Reviewed, UniProtKB/Swiss-Prot Q9XT55 (UDB19_MACFA)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 2B19
      Short name=UDPGT 2B19
    EC=2.4.1.17

Gene names

Name:

UGT2B19

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	528 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates: eugenol, 4-methyllumbelliferone, p-nitrophenol, 1-naphthol, p,p'-biphenol, naringenin and o,o'-biphenol. Active also on 3a-hydroxy and 17b-hydroxy positions of steroids. Contributes to the formation of androgen glucuronide in extrahepatic steroid target tissues such as the prostate.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome membrane; Single-pass membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Tissue specificity	Expressed in liver, ovary, prostate, colon, kidney, pancreas, brain, cerebellum, mammary gland and epididymis. Not expressed in small intestine, spleen, bladder, adrenal gland and testis.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 528	507	UDP-glucuronosyltransferase 2B19		PRO_0000036043
Regions
	Transmembrane	493 – 513	21	Potential
Amino acid modifications
	Glycosylation	315	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9XT55-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 3BFD2AE714A27AEE	FASTA	528	60,742
	10 20 30 40 50 60 MSMKWTSALL LIQLSCYLSF GSCGKVLVWP TEFSHWMNIK TILDELVQRG HEVTVLAYST 70 80 90 100 110 120 SILPDPNNPS PLKFEICPTS LTETEFQDSV TQLVKRWSDI RKDTFWPHFL HVQEMMWTYG 130 140 150 160 170 180 DMIRKFCKDV VSNKKLMKKL QESRFDVVLA DAISPCGELL AELLKIPFVY SLRFSPGYAL 190 200 210 220 230 240 EKHGGGFLFP PSYVPVTMSE LRDQMTFMER VQNMIYMVYF DFWFQVWDVK NWDQFYSKVL 250 260 270 280 290 300 GRPTTLFEIM AKAEIWLIRN YWDFQFPHPL LPNVEFVGGL HCKPAKPLPK EMEEFVQSSG 310 320 330 340 350 360 DNGVVVFSLG SMVSNMSEER ANVIASALAK IPQKVLWRFD GNKPDTLGLN TQLYKWLPQN 370 380 390 400 410 420 DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGVPLFADQP DNIAHMKAKG AAVRLDFDTM 430 440 450 460 470 480 SSTDLLNALK TVINDPIYKE NAMKLSSIHH DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA 490 500 510 520 HDLTWFQYHS LDVIGFLLAC VATVIFIITK CLFCVWKFVR TRKKGKRD

References

[1]

"Molecular cloning, expression and characterization of a monkey steroid UDP-glucuronosyltransferase, UGT2B19, that conjugates testosterone." Belanger G., Barbier O., Hum D.W., Belanger A. Eur. J. Biochem. 260:701-708(1999) [PubMed: 10102998] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: Liver and Prostate.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF112112 mRNA. Translation: AAD24435.1.
3D structure databases
SMR	Q9XT55. Positions 285-446.
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Phylogenomic databases
HOVERGEN	Q9XT55.
Enzyme and pathway databases
BRENDA	2.4.1.17. 3438.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UDB19_MACFA

Accession

Primary (citable) accession number: Q9XT55

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)