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Q9XT55

- UDB19_MACFA

UniProt

Q9XT55 - UDB19_MACFA

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Protein

UDP-glucuronosyltransferase 2B19

Gene

UGT2B19

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates: eugenol, 4-methyllumbelliferone, p-nitrophenol, 1-naphthol, p,p'-biphenol, naringenin and o,o'-biphenol. Active also on 3a-hydroxy and 17b-hydroxy positions of steroids.
Contributes to the formation of androgen glucuronide in extrahepatic steroid target tissues such as the prostate.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

SABIO-RKQ9XT55.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B19 (EC:2.4.1.17)
Short name:
UDPGT 2B19
Gene namesi
Name:UGT2B19
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei493 – 51321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 528507UDP-glucuronosyltransferase 2B19PRO_0000036043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Expressed in liver, ovary, prostate, colon, kidney, pancreas, brain, cerebellum, mammary gland and epididymis. Not expressed in small intestine, spleen, bladder, adrenal gland and testis.

Structurei

3D structure databases

ProteinModelPortaliQ9XT55.
SMRiQ9XT55. Positions 285-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XT55-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSMKWTSALL LIQLSCYLSF GSCGKVLVWP TEFSHWMNIK TILDELVQRG
60 70 80 90 100
HEVTVLAYST SILPDPNNPS PLKFEICPTS LTETEFQDSV TQLVKRWSDI
110 120 130 140 150
RKDTFWPHFL HVQEMMWTYG DMIRKFCKDV VSNKKLMKKL QESRFDVVLA
160 170 180 190 200
DAISPCGELL AELLKIPFVY SLRFSPGYAL EKHGGGFLFP PSYVPVTMSE
210 220 230 240 250
LRDQMTFMER VQNMIYMVYF DFWFQVWDVK NWDQFYSKVL GRPTTLFEIM
260 270 280 290 300
AKAEIWLIRN YWDFQFPHPL LPNVEFVGGL HCKPAKPLPK EMEEFVQSSG
310 320 330 340 350
DNGVVVFSLG SMVSNMSEER ANVIASALAK IPQKVLWRFD GNKPDTLGLN
360 370 380 390 400
TQLYKWLPQN DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGVPLFADQP
410 420 430 440 450
DNIAHMKAKG AAVRLDFDTM SSTDLLNALK TVINDPIYKE NAMKLSSIHH
460 470 480 490 500
DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA HDLTWFQYHS LDVIGFLLAC
510 520
VATVIFIITK CLFCVWKFVR TRKKGKRD
Length:528
Mass (Da):60,742
Last modified:November 1, 1999 - v1
Checksum:i3BFD2AE714A27AEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112112 mRNA. Translation: AAD24435.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF112112 mRNA. Translation: AAD24435.1 .

3D structure databases

ProteinModelPortali Q9XT55.
SMRi Q9XT55. Positions 285-446.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG004033.

Enzyme and pathway databases

SABIO-RK Q9XT55.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, expression and characterization of a monkey steroid UDP-glucuronosyltransferase, UGT2B19, that conjugates testosterone."
    Belanger G., Barbier O., Hum D.W., Belanger A.
    Eur. J. Biochem. 260:701-708(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Liver and Prostate.

Entry informationi

Entry nameiUDB19_MACFA
AccessioniPrimary (citable) accession number: Q9XT55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3