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Protein

Cyclin-T1

Gene

CCNT1

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (By similarity). In case of equine infectious anemia virus (EIAV) infection, binds to the nuclear transcriptional activator Tat, increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Host-virus interaction, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-T1
Short name:
CycT1
Short name:
Cyclin-T
Gene namesi
Name:CCNT1
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804921 – 727Cyclin-T1Add BLAST727

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphoserineBy similarity1
Modified residuei390PhosphoserineBy similarity1
Modified residuei392N6-acetyllysineBy similarity1
Modified residuei497PhosphoserineBy similarity1
Modified residuei501PhosphoserineBy similarity1
Modified residuei566PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9XT26.

Interactioni

Subunit structurei

Associates with CDK9 to form P-TEFb. Cyclin-T1 is the predominant cyclin associated with CDK9. P-TEFb forms a complex with AFF4/AF5Q31. Interacts with MDFIC (By similarity). Interacts with the transactivation region of EIAV Tat, but not with HIV-1 tat. Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb, RNA pol II. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with BRD4, probably to target chromatin binding (By similarity).By similarity

Protein-protein interaction databases

STRINGi9796.ENSECAP00000013646.

Structurei

Secondary structure

1727
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 12Combined sources3
Turni16 – 18Combined sources3
Turni23 – 25Combined sources3
Beta strandi26 – 28Combined sources3
Helixi31 – 52Combined sources22
Helixi56 – 69Combined sources14
Turni75 – 77Combined sources3
Helixi80 – 94Combined sources15
Helixi101 – 112Combined sources12
Helixi126 – 143Combined sources18
Turni144 – 146Combined sources3
Helixi153 – 157Combined sources5
Beta strandi160 – 164Combined sources5
Helixi168 – 170Combined sources3
Helixi175 – 178Combined sources4
Turni179 – 184Combined sources6
Helixi186 – 189Combined sources4
Helixi193 – 202Combined sources10
Helixi204 – 207Combined sources4
Turni216 – 218Combined sources3
Turni221 – 225Combined sources5
Helixi231 – 245Combined sources15
Beta strandi246 – 248Combined sources3
Beta strandi262 – 265Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W2HX-ray3.25A/B5-267[»]
ProteinModelPortaliQ9XT26.
SMRiQ9XT26.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9XT26.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili386 – 427Sequence analysisAdd BLAST42

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi253 – 270Nuclear localization signal, and interaction with Tat-TAR RNASequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi508 – 532His-richAdd BLAST25
Compositional biasi550 – 573Ser-richAdd BLAST24
Compositional biasi709 – 726Pro-richAdd BLAST18

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0834. Eukaryota.
COG5333. LUCA.
GeneTreeiENSGT00760000119191.
HOGENOMiHOG000013208.
HOVERGENiHBG050843.
InParanoidiQ9XT26.
KOiK15188.
OMAiTMAQLPG.
OrthoDBiEOG091G03Z2.
TreeFamiTF101014.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR028863. CCNT1.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10026:SF42. PTHR10026:SF42. 3 hits.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9XT26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGERKNNNK RWYFTREQLE NSPSRRFGLD PDKELSYRQQ AANLLQDMGQ
60 70 80 90 100
RLNVSQLTIN TAIVYMHRFY MIQSFTQFHR NSVAPAALFL AAKVEEQPKK
110 120 130 140 150
LEHVIKVAHA CLHPQESLPD TRSEAYLQQV QDLVILESII LQTLGFELTI
160 170 180 190 200
DHPHTHVVKC TQLVRASKDL AQTSYFMATN SLHLTTFSLQ YTPPVVACVC
210 220 230 240 250
IHLACKWSNW EIPVSTDGKH WWEYVDATVT LELLDELTHE FLQILEKTPN
260 270 280 290 300
RLKRIRNWRA CQAAKKTKAD DRGTDENTSE QTILNMISQS SSDTTIAGLM
310 320 330 340 350
SMSTSSTTST VPSLPTTEES SSNLSGVEML QGERWLSSQP PFKLEPAQGH
360 370 380 390 400
RTSENLALIG VDHSLQQDGS NAFISQKQNS SKSVPSAKVS LKEYRAKHAE
410 420 430 440 450
ELAAQKRQLE NMEANVKSQY AYAAQNLLSH HDSHSSVILK MPIEGSENPE
460 470 480 490 500
RPFLEKPDKT ALKMRIPVAS GDKAASSKPE EIKMRIKVHA APDKHNSIDD
510 520 530 540 550
SVTKSREHKE KHKTHPSNHH HHHNHHSHKH SHSQLPAGTG NKRPGDPKHS
560 570 580 590 600
SQTSTLAHKT YSLSSSFSSS SSSRKRGPPE ETGGALFDHP AKIAKSTKSS
610 620 630 640 650
SINFFPPLPT MAQLPGHSSD TSGLPFSQPS CKTRVPHMKL DKGPTGANGH
660 670 680 690 700
NTTQTIDYQD TVNMLHSLLH AQGVQPTQPP ALEFVHSYGE YLNPRAGGMP
710 720
SRSGNTDKPR LPPLPSEPPP PLPPLPK
Length:727
Mass (Da):81,013
Last modified:November 1, 1999 - v1
Checksum:iBFC2A398D6B35BCE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96E → G in AAF04138 (PubMed:10623752).Curated1
Sequence conflicti256R → W in AAF04138 (PubMed:10623752).Curated1
Sequence conflicti262Q → E in AAF04138 (PubMed:10623752).Curated1
Sequence conflicti277N → K in AAF04138 (PubMed:10623752).Curated1
Sequence conflicti359I → T in AAF04138 (PubMed:10623752).Curated1
Sequence conflicti537A → V in AAF04138 (PubMed:10623752).Curated1
Sequence conflicti681A → T in AAF04138 (PubMed:10623752).Curated1
Sequence conflicti687S → P in AAF04138 (PubMed:10623752).Curated1
Sequence conflicti699M → I in AAF04138 (PubMed:10623752).Curated1
Sequence conflicti711L → P in AAF04138 (PubMed:10623752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137509 mRNA. Translation: AAD38518.1.
AF190905 mRNA. Translation: AAF04138.1.
RefSeqiNP_001075315.1. NM_001081846.1.
UniGeneiEca.12914.

Genome annotation databases

EnsembliENSECAT00000016868; ENSECAP00000013646; ENSECAG00000015768.
GeneIDi100033893.
KEGGiecb:100033893.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137509 mRNA. Translation: AAD38518.1.
AF190905 mRNA. Translation: AAF04138.1.
RefSeqiNP_001075315.1. NM_001081846.1.
UniGeneiEca.12914.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W2HX-ray3.25A/B5-267[»]
ProteinModelPortaliQ9XT26.
SMRiQ9XT26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000013646.

Proteomic databases

PaxDbiQ9XT26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000016868; ENSECAP00000013646; ENSECAG00000015768.
GeneIDi100033893.
KEGGiecb:100033893.

Organism-specific databases

CTDi904.

Phylogenomic databases

eggNOGiKOG0834. Eukaryota.
COG5333. LUCA.
GeneTreeiENSGT00760000119191.
HOGENOMiHOG000013208.
HOVERGENiHBG050843.
InParanoidiQ9XT26.
KOiK15188.
OMAiTMAQLPG.
OrthoDBiEOG091G03Z2.
TreeFamiTF101014.

Miscellaneous databases

EvolutionaryTraceiQ9XT26.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR028863. CCNT1.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10026:SF42. PTHR10026:SF42. 3 hits.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCCNT1_HORSE
AccessioniPrimary (citable) accession number: Q9XT26
Secondary accession number(s): Q9TTX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.