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Q9XSX5 (IL8_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-8

Short name=IL-8
Alternative name(s):
C-X-C motif chemokine 8
Chemokine (C-X-C motif) ligand 8
Gene names
Name:CXCL8
Synonyms:IL8
OrganismFelis catus (Cat) (Felis silvestris catus) [Reference proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length101 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted.

Post-translational modification

Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation By similarity.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMCitrullination
Disulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell chemotaxis

Inferred from electronic annotation. Source: GOC

cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

cellular response to fibroblast growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-1

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

embryonic digestive tract development

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

induction of positive chemotaxis

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

intracellular signal transduction

Inferred from electronic annotation. Source: Ensembl

negative regulation of G-protein coupled receptor protein signaling pathway

Inferred from electronic annotation. Source: Ensembl

receptor internalization

Inferred from electronic annotation. Source: Ensembl

regulation of cell adhesion

Inferred from electronic annotation. Source: Ensembl

regulation of single stranded viral RNA replication via double stranded DNA intermediate

Inferred from electronic annotation. Source: Ensembl

response to endoplasmic reticulum stress

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 10179Interleukin-8
PRO_0000005124

Amino acid modifications

Modified residue271Citrulline By similarity
Disulfide bond34 ↔ 61 By similarity
Disulfide bond36 ↔ 77 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9XSX5 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 690D97F13EF79170

FASTA10111,165
        10         20         30         40         50         60 
MTSKLVVALL AAFMLSAALC EAAVLSRISS ELRCQCIKTH STPFNPKLIK ELTVIDSGPH 

        70         80         90        100 
CENSEIIVKL VNGKEVCLDP KQKWVQKVVE IFLKKAEKQN A 

« Hide

References

[1]"Feline interleukin-8 mRNA."
Straubinger A.F., Simpson K.W., Straubinger R.K.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF158598 mRNA. Translation: AAD40323.1.
RefSeqNP_001009281.1. NM_001009281.1.

3D structure databases

ProteinModelPortalQ9XSX5.
SMRQ9XSX5. Positions 31-97.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9685.ENSFCAP00000004310.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSFCAT00000004666; ENSFCAP00000004310; ENSFCAG00000004666.
GeneID493836.
KEGGfca:493836.

Organism-specific databases

CTD100195681.

Phylogenomic databases

eggNOGNOG73311.
GeneTreeENSGT00530000062901.
HOGENOMHOG000220915.
HOVERGENHBG107789.
KOK10030.
OMAPFHPKYI.
OrthoDBEOG7GTT6P.
TreeFamTF333433.

Family and domain databases

InterProIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR028469. Interleukin-8.
[Graphical view]
PANTHERPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF35. PTHR10179:SF35. 1 hit.
PfamPF00048. IL8. 1 hit.
[Graphical view]
PRINTSPR00437. SMALLCYTKCXC.
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIL8_FELCA
AccessionPrimary (citable) accession number: Q9XSX5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families