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Q9XT55

- UDB19_MACFA

UniProt

Q9XT55 - UDB19_MACFA

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Protein
UDP-glucuronosyltransferase 2B19
Gene
UGT2B19
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates: eugenol, 4-methyllumbelliferone, p-nitrophenol, 1-naphthol, p,p'-biphenol, naringenin and o,o'-biphenol. Active also on 3a-hydroxy and 17b-hydroxy positions of steroids.
Contributes to the formation of androgen glucuronide in extrahepatic steroid target tissues such as the prostate.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    SABIO-RKQ9XT55.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 2B19 (EC:2.4.1.17)
    Short name:
    UDPGT 2B19
    Gene namesi
    Name:UGT2B19
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei493 – 51321Helical; Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121 Reviewed prediction
    Add
    BLAST
    Chaini22 – 528507UDP-glucuronosyltransferase 2B19
    PRO_0000036043Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi315 – 3151N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed in liver, ovary, prostate, colon, kidney, pancreas, brain, cerebellum, mammary gland and epididymis. Not expressed in small intestine, spleen, bladder, adrenal gland and testis.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XT55.
    SMRiQ9XT55. Positions 285-446.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004033.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9XT55-1 [UniParc]FASTAAdd to Basket

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    MSMKWTSALL LIQLSCYLSF GSCGKVLVWP TEFSHWMNIK TILDELVQRG    50
    HEVTVLAYST SILPDPNNPS PLKFEICPTS LTETEFQDSV TQLVKRWSDI 100
    RKDTFWPHFL HVQEMMWTYG DMIRKFCKDV VSNKKLMKKL QESRFDVVLA 150
    DAISPCGELL AELLKIPFVY SLRFSPGYAL EKHGGGFLFP PSYVPVTMSE 200
    LRDQMTFMER VQNMIYMVYF DFWFQVWDVK NWDQFYSKVL GRPTTLFEIM 250
    AKAEIWLIRN YWDFQFPHPL LPNVEFVGGL HCKPAKPLPK EMEEFVQSSG 300
    DNGVVVFSLG SMVSNMSEER ANVIASALAK IPQKVLWRFD GNKPDTLGLN 350
    TQLYKWLPQN DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGVPLFADQP 400
    DNIAHMKAKG AAVRLDFDTM SSTDLLNALK TVINDPIYKE NAMKLSSIHH 450
    DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA HDLTWFQYHS LDVIGFLLAC 500
    VATVIFIITK CLFCVWKFVR TRKKGKRD 528
    Length:528
    Mass (Da):60,742
    Last modified:November 1, 1999 - v1
    Checksum:i3BFD2AE714A27AEE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF112112 mRNA. Translation: AAD24435.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF112112 mRNA. Translation: AAD24435.1 .

    3D structure databases

    ProteinModelPortali Q9XT55.
    SMRi Q9XT55. Positions 285-446.
    ModBasei Search...

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG004033.

    Enzyme and pathway databases

    SABIO-RK Q9XT55.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, expression and characterization of a monkey steroid UDP-glucuronosyltransferase, UGT2B19, that conjugates testosterone."
      Belanger G., Barbier O., Hum D.W., Belanger A.
      Eur. J. Biochem. 260:701-708(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Tissue: Liver and Prostate.

    Entry informationi

    Entry nameiUDB19_MACFA
    AccessioniPrimary (citable) accession number: Q9XT55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: February 19, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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