SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9XT27

- CERU_SHEEP

UniProt

Q9XT27 - CERU_SHEEP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Ceruloplasmin
Gene
CP
Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Binds 6 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201Copper 1; type 2 By similarity
Metal bindingi122 – 1221Copper 2; type 3 By similarity
Metal bindingi180 – 1801Copper 2; type 3 By similarity
Metal bindingi182 – 1821Copper 3; type 3 By similarity
Metal bindingi295 – 2951Copper 4; type 1 By similarity
Metal bindingi338 – 3381Copper 4; type 1 By similarity
Metal bindingi343 – 3431Copper 4; type 1 By similarity
Metal bindingi650 – 6501Copper 5; type 1 By similarity
Metal bindingi693 – 6931Copper 5; type 1 By similarity
Metal bindingi698 – 6981Copper 5; type 1 By similarity
Metal bindingi703 – 7031Copper 5; type 1 By similarity
Metal bindingi977 – 9771Copper 6; type 1 By similarity
Metal bindingi980 – 9801Copper 1; type 2 By similarity
Metal bindingi982 – 9821Copper 3; type 3 By similarity
Metal bindingi1022 – 10221Copper 3; type 3 By similarity
Metal bindingi1023 – 10231Copper 6; type 1 By similarity
Metal bindingi1024 – 10241Copper 2; type 3 By similarity
Metal bindingi1028 – 10281Copper 6; type 1 By similarity
Metal bindingi1033 – 10331Copper 6; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular iron ion homeostasis Source: InterPro
  2. copper ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ceruloplasmin (EC:1.16.3.1)
Alternative name(s):
Ferroxidase
Gene namesi
Name:CP
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
ProteomesiUP000002356: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 10481029Ceruloplasmin
PRO_0000227940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi138 – 1381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi227 – 2271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi556 – 5561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi582 – 5821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi756 – 7561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi920 – 9201N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9XT27.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma. Also expressed in the hypothalamus, spleen and uterus. No expression in the cortex, heart, intestine or kidney.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9XT27.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 357338F5/8 type A 1
Add
BLAST
Domaini20 – 200181Plastocyanin-like 1
Add
BLAST
Domaini209 – 355147Plastocyanin-like 2
Add
BLAST
Domaini370 – 712343F5/8 type A 2
Add
BLAST
Domaini370 – 554185Plastocyanin-like 3
Add
BLAST
Domaini564 – 710147Plastocyanin-like 4
Add
BLAST
Domaini724 – 1044321F5/8 type A 3
Add
BLAST
Domaini724 – 894171Plastocyanin-like 5
Add
BLAST
Domaini902 – 1040139Plastocyanin-like 6
Add
BLAST

Sequence similaritiesi

Contains 3 F5/8 type A domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG003674.

Family and domain databases

Gene3Di2.60.40.420. 6 hits.
InterProiIPR027150. CP.
IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PANTHERiPTHR10127:SF294. PTHR10127:SF294. 1 hit.
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 3 hits.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 6 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 3 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XT27-1 [UniParc]FASTAAdd to Basket

« Hide

MKIFLLCIFL ILCGTSVWAK DKHYYIGIIE TAWNYASDHA EKKLISVDTE     50
HSNIYLQNGP NRIGSVYKKA VYLQYTDENF RTVIEKPVWL GFLGPIIKAE 100
TGDKVYVHLK NFASRPYTFH AHGLTYYKEH EGAIYPDNTT DLQKADDKVQ 150
PGEQCLYILH ANPEQGPGEE DSNCVTRIYH SHIDAPKDIA SGLIGPLIHC 200
KKDSLDEEKE KNIDKEFVVM FSVVDENLSW YLEENIKTYC SEPEKVEQDN 250
EDFQESNRMY SVNGYAFGSL PGLSMCAEDR VKWYLFGMGN EIDVHAAFFH 300
GQVLTSKNYR VDTINLFPAT LFDAFMVAQN PGQWMLSCQN LNHLKAGLQA 350
FFWVQDCKKS SSEDNIHGKN VRHYYIAAEE VIWNYAPSGI DAFTKENLRA 400
PGSASEAFFE QGPTRIGGSY KKLVYREYTD ASFSNQKERG PEEEHLGILG 450
PVIAAEVGDT IRVTFHNKAA HPLSIEPIGV RVDKNNEGTY YSPTGSGPPP 500
SGSHVAPKGT FTYEWTVPKE VGPTYKDPVC LAKMYYSGST KDIFTGLIGP 550
MKICRNGSLL ANGRLKNVDK EFYLFPTVFD ENESLLLDDN IKMFTTAPDQ 600
VDKENEDFQE SNKMHSMNGF MYGNQPGLSM CQGDSVMWYL FSAGNEVDIH 650
GIYFSGNTYL SRGERRDTAN LFPQTSLSLF MQPDTAGTFD VECLTTDHYT 700
GGMKQKYTVS QCGQRSEDLY LYLGERTYYI AAVEVEWDYS PSRKWEKELH 750
HLQEQNLSNA FLDKEEFYIG SKYKKVVYRQ FTDSTFQVPV ERKGEEEHLG 800
ILGPQLHADV GDKVNIIFKN MATRPYSIHA HGVKTESSTV TPTAPGETRT 850
YIWKIPERSG AGMGDSPCIP WVYYSTVDRV KDLFSGLIGP LIVCRKHYLK 900
VSNPIKKLEF SLLFLVFDEN ESWYLDDNIK TYSDHPEKVD KANEEFMESN 950
KMHAINGRMF GNLQGLTMHV GNEVDLHSVH FHGHSFQYQH RGIYTSDVFD 1000
LFPGTYQTLE MTPKTPGIWL LHCHVTDHIH AGMETTYTVL PNEEIKSG 1048
Length:1,048
Mass (Da):119,126
Last modified:November 1, 1999 - v1
Checksum:i925F16D7B0549CBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF134814 mRNA. Translation: AAD41477.1.
RefSeqiNP_001009733.1. NM_001009733.1.
UniGeneiOar.706.

Genome annotation databases

GeneIDi443053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF134814 mRNA. Translation: AAD41477.1 .
RefSeqi NP_001009733.1. NM_001009733.1.
UniGenei Oar.706.

3D structure databases

ProteinModelPortali Q9XT27.
ModBasei Search...

Proteomic databases

PRIDEi Q9XT27.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 443053.

Organism-specific databases

CTDi 1356.

Phylogenomic databases

HOVERGENi HBG003674.

Family and domain databases

Gene3Di 2.60.40.420. 6 hits.
InterProi IPR027150. CP.
IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
PANTHERi PTHR10127:SF294. PTHR10127:SF294. 1 hit.
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 3 hits.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 6 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 3 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression analysis of the sheep ceruloplasmin cDNA."
    Lockhart P.J., Mercer J.F.B.
    Gene 236:251-257(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Liver.

Entry informationi

Entry nameiCERU_SHEEP
AccessioniPrimary (citable) accession number: Q9XT27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi