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Q9XT75

- HEM0_DELLE

UniProt

Q9XT75 - HEM0_DELLE

Protein

5-aminolevulinate synthase, erythroid-specific, mitochondrial

Gene

ALAS2

Organism
Delphinapterus leucas (Beluga whale)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei158 – 1581SubstrateBy similarity
    Binding sitei275 – 2751SubstrateBy similarity
    Binding sitei294 – 2941SubstrateBy similarity
    Binding sitei327 – 3271Pyridoxal phosphateBy similarity
    Binding sitei355 – 3551Pyridoxal phosphateBy similarity
    Binding sitei383 – 3831Pyridoxal phosphateBy similarity
    Active sitei386 – 3861By similarity
    Binding sitei415 – 4151Pyridoxal phosphateBy similarity
    Binding sitei416 – 4161Pyridoxal phosphateBy similarity
    Binding sitei503 – 5031SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. erythrocyte differentiation Source: UniProtKB
    2. heme biosynthetic process Source: UniProtKB
    3. hemoglobin biosynthetic process Source: UniProtKB
    4. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
    5. response to hypoxia Source: UniProtKB

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase, erythroid-specific, mitochondrial (EC:2.3.1.37)
    Short name:
    ALAS-E
    Alternative name(s):
    5-aminolevulinic acid synthase 2
    Delta-ALA synthase 2
    Delta-aminolevulinate synthase 2
    Gene namesi
    Name:ALAS2
    Synonyms:ALS2
    OrganismiDelphinapterus leucas (Beluga whale)
    Taxonomic identifieri9749 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiMonodontidaeDelphinapterus

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB
    2. mitochondrial matrix Source: UniProtKB-SubCell
    3. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – ?4444MitochondrionSequence AnalysisAdd
    BLAST
    Chaini?45 – 5825385-aminolevulinate synthase, erythroid-specific, mitochondrialPRO_0000001222Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei386 – 3861N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Subunit structurei

    Homodimer. Interacts with SUCLA2 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XT75.
    SMRiQ9XT75. Positions 1-44.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG005954.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR015118. 5aminolev_synth_preseq.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    PF09029. Preseq_ALAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9XT75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLQRCPVLI RSPTAILGKM IKTHQFLIGI GRCPILATQG TTCSQIHLKA    50
    TKAGGDSPSW AKSHCPFMLL ELQDGKSKIV QKAAPEVQED VKTFKTDLPI 100
    SLASTSLRKP FFSPQEPEKN SEKVTHLIQN NMAGNHVFGY DQFFRNKIME 150
    KKQDHTYRVF KTVNRWADAY PFAEHFFEAS VASKDVSVWC SNDYLGMSRH 200
    PRVLQATQET LQRHGAGAGG TRNISGTSRF HVELEQELAE LHQKDSALLF 250
    SSCFVANDST LFTLAKILPG CEIYSDAGNH ASMIQGIRNS GAAKFVFRHN 300
    DPDHLKKLLK KSNPETPKIV AFETVHSMDG AICPLEELCD VAHQYGALTF 350
    VDEVHAVGLY GSRGAGIGER DGIMHKIDII SGTLGKAFGC VGGYIASTRD 400
    LVDMVRSYAA GFIFTTSLPP MVLSGALESV RLLKGEEGQA LRRAHQRNVK 450
    HMRQLLMDRG LPVIPCPSHI IPIRVGDAAL NSRICDLLLS KHGIYVQAIN 500
    YPTVPRGEEL LRLAPSPHHS PQMMEDFVEK LLAAWTEVGL PLQDVSIAAC 550
    NFCRRPVHFE LMSEWERSYF GNMGPQYVTT YA 582
    Length:582
    Mass (Da):64,555
    Last modified:November 1, 1999 - v1
    Checksum:i7C15EBF6C154C34D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF086786 mRNA. Translation: AAD41464.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF086786 mRNA. Translation: AAD41464.1 .

    3D structure databases

    ProteinModelPortali Q9XT75.
    SMRi Q9XT75. Positions 1-44.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG005954.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR015118. 5aminolev_synth_preseq.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    PF09029. Preseq_ALAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the beluga whale (Delphinapterus leucas) expressed genes for 5-aminolevulinate synthase with those in other vertebrates."
      Kreiling J.A., Duncan R., Faggart M.A., Cornell N.W.
      Comp. Biochem. Physiol. 123B:163-174(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHEM0_DELLE
    AccessioniPrimary (citable) accession number: Q9XT75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3