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Q9XSH5

- FKBP5_SAIBB

UniProt

Q9XSH5 - FKBP5_SAIBB

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Protein

Peptidyl-prolyl cis-trans isomerase FKBP5

Gene
FKBP5, FKBP51
Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded By similarity.2 Publications

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by FK506 but not cyclosporin.

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB

GO - Biological processi

  1. chaperone-mediated protein folding Source: UniProtKB
  2. protein peptidyl-prolyl isomerization Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP5 (EC:5.2.1.8)
Short name:
PPIase FKBP5
Alternative name(s):
51 kDa FK506-binding protein
Short name:
51 kDa FKBP
Short name:
FKBP-51
FK506-binding protein 5
Short name:
FKBP-5
Rotamase
Gene namesi
Name:FKBP5
Synonyms:FKBP51
OrganismiSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
Taxonomic identifieri39432 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeSaimiriinaeSaimiri

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Peptidyl-prolyl cis-trans isomerase FKBP5PRO_0000075328Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei445 – 4451Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ9XSH5.

Interactioni

Subunit structurei

Part of a heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B and steroid receptors. Upon ligand binding dissociates from the complex and FKBP4 takes its place. Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP By similarity.

Structurei

Secondary structure

1
457
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi34 – 363
Beta strandi52 – 565
Beta strandi77 – 804
Beta strandi83 – 864
Helixi88 – 925
Turni94 – 963
Beta strandi103 – 1064
Turni115 – 1173
Turni119 – 1213
Beta strandi129 – 13810
Beta strandi144 – 15411
Beta strandi167 – 17610
Beta strandi179 – 18911
Helixi193 – 1964
Helixi200 – 2067
Beta strandi214 – 2196
Helixi221 – 2233
Turni231 – 2344
Beta strandi241 – 25111
Helixi256 – 2583
Helixi261 – 28020
Helixi284 – 29815
Helixi306 – 32924
Helixi333 – 34614
Helixi351 – 36313
Helixi367 – 37913
Helixi385 – 41733

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KT1X-ray2.80A1-457[»]
ProteinModelPortaliQ9XSH5.
SMRiQ9XSH5. Positions 28-421.

Miscellaneous databases

EvolutionaryTraceiQ9XSH5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 13889PPIase FKBP-type 1Add
BLAST
Domaini165 – 25187PPIase FKBP-type 2Add
BLAST
Repeati268 – 30134TPR 1Add
BLAST
Repeati317 – 35034TPR 2Add
BLAST
Repeati351 – 38434TPR 3Add
BLAST

Sequence similaritiesi

Contains 3 TPR repeats.

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

HOVERGENiHBG051624.

Family and domain databases

Gene3Di1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProiIPR023114. Elongated_TPR_rpt_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 2 hits.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XSH5-1 [UniParc]FASTAAdd to Basket

« Hide

MTTDEGAKNS RGNPAATVAE QGEDVTSKKD RGVLKIVKRV GHGEETPMIG    50
DRVYVHYNGK LANGKKFDSS HDRNEPFVFS IGKGQVIKAW DIGVATMKKG 100
EICHLLCKPE YAYGATGSLP KIPSNATLFF EVELLDFKGE DLLEDGGIIR 150
RTKRRGEGYS NPNEGARVQI HLEGRCGGRV FDCRDVAFTV GEGEDHDIPI 200
GIDKALEKMQ REEQCILHLG PRYGFGEAGK PKFGIEPNAE LIYEVTLKSF 250
EKAKESWEMD TKEKLEQAAI VKEKGTVYFK GGKYVQAVIQ YGKIVSWLEM 300
EYGLSEKESK ASESFLLAAF LNLAMCYLKL REYTKAVECC DKALGLDSAN 350
EKGLYRRGEA QLLMNEFESA KGDFEKVLEV NPQNKAARLQ IFMCQKKAKE 400
HNERDRRTYA NMFKKFAEQD AKEEANKAMS KKTSEGVTNE KLTASHAVEE 450
EKPEGHV 457
Length:457
Mass (Da):51,169
Last modified:November 1, 1999 - v1
Checksum:iDFF9E1D81F7759A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF140759 mRNA. Translation: AAD32678.1.
RefSeqiNP_001266943.1. NM_001280014.1.

Genome annotation databases

GeneIDi101034484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF140759 mRNA. Translation: AAD32678.1 .
RefSeqi NP_001266943.1. NM_001280014.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KT1 X-ray 2.80 A 1-457 [» ]
ProteinModelPortali Q9XSH5.
SMRi Q9XSH5. Positions 28-421.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9XSH5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101034484.

Organism-specific databases

CTDi 2289.

Phylogenomic databases

HOVERGENi HBG051624.

Miscellaneous databases

EvolutionaryTracei Q9XSH5.

Family and domain databases

Gene3Di 1.10.150.160. 1 hit.
1.25.40.10. 1 hit.
InterProi IPR023114. Elongated_TPR_rpt_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 2 hits.
[Graphical view ]
PROSITEi PS50059. FKBP_PPIASE. 2 hits.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding."
    Denny W.B., Valentine D.L., Reynolds P.D., Smith D.F., Scammell J.G.
    Endocrinology 141:4107-4113(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    Tissue: B-cell.
  2. "Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes."
    Sinars C.R., Cheung-Flynn J., Rimerman R.A., Scammell J.G., Smith D.F., Clardy J.
    Proc. Natl. Acad. Sci. U.S.A. 100:868-873(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 28-421, FUNCTION.

Entry informationi

Entry nameiFKBP5_SAIBB
AccessioniPrimary (citable) accession number: Q9XSH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The relative resistance of squirrel monkeys to glucocorticoids is associated with a high level of expression of FKBP5, but is also due to intrinsic differences between the human and the monkey proteins. Human FKBP5 has a much lower effect on glucocorticoid sensitivity.

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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