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Protein

Prostaglandin E2 receptor EP2 subtype

Gene

PTGER2

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle (By similarity).By similarity

GO - Molecular functioni

  1. prostaglandin E receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP2 subtype
Short name:
PGE receptor EP2 subtype
Short name:
PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
Gene namesi
Name:PTGER2
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 6518CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei66 – 9126Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 11120ExtracellularSequence AnalysisAdd
BLAST
Transmembranei112 – 13221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini133 – 15119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei152 – 17625Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini177 – 19822ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 22325Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini224 – 26239CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei263 – 28624Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini287 – 29913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei300 – 32324Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini324 – 36138CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Prostaglandin E2 receptor EP2 subtypePRO_0000070053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi109 ↔ 187PROSITE-ProRule annotation
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000021671.

Structurei

3D structure databases

ProteinModelPortaliQ9XT82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275624.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiQ9XT82.
KOiK04259.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XT82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSISNNSGS EDCESREWLP SGESPAISSA MFSAGVLGNL IALALLARRW
60 70 80 90 100
RGDAGRRAGR GNSISLFHVL VTELVFTDLL GTCLISPVVL ASYARNQTLM
110 120 130 140 150
ALEPERRACT YFAFAMTFFS LATMLMLFAM ALERYLSIGR PYFYQRHVTR
160 170 180 190 200
RGGLAVLPTI YTVSLLFCSL PLLGYGQYVQ YCPGTWCFIR HGRTAYLQLY
210 220 230 240 250
ATLLLLLIVA VLACNFSVIL NLIRMHRRSG RSRCGPSLGS CRDGSGTRRR
260 270 280 290 300
GERVSVAEET DHLILLAIMT ITFAICSLPF TIFAYMNETS SRREKWDLQA
310 320 330 340 350
LRFLSINSII DPWVFAIFRP PVLRLMRSVL CCRVSLRAQD ATQTSCSIQS
360
NASRLTFVDT S
Length:361
Mass (Da):40,275
Last modified:November 1, 1999 - v1
Checksum:iBC997FC8DD4FBDCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075602 mRNA. Translation: AAD43140.1.
RefSeqiNP_001003170.1. NM_001003170.1.
UniGeneiCfa.3657.

Genome annotation databases

GeneIDi403797.
KEGGicfa:403797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075602 mRNA. Translation: AAD43140.1.
RefSeqiNP_001003170.1. NM_001003170.1.
UniGeneiCfa.3657.

3D structure databases

ProteinModelPortaliQ9XT82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000021671.

Chemistry

BindingDBiQ9XT82.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403797.
KEGGicfa:403797.

Organism-specific databases

CTDi5732.

Phylogenomic databases

eggNOGiNOG275624.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiQ9XT82.
KOiK04259.

Miscellaneous databases

NextBioi20817294.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of the canine prostaglandin E receptor EP2 subtype."
    Hibbs T.A., Lu B., Smock S.L., Vestergaard P., Pan L.C., Owen T.A.
    Prostaglandins Other Lipid Mediat. 57:133-147(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiPE2R2_CANFA
AccessioniPrimary (citable) accession number: Q9XT82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: January 7, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.