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Protein

Cone-rod homeobox protein

Gene

CRX

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi39 – 9860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Sensory transduction, Transcription, Transcription regulation, Vision

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cone-rod homeobox protein
Gene namesi
Name:CRX
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Cone-rod homeobox proteinPRO_0000048860Add
BLAST

Proteomic databases

PaxDbiQ9XSK0.
PRIDEiQ9XSK0.

Expressioni

Tissue specificityi

Retina.

Interactioni

Subunit structurei

Interacts (via the homeobox) with NRL (via the leucine-zipper domain). Interacts with PDC, RAX2, RORB and SCA7 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NRLP548456EBI-8843794,EBI-8843813From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi158156. 1 interaction.
IntActiQ9XSK0. 2 interactions.
STRINGi9913.ENSBTAP00000028232.

Structurei

3D structure databases

ProteinModelPortaliQ9XSK0.
SMRiQ9XSK0. Positions 34-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2251. Eukaryota.
ENOG4111XIJ. LUCA.
GeneTreeiENSGT00820000126963.
HOGENOMiHOG000082677.
HOVERGENiHBG004028.
InParanoidiQ9XSK0.
KOiK09337.
OMAiSDVCPDP.
OrthoDBiEOG74J98P.
TreeFamiTF351179.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR032966. CRX.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR013851. Otx_TF_C.
[Graphical view]
PANTHERiPTHR24329:SF331. PTHR24329:SF331. 2 hits.
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XSK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAYMNPGPH YSVNALALSG PSVDLMHPAV SYPSAPRKQR RERTTFTRSQ
60 70 80 90 100
LEELEALFAK TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ
110 120 130 140 150
QKQQQQPPGA QAKARPAKRK AGTSPRSSTD VCPDPLGISD SYSPPLPGPS
160 170 180 190 200
GSPTTAVATV SIWSPASESP LPEAQRAGLV ASGPSLTSAP YAMTYAPASA
210 220 230 240 250
FCSSPSAYGS PSSYFSGLDP YLSPMVPPLG GPALSPLSGP SVGPSLTQSP
260 270 280 290
TSLSGQSYGT YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL
Length:299
Mass (Da):32,253
Last modified:November 1, 1999 - v1
Checksum:i512ED6A6DAFBAC19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154123 mRNA. Translation: AAD34645.1.
RefSeqiNP_776329.1. NM_173904.2.
UniGeneiBt.283.

Genome annotation databases

EnsembliENSBTAT00000028232; ENSBTAP00000028232; ENSBTAG00000021185.
GeneIDi280756.
KEGGibta:280756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154123 mRNA. Translation: AAD34645.1.
RefSeqiNP_776329.1. NM_173904.2.
UniGeneiBt.283.

3D structure databases

ProteinModelPortaliQ9XSK0.
SMRiQ9XSK0. Positions 34-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi158156. 1 interaction.
IntActiQ9XSK0. 2 interactions.
STRINGi9913.ENSBTAP00000028232.

Proteomic databases

PaxDbiQ9XSK0.
PRIDEiQ9XSK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028232; ENSBTAP00000028232; ENSBTAG00000021185.
GeneIDi280756.
KEGGibta:280756.

Organism-specific databases

CTDi1406.

Phylogenomic databases

eggNOGiKOG2251. Eukaryota.
ENOG4111XIJ. LUCA.
GeneTreeiENSGT00820000126963.
HOGENOMiHOG000082677.
HOVERGENiHBG004028.
InParanoidiQ9XSK0.
KOiK09337.
OMAiSDVCPDP.
OrthoDBiEOG74J98P.
TreeFamiTF351179.

Miscellaneous databases

NextBioi20804923.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR032966. CRX.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR013851. Otx_TF_C.
[Graphical view]
PANTHERiPTHR24329:SF331. PTHR24329:SF331. 2 hits.
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Interaction of phosducin and PhLOP1 with CRX: potential transcriptional regulation function."
    Zhu X., Craft C.M.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Retina.

Entry informationi

Entry nameiCRX_BOVIN
AccessioniPrimary (citable) accession number: Q9XSK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.