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Q9XSU0 (RL13A_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
60S ribosomal protein L13a
Gene names
Name:RPL13A
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex By similarity. HAMAP-Rule MF_01366

Subunit structure

Component of the 60S ribosome. Component of the GAIT complex. Interacts with EIF4G1 By similarity.

Post-translational modification

Phosphorylation at Ser-77 is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition By similarity. HAMAP-Rule MF_01366

Citrullinated by PADI4 By similarity. HAMAP-Rule MF_01366

Sequence similarities

Belongs to the ribosomal protein L13P family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 20320260S ribosomal protein L13a HAMAP-Rule MF_01366
PRO_0000405587

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue591Citrulline By similarity
Modified residue771Phosphoserine By similarity
Modified residue1401Citrulline By similarity
Modified residue1911N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9XSU0 [UniParc].

Last modified March 8, 2011. Version 2.
Checksum: 42C3DCBA129ED7FA

FASTA20323,499
        10         20         30         40         50         60 
MAEGQVLVLD GRGHLLGRLA AIVAKQVLLG RKVVVVRCEG INISGNFYRN KLNYLAFLRK 

        70         80         90        100        110        120 
RMNTNPSRGP YDFRAPSRIF WRTVRGMLPH KTKRGQAALD RLKVFDGIPP PYDKKKRMVV 

       130        140        150        160        170        180 
PAALKVVRLK PTRKFAYLGR LAHEVGWKYQ AVTATLEEKR KEKAKIHYRK KKQLMRLRKQ 

       190        200 
AEKNVEKKID KYTEVLKTHG LLV 

« Hide

References

[1]Staten N.R.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-129.
Strain: Beagle.
Tissue: Pancreas.
[2]"A method for the large-scale cloning of nuclear proteins and nuclear targeting sequences on a functional basis."
Pichon B., Mercan D., Pouillon V., Christophe-Hobertus C., Christophe D.
Anal. Biochem. 284:231-239(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-143.
Tissue: Thyroid.
[3]"Dog arrayTAG cDNA clone collection."
Schlueter T., Hermanns J., Weindel M., Schuette D., Kranz H., Henrich J., Loebbert R.
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-203.
Strain: Beagle.
Tissue: Jejunum.
[4]"Structure of the mammalian 80S ribosome at 8.7 A resolution."
Chandramouli P., Topf M., Menetret J.F., Eswar N., Cannone J.J., Gutell R.R., Sali A., Akey C.W.
Structure 16:535-548(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (8.70 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DN325227 mRNA. No translation available.
AJ388525 mRNA. Translation: CAB46827.1.
CO660712 mRNA. No translation available.
UniGeneCfa.40191.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZKRelectron microscopy8.70j1-203[»]
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9XSU0.
PRIDEQ9XSU0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0102.
HOGENOMHOG000225289.
HOVERGENHBG062176.

Family and domain databases

Gene3D3.90.1180.10. 1 hit.
HAMAPMF_01366. Ribosomal_L13.
InterProIPR005822. Ribosomal_L13.
IPR023563. Ribosomal_L13_CS.
IPR023564. Ribosomal_L13_dom.
IPR005755. Ribosomal_L13_euk/arc.
[Graphical view]
PANTHERPTHR11545. PTHR11545. 1 hit.
PTHR11545:SF3. PTHR11545:SF3. 1 hit.
PfamPF00572. Ribosomal_L13. 1 hit.
[Graphical view]
SUPFAMSSF52161. SSF52161. 1 hit.
TIGRFAMsTIGR01077. L13_A_E. 1 hit.
PROSITEPS00783. RIBOSOMAL_L13. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9XSU0.

Entry information

Entry nameRL13A_CANFA
AccessionPrimary (citable) accession number: Q9XSU0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: March 19, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references