16, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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