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Q9XSJ7

- CO1A1_CANFA

UniProt

Q9XSJ7 - CO1A1_CANFA

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Protein

Collagen alpha-1(I) chain

Gene

COL1A1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Type I collagen is a member of group I collagen (fibrillar forming collagen).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1273 – 12731CalciumBy similarity
Metal bindingi1275 – 12751CalciumBy similarity
Metal bindingi1276 – 12761Calcium; via carbonyl oxygenBy similarity
Metal bindingi1278 – 12781Calcium; via carbonyl oxygenBy similarity
Metal bindingi1281 – 12811CalciumBy similarity

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(I) chain
Alternative name(s):
Alpha-1 type I collagen
Gene namesi
Name:COL1A1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Unplaced

Subcellular locationi

Secretedextracellular spaceextracellular matrix PROSITE-ProRule annotation

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Defects in COL1A1 are a cause of osteogenesis imperfecta (OI).

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Propeptidei23 – 157135N-terminal propeptidePRO_0000005713Add
BLAST
Chaini158 – 12141057Collagen alpha-1(I) chainPRO_0000005714Add
BLAST
Propeptidei1215 – 1460246C-terminal propeptidePRO_0000005715Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei158 – 1581Pyrrolidone carboxylic acidBy similarity
Modified residuei166 – 1661AllysineBy similarity
Modified residuei261 – 26115-hydroxylysine; alternateBy similarity
Glycosylationi261 – 2611O-linked (Gal...); alternateBy similarity
Modified residuei1160 – 116013-hydroxyprolineBy similarity
Disulfide bondi1255 ↔ 1287PROSITE-ProRule annotation
Disulfide bondi1261 – 1261Interchain (with C-1278)PROSITE-ProRule annotation
Disulfide bondi1278 – 1278Interchain (with C-1261)PROSITE-ProRule annotation
Disulfide bondi1295 ↔ 1458PROSITE-ProRule annotation
Glycosylationi1361 – 13611N-linked (GlcNAc...)By similarity
Disulfide bondi1366 ↔ 1411PROSITE-ProRule annotation

Post-translational modificationi

Proline residues at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Proline residues at the second position of the tripeptide repeating unit (G-P-X) are hydroxylated in some of the chains.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ9XSJ7.

Interactioni

Subunit structurei

Trimers of one alpha 2(I) and two alpha 1(I) chains. Interacts with MRC2 (By similarity). Interacts with TRAM2 (By similarity).By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 9259VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini1225 – 1460236Fibrillar collagen NC1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni158 – 17417Nonhelical region (N-terminal)Add
BLAST
Regioni175 – 11881014Triple-helical regionAdd
BLAST
Regioni1189 – 121426Nonhelical region (C-terminal)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi741 – 7433Cell attachment siteSequence Analysis
Motifi1089 – 10913Cell attachment siteSequence Analysis

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation
Contains 1 fibrillar collagen NC1 domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000085654.
HOVERGENiHBG004933.
InParanoidiQ9XSJ7.
KOiK06236.

Family and domain databases

InterProiIPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR001007. VWF_C.
[Graphical view]
PfamiPF01410. COLFI. 1 hit.
PF01391. Collagen. 12 hits.
PF00093. VWC. 1 hit.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
PROSITEiPS51461. NC1_FIB. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XSJ7-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MFSFVDLRLL LLLAATALLT HGQEEGQEED IPPVTCVQNG LRYYDRDVWK
60 70 80 90 100
PEACRICVCD NGNVLCDDVI CDETKNCPGA QVPPGECCPV CPDGEASPTD
110 120 130 140 150
QETTGVEGPK GDTGPRGPRG PAGPPGRDGI PGQPGLPGPP GPPGPPGPPG
160 170 180 190 200
LGGNFAPQMS YGYDEKSTGG ISVPGPMGPS GPRGLPGPPG APGPQGFQGP
210 220 230 240 250
PGEPGEPGAS GPMGPRGPPG PPGKNGDDGE AGKPGRPGER GPPGPQGARG
260 270 280 290 300
LPGTAGLPGM KGHRGFSGLD GAKGDAGPAG PKGEPGSPGE NGAPGQMGPR
310 320 330 340 350
GLPGERGRPG APGPAGARGN DGATGAAGPP GPTGPAGPPG FPGAVGAKGE
360 370 380 390 400
AGPQGARGSE GPQGVRGEPG PPGPAGAAGP AGNPGADGQP GAKGANGAPG
410 420 430 440 450
IAGAPGFPGA RGPSGPQGPS GPPGPKGNSG EPGAPGNKGD TGAKGEPGPT
460 470 480 490 500
GIQGPPGPAG EEGKRGARGE PGPTGLPGPP GERGGPGSRG FPGADGVAGP
510 520 530 540 550
KGPAGERGSP GPAGPKGSPG EAGRPGEAGL PGAKGLTGSP GSPGPDGKTG
560 570 580 590 600
PPGPAGQDGR PGPPGPPGAR GQAGVMGFPG PKGAAGEPGK AGERGVPGPP
610 620 630 640 650
GAVGPAGKDG EAGAQGPPGP AGPAGERGEQ GPAGSPGFQG LPGPAGPPGE
660 670 680 690 700
AGKPGEQGVP GDLGAPGPSG ARGERGFPGE RGVQGPPGPA GPRGANGAPG
710 720 730 740 750
NDGAKGDAGA PGAPGSQGAP GLQGMPGERG AAGLPGPKGD RGDAGPKGAD
760 770 780 790 800
GSPGKDGVRG LTGPIGPPGP AGAPGDKGEA GPSGPAGPTG ARGAPGDRGE
810 820 830 840 850
PGPPGPAGFA GPPGADGQPG AKGEPGDAGA KGDAGPPGPA GPTGPPGPIG
860 870 880 890 900
NVGAPGPKGA RGSAGPPGAT GFPGAAGRVG PPGPSGNAGP PGPPGPAGKE
910 920 930 940 950
GGKGARGETG PAGRPGEVGP PGPPGPAGEK GSPGADGPAG APGTPGPQGI
960 970 980 990 1000
AGQRGVVGLP GQRGERGFPG LPGPSGEPGK QGPSGTSGER GPPGPMGPPG
1010 1020 1030 1040 1050
LAGPPGESGR EGSPGAEGSP GRDGSPGPKG DRGETGPAGP PGAPGAPGAP
1060 1070 1080 1090 1100
GPVGPAGKNG DRGETGPAGP AGPIGPVGAR GPAGPQGPRG DKGETGEQGD
1110 1120 1130 1140 1150
RGIKGHRGFS GLQGPPGPPG SPGEQGPSGA SGPAGPRGPP GSAGSPGKDG
1160 1170 1180 1190 1200
LNGLPGPIGP PGPRGRTGDA GPVGPPGPPG PPGPPGPPSG GFDFSFLPQP
1210 1220 1230 1240 1250
PQEKAHDGGR YYRADDANVV RDRDLEVDTT LKSLSQQIEN IRSPEGSRKN
1260 1270 1280 1290 1300
PARTCRDLKM CHSDWKSGEY WIDPNQGCNL DAIKVFCNME TGETCVYPTQ
1310 1320 1330 1340 1350
PQVAQKNWYI SKNPKEKRHV WYGESMTDGF QFEYGGQGSD PADVAIQLTF
1360 1370 1380 1390 1400
LRLMSTEASQ NITYHCKNSV AYMDQQTGNL KKALLLQGSN EIEIRAEGNS
1410 1420 1430 1440 1450
RFTYSVTYDG CTSHTGAWGK TVIEYKTTKT SRLPIIDVAP LDVGAPDQEF
1460
GMDIGPVCFL
Length:1,460
Mass (Da):138,762
Last modified:November 1, 1999 - v1
Checksum:i58E3674D2B570697
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti208 – 2081G → A in OI; severe. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF153062 mRNA. Translation: AAD34619.1.
RefSeqiNP_001003090.1. NM_001003090.1.
UniGeneiCfa.100.

Genome annotation databases

GeneIDi403651.
KEGGicfa:403651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF153062 mRNA. Translation: AAD34619.1 .
RefSeqi NP_001003090.1. NM_001003090.1.
UniGenei Cfa.100.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9XSJ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 403651.
KEGGi cfa:403651.

Organism-specific databases

CTDi 1277.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000085654.
HOVERGENi HBG004933.
InParanoidi Q9XSJ7.
KOi K06236.

Miscellaneous databases

NextBioi 20817156.

Family and domain databases

InterProi IPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF01410. COLFI. 1 hit.
PF01391. Collagen. 12 hits.
PF00093. VWC. 1 hit.
[Graphical view ]
ProDomi PD002078. Fib_collagen_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00038. COLFI. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
PROSITEi PS51461. NC1_FIB. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence of normal canine COL1A1 cDNA and identification of a heterozygous alpha1(I) collagen Gly208Ala mutation in a severe case of canine osteogenesis imperfecta."
    Campbell B.G., Wootton J.A.M., MacLeod J.N., Minor R.R.
    Arch. Biochem. Biophys. 384:37-46(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT OI ALA-208.
    Tissue: Skin.

Entry informationi

Entry nameiCO1A1_CANFA
AccessioniPrimary (citable) accession number: Q9XSJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3