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Q9XSX5

- IL8_FELCA

UniProt

Q9XSX5 - IL8_FELCA

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Protein
Interleukin-8
Gene
CXCL8, IL8
Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus By similarity.

GO - Biological processi

  1. cell cycle arrest Source: Ensembl
  2. cellular response to fibroblast growth factor stimulus Source: Ensembl
  3. cellular response to interleukin-1 Source: Ensembl
  4. cellular response to lipopolysaccharide Source: Ensembl
  5. cellular response to tumor necrosis factor Source: Ensembl
  6. embryonic digestive tract development Source: Ensembl
  7. immune response Source: InterPro
  8. induction of positive chemotaxis Source: Ensembl
  9. inflammatory response Source: UniProtKB-KW
  10. intracellular signal transduction Source: Ensembl
  11. negative regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
  12. neutrophil activation Source: InterPro
  13. neutrophil chemotaxis Source: InterPro
  14. receptor internalization Source: Ensembl
  15. regulation of cell adhesion Source: Ensembl
  16. regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: Ensembl
  17. response to endoplasmic reticulum stress Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-8
Short name:
IL-8
Alternative name(s):
C-X-C motif chemokine 8
Chemokine (C-X-C motif) ligand 8
Gene namesi
Name:CXCL8
Synonyms:IL8
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712: Chromosome B1

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarity
Add
BLAST
Chaini23 – 10179Interleukin-8
PRO_0000005124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271Citrulline By similarity
Disulfide bondi34 ↔ 61 By similarity
Disulfide bondi36 ↔ 77 By similarity

Post-translational modificationi

Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation By similarity.

Keywords - PTMi

Citrullination, Disulfide bond

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000004310.

Structurei

3D structure databases

ProteinModelPortaliQ9XSX5.
SMRiQ9XSX5. Positions 31-97.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG73311.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
KOiK10030.
OMAiPFHPKYI.
OrthoDBiEOG7GTT6P.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR028469. Interleukin-8.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF35. PTHR10179:SF35. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XSX5-1 [UniParc]FASTAAdd to Basket

« Hide

MTSKLVVALL AAFMLSAALC EAAVLSRISS ELRCQCIKTH STPFNPKLIK    50
ELTVIDSGPH CENSEIIVKL VNGKEVCLDP KQKWVQKVVE IFLKKAEKQN 100
A 101
Length:101
Mass (Da):11,165
Last modified:November 1, 1999 - v1
Checksum:i690D97F13EF79170
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF158598 mRNA. Translation: AAD40323.1.
RefSeqiNP_001009281.1. NM_001009281.1.

Genome annotation databases

EnsembliENSFCAT00000004666; ENSFCAP00000004310; ENSFCAG00000004666.
GeneIDi493836.
KEGGifca:493836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF158598 mRNA. Translation: AAD40323.1 .
RefSeqi NP_001009281.1. NM_001009281.1.

3D structure databases

ProteinModelPortali Q9XSX5.
SMRi Q9XSX5. Positions 31-97.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9685.ENSFCAP00000004310.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSFCAT00000004666 ; ENSFCAP00000004310 ; ENSFCAG00000004666 .
GeneIDi 493836.
KEGGi fca:493836.

Organism-specific databases

CTDi 100195681.

Phylogenomic databases

eggNOGi NOG73311.
GeneTreei ENSGT00530000062901.
HOGENOMi HOG000220915.
HOVERGENi HBG107789.
KOi K10030.
OMAi PFHPKYI.
OrthoDBi EOG7GTT6P.
TreeFami TF333433.

Family and domain databases

InterProi IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR028469. Interleukin-8.
[Graphical view ]
PANTHERi PTHR10179. PTHR10179. 1 hit.
PTHR10179:SF35. PTHR10179:SF35. 1 hit.
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
PRINTSi PR00437. SMALLCYTKCXC.
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Feline interleukin-8 mRNA."
    Straubinger A.F., Simpson K.W., Straubinger R.K.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL8_FELCA
AccessioniPrimary (citable) accession number: Q9XSX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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