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Protein

Pro-neuropeptide Y

Gene

NPY

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-neuropeptide Y
Cleaved into the following 2 chains:
Alternative name(s):
Neuropeptide tyrosine
Short name:
NPY
Gene namesi
Name:NPY
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28By similarityAdd BLAST28
PeptideiPRO_000002532329 – 64Neuropeptide YAdd BLAST36
PeptideiPRO_000002532468 – 97C-flanking peptide of NPYAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Tyrosine amideBy similarity1
Modified residuei83PhosphothreonineBy similarity1

Post-translational modificationi

The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei30 – 31Cleavage; by FAPBy similarity2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Expressioni

Gene expression databases

BgeeiENSMMUG00000009818.
ExpressionAtlasiQ9XSW6. baseline.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000012853.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R9NX-ray2.30E/F/G/H29-38[»]
ProteinModelPortaliQ9XSW6.
SMRiQ9XSW6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9XSW6.

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0KC. Eukaryota.
ENOG41128I2. LUCA.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiQ9XSW6.
KOiK05232.
OMAiFEDPSMW.
OrthoDBiEOG091G0ZRE.
TreeFamiTF332778.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiView protein in InterPro
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiView protein in Pfam
PF00159. Hormone_3. 1 hit.
PRINTSiPR00278. PANCHORMONE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267. Pancreatic_hormone-like. 1 hit.
SMARTiView protein in SMART
SM00309. PAH. 1 hit.
PROSITEiView protein in PROSITE
PS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XSW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSKRLGLS GLTLALSLLV CLGALAEAYP SKPDNPGEDA PAEDMARYYS
60 70 80 90
ALRHYINLIT RQRYGKRSSP ETLISDLLMR ESTENVPRTR LEDPSMW
Length:97
Mass (Da):10,840
Last modified:November 1, 1999 - v1
Checksum:i2D2209BAC20BD5EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162280 mRNA. Translation: AAD43583.1.
RefSeqiNP_001027986.1. NM_001032814.1.
UniGeneiMmu.3466.

Genome annotation databases

EnsembliENSMMUT00000071340; ENSMMUP00000051181; ENSMMUG00000009818.
GeneIDi574114.
KEGGimcc:574114.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNPY_MACMU
AccessioniPrimary (citable) accession number: Q9XSW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: November 1, 1999
Last modified: March 15, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families