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Q9XT73 (FRIH_TRIVU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin heavy chain

Short name=Ferritin H subunit
EC=1.16.3.1

Cleaved into the following chain:

  1. Ferritin heavy chain, N-terminally processed
Gene names
Name:FTH1
Synonyms:FTH
OrganismTrichosurus vulpecula (Brush-tailed possum)
Taxonomic identifier9337 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDiprotodontiaPhalangeridaeTrichosurus

Protein attributes

Sequence length183 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 183183Ferritin heavy chain
PRO_0000201055
Initiator methionine11Removed; alternate By similarity
Chain2 – 183182Ferritin heavy chain, N-terminally processed
PRO_0000424478

Regions

Domain11 – 160150Ferritin-like diiron

Sites

Metal binding281Iron 1 By similarity
Metal binding631Iron 1 By similarity
Metal binding631Iron 2 By similarity
Metal binding661Iron 1 By similarity
Metal binding1081Iron 2 By similarity
Metal binding1421Iron 2 By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue21N-acetylthreonine; in Ferritin heavy chain, N-terminally processed By similarity
Modified residue1791Phosphoserine By similarity
Modified residue1831Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9XT73 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: F95E85F7C881B172

FASTA18321,295
        10         20         30         40         50         60 
MTTSSPSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK NFAKYFLHQS 

        70         80         90        100        110        120 
HEEREHAEKL MKLQNQRGGR IFLQDIKKPD RDDWESGLNA MECALHLEKN VNQSLLELHK 

       130        140        150        160        170        180 
LATDKNDPHL CDFIETHYLD EQVKAIKQLG DHVTNLRKMG APDSGMAEYL FDKHTLGDSD 


NES 

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References

[1]"Cloning and expression of the transferrin and ferritin genes in a marsupial, the brushtail possum (Trichosurus vulpecula)."
Demmer J., Stasiuk S.J., Adamski F.M., Grigor M.R.
Biochim. Biophys. Acta 1445:65-74(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lactating mammary gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF092509 mRNA. Translation: AAD38330.1.

3D structure databases

ProteinModelPortalQ9XT73.
SMRQ9XT73. Positions 7-177.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9XT73.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000410.

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRIH_TRIVU
AccessionPrimary (citable) accession number: Q9XT73
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 23, 2007
Last modified: November 13, 2013
This is version 70 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families