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Q9XSH5 (FKBP5_SAIBB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase FKBP5

Short name=PPIase FKBP5
EC=5.2.1.8
Alternative name(s):
51 kDa FK506-binding protein
Short name=51 kDa FKBP
Short name=FKBP-51
FK506-binding protein 5
Short name=FKBP-5
Rotamase
Gene names
Name:FKBP5
Synonyms:FKBP51
OrganismSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
Taxonomic identifier39432 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeSaimiriinaeSaimiri

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded By similarity. Ref.1 Ref.2

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by FK506 but not cyclosporin.

Subunit structure

Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place. Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP By similarity.

Subcellular location

Cytoplasm Ref.1.

Miscellaneous

The relative resistance of squirrel monkeys to glucocorticoids is associated with a high level of expression of FKBP5, but is also due to intrinsic differences between the human and the monkey proteins. Human FKBP5 has a much lower effect on glucocorticoid sensitivity.

Sequence similarities

Contains 2 PPIase FKBP-type domains.

Contains 3 TPR repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Peptidyl-prolyl cis-trans isomerase FKBP5
PRO_0000075328

Regions

Domain50 – 13889PPIase FKBP-type 1
Domain165 – 25187PPIase FKBP-type 2
Repeat268 – 30134TPR 1
Repeat317 – 35034TPR 2
Repeat351 – 38434TPR 3

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue4451Phosphoserine By similarity

Secondary structure

....................................................... 457
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9XSH5 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: DFF9E1D81F7759A8

FASTA45751,169
        10         20         30         40         50         60 
MTTDEGAKNS RGNPAATVAE QGEDVTSKKD RGVLKIVKRV GHGEETPMIG DRVYVHYNGK 

        70         80         90        100        110        120 
LANGKKFDSS HDRNEPFVFS IGKGQVIKAW DIGVATMKKG EICHLLCKPE YAYGATGSLP 

       130        140        150        160        170        180 
KIPSNATLFF EVELLDFKGE DLLEDGGIIR RTKRRGEGYS NPNEGARVQI HLEGRCGGRV 

       190        200        210        220        230        240 
FDCRDVAFTV GEGEDHDIPI GIDKALEKMQ REEQCILHLG PRYGFGEAGK PKFGIEPNAE 

       250        260        270        280        290        300 
LIYEVTLKSF EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYVQAVIQ YGKIVSWLEM 

       310        320        330        340        350        360 
EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN EKGLYRRGEA 

       370        380        390        400        410        420 
QLLMNEFESA KGDFEKVLEV NPQNKAARLQ IFMCQKKAKE HNERDRRTYA NMFKKFAEQD 

       430        440        450 
AKEEANKAMS KKTSEGVTNE KLTASHAVEE EKPEGHV 

« Hide

References

[1]"Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding."
Denny W.B., Valentine D.L., Reynolds P.D., Smith D.F., Scammell J.G.
Endocrinology 141:4107-4113(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
Tissue: B-cell.
[2]"Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes."
Sinars C.R., Cheung-Flynn J., Rimerman R.A., Scammell J.G., Smith D.F., Clardy J.
Proc. Natl. Acad. Sci. U.S.A. 100:868-873(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 28-421, FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF140759 mRNA. Translation: AAD32678.1.
RefSeqNP_001266943.1. NM_001280014.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1KT1X-ray2.80A1-457[»]
ProteinModelPortalQ9XSH5.
SMRQ9XSH5. Positions 28-421.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9XSH5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101034484.

Organism-specific databases

CTD2289.

Phylogenomic databases

HOVERGENHBG051624.

Family and domain databases

Gene3D1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProIPR023114. Elongated_TPR_rpt_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF00254. FKBP_C. 2 hits.
[Graphical view]
PROSITEPS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9XSH5.

Entry information

Entry nameFKBP5_SAIBB
AccessionPrimary (citable) accession number: Q9XSH5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references