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Q9XSX5

- IL8_FELCA

UniProt

Q9XSX5 - IL8_FELCA

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Protein

Interleukin-8

Gene

CXCL8

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus By similarity.By similarity

GO - Biological processi

  1. cell cycle arrest Source: Ensembl
  2. cellular response to fibroblast growth factor stimulus Source: Ensembl
  3. cellular response to interleukin-1 Source: Ensembl
  4. cellular response to lipopolysaccharide Source: Ensembl
  5. cellular response to tumor necrosis factor Source: Ensembl
  6. embryonic digestive tract development Source: Ensembl
  7. immune response Source: InterPro
  8. induction of positive chemotaxis Source: Ensembl
  9. inflammatory response Source: UniProtKB-KW
  10. intracellular signal transduction Source: Ensembl
  11. negative regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  12. neutrophil activation Source: InterPro
  13. neutrophil chemotaxis Source: InterPro
  14. receptor internalization Source: Ensembl
  15. regulation of cell adhesion Source: Ensembl
  16. regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: Ensembl
  17. response to endoplasmic reticulum stress Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-8
Short name:
IL-8
Alternative name(s):
C-X-C motif chemokine 8
Chemokine (C-X-C motif) ligand 8
Gene namesi
Name:CXCL8
Synonyms:IL8
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Chromosome B1

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 10179Interleukin-8PRO_0000005124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271CitrullineBy similarity
Disulfide bondi34 ↔ 61By similarity
Disulfide bondi36 ↔ 77By similarity

Post-translational modificationi

Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000004310.

Structurei

3D structure databases

ProteinModelPortaliQ9XSX5.
SMRiQ9XSX5. Positions 31-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG73311.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiQ9XSX5.
KOiK10030.
OMAiPFHPKYI.
OrthoDBiEOG7GTT6P.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR028469. Interleukin-8.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF35. PTHR10179:SF35. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XSX5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSKLVVALL AAFMLSAALC EAAVLSRISS ELRCQCIKTH STPFNPKLIK
60 70 80 90 100
ELTVIDSGPH CENSEIIVKL VNGKEVCLDP KQKWVQKVVE IFLKKAEKQN

A
Length:101
Mass (Da):11,165
Last modified:November 1, 1999 - v1
Checksum:i690D97F13EF79170
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF158598 mRNA. Translation: AAD40323.1.
RefSeqiNP_001009281.1. NM_001009281.1.

Genome annotation databases

EnsembliENSFCAT00000004666; ENSFCAP00000004310; ENSFCAG00000004666.
GeneIDi493836.
KEGGifca:493836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF158598 mRNA. Translation: AAD40323.1 .
RefSeqi NP_001009281.1. NM_001009281.1.

3D structure databases

ProteinModelPortali Q9XSX5.
SMRi Q9XSX5. Positions 31-97.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000004310.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSFCAT00000004666 ; ENSFCAP00000004310 ; ENSFCAG00000004666 .
GeneIDi 493836.
KEGGi fca:493836.

Organism-specific databases

CTDi 3576.

Phylogenomic databases

eggNOGi NOG73311.
GeneTreei ENSGT00530000062901.
HOGENOMi HOG000220915.
HOVERGENi HBG107789.
InParanoidi Q9XSX5.
KOi K10030.
OMAi PFHPKYI.
OrthoDBi EOG7GTT6P.
TreeFami TF333433.

Family and domain databases

InterProi IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR028469. Interleukin-8.
[Graphical view ]
PANTHERi PTHR10179. PTHR10179. 1 hit.
PTHR10179:SF35. PTHR10179:SF35. 1 hit.
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
PRINTSi PR00437. SMALLCYTKCXC.
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Feline interleukin-8 mRNA."
    Straubinger A.F., Simpson K.W., Straubinger R.K.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL8_FELCA
AccessioniPrimary (citable) accession number: Q9XSX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3