Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-prolyl cis-trans isomerase FKBP5

Gene

FKBP5

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (By similarity).By similarity2 Publications

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by FK506 but not cyclosporin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP5 (EC:5.2.1.8)
Short name:
PPIase FKBP5
Alternative name(s):
51 kDa FK506-binding protein
Short name:
51 kDa FKBP
Short name:
FKBP-51
FK506-binding protein 5
Short name:
FKBP-5
Rotamase
Gene namesi
Name:FKBP5
Synonyms:FKBP51
OrganismiSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
Taxonomic identifieri39432 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeSaimiriinaeSaimiri

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000753281 – 457Peptidyl-prolyl cis-trans isomerase FKBP5Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei445PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ9XSH5.

Interactioni

Subunit structurei

Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place. Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP (By similarity).By similarity

Structurei

Secondary structure

1457
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 36Combined sources3
Beta strandi52 – 56Combined sources5
Beta strandi77 – 80Combined sources4
Beta strandi83 – 86Combined sources4
Helixi88 – 92Combined sources5
Turni94 – 96Combined sources3
Beta strandi103 – 106Combined sources4
Turni115 – 117Combined sources3
Turni119 – 121Combined sources3
Beta strandi129 – 138Combined sources10
Beta strandi144 – 154Combined sources11
Beta strandi167 – 176Combined sources10
Beta strandi179 – 189Combined sources11
Helixi193 – 196Combined sources4
Helixi200 – 206Combined sources7
Beta strandi214 – 219Combined sources6
Helixi221 – 223Combined sources3
Turni231 – 234Combined sources4
Beta strandi241 – 251Combined sources11
Helixi256 – 258Combined sources3
Helixi261 – 280Combined sources20
Helixi284 – 298Combined sources15
Helixi306 – 329Combined sources24
Helixi333 – 346Combined sources14
Helixi351 – 363Combined sources13
Helixi367 – 379Combined sources13
Helixi385 – 417Combined sources33

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KT1X-ray2.80A1-457[»]
ProteinModelPortaliQ9XSH5.
SMRiQ9XSH5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9XSH5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 138PPIase FKBP-type 1PROSITE-ProRule annotationAdd BLAST89
Domaini165 – 251PPIase FKBP-type 2PROSITE-ProRule annotationAdd BLAST87
Repeati268 – 301TPR 1Add BLAST34
Repeati317 – 350TPR 2Add BLAST34
Repeati351 – 384TPR 3Add BLAST34

Sequence similaritiesi

Contains 2 PPIase FKBP-type domains.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

HOVERGENiHBG051624.
KOiK09571.

Family and domain databases

Gene3Di1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProiIPR023114. Elongated_TPR_rpt_dom.
IPR031210. FKBP5.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PTHR10516:SF26. PTHR10516:SF26. 2 hits.
PfamiPF00254. FKBP_C. 2 hits.
PF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XSH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTDEGAKNS RGNPAATVAE QGEDVTSKKD RGVLKIVKRV GHGEETPMIG
60 70 80 90 100
DRVYVHYNGK LANGKKFDSS HDRNEPFVFS IGKGQVIKAW DIGVATMKKG
110 120 130 140 150
EICHLLCKPE YAYGATGSLP KIPSNATLFF EVELLDFKGE DLLEDGGIIR
160 170 180 190 200
RTKRRGEGYS NPNEGARVQI HLEGRCGGRV FDCRDVAFTV GEGEDHDIPI
210 220 230 240 250
GIDKALEKMQ REEQCILHLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF
260 270 280 290 300
EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYVQAVIQ YGKIVSWLEM
310 320 330 340 350
EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN
360 370 380 390 400
EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ IFMCQKKAKE
410 420 430 440 450
HNERDRRTYA NMFKKFAEQD AKEEANKAMS KKTSEGVTNE KLTASHAVEE

EKPEGHV
Length:457
Mass (Da):51,169
Last modified:November 1, 1999 - v1
Checksum:iDFF9E1D81F7759A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140759 mRNA. Translation: AAD32678.1.
RefSeqiNP_001266943.1. NM_001280014.1.
XP_010332065.1. XM_010333763.1.

Genome annotation databases

GeneIDi101034484.
KEGGisbq:101034484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF140759 mRNA. Translation: AAD32678.1.
RefSeqiNP_001266943.1. NM_001280014.1.
XP_010332065.1. XM_010333763.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KT1X-ray2.80A1-457[»]
ProteinModelPortaliQ9XSH5.
SMRiQ9XSH5.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9XSH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101034484.
KEGGisbq:101034484.

Organism-specific databases

CTDi2289.

Phylogenomic databases

HOVERGENiHBG051624.
KOiK09571.

Miscellaneous databases

EvolutionaryTraceiQ9XSH5.

Family and domain databases

Gene3Di1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProiIPR023114. Elongated_TPR_rpt_dom.
IPR031210. FKBP5.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PTHR10516:SF26. PTHR10516:SF26. 2 hits.
PfamiPF00254. FKBP_C. 2 hits.
PF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP5_SAIBB
AccessioniPrimary (citable) accession number: Q9XSH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The relative resistance of squirrel monkeys to glucocorticoids is associated with a high level of expression of FKBP5, but is also due to intrinsic differences between the human and the monkey proteins. Human FKBP5 has a much lower effect on glucocorticoid sensitivity.

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.