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Protein

Interleukin-8

Gene

CXCL8

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-8
Short name:
IL-8
Alternative name(s):
C-X-C motif chemokine 8
Chemokine (C-X-C motif) ligand 8
Gene namesi
Name:CXCL8
Synonyms:IL8
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
ProteomesiUP000011712 Componenti: Chromosome B1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 10179Interleukin-8PRO_0000005124Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271CitrullineBy similarity
Disulfide bondi34 ↔ 61By similarity
Disulfide bondi36 ↔ 77By similarity

Post-translational modificationi

Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.By similarity

Keywords - PTMi

Citrullination, Disulfide bond

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000004310.

Structurei

3D structure databases

ProteinModelPortaliQ9XSX5.
SMRiQ9XSX5. Positions 31-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG73311.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiQ9XSX5.
KOiK10030.
OMAiCEAAVLT.
OrthoDBiEOG7GTT6P.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR028469. Interleukin-8.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF35. PTHR10179:SF35. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XSX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKLVVALL AAFMLSAALC EAAVLSRISS ELRCQCIKTH STPFNPKLIK
60 70 80 90 100
ELTVIDSGPH CENSEIIVKL VNGKEVCLDP KQKWVQKVVE IFLKKAEKQN

A
Length:101
Mass (Da):11,165
Last modified:November 1, 1999 - v1
Checksum:i690D97F13EF79170
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF158598 mRNA. Translation: AAD40323.1.
RefSeqiNP_001009281.1. NM_001009281.1.

Genome annotation databases

EnsembliENSFCAT00000004666; ENSFCAP00000004310; ENSFCAG00000004666.
GeneIDi493836.
KEGGifca:493836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF158598 mRNA. Translation: AAD40323.1.
RefSeqiNP_001009281.1. NM_001009281.1.

3D structure databases

ProteinModelPortaliQ9XSX5.
SMRiQ9XSX5. Positions 31-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000004310.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFCAT00000004666; ENSFCAP00000004310; ENSFCAG00000004666.
GeneIDi493836.
KEGGifca:493836.

Organism-specific databases

CTDi3576.

Phylogenomic databases

eggNOGiNOG73311.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiQ9XSX5.
KOiK10030.
OMAiCEAAVLT.
OrthoDBiEOG7GTT6P.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR028469. Interleukin-8.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF35. PTHR10179:SF35. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Feline interleukin-8 mRNA."
    Straubinger A.F., Simpson K.W., Straubinger R.K.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL8_FELCA
AccessioniPrimary (citable) accession number: Q9XSX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: July 22, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.