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Q9XSH5

- FKBP5_SAIBB

UniProt

Q9XSH5 - FKBP5_SAIBB

Protein

Peptidyl-prolyl cis-trans isomerase FKBP5

Gene

FKBP5

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded By similarity.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Enzyme regulationi

    Inhibited by FK506 but not cyclosporin.

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB

    GO - Biological processi

    1. chaperone-mediated protein folding Source: UniProtKB
    2. protein peptidyl-prolyl isomerization Source: GOC

    Keywords - Molecular functioni

    Chaperone, Isomerase, Rotamase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP5 (EC:5.2.1.8)
    Short name:
    PPIase FKBP5
    Alternative name(s):
    51 kDa FK506-binding protein
    Short name:
    51 kDa FKBP
    Short name:
    FKBP-51
    FK506-binding protein 5
    Short name:
    FKBP-5
    Rotamase
    Gene namesi
    Name:FKBP5
    Synonyms:FKBP51
    OrganismiSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
    Taxonomic identifieri39432 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeSaimiriinaeSaimiri

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Peptidyl-prolyl cis-trans isomerase FKBP5PRO_0000075328Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei445 – 4451PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ9XSH5.

    Interactioni

    Subunit structurei

    Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place. Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP By similarity.By similarity

    Structurei

    Secondary structure

    1
    457
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi34 – 363
    Beta strandi52 – 565
    Beta strandi77 – 804
    Beta strandi83 – 864
    Helixi88 – 925
    Turni94 – 963
    Beta strandi103 – 1064
    Turni115 – 1173
    Turni119 – 1213
    Beta strandi129 – 13810
    Beta strandi144 – 15411
    Beta strandi167 – 17610
    Beta strandi179 – 18911
    Helixi193 – 1964
    Helixi200 – 2067
    Beta strandi214 – 2196
    Helixi221 – 2233
    Turni231 – 2344
    Beta strandi241 – 25111
    Helixi256 – 2583
    Helixi261 – 28020
    Helixi284 – 29815
    Helixi306 – 32924
    Helixi333 – 34614
    Helixi351 – 36313
    Helixi367 – 37913
    Helixi385 – 41733

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KT1X-ray2.80A1-457[»]
    ProteinModelPortaliQ9XSH5.
    SMRiQ9XSH5. Positions 28-421.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9XSH5.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 13889PPIase FKBP-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini165 – 25187PPIase FKBP-type 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati268 – 30134TPR 1Add
    BLAST
    Repeati317 – 35034TPR 2Add
    BLAST
    Repeati351 – 38434TPR 3Add
    BLAST

    Sequence similaritiesi

    Contains 2 PPIase FKBP-type domains.PROSITE-ProRule annotation
    Contains 3 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    HOVERGENiHBG051624.

    Family and domain databases

    Gene3Di1.10.150.160. 1 hit.
    1.25.40.10. 1 hit.
    InterProiIPR023114. Elongated_TPR_rpt_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 2 hits.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 2 hits.
    PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9XSH5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTDEGAKNS RGNPAATVAE QGEDVTSKKD RGVLKIVKRV GHGEETPMIG    50
    DRVYVHYNGK LANGKKFDSS HDRNEPFVFS IGKGQVIKAW DIGVATMKKG 100
    EICHLLCKPE YAYGATGSLP KIPSNATLFF EVELLDFKGE DLLEDGGIIR 150
    RTKRRGEGYS NPNEGARVQI HLEGRCGGRV FDCRDVAFTV GEGEDHDIPI 200
    GIDKALEKMQ REEQCILHLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF 250
    EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYVQAVIQ YGKIVSWLEM 300
    EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN 350
    EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ IFMCQKKAKE 400
    HNERDRRTYA NMFKKFAEQD AKEEANKAMS KKTSEGVTNE KLTASHAVEE 450
    EKPEGHV 457
    Length:457
    Mass (Da):51,169
    Last modified:November 1, 1999 - v1
    Checksum:iDFF9E1D81F7759A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF140759 mRNA. Translation: AAD32678.1.
    RefSeqiNP_001266943.1. NM_001280014.1.

    Genome annotation databases

    GeneIDi101034484.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF140759 mRNA. Translation: AAD32678.1 .
    RefSeqi NP_001266943.1. NM_001280014.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KT1 X-ray 2.80 A 1-457 [» ]
    ProteinModelPortali Q9XSH5.
    SMRi Q9XSH5. Positions 28-421.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9XSH5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101034484.

    Organism-specific databases

    CTDi 2289.

    Phylogenomic databases

    HOVERGENi HBG051624.

    Miscellaneous databases

    EvolutionaryTracei Q9XSH5.

    Family and domain databases

    Gene3Di 1.10.150.160. 1 hit.
    1.25.40.10. 1 hit.
    InterProi IPR023114. Elongated_TPR_rpt_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 2 hits.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 2 hits.
    PS50005. TPR. 3 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding."
      Denny W.B., Valentine D.L., Reynolds P.D., Smith D.F., Scammell J.G.
      Endocrinology 141:4107-4113(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
      Tissue: B-cell.
    2. "Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes."
      Sinars C.R., Cheung-Flynn J., Rimerman R.A., Scammell J.G., Smith D.F., Clardy J.
      Proc. Natl. Acad. Sci. U.S.A. 100:868-873(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 28-421, FUNCTION.

    Entry informationi

    Entry nameiFKBP5_SAIBB
    AccessioniPrimary (citable) accession number: Q9XSH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The relative resistance of squirrel monkeys to glucocorticoids is associated with a high level of expression of FKBP5, but is also due to intrinsic differences between the human and the monkey proteins. Human FKBP5 has a much lower effect on glucocorticoid sensitivity.

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3