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Protein

Interleukin-13

Gene

IL13

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-BTA-6785807. Interleukin-4 and 13 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13
Short name:
IL-13
Gene namesi
Name:IL13
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001554521 – 132Interleukin-13Add BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi48 ↔ 76By similarity
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi64 ↔ 90By similarity
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9XSV9.

Expressioni

Gene expression databases

BgeeiENSBTAG00000015953.

Interactioni

Subunit structurei

Interacts with IL13RA2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021212.

Structurei

3D structure databases

ProteinModelPortaliQ9XSV9.
SMRiQ9XSV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-4/IL-13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCI3. Eukaryota.
ENOG4111BX2. LUCA.
GeneTreeiENSGT00390000003225.
HOGENOMiHOG000113028.
HOVERGENiHBG006140.
InParanoidiQ9XSV9.
KOiK05435.
OMAiVYCAALE.
OrthoDBiEOG091G10SR.
TreeFamiTF336383.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR020470. IL-13.
IPR001325. IL-4/IL-13.
IPR018096. IL-4/IL-13_CS.
PANTHERiPTHR10078:SF38. PTHR10078:SF38. 1 hit.
PfamiView protein in Pfam
PF03487. IL13. 1 hit.
PRINTSiPR01929. INTRLEUKIN13.
SMARTiView protein in SMART
SM00190. IL4_13. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00838. INTERLEUKIN_4_13. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XSV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLTAVIV LICFGGLTSP SPVPSATALK ELIEELVNIT QNQKVPLCNG
60 70 80 90 100
SMVWSLNLTS SMYCAALDSL ISISNCSVIQ RTKRMLNALC PHKPSAKQVS
110 120 130
SEYVRDTKIE VAQFLKDLLR HSRIVFRNER FN
Length:132
Mass (Da):14,651
Last modified:March 18, 2008 - v2
Checksum:i61A662EB85C161F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84R → K in CAB46636 (PubMed:10436181).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132441 Genomic DNA. Translation: CAB46636.1.
EU276077 mRNA. Translation: ABX72075.1.
AF072807 mRNA. Translation: AAD22748.1.
RefSeqiNP_776514.1. NM_174089.1.
UniGeneiBt.12928.

Genome annotation databases

EnsembliENSBTAT00000021212; ENSBTAP00000021212; ENSBTAG00000015953.
GeneIDi281247.
KEGGibta:281247.

Similar proteinsi

Entry informationi

Entry nameiIL13_BOVIN
AccessioniPrimary (citable) accession number: Q9XSV9
Secondary accession number(s): A9QWR5, Q9TV84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 18, 2008
Last modified: August 30, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families