Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9XST5 (MT2_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothionein-2

Short name=MT-2
Alternative name(s):
Metallothionein-II
Short name=MT-II
Gene names
Name:MT2A
Synonyms:MT2
ORF Names:B28
OrganismCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length61 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Subunit structure

Monomer By similarity.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6161Metallothionein-2
PRO_0000197199

Regions

Region1 – 2929Beta
Region30 – 6132Alpha

Sites

Metal binding51Divalent metal cation; cluster B By similarity
Metal binding71Divalent metal cation; cluster B By similarity
Metal binding131Divalent metal cation; cluster B By similarity
Metal binding151Divalent metal cation; cluster B By similarity
Metal binding191Divalent metal cation; cluster B By similarity
Metal binding211Divalent metal cation; cluster B By similarity
Metal binding241Divalent metal cation; cluster B By similarity
Metal binding261Divalent metal cation; cluster B By similarity
Metal binding291Divalent metal cation; cluster B By similarity
Metal binding331Divalent metal cation; cluster A By similarity
Metal binding341Divalent metal cation; cluster A By similarity
Metal binding361Divalent metal cation; cluster A By similarity
Metal binding371Divalent metal cation; cluster A By similarity
Metal binding411Divalent metal cation; cluster A By similarity
Metal binding441Divalent metal cation; cluster A By similarity
Metal binding481Divalent metal cation; cluster A By similarity
Metal binding501Divalent metal cation; cluster A By similarity
Metal binding571Divalent metal cation; cluster A By similarity
Metal binding591Divalent metal cation; cluster A By similarity
Metal binding601Divalent metal cation; cluster A By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue511N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9XST5 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 7B0A7C54E272C448

FASTA616,012
        10         20         30         40         50         60 
MDPNCSCAAG GSCTCAGSCK CKECRCTSCK KSCCSCCPVG CAKCAQGCIC KGASDKCSCC 


A 

« Hide

References

« Hide 'large scale' references
[1]"Canine hepatic lysosomal copper protein: identification as metallothionein."
Lerch K., Johnson G.F., Grushoff P.S., Sternlieb I.
Arch. Biochem. Biophys. 243:108-114(1985) [PubMed: 4062298] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Liver.
[2]"Molecular cloning and expression of canine metallothionein-II."
Kobayashi K., Morita T., Shimada A.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Beagle.
Tissue: Kidney.
[3]"A method for the large-scale cloning of nuclear proteins and nuclear targeting sequences on a functional basis."
Pichon B., Mercan D., Pouillon V., Christophe-Hobertus C., Christophe D.
Anal. Biochem. 284:231-239(2000) [PubMed: 10964405] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thyroid.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB028042 mRNA. Translation: BAA87327.1.
AJ388530 mRNA. Translation: CAB46832.1.
RefSeqNP_001003149.1. NM_001003149.1.
UniGeneCfa.3542.

3D structure databases

ProteinModelPortalQ9XST5.
SMRQ9XST5. Positions 1-61.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000014487; ENSCAFP00000013399; ENSCAFG00000023759.
GeneID403768.
KEGGcfa:403768.

Organism-specific databases

CTD4502.

Phylogenomic databases

eggNOGmaNOG21730.
GeneTreeENSGT00390000010461.
InParanoidQ9XST5.
OMANCAGSCK.

Family and domain databases

InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
Gene3DG3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
KOK14739.
PANTHERPTHR23299. Metallothionein_vert. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. Metallothionein_sfam. 1 hit.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMT2_CANFA
AccessionPrimary (citable) accession number: Q9XST5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: December 14, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Metallothioneins

Classification of metallothioneins and list of entries

SIMILARITY comments

Index of protein domains and families