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Protein

Transient receptor potential cation channel subfamily V member 5

Gene

Trpv5

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Constitutively active calcium selective cation channel thought to be involved in Ca2+ reabsorption in kidney and intestine (PubMed:12574114). Required for normal Ca2+ reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (By similarity). A Ca2+-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (PubMed:12574114).By similarity3 Publications

Enzyme regulationi

Activated by WNK3.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi542Calcium; shared with neighboring subunitsBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Calmodulin-binding, Metal-binding

Protein family/group databases

TCDBi1.A.4.2.3. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 5
Short name:
TrpV5
Alternative name(s):
Epithelial calcium channel 1
Short name:
ECaC1
Osm-9-like TRP channel 3
Short name:
OTRPC3
Gene namesi
Name:Trpv5
Synonyms:Ecac1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 7

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 327CytoplasmicSequence analysisAdd BLAST327
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Topological domaini349 – 387ExtracellularSequence analysisAdd BLAST39
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 419CytoplasmicSequence analysisAdd BLAST11
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Topological domaini441 – 448ExtracellularSequence analysis8
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 492CytoplasmicSequence analysisAdd BLAST23
Transmembranei493 – 513HelicalSequence analysisAdd BLAST21
Intramembranei524 – 544Pore-formingCuratedAdd BLAST21
Transmembranei557 – 577HelicalSequence analysisAdd BLAST21
Topological domaini578 – 730CytoplasmicSequence analysisAdd BLAST153

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi535E → A: Minor effects on Ca(2+) permeation. 1 Publication1
Mutagenesisi542D → A: Abolishes Ca(2+) permeation and Ca(2+)-dependent current decay; no effect on monovalent cations permeation. 1 Publication1
Mutagenesisi542D → E, N or M: Attenuates Ca(2+) permeation and Ca(2+)-dependent current decay. 1 Publication1
Mutagenesisi542D → K: Abolishes channel activity. 1 Publication1
Mutagenesisi550D → A: Minor effects on Ca(2+) permeation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153521 – 730Transient receptor potential cation channel subfamily V member 5Add BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi358N-linked (GlcNAc...)Sequence analysis1
Modified residuei685PhosphothreonineBy similarity1
Modified residuei689PhosphoserineBy similarity1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

PTM databases

iPTMnetiQ9XSM3.

Interactioni

Subunit structurei

Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6 (PubMed:12574114). Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation.By similarity1 Publication

Protein-protein interaction databases

DIPiDIP-46154N.
STRINGi9986.ENSOCUP00000006536.

Structurei

3D structure databases

ProteinModelPortaliQ9XSM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati44 – 74ANK 1Sequence analysisAdd BLAST31
Repeati78 – 107ANK 2Sequence analysisAdd BLAST30
Repeati116 – 145ANK 3Sequence analysisAdd BLAST30
Repeati162 – 191ANK 4Sequence analysisAdd BLAST30
Repeati195 – 228ANK 5Sequence analysisAdd BLAST34
Repeati239 – 268ANK 6Sequence analysisAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni598 – 602Interaction with S100A10By similarity5
Regioni650 – 653Involved in Ca(2+)-dependent inactivation4
Regioni701 – 730Involved in Ca(2+)-dependent inactivationAdd BLAST30

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3676. Eukaryota.
ENOG4110DG4. LUCA.
GeneTreeiENSGT00550000074425.
HOGENOMiHOG000234397.
HOVERGENiHBG061442.
InParanoidiQ9XSM3.
KOiK04974.
OMAiVNLPFMF.
OrthoDBiEOG091G0314.
TreeFamiTF314711.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008346. TRPV5.
IPR008344. TRPV5/TRPV6.
[Graphical view]
PANTHERiPTHR10582:SF11. PTHR10582:SF11. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
PR01765. ECACCHANNEL.
PR01767. ECACCHANNEL2.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XSM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGACPPKAKG PWAQLQKLLI SWPVGEQDWE QYRDRVNMLQ QERIRDSPLL
60 70 80 90 100
QAAKENDLRL LKILLLNQSC DFQQRGAVGE TALHVAALYD NLEAATLLME
110 120 130 140 150
AAPELAKEPA LCEPFVGQTA LHIAVMNQNL NLVRALLARG ASVSARATGA
160 170 180 190 200
AFRRSPHNLI YYGEHPLSFA ACVGSEEIVR LLIEHGADIR AQDSLGNTVL
210 220 230 240 250
HILILQPNKT FACQMYNLLL SYDEHSDHLQ SLELVPNHQG LTPFKLAGVE
260 270 280 290 300
GNTVMFQHLM QKRKHVQWTC GPLTSTLYDL TEIDSWGEEL SFLELVVSSK
310 320 330 340 350
KREARQILEQ TPVKELVSFK WKKYGRPYFC VLASLYILYM ICFTTCCIYR
360 370 380 390 400
PLKLRDDNRT DPRDITILQQ KLLQEAYVTH QDNIRLVGEL VTVTGAVIIL
410 420 430 440 450
LLEIPDIFRV GASRYFGQTI LGGPFHVIII TYASLVLLTM VMRLTNMNGE
460 470 480 490 500
VVPLSFALVL GWCSVMYFAR GFQMLGPFTI MIQKMIFGDL MRFCWLMAVV
510 520 530 540 550
ILGFASAFHI TFQTEDPNNL GEFSDYPTAL FSTFELFLTI IDGPANYSVD
560 570 580 590 600
LPFMYCITYA AFAIIATLLM LNLFIAMMGD THWRVAQERD ELWRAQVVAT
610 620 630 640 650
TVMLERKMPR FLWPRSGICG YEYGLGDRWF LRVENHHDQN PLRVLRYVEA
660 670 680 690 700
FKCSDKEDGQ EQLSEKRPST VESGMLSRAS VAFQTPSLSR TTSQSSNSHR
710 720 730
GWEILRRNTL GHLNLGLDLG EGDGEEVYHF
Length:730
Mass (Da):82,814
Last modified:November 1, 1999 - v1
Checksum:i0CB9FBAD916B1400
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133128 mRNA. Translation: CAB40138.1.
RefSeqiNP_001076126.1. NM_001082657.1.
UniGeneiOcu.3235.

Genome annotation databases

EnsembliENSOCUT00000007559; ENSOCUP00000006536; ENSOCUG00000007559.
GeneIDi100009364.
KEGGiocu:100009364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ133128 mRNA. Translation: CAB40138.1.
RefSeqiNP_001076126.1. NM_001082657.1.
UniGeneiOcu.3235.

3D structure databases

ProteinModelPortaliQ9XSM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46154N.
STRINGi9986.ENSOCUP00000006536.

Protein family/group databases

TCDBi1.A.4.2.3. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

iPTMnetiQ9XSM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000007559; ENSOCUP00000006536; ENSOCUG00000007559.
GeneIDi100009364.
KEGGiocu:100009364.

Organism-specific databases

CTDi56302.

Phylogenomic databases

eggNOGiKOG3676. Eukaryota.
ENOG4110DG4. LUCA.
GeneTreeiENSGT00550000074425.
HOGENOMiHOG000234397.
HOVERGENiHBG061442.
InParanoidiQ9XSM3.
KOiK04974.
OMAiVNLPFMF.
OrthoDBiEOG091G0314.
TreeFamiTF314711.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008346. TRPV5.
IPR008344. TRPV5/TRPV6.
[Graphical view]
PANTHERiPTHR10582:SF11. PTHR10582:SF11. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
PR01765. ECACCHANNEL.
PR01767. ECACCHANNEL2.
SMARTiSM00248. ANK. 5 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPV5_RABIT
AccessioniPrimary (citable) accession number: Q9XSM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.