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Protein

Junctional adhesion molecule A

Gene

F11R

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-202733 Cell surface interactions at the vascular wall
R-BTA-216083 Integrin cell surface interactions
R-BTA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-BTA-420029 Tight junction interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Junctional adhesion molecule A
Short name:
JAM-A
Alternative name(s):
Junctional adhesion molecule 1
Short name:
JAM-1
CD_antigen: CD321
Gene namesi
Name:F11R
Synonyms:JAM1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:50010 F11R

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 237ExtracellularSequence analysisAdd BLAST213
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 298CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001506525 – 298Junctional adhesion molecule AAdd BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 108PROSITE-ProRule annotation
Disulfide bondi152 ↔ 211PROSITE-ProRule annotation
Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei280PhosphoserineBy similarity1
Modified residuei286PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9XT56
PRIDEiQ9XT56

Expressioni

Gene expression databases

BgeeiENSBTAG00000017846

Interactioni

Subunit structurei

Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with ITGAL (via I-domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023725

Structurei

3D structure databases

ProteinModelPortaliQ9XT56
SMRiQ9XT56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 124Ig-like V-type 1Add BLAST97
Domaini134 – 227Ig-like V-type 2Add BLAST94

Domaini

The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.By similarity

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWUE Eukaryota
ENOG410YHHV LUCA
GeneTreeiENSGT00730000110678
HOGENOMiHOG000247041
HOVERGENiHBG000518
InParanoidiQ9XT56
KOiK06089
OMAiNRAFSNS
OrthoDBiEOG091G05PI
TreeFamiTF331459

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XT56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTKAKVGST ELLLFTSMIL CSLALGRGAV QTYEPVVRVP ENNPAKLSCS
60 70 80 90 100
YSGFSSPRVE WKFTHGDIRG LVCYNNKITA SYENRVTFSD TGITFHSVTR
110 120 130 140 150
KDTGMYTCMV SDEGGNTYGE VTVQLIVLVP PSKPTINVPS SVTIGTRAVL
160 170 180 190 200
TCSERDGSPP SEYKWFKDGV EMPLEPKSNR AFSNSSYTLN QKTGELIFDP
210 220 230 240 250
VSASDTGDFT CQAQNGYASP VKSDTVHMDA VELNVGGIVA AVFVTLILLG
260 270 280 290
ALIFGIWFAY SRGYFDRAKK GTSNKKVIYS QPNARSDGEF RQTSSFLV
Length:298
Mass (Da):32,456
Last modified:November 1, 1999 - v1
Checksum:i714FE1C1714769A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111714 mRNA Translation: AAD42051.1
BT020812 mRNA Translation: AAX08829.1
BC103325 mRNA Translation: AAI03326.1
RefSeqiNP_776520.1, NM_174095.5
UniGeneiBt.34094

Genome annotation databases

EnsembliENSBTAT00000023725; ENSBTAP00000023725; ENSBTAG00000017846
GeneIDi281258
KEGGibta:281258

Similar proteinsi

Entry informationi

Entry nameiJAM1_BOVIN
AccessioniPrimary (citable) accession number: Q9XT56
Secondary accession number(s): Q5E9V8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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