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Q9XSU0

- RL13A_CANFA

UniProt

Q9XSU0 - RL13A_CANFA

Protein

60S ribosomal protein L13a

Gene

RPL13A

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 2 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex By similarity.By similarity

    GO - Molecular functioni

    1. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. negative regulation of formation of translation preinitiation complex Source: UniProtKB
    2. negative regulation of translation Source: UniProtKB
    3. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Biological processi

    Translation regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L13a
    Gene namesi
    Name:RPL13A
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. GAIT complex Source: UniProtKB
    2. large ribosomal subunit Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 20320260S ribosomal protein L13aPRO_0000405587Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei59 – 591CitrullineBy similarity
    Modified residuei77 – 771PhosphoserineBy similarity
    Modified residuei140 – 1401CitrullineBy similarity
    Modified residuei191 – 1911N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylation at Ser-77 is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition.By similarity
    Citrullinated by PADI4.By similarity

    Keywords - PTMi

    Acetylation, Citrullination, Phosphoprotein

    Proteomic databases

    PaxDbiQ9XSU0.
    PRIDEiQ9XSU0.

    Interactioni

    Subunit structurei

    Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1 By similarity.By similarity

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ZKRelectron microscopy8.70j1-203[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9XSU0.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L13P family.Curated

    Phylogenomic databases

    eggNOGiCOG0102.
    HOGENOMiHOG000225289.
    HOVERGENiHBG062176.

    Family and domain databases

    Gene3Di3.90.1180.10. 1 hit.
    HAMAPiMF_01366. Ribosomal_L13.
    InterProiIPR005822. Ribosomal_L13.
    IPR023563. Ribosomal_L13_CS.
    IPR023564. Ribosomal_L13_dom.
    IPR005755. Ribosomal_L13_euk/arc.
    [Graphical view]
    PANTHERiPTHR11545. PTHR11545. 1 hit.
    PTHR11545:SF3. PTHR11545:SF3. 1 hit.
    PfamiPF00572. Ribosomal_L13. 1 hit.
    [Graphical view]
    SUPFAMiSSF52161. SSF52161. 1 hit.
    TIGRFAMsiTIGR01077. L13_A_E. 1 hit.
    PROSITEiPS00783. RIBOSOMAL_L13. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9XSU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEGQVLVLD GRGHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN    50
    KLNYLAFLRK RMNTNPSRGP YDFRAPSRIF WRTVRGMLPH KTKRGQAALD 100
    RLKVFDGIPP PYDKKKRMVV PAALKVVRLK PTRKFAYLGR LAHEVGWKYQ 150
    AVTATLEEKR KEKAKIHYRK KKQLMRLRKQ AEKNVEKKID KYTEVLKTHG 200
    LLV 203
    Length:203
    Mass (Da):23,499
    Last modified:March 8, 2011 - v2
    Checksum:i42C3DCBA129ED7FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DN325227 mRNA. No translation available.
    AJ388525 mRNA. Translation: CAB46827.1.
    CO660712 mRNA. No translation available.
    UniGeneiCfa.40191.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DN325227 mRNA. No translation available.
    AJ388525 mRNA. Translation: CAB46827.1 .
    CO660712 mRNA. No translation available.
    UniGenei Cfa.40191.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ZKR electron microscopy 8.70 j 1-203 [» ]
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9XSU0.
    PRIDEi Q9XSU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0102.
    HOGENOMi HOG000225289.
    HOVERGENi HBG062176.

    Miscellaneous databases

    EvolutionaryTracei Q9XSU0.

    Family and domain databases

    Gene3Di 3.90.1180.10. 1 hit.
    HAMAPi MF_01366. Ribosomal_L13.
    InterProi IPR005822. Ribosomal_L13.
    IPR023563. Ribosomal_L13_CS.
    IPR023564. Ribosomal_L13_dom.
    IPR005755. Ribosomal_L13_euk/arc.
    [Graphical view ]
    PANTHERi PTHR11545. PTHR11545. 1 hit.
    PTHR11545:SF3. PTHR11545:SF3. 1 hit.
    Pfami PF00572. Ribosomal_L13. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52161. SSF52161. 1 hit.
    TIGRFAMsi TIGR01077. L13_A_E. 1 hit.
    PROSITEi PS00783. RIBOSOMAL_L13. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Staten N.R.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-129.
      Strain: Beagle.
      Tissue: Pancreas.
    2. "A method for the large-scale cloning of nuclear proteins and nuclear targeting sequences on a functional basis."
      Pichon B., Mercan D., Pouillon V., Christophe-Hobertus C., Christophe D.
      Anal. Biochem. 284:231-239(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-143.
      Tissue: Thyroid.
    3. "Dog arrayTAG cDNA clone collection."
      Schlueter T., Hermanns J., Weindel M., Schuette D., Kranz H., Henrich J., Loebbert R.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-203.
      Strain: Beagle.
      Tissue: Jejunum.
    4. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (8.70 ANGSTROMS).

    Entry informationi

    Entry nameiRL13A_CANFA
    AccessioniPrimary (citable) accession number: Q9XSU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 68 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3