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Q9XSX5

- IL8_FELCA

UniProt

Q9XSX5 - IL8_FELCA

Protein

Interleukin-8

Gene

CXCL8

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
  1. Functioni

    IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus By similarity.By similarity

    GO - Biological processi

    1. cell cycle arrest Source: Ensembl
    2. cellular response to fibroblast growth factor stimulus Source: Ensembl
    3. cellular response to interleukin-1 Source: Ensembl
    4. cellular response to lipopolysaccharide Source: Ensembl
    5. cellular response to tumor necrosis factor Source: Ensembl
    6. embryonic digestive tract development Source: Ensembl
    7. immune response Source: InterPro
    8. induction of positive chemotaxis Source: Ensembl
    9. inflammatory response Source: UniProtKB-KW
    10. intracellular signal transduction Source: Ensembl
    11. negative regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
    12. neutrophil activation Source: InterPro
    13. neutrophil chemotaxis Source: InterPro
    14. receptor internalization Source: Ensembl
    15. regulation of cell adhesion Source: Ensembl
    16. regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: Ensembl
    17. response to endoplasmic reticulum stress Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-8
    Short name:
    IL-8
    Alternative name(s):
    C-X-C motif chemokine 8
    Chemokine (C-X-C motif) ligand 8
    Gene namesi
    Name:CXCL8
    Synonyms:IL8
    OrganismiFelis catus (Cat) (Felis silvestris catus)
    Taxonomic identifieri9685 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
    ProteomesiUP000011712: Chromosome B1

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 10179Interleukin-8PRO_0000005124Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei27 – 271CitrullineBy similarity
    Disulfide bondi34 ↔ 61By similarity
    Disulfide bondi36 ↔ 77By similarity

    Post-translational modificationi

    Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.By similarity

    Keywords - PTMi

    Citrullination, Disulfide bond

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9685.ENSFCAP00000004310.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XSX5.
    SMRiQ9XSX5. Positions 31-97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG73311.
    GeneTreeiENSGT00530000062901.
    HOGENOMiHOG000220915.
    HOVERGENiHBG107789.
    KOiK10030.
    OMAiPFHPKYI.
    OrthoDBiEOG7GTT6P.
    TreeFamiTF333433.

    Family and domain databases

    InterProiIPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    IPR028469. Interleukin-8.
    [Graphical view]
    PANTHERiPTHR10179. PTHR10179. 1 hit.
    PTHR10179:SF35. PTHR10179:SF35. 1 hit.
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR00437. SMALLCYTKCXC.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9XSX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSKLVVALL AAFMLSAALC EAAVLSRISS ELRCQCIKTH STPFNPKLIK    50
    ELTVIDSGPH CENSEIIVKL VNGKEVCLDP KQKWVQKVVE IFLKKAEKQN 100
    A 101
    Length:101
    Mass (Da):11,165
    Last modified:November 1, 1999 - v1
    Checksum:i690D97F13EF79170
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF158598 mRNA. Translation: AAD40323.1.
    RefSeqiNP_001009281.1. NM_001009281.1.

    Genome annotation databases

    EnsembliENSFCAT00000004666; ENSFCAP00000004310; ENSFCAG00000004666.
    GeneIDi493836.
    KEGGifca:493836.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF158598 mRNA. Translation: AAD40323.1 .
    RefSeqi NP_001009281.1. NM_001009281.1.

    3D structure databases

    ProteinModelPortali Q9XSX5.
    SMRi Q9XSX5. Positions 31-97.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9685.ENSFCAP00000004310.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSFCAT00000004666 ; ENSFCAP00000004310 ; ENSFCAG00000004666 .
    GeneIDi 493836.
    KEGGi fca:493836.

    Organism-specific databases

    CTDi 3576.

    Phylogenomic databases

    eggNOGi NOG73311.
    GeneTreei ENSGT00530000062901.
    HOGENOMi HOG000220915.
    HOVERGENi HBG107789.
    KOi K10030.
    OMAi PFHPKYI.
    OrthoDBi EOG7GTT6P.
    TreeFami TF333433.

    Family and domain databases

    InterProi IPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    IPR028469. Interleukin-8.
    [Graphical view ]
    PANTHERi PTHR10179. PTHR10179. 1 hit.
    PTHR10179:SF35. PTHR10179:SF35. 1 hit.
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR00437. SMALLCYTKCXC.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Feline interleukin-8 mRNA."
      Straubinger A.F., Simpson K.W., Straubinger R.K.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiIL8_FELCA
    AccessioniPrimary (citable) accession number: Q9XSX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3