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Protein

Hemoglobin subunit alpha

Gene

HBA

Organism
Equus przewalskii (Przewalski's horse) (Equus caballus przewalskii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme distal ligand)
Metal bindingi88 – 881Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:HBA
OrganismiEquus przewalskii (Przewalski's horse) (Equus caballus przewalskii)
Taxonomic identifieri9798 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 142141Hemoglobin subunit alphaPRO_0000052631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41PhosphoserineBy similarity
Modified residuei8 – 81N6-succinyllysineBy similarity
Modified residuei9 – 91PhosphothreonineBy similarity
Modified residuei12 – 121N6-succinyllysineBy similarity
Modified residuei17 – 171N6-acetyllysine; alternateBy similarity
Modified residuei17 – 171N6-succinyllysine; alternateBy similarity
Modified residuei41 – 411N6-succinyllysineBy similarity
Modified residuei50 – 501PhosphoserineBy similarity
Modified residuei103 – 1031PhosphoserineBy similarity
Modified residuei109 – 1091PhosphothreonineBy similarity
Modified residuei125 – 1251PhosphoserineBy similarity
Modified residuei132 – 1321PhosphoserineBy similarity
Modified residuei135 – 1351PhosphothreonineBy similarity
Modified residuei138 – 1381PhosphothreonineBy similarity
Modified residuei139 – 1391PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PeptideAtlasiQ9XSE9.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

MINTiMINT-1520947.

Structurei

3D structure databases

ProteinModelPortaliQ9XSE9.
SMRiQ9XSE9. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.
OrthoDBiEOG091G0S0X.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XSE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSAADKTN VKAAWSKVGG HAGEFGAEAL ERMFLGFPTT KTYFPHFDLS
60 70 80 90 100
HGSAQVKAHG KKVGDALTLA VGHLDDLPGA LSNLSDLHAH KLRVDPVNFK
110 120 130 140
LLSHCLLSTL AVHLPNDFTP AVHASLDKFL SSVSTVLTSK YR
Length:142
Mass (Da):15,229
Last modified:January 23, 2007 - v3
Checksum:i93BB916115C1D173
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129141, AF129140 Genomic DNA. Translation: AAB93467.1.
RefSeqiXP_008536600.1. XM_008538378.1.

Genome annotation databases

GeneIDi103563135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129141, AF129140 Genomic DNA. Translation: AAB93467.1.
RefSeqiXP_008536600.1. XM_008538378.1.

3D structure databases

ProteinModelPortaliQ9XSE9.
SMRiQ9XSE9. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1520947.

Proteomic databases

PeptideAtlasiQ9XSE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi103563135.

Organism-specific databases

CTDi3039.

Phylogenomic databases

HOVERGENiHBG009709.
OrthoDBiEOG091G0S0X.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBA_EQUPR
AccessioniPrimary (citable) accession number: Q9XSE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.