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Q9XT75

- HEM0_DELLE

UniProt

Q9XT75 - HEM0_DELLE

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Protein

5-aminolevulinate synthase, erythroid-specific, mitochondrial

Gene

ALAS2

Organism
Delphinapterus leucas (Beluga whale)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei158 – 1581SubstrateBy similarity
Binding sitei275 – 2751SubstrateBy similarity
Binding sitei294 – 2941SubstrateBy similarity
Binding sitei327 – 3271Pyridoxal phosphateBy similarity
Binding sitei355 – 3551Pyridoxal phosphateBy similarity
Binding sitei383 – 3831Pyridoxal phosphateBy similarity
Active sitei386 – 3861By similarity
Binding sitei415 – 4151Pyridoxal phosphateBy similarity
Binding sitei416 – 4161Pyridoxal phosphateBy similarity
Binding sitei503 – 5031SubstrateBy similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. erythrocyte differentiation Source: UniProtKB
  2. heme biosynthetic process Source: UniProtKB
  3. hemoglobin biosynthetic process Source: UniProtKB
  4. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
  5. response to hypoxia Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, erythroid-specific, mitochondrial (EC:2.3.1.37)
Short name:
ALAS-E
Alternative name(s):
5-aminolevulinic acid synthase 2
Delta-ALA synthase 2
Delta-aminolevulinate synthase 2
Gene namesi
Name:ALAS2
Synonyms:ALS2
OrganismiDelphinapterus leucas (Beluga whale)
Taxonomic identifieri9749 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiMonodontidaeDelphinapterus

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB
  2. mitochondrial matrix Source: InterPro
  3. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – ?4444MitochondrionSequence AnalysisAdd
BLAST
Chaini?45 – 5825385-aminolevulinate synthase, erythroid-specific, mitochondrialPRO_0000001222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei386 – 3861N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Homodimer. Interacts with SUCLA2 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9XT75.
SMRiQ9XT75. Positions 1-44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG005954.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XT75-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLQRCPVLI RSPTAILGKM IKTHQFLIGI GRCPILATQG TTCSQIHLKA
60 70 80 90 100
TKAGGDSPSW AKSHCPFMLL ELQDGKSKIV QKAAPEVQED VKTFKTDLPI
110 120 130 140 150
SLASTSLRKP FFSPQEPEKN SEKVTHLIQN NMAGNHVFGY DQFFRNKIME
160 170 180 190 200
KKQDHTYRVF KTVNRWADAY PFAEHFFEAS VASKDVSVWC SNDYLGMSRH
210 220 230 240 250
PRVLQATQET LQRHGAGAGG TRNISGTSRF HVELEQELAE LHQKDSALLF
260 270 280 290 300
SSCFVANDST LFTLAKILPG CEIYSDAGNH ASMIQGIRNS GAAKFVFRHN
310 320 330 340 350
DPDHLKKLLK KSNPETPKIV AFETVHSMDG AICPLEELCD VAHQYGALTF
360 370 380 390 400
VDEVHAVGLY GSRGAGIGER DGIMHKIDII SGTLGKAFGC VGGYIASTRD
410 420 430 440 450
LVDMVRSYAA GFIFTTSLPP MVLSGALESV RLLKGEEGQA LRRAHQRNVK
460 470 480 490 500
HMRQLLMDRG LPVIPCPSHI IPIRVGDAAL NSRICDLLLS KHGIYVQAIN
510 520 530 540 550
YPTVPRGEEL LRLAPSPHHS PQMMEDFVEK LLAAWTEVGL PLQDVSIAAC
560 570 580
NFCRRPVHFE LMSEWERSYF GNMGPQYVTT YA
Length:582
Mass (Da):64,555
Last modified:November 1, 1999 - v1
Checksum:i7C15EBF6C154C34D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086786 mRNA. Translation: AAD41464.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086786 mRNA. Translation: AAD41464.1 .

3D structure databases

ProteinModelPortali Q9XT75.
SMRi Q9XT75. Positions 1-44.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005954.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of the beluga whale (Delphinapterus leucas) expressed genes for 5-aminolevulinate synthase with those in other vertebrates."
    Kreiling J.A., Duncan R., Faggart M.A., Cornell N.W.
    Comp. Biochem. Physiol. 123B:163-174(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHEM0_DELLE
AccessioniPrimary (citable) accession number: Q9XT75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3