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Q9XT27 (CERU_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ceruloplasmin
EC=1.16.3.1
Alternative name(s):
Ferroxidase
Gene names
Name:CP
OrganismOvis aries (Sheep)
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length1048 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactor

Binds 6 copper ions per monomer By similarity.

Subcellular location

Secreted.

Tissue specificity

Expressed by the liver and secreted in plasma. Also expressed in the hypothalamus, spleen and uterus. No expression in the cortex, heart, intestine or kidney. Ref.1

Sequence similarities

Belongs to the multicopper oxidase family.

Contains 3 F5/8 type A domains.

Contains 6 plastocyanin-like domains.

Ontologies

Keywords
   Biological processCopper transport
Ion transport
Transport
   Cellular componentSecreted
   DomainRepeat
Signal
   LigandCopper
Metal-binding
   Molecular functionOxidoreductase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: InterPro

copper ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncopper ion binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 10481029Ceruloplasmin
PRO_0000227940

Regions

Domain20 – 357338F5/8 type A 1
Domain20 – 200181Plastocyanin-like 1
Domain209 – 355147Plastocyanin-like 2
Domain370 – 712343F5/8 type A 2
Domain370 – 554185Plastocyanin-like 3
Domain564 – 710147Plastocyanin-like 4
Domain724 – 1044321F5/8 type A 3
Domain724 – 894171Plastocyanin-like 5
Domain902 – 1040139Plastocyanin-like 6

Sites

Metal binding1201Copper 1; type 2 By similarity
Metal binding1221Copper 2; type 3 By similarity
Metal binding1801Copper 2; type 3 By similarity
Metal binding1821Copper 3; type 3 By similarity
Metal binding2951Copper 4; type 1 By similarity
Metal binding3381Copper 4; type 1 By similarity
Metal binding3431Copper 4; type 1 By similarity
Metal binding6501Copper 5; type 1 By similarity
Metal binding6931Copper 5; type 1 By similarity
Metal binding6981Copper 5; type 1 By similarity
Metal binding7031Copper 5; type 1 By similarity
Metal binding9771Copper 6; type 1 By similarity
Metal binding9801Copper 1; type 2 By similarity
Metal binding9821Copper 3; type 3 By similarity
Metal binding10221Copper 3; type 3 By similarity
Metal binding10231Copper 6; type 1 By similarity
Metal binding10241Copper 2; type 3 By similarity
Metal binding10281Copper 6; type 1 By similarity
Metal binding10331Copper 6; type 1 By similarity

Amino acid modifications

Glycosylation1381N-linked (GlcNAc...) Potential
Glycosylation2271N-linked (GlcNAc...) Potential
Glycosylation5561N-linked (GlcNAc...) Potential
Glycosylation5821N-linked (GlcNAc...) Potential
Glycosylation7561N-linked (GlcNAc...) Potential
Glycosylation9201N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9XT27 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 925F16D7B0549CBB

FASTA1,048119,126
        10         20         30         40         50         60 
MKIFLLCIFL ILCGTSVWAK DKHYYIGIIE TAWNYASDHA EKKLISVDTE HSNIYLQNGP 

        70         80         90        100        110        120 
NRIGSVYKKA VYLQYTDENF RTVIEKPVWL GFLGPIIKAE TGDKVYVHLK NFASRPYTFH 

       130        140        150        160        170        180 
AHGLTYYKEH EGAIYPDNTT DLQKADDKVQ PGEQCLYILH ANPEQGPGEE DSNCVTRIYH 

       190        200        210        220        230        240 
SHIDAPKDIA SGLIGPLIHC KKDSLDEEKE KNIDKEFVVM FSVVDENLSW YLEENIKTYC 

       250        260        270        280        290        300 
SEPEKVEQDN EDFQESNRMY SVNGYAFGSL PGLSMCAEDR VKWYLFGMGN EIDVHAAFFH 

       310        320        330        340        350        360 
GQVLTSKNYR VDTINLFPAT LFDAFMVAQN PGQWMLSCQN LNHLKAGLQA FFWVQDCKKS 

       370        380        390        400        410        420 
SSEDNIHGKN VRHYYIAAEE VIWNYAPSGI DAFTKENLRA PGSASEAFFE QGPTRIGGSY 

       430        440        450        460        470        480 
KKLVYREYTD ASFSNQKERG PEEEHLGILG PVIAAEVGDT IRVTFHNKAA HPLSIEPIGV 

       490        500        510        520        530        540 
RVDKNNEGTY YSPTGSGPPP SGSHVAPKGT FTYEWTVPKE VGPTYKDPVC LAKMYYSGST 

       550        560        570        580        590        600 
KDIFTGLIGP MKICRNGSLL ANGRLKNVDK EFYLFPTVFD ENESLLLDDN IKMFTTAPDQ 

       610        620        630        640        650        660 
VDKENEDFQE SNKMHSMNGF MYGNQPGLSM CQGDSVMWYL FSAGNEVDIH GIYFSGNTYL 

       670        680        690        700        710        720 
SRGERRDTAN LFPQTSLSLF MQPDTAGTFD VECLTTDHYT GGMKQKYTVS QCGQRSEDLY 

       730        740        750        760        770        780 
LYLGERTYYI AAVEVEWDYS PSRKWEKELH HLQEQNLSNA FLDKEEFYIG SKYKKVVYRQ 

       790        800        810        820        830        840 
FTDSTFQVPV ERKGEEEHLG ILGPQLHADV GDKVNIIFKN MATRPYSIHA HGVKTESSTV 

       850        860        870        880        890        900 
TPTAPGETRT YIWKIPERSG AGMGDSPCIP WVYYSTVDRV KDLFSGLIGP LIVCRKHYLK 

       910        920        930        940        950        960 
VSNPIKKLEF SLLFLVFDEN ESWYLDDNIK TYSDHPEKVD KANEEFMESN KMHAINGRMF 

       970        980        990       1000       1010       1020 
GNLQGLTMHV GNEVDLHSVH FHGHSFQYQH RGIYTSDVFD LFPGTYQTLE MTPKTPGIWL 

      1030       1040 
LHCHVTDHIH AGMETTYTVL PNEEIKSG

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References

[1]"Cloning and expression analysis of the sheep ceruloplasmin cDNA."
Lockhart P.J., Mercer J.F.B.
Gene 236:251-257(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF134814 mRNA. Translation: AAD41477.1.
RefSeqNP_001009733.1. NM_001009733.1.
UniGeneOar.706.

3D structure databases

ProteinModelPortalQ9XT27.
ModBaseSearch...

Proteomic databases

PRIDEQ9XT27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID443053.

Organism-specific databases

CTD1356.

Phylogenomic databases

HOVERGENHBG003674.

Family and domain databases

Gene3D2.60.40.420. 6 hits.
InterProIPR027150. CP.
IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PANTHERPTHR10127:SF89. PTHR10127:SF89. 1 hit.
PfamPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 3 hits.
[Graphical view]
SUPFAMSSF49503. Cupredoxin. 6 hits.
PROSITEPS00079. MULTICOPPER_OXIDASE1. 3 hits.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCERU_SHEEP
AccessionPrimary (citable) accession number: Q9XT27
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 1, 1999
Last modified: May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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