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Q9XT82 (PE2R2_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prostaglandin E2 receptor EP2 subtype

Short name=PGE receptor EP2 subtype
Short name=PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
Gene names
Name:PTGER2
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Prostaglandin E2 receptor EP2 subtype
PRO_0000070053

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4724Helical; Name=1; Potential
Topological domain48 – 6518Cytoplasmic Potential
Transmembrane66 – 9126Helical; Name=2; Potential
Topological domain92 – 11120Extracellular Potential
Transmembrane112 – 13221Helical; Name=3; Potential
Topological domain133 – 15119Cytoplasmic Potential
Transmembrane152 – 17625Helical; Name=4; Potential
Topological domain177 – 19822Extracellular Potential
Transmembrane199 – 22325Helical; Name=5; Potential
Topological domain224 – 26239Cytoplasmic Potential
Transmembrane263 – 28624Helical; Name=6; Potential
Topological domain287 – 29913Extracellular Potential
Transmembrane300 – 32324Helical; Name=7; Potential
Topological domain324 – 36138Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation2871N-linked (GlcNAc...) Potential
Disulfide bond109 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9XT82 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: BC997FC8DD4FBDCB

FASTA36140,275
        10         20         30         40         50         60 
MGSISNNSGS EDCESREWLP SGESPAISSA MFSAGVLGNL IALALLARRW RGDAGRRAGR 

        70         80         90        100        110        120 
GNSISLFHVL VTELVFTDLL GTCLISPVVL ASYARNQTLM ALEPERRACT YFAFAMTFFS 

       130        140        150        160        170        180 
LATMLMLFAM ALERYLSIGR PYFYQRHVTR RGGLAVLPTI YTVSLLFCSL PLLGYGQYVQ 

       190        200        210        220        230        240 
YCPGTWCFIR HGRTAYLQLY ATLLLLLIVA VLACNFSVIL NLIRMHRRSG RSRCGPSLGS 

       250        260        270        280        290        300 
CRDGSGTRRR GERVSVAEET DHLILLAIMT ITFAICSLPF TIFAYMNETS SRREKWDLQA 

       310        320        330        340        350        360 
LRFLSINSII DPWVFAIFRP PVLRLMRSVL CCRVSLRAQD ATQTSCSIQS NASRLTFVDT 


S 

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References

[1]"Molecular cloning and characterization of the canine prostaglandin E receptor EP2 subtype."
Hibbs T.A., Lu B., Smock S.L., Vestergaard P., Pan L.C., Owen T.A.
Prostaglandins Other Lipid Mediat. 57:133-147(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF075602 mRNA. Translation: AAD43140.1.
RefSeqNP_001003170.1. NM_001003170.1.
UniGeneCfa.3657.

3D structure databases

ProteinModelPortalQ9XT82.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000021671.

Chemistry

BindingDBQ9XT82.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403797.
KEGGcfa:403797.

Organism-specific databases

CTD5732.

Phylogenomic databases

eggNOGNOG275624.
HOGENOMHOG000115475.
HOVERGENHBG003074.
InParanoidQ9XT82.
KOK04259.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20817294.

Entry information

Entry namePE2R2_CANFA
AccessionPrimary (citable) accession number: Q9XT82
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries