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Q9XT55 (UDB19_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 2B19

Short name=UDPGT 2B19
EC=2.4.1.17
Gene names
Name:UGT2B19
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates: eugenol, 4-methyllumbelliferone, p-nitrophenol, 1-naphthol, p,p'-biphenol, naringenin and o,o'-biphenol. Active also on 3a-hydroxy and 17b-hydroxy positions of steroids.

Contributes to the formation of androgen glucuronide in extrahepatic steroid target tissues such as the prostate.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome membrane; Single-pass membrane protein By similarity. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Tissue specificity

Expressed in liver, ovary, prostate, colon, kidney, pancreas, brain, cerebellum, mammary gland and epididymis. Not expressed in small intestine, spleen, bladder, adrenal gland and testis.

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 528507UDP-glucuronosyltransferase 2B19
PRO_0000036043

Regions

Transmembrane493 – 51321Helical; Potential

Amino acid modifications

Glycosylation3151N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9XT55 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 3BFD2AE714A27AEE

FASTA52860,742
        10         20         30         40         50         60 
MSMKWTSALL LIQLSCYLSF GSCGKVLVWP TEFSHWMNIK TILDELVQRG HEVTVLAYST 

        70         80         90        100        110        120 
SILPDPNNPS PLKFEICPTS LTETEFQDSV TQLVKRWSDI RKDTFWPHFL HVQEMMWTYG 

       130        140        150        160        170        180 
DMIRKFCKDV VSNKKLMKKL QESRFDVVLA DAISPCGELL AELLKIPFVY SLRFSPGYAL 

       190        200        210        220        230        240 
EKHGGGFLFP PSYVPVTMSE LRDQMTFMER VQNMIYMVYF DFWFQVWDVK NWDQFYSKVL 

       250        260        270        280        290        300 
GRPTTLFEIM AKAEIWLIRN YWDFQFPHPL LPNVEFVGGL HCKPAKPLPK EMEEFVQSSG 

       310        320        330        340        350        360 
DNGVVVFSLG SMVSNMSEER ANVIASALAK IPQKVLWRFD GNKPDTLGLN TQLYKWLPQN 

       370        380        390        400        410        420 
DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGVPLFADQP DNIAHMKAKG AAVRLDFDTM 

       430        440        450        460        470        480 
SSTDLLNALK TVINDPIYKE NAMKLSSIHH DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA 

       490        500        510        520 
HDLTWFQYHS LDVIGFLLAC VATVIFIITK CLFCVWKFVR TRKKGKRD 

« Hide

References

[1]"Molecular cloning, expression and characterization of a monkey steroid UDP-glucuronosyltransferase, UGT2B19, that conjugates testosterone."
Belanger G., Barbier O., Hum D.W., Belanger A.
Eur. J. Biochem. 260:701-708(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Tissue: Liver and Prostate.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF112112 mRNA. Translation: AAD24435.1.

3D structure databases

ProteinModelPortalQ9XT55.
SMRQ9XT55. Positions 285-446.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG004033.

Enzyme and pathway databases

SABIO-RKQ9XT55.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUDB19_MACFA
AccessionPrimary (citable) accession number: Q9XT55
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families