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Protein

Junctional adhesion molecule A

Gene

F11R

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiR-BTA-202733. Cell surface interactions at the vascular wall.
R-BTA-216083. Integrin cell surface interactions.
R-BTA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-BTA-420029. Tight junction interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Junctional adhesion molecule A
Short name:
JAM-A
Alternative name(s):
Junctional adhesion molecule 1
Short name:
JAM-1
CD_antigen: CD321
Gene namesi
Name:F11R
Synonyms:JAM1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 237213ExtracellularSequence analysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence analysisAdd
BLAST
Topological domaini259 – 29840CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 298274Junctional adhesion molecule APRO_0000015065Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 108PROSITE-ProRule annotation
Disulfide bondi152 ↔ 211PROSITE-ProRule annotation
Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence analysis
Modified residuei280 – 2801PhosphoserineBy similarity
Modified residuei286 – 2861PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9XT56.

Interactioni

Subunit structurei

Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023725.

Structurei

3D structure databases

ProteinModelPortaliQ9XT56.
SMRiQ9XT56. Positions 24-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 12497Ig-like V-type 1Add
BLAST
Domaini134 – 22794Ig-like V-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWUE. Eukaryota.
ENOG410YHHV. LUCA.
GeneTreeiENSGT00730000110678.
HOGENOMiHOG000247041.
HOVERGENiHBG000518.
InParanoidiQ9XT56.
KOiK06089.
OMAiSCSYSGF.
OrthoDBiEOG7MH0Z1.
TreeFamiTF331459.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XT56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTKAKVGST ELLLFTSMIL CSLALGRGAV QTYEPVVRVP ENNPAKLSCS
60 70 80 90 100
YSGFSSPRVE WKFTHGDIRG LVCYNNKITA SYENRVTFSD TGITFHSVTR
110 120 130 140 150
KDTGMYTCMV SDEGGNTYGE VTVQLIVLVP PSKPTINVPS SVTIGTRAVL
160 170 180 190 200
TCSERDGSPP SEYKWFKDGV EMPLEPKSNR AFSNSSYTLN QKTGELIFDP
210 220 230 240 250
VSASDTGDFT CQAQNGYASP VKSDTVHMDA VELNVGGIVA AVFVTLILLG
260 270 280 290
ALIFGIWFAY SRGYFDRAKK GTSNKKVIYS QPNARSDGEF RQTSSFLV
Length:298
Mass (Da):32,456
Last modified:November 1, 1999 - v1
Checksum:i714FE1C1714769A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111714 mRNA. Translation: AAD42051.1.
BT020812 mRNA. Translation: AAX08829.1.
BC103325 mRNA. Translation: AAI03326.1.
RefSeqiNP_776520.1. NM_174095.5.
UniGeneiBt.34094.

Genome annotation databases

EnsembliENSBTAT00000023725; ENSBTAP00000023725; ENSBTAG00000017846.
GeneIDi281258.
KEGGibta:281258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111714 mRNA. Translation: AAD42051.1.
BT020812 mRNA. Translation: AAX08829.1.
BC103325 mRNA. Translation: AAI03326.1.
RefSeqiNP_776520.1. NM_174095.5.
UniGeneiBt.34094.

3D structure databases

ProteinModelPortaliQ9XT56.
SMRiQ9XT56. Positions 24-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023725.

Proteomic databases

PaxDbiQ9XT56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000023725; ENSBTAP00000023725; ENSBTAG00000017846.
GeneIDi281258.
KEGGibta:281258.

Organism-specific databases

CTDi50848.

Phylogenomic databases

eggNOGiENOG410IWUE. Eukaryota.
ENOG410YHHV. LUCA.
GeneTreeiENSGT00730000110678.
HOGENOMiHOG000247041.
HOVERGENiHBG000518.
InParanoidiQ9XT56.
KOiK06089.
OMAiSCSYSGF.
OrthoDBiEOG7MH0Z1.
TreeFamiTF331459.

Enzyme and pathway databases

ReactomeiR-BTA-202733. Cell surface interactions at the vascular wall.
R-BTA-216083. Integrin cell surface interactions.
R-BTA-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-BTA-420029. Tight junction interactions.

Miscellaneous databases

NextBioi20805297.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells."
    Ozaki H., Ishii K., Horiuchi H., Arai H., Kawamoto T., Okawa K., Iwamatsu A., Kita T.
    J. Immunol. 163:553-557(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiJAM1_BOVIN
AccessioniPrimary (citable) accession number: Q9XT56
Secondary accession number(s): Q5E9V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.