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Protein

Pro-neuropeptide Y

Gene

NPY

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-neuropeptide Y
Cleaved into the following 2 chains:
Alternative name(s):
Neuropeptide tyrosine
Short name:
NPY
Gene namesi
Name:NPY
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28By similarityAdd BLAST28
PeptideiPRO_000002532329 – 64Neuropeptide YAdd BLAST36
PeptideiPRO_000002532468 – 97C-flanking peptide of NPYAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Tyrosine amideBy similarity1
Modified residuei83PhosphothreonineBy similarity1

Post-translational modificationi

The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei30 – 31Cleavage; by FAPBy similarity2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000009818.
ExpressionAtlasiQ9XSW6. baseline.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000012853.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R9NX-ray2.30E/F/G/H29-38[»]
ProteinModelPortaliQ9XSW6.
SMRiQ9XSW6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9XSW6.

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0KC. Eukaryota.
ENOG41128I2. LUCA.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiQ9XSW6.
KOiK05232.
OMAiFEDPSMW.
OrthoDBiEOG091G0ZRE.
TreeFamiTF332778.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiView protein in InterPro
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiView protein in Pfam
PF00159. Hormone_3. 1 hit.
PRINTSiPR00278. PANCHORMONE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267. Pancreatic_hormone-like. 1 hit.
SMARTiView protein in SMART
SM00309. PAH. 1 hit.
PROSITEiView protein in PROSITE
PS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XSW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSKRLGLS GLTLALSLLV CLGALAEAYP SKPDNPGEDA PAEDMARYYS
60 70 80 90
ALRHYINLIT RQRYGKRSSP ETLISDLLMR ESTENVPRTR LEDPSMW
Length:97
Mass (Da):10,840
Last modified:November 1, 1999 - v1
Checksum:i2D2209BAC20BD5EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162280 mRNA. Translation: AAD43583.1.
RefSeqiNP_001027986.1. NM_001032814.1.
UniGeneiMmu.3466.

Genome annotation databases

EnsembliENSMMUT00000071340; ENSMMUP00000051181; ENSMMUG00000009818.
GeneIDi574114.
KEGGimcc:574114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162280 mRNA. Translation: AAD43583.1.
RefSeqiNP_001027986.1. NM_001032814.1.
UniGeneiMmu.3466.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R9NX-ray2.30E/F/G/H29-38[»]
ProteinModelPortaliQ9XSW6.
SMRiQ9XSW6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000012853.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000071340; ENSMMUP00000051181; ENSMMUG00000009818.
GeneIDi574114.
KEGGimcc:574114.

Organism-specific databases

CTDi4852.

Phylogenomic databases

eggNOGiENOG410J0KC. Eukaryota.
ENOG41128I2. LUCA.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiQ9XSW6.
KOiK05232.
OMAiFEDPSMW.
OrthoDBiEOG091G0ZRE.
TreeFamiTF332778.

Miscellaneous databases

EvolutionaryTraceiQ9XSW6.

Gene expression databases

BgeeiENSMMUG00000009818.
ExpressionAtlasiQ9XSW6. baseline.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiView protein in InterPro
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiView protein in Pfam
PF00159. Hormone_3. 1 hit.
PRINTSiPR00278. PANCHORMONE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267. Pancreatic_hormone-like. 1 hit.
SMARTiView protein in SMART
SM00309. PAH. 1 hit.
PROSITEiView protein in PROSITE
PS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNPY_MACMU
AccessioniPrimary (citable) accession number: Q9XSW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: November 1, 1999
Last modified: March 15, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.