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Q9XT27

- CERU_SHEEP

UniProt

Q9XT27 - CERU_SHEEP

Protein

Ceruloplasmin

Gene

CP

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane By similarity.By similarity

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Cofactori

    Binds 6 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi120 – 1201Copper 1; type 2By similarity
    Metal bindingi122 – 1221Copper 2; type 3By similarity
    Metal bindingi180 – 1801Copper 2; type 3By similarity
    Metal bindingi182 – 1821Copper 3; type 3By similarity
    Metal bindingi295 – 2951Copper 4; type 1By similarity
    Metal bindingi338 – 3381Copper 4; type 1By similarity
    Metal bindingi343 – 3431Copper 4; type 1By similarity
    Metal bindingi650 – 6501Copper 5; type 1By similarity
    Metal bindingi693 – 6931Copper 5; type 1By similarity
    Metal bindingi698 – 6981Copper 5; type 1By similarity
    Metal bindingi703 – 7031Copper 5; type 1By similarity
    Metal bindingi977 – 9771Copper 6; type 1By similarity
    Metal bindingi980 – 9801Copper 1; type 2By similarity
    Metal bindingi982 – 9821Copper 3; type 3By similarity
    Metal bindingi1022 – 10221Copper 3; type 3By similarity
    Metal bindingi1023 – 10231Copper 6; type 1By similarity
    Metal bindingi1024 – 10241Copper 2; type 3By similarity
    Metal bindingi1028 – 10281Copper 6; type 1By similarity
    Metal bindingi1033 – 10331Copper 6; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: InterPro
    2. copper ion transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Copper transport, Ion transport, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ceruloplasmin (EC:1.16.3.1)
    Alternative name(s):
    Ferroxidase
    Gene namesi
    Name:CP
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 10481029CeruloplasminPRO_0000227940Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi556 – 5561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi582 – 5821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi756 – 7561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi920 – 9201N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9XT27.

    Expressioni

    Tissue specificityi

    Expressed by the liver and secreted in plasma. Also expressed in the hypothalamus, spleen and uterus. No expression in the cortex, heart, intestine or kidney.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XT27.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 357338F5/8 type A 1Add
    BLAST
    Domaini20 – 200181Plastocyanin-like 1Add
    BLAST
    Domaini209 – 355147Plastocyanin-like 2Add
    BLAST
    Domaini370 – 712343F5/8 type A 2Add
    BLAST
    Domaini370 – 554185Plastocyanin-like 3Add
    BLAST
    Domaini564 – 710147Plastocyanin-like 4Add
    BLAST
    Domaini724 – 1044321F5/8 type A 3Add
    BLAST
    Domaini724 – 894171Plastocyanin-like 5Add
    BLAST
    Domaini902 – 1040139Plastocyanin-like 6Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 F5/8 type A domains.Curated
    Contains 6 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG003674.

    Family and domain databases

    Gene3Di2.60.40.420. 6 hits.
    InterProiIPR027150. CP.
    IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view]
    PANTHERiPTHR10127:SF294. PTHR10127:SF294. 1 hit.
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 3 hits.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 6 hits.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 3 hits.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9XT27-1 [UniParc]FASTAAdd to Basket

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    MKIFLLCIFL ILCGTSVWAK DKHYYIGIIE TAWNYASDHA EKKLISVDTE     50
    HSNIYLQNGP NRIGSVYKKA VYLQYTDENF RTVIEKPVWL GFLGPIIKAE 100
    TGDKVYVHLK NFASRPYTFH AHGLTYYKEH EGAIYPDNTT DLQKADDKVQ 150
    PGEQCLYILH ANPEQGPGEE DSNCVTRIYH SHIDAPKDIA SGLIGPLIHC 200
    KKDSLDEEKE KNIDKEFVVM FSVVDENLSW YLEENIKTYC SEPEKVEQDN 250
    EDFQESNRMY SVNGYAFGSL PGLSMCAEDR VKWYLFGMGN EIDVHAAFFH 300
    GQVLTSKNYR VDTINLFPAT LFDAFMVAQN PGQWMLSCQN LNHLKAGLQA 350
    FFWVQDCKKS SSEDNIHGKN VRHYYIAAEE VIWNYAPSGI DAFTKENLRA 400
    PGSASEAFFE QGPTRIGGSY KKLVYREYTD ASFSNQKERG PEEEHLGILG 450
    PVIAAEVGDT IRVTFHNKAA HPLSIEPIGV RVDKNNEGTY YSPTGSGPPP 500
    SGSHVAPKGT FTYEWTVPKE VGPTYKDPVC LAKMYYSGST KDIFTGLIGP 550
    MKICRNGSLL ANGRLKNVDK EFYLFPTVFD ENESLLLDDN IKMFTTAPDQ 600
    VDKENEDFQE SNKMHSMNGF MYGNQPGLSM CQGDSVMWYL FSAGNEVDIH 650
    GIYFSGNTYL SRGERRDTAN LFPQTSLSLF MQPDTAGTFD VECLTTDHYT 700
    GGMKQKYTVS QCGQRSEDLY LYLGERTYYI AAVEVEWDYS PSRKWEKELH 750
    HLQEQNLSNA FLDKEEFYIG SKYKKVVYRQ FTDSTFQVPV ERKGEEEHLG 800
    ILGPQLHADV GDKVNIIFKN MATRPYSIHA HGVKTESSTV TPTAPGETRT 850
    YIWKIPERSG AGMGDSPCIP WVYYSTVDRV KDLFSGLIGP LIVCRKHYLK 900
    VSNPIKKLEF SLLFLVFDEN ESWYLDDNIK TYSDHPEKVD KANEEFMESN 950
    KMHAINGRMF GNLQGLTMHV GNEVDLHSVH FHGHSFQYQH RGIYTSDVFD 1000
    LFPGTYQTLE MTPKTPGIWL LHCHVTDHIH AGMETTYTVL PNEEIKSG 1048
    Length:1,048
    Mass (Da):119,126
    Last modified:November 1, 1999 - v1
    Checksum:i925F16D7B0549CBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF134814 mRNA. Translation: AAD41477.1.
    RefSeqiNP_001009733.1. NM_001009733.1.
    UniGeneiOar.706.

    Genome annotation databases

    GeneIDi443053.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF134814 mRNA. Translation: AAD41477.1 .
    RefSeqi NP_001009733.1. NM_001009733.1.
    UniGenei Oar.706.

    3D structure databases

    ProteinModelPortali Q9XT27.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9XT27.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 443053.

    Organism-specific databases

    CTDi 1356.

    Phylogenomic databases

    HOVERGENi HBG003674.

    Family and domain databases

    Gene3Di 2.60.40.420. 6 hits.
    InterProi IPR027150. CP.
    IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view ]
    PANTHERi PTHR10127:SF294. PTHR10127:SF294. 1 hit.
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 6 hits.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 3 hits.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression analysis of the sheep ceruloplasmin cDNA."
      Lockhart P.J., Mercer J.F.B.
      Gene 236:251-257(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Liver.

    Entry informationi

    Entry nameiCERU_SHEEP
    AccessioniPrimary (citable) accession number: Q9XT27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3