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Protein

Transcobalamin-2

Gene

TCN2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041Cobalamin2 Publications
Metal bindingi193 – 1931Cobalt (cobalamin axial ligand)
Binding sitei245 – 2451Cobalamin2 Publications
Binding sitei248 – 2481Cobalamin2 Publications
Binding sitei294 – 2941Cobalamin2 Publications

GO - Molecular functioni

  • cobalamin binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cobalt transport, Ion transport, Transport

Keywords - Ligandi

Cobalt, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcobalamin-2
Short name:
TC-2
Alternative name(s):
Transcobalamin II
Short name:
TC II
Short name:
TCII
Gene namesi
Name:TCN2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 432414Transcobalamin-2PRO_0000005563Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 270
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence analysis
Disulfide bondi116 ↔ 312
Disulfide bondi165 ↔ 208

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9XSC9.

Expressioni

Tissue specificityi

Expressed in mammary gland, kidney, lymphatic nodes and liver.

Gene expression databases

BgeeiENSBTAG00000002770.
ExpressionAtlasiQ9XSC9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029446.

Structurei

Secondary structure

1
432
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi28 – 3811Combined sources
Helixi39 – 435Combined sources
Turni47 – 493Combined sources
Helixi52 – 598Combined sources
Beta strandi61 – 644Combined sources
Helixi68 – 8417Combined sources
Turni91 – 933Combined sources
Helixi102 – 11413Combined sources
Helixi121 – 14222Combined sources
Beta strandi144 – 1474Combined sources
Helixi154 – 16613Combined sources
Helixi173 – 18412Combined sources
Beta strandi185 – 1873Combined sources
Turni192 – 1943Combined sources
Helixi195 – 21218Combined sources
Helixi216 – 2183Combined sources
Helixi219 – 23517Combined sources
Beta strandi243 – 2453Combined sources
Turni246 – 2483Combined sources
Helixi249 – 2568Combined sources
Helixi264 – 28118Combined sources
Turni282 – 2843Combined sources
Helixi289 – 29810Combined sources
Turni299 – 3013Combined sources
Helixi304 – 3085Combined sources
Beta strandi312 – 3143Combined sources
Beta strandi334 – 34613Combined sources
Beta strandi348 – 3558Combined sources
Helixi360 – 36910Combined sources
Beta strandi370 – 3723Combined sources
Beta strandi375 – 3784Combined sources
Beta strandi385 – 3895Combined sources
Beta strandi398 – 4047Combined sources
Turni405 – 4073Combined sources
Turni414 – 4163Combined sources
Beta strandi424 – 4318Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BB6X-ray2.00A/B/C/D19-432[»]
2BBCX-ray2.40A19-432[»]
2V3NX-ray2.73A19-432[»]
2V3PX-ray2.90A19-432[»]
ProteinModelPortaliQ9XSC9.
SMRiQ9XSC9. Positions 19-432.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9XSC9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni152 – 1565Cobalamin binding
Regioni193 – 1975Cobalamin binding
Regioni400 – 4023Cobalamin binding

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IDZK. Eukaryota.
ENOG410XSU1. LUCA.
GeneTreeiENSGT00530000063370.
HOGENOMiHOG000074060.
HOVERGENiHBG001328.
InParanoidiQ9XSC9.
KOiK14619.
OMAiGEREFWQ.
OrthoDBiEOG091G095C.
TreeFamiTF333092.

Family and domain databases

InterProiIPR002157. Cbl-bd_transpt_euk.
[Graphical view]
PANTHERiPTHR10559. PTHR10559. 1 hit.
PfamiPF01122. Cobalamin_bind. 1 hit.
[Graphical view]
PROSITEiPS00468. COBALAMIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XSC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHLGALLFL LGGLGALANI CEITEVDSTL VERLGQRLLP WMDRLSQEQL
60 70 80 90 100
NPSIYVGLRL SSLQAGAKEA HYLHSLKLSY QQSLLRPASN KDDNDSEAKP
110 120 130 140 150
SMGQLALYLL ALRANCEFIG GRKGDRLVSQ LKRFLEDEKR AIGHNHQGHP
160 170 180 190 200
RTSYYQYSLG ILALCVHQKR VHDSVVGKLL YAVEHKPHLL QDHVSVDTMA
210 220 230 240 250
MAGMAFSCLE LSNLNPKQRN RINLALKRVQ EKILKAQTPE GYFGNVYSTP
260 270 280 290 300
LALQLLMGSL RPSVELGTAC LKAKAALQAS LQHKTFQNPL MISQLLPVLN
310 320 330 340 350
QKSYVDLISP DCQAPRALLE PALETPPQAK VPKFIDVLLK VSGISPSYRH
360 370 380 390 400
SVSVPAGSSL EDILKNAQEH GRFRFRTQAS LSGPFLTSVL GRKAGEREFW
410 420 430
QVLRDPDTPL QQGIADYRPK DGETIELRLV GW
Length:432
Mass (Da):47,958
Last modified:November 1, 1999 - v1
Checksum:i5690AB18AC62DA11
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti124 – 1241G → A in AAX46426 (PubMed:16305752).Curated
Sequence conflicti413 – 4131G → S in ABG67017 (PubMed:16305752).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471Q → P.2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121289 mRNA. Translation: AAD23829.1.
BT021579 mRNA. Translation: AAX46426.1.
BT021659 mRNA. Translation: AAX46506.1.
BT021880 mRNA. Translation: AAX46727.1.
BT021899 mRNA. Translation: AAX46746.1.
BT026178 mRNA. Translation: ABG67017.1.
BT026282 mRNA. Translation: ABG81438.1.
BC114678 mRNA. Translation: AAI14679.1.
PIRiS62672.
RefSeqiNP_776620.2. NM_174195.3.
UniGeneiBt.44412.

Genome annotation databases

EnsembliENSBTAT00000029446; ENSBTAP00000029446; ENSBTAG00000002770.
GeneIDi281518.
KEGGibta:281518.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121289 mRNA. Translation: AAD23829.1.
BT021579 mRNA. Translation: AAX46426.1.
BT021659 mRNA. Translation: AAX46506.1.
BT021880 mRNA. Translation: AAX46727.1.
BT021899 mRNA. Translation: AAX46746.1.
BT026178 mRNA. Translation: ABG67017.1.
BT026282 mRNA. Translation: ABG81438.1.
BC114678 mRNA. Translation: AAI14679.1.
PIRiS62672.
RefSeqiNP_776620.2. NM_174195.3.
UniGeneiBt.44412.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BB6X-ray2.00A/B/C/D19-432[»]
2BBCX-ray2.40A19-432[»]
2V3NX-ray2.73A19-432[»]
2V3PX-ray2.90A19-432[»]
ProteinModelPortaliQ9XSC9.
SMRiQ9XSC9. Positions 19-432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029446.

Proteomic databases

PaxDbiQ9XSC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000029446; ENSBTAP00000029446; ENSBTAG00000002770.
GeneIDi281518.
KEGGibta:281518.

Organism-specific databases

CTDi6948.

Phylogenomic databases

eggNOGiENOG410IDZK. Eukaryota.
ENOG410XSU1. LUCA.
GeneTreeiENSGT00530000063370.
HOGENOMiHOG000074060.
HOVERGENiHBG001328.
InParanoidiQ9XSC9.
KOiK14619.
OMAiGEREFWQ.
OrthoDBiEOG091G095C.
TreeFamiTF333092.

Enzyme and pathway databases

ReactomeiR-BTA-196741. Cobalamin (Cbl, vitamin B12) transport and metabolism.

Miscellaneous databases

EvolutionaryTraceiQ9XSC9.

Gene expression databases

BgeeiENSBTAG00000002770.
ExpressionAtlasiQ9XSC9. baseline and differential.

Family and domain databases

InterProiIPR002157. Cbl-bd_transpt_euk.
[Graphical view]
PANTHERiPTHR10559. PTHR10559. 1 hit.
PfamiPF01122. Cobalamin_bind. 1 hit.
[Graphical view]
PROSITEiPS00468. COBALAMIN_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCO2_BOVIN
AccessioniPrimary (citable) accession number: Q9XSC9
Secondary accession number(s): Q0V8P0
, Q1RMV8, Q58CR7, Q58DL8, Q9TR25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.