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Protein

Transcobalamin-2

Gene

TCN2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei104Cobalamin2 Publications1
Metal bindingi193Cobalt (cobalamin axial ligand)1
Binding sitei245Cobalamin2 Publications1
Binding sitei248Cobalamin2 Publications1
Binding sitei294Cobalamin2 Publications1

GO - Molecular functioni

  • cobalamin binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processCobalt transport, Ion transport, Transport
LigandCobalt, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Transcobalamin-2
Short name:
TC-2
Alternative name(s):
Transcobalamin II
Short name:
TC II
Short name:
TCII
Gene namesi
Name:TCN2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Organism-specific databases

VGNCiVGNC:35699 TCN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000000556319 – 432Transcobalamin-2Add BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 270
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi116 ↔ 312
Disulfide bondi165 ↔ 208

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9XSC9
PRIDEiQ9XSC9

Expressioni

Tissue specificityi

Expressed in mammary gland, kidney, lymphatic nodes and liver.

Gene expression databases

BgeeiENSBTAG00000002770
ExpressionAtlasiQ9XSC9 baseline and differential

Interactioni

Subunit structurei

Interacts with CD320 (via LDL-receptor class A domains).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029446

Structurei

Secondary structure

1432
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 38Combined sources11
Helixi39 – 43Combined sources5
Turni47 – 49Combined sources3
Helixi52 – 59Combined sources8
Beta strandi61 – 64Combined sources4
Helixi68 – 84Combined sources17
Turni91 – 93Combined sources3
Helixi102 – 114Combined sources13
Helixi121 – 142Combined sources22
Beta strandi144 – 147Combined sources4
Helixi154 – 166Combined sources13
Helixi173 – 184Combined sources12
Beta strandi185 – 187Combined sources3
Turni192 – 194Combined sources3
Helixi195 – 212Combined sources18
Helixi216 – 218Combined sources3
Helixi219 – 235Combined sources17
Beta strandi243 – 245Combined sources3
Turni246 – 248Combined sources3
Helixi249 – 256Combined sources8
Helixi264 – 281Combined sources18
Turni282 – 284Combined sources3
Helixi289 – 298Combined sources10
Turni299 – 301Combined sources3
Helixi304 – 308Combined sources5
Beta strandi312 – 314Combined sources3
Beta strandi334 – 346Combined sources13
Beta strandi348 – 355Combined sources8
Helixi360 – 369Combined sources10
Beta strandi370 – 372Combined sources3
Beta strandi375 – 378Combined sources4
Beta strandi385 – 389Combined sources5
Beta strandi398 – 404Combined sources7
Turni405 – 407Combined sources3
Turni414 – 416Combined sources3
Beta strandi424 – 431Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BB6X-ray2.00A/B/C/D19-432[»]
2BBCX-ray2.40A19-432[»]
2V3NX-ray2.73A19-432[»]
2V3PX-ray2.90A19-432[»]
ProteinModelPortaliQ9XSC9
SMRiQ9XSC9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9XSC9

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 156Cobalamin binding5
Regioni193 – 197Cobalamin binding5
Regioni400 – 402Cobalamin binding3

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IDZK Eukaryota
ENOG410XSU1 LUCA
GeneTreeiENSGT00530000063370
HOGENOMiHOG000074060
HOVERGENiHBG001328
InParanoidiQ9XSC9
KOiK14619
OMAiGEREFWQ
OrthoDBiEOG091G095C
TreeFamiTF333092

Family and domain databases

InterProiView protein in InterPro
IPR002157 Cbl-bd_prot
PfamiView protein in Pfam
PF01122 Cobalamin_bind, 1 hit
PROSITEiView protein in PROSITE
PS00468 COBALAMIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XSC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHLGALLFL LGGLGALANI CEITEVDSTL VERLGQRLLP WMDRLSQEQL
60 70 80 90 100
NPSIYVGLRL SSLQAGAKEA HYLHSLKLSY QQSLLRPASN KDDNDSEAKP
110 120 130 140 150
SMGQLALYLL ALRANCEFIG GRKGDRLVSQ LKRFLEDEKR AIGHNHQGHP
160 170 180 190 200
RTSYYQYSLG ILALCVHQKR VHDSVVGKLL YAVEHKPHLL QDHVSVDTMA
210 220 230 240 250
MAGMAFSCLE LSNLNPKQRN RINLALKRVQ EKILKAQTPE GYFGNVYSTP
260 270 280 290 300
LALQLLMGSL RPSVELGTAC LKAKAALQAS LQHKTFQNPL MISQLLPVLN
310 320 330 340 350
QKSYVDLISP DCQAPRALLE PALETPPQAK VPKFIDVLLK VSGISPSYRH
360 370 380 390 400
SVSVPAGSSL EDILKNAQEH GRFRFRTQAS LSGPFLTSVL GRKAGEREFW
410 420 430
QVLRDPDTPL QQGIADYRPK DGETIELRLV GW
Length:432
Mass (Da):47,958
Last modified:November 1, 1999 - v1
Checksum:i5690AB18AC62DA11
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124G → A in AAX46426 (PubMed:16305752).Curated1
Sequence conflicti413G → S in ABG67017 (PubMed:16305752).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti47Q → P2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121289 mRNA Translation: AAD23829.1
BT021579 mRNA Translation: AAX46426.1
BT021659 mRNA Translation: AAX46506.1
BT021880 mRNA Translation: AAX46727.1
BT021899 mRNA Translation: AAX46746.1
BT026178 mRNA Translation: ABG67017.1
BT026282 mRNA Translation: ABG81438.1
BC114678 mRNA Translation: AAI14679.1
PIRiS62672
RefSeqiNP_776620.2, NM_174195.3
UniGeneiBt.44412

Genome annotation databases

EnsembliENSBTAT00000029446; ENSBTAP00000029446; ENSBTAG00000002770
GeneIDi281518
KEGGibta:281518

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTCO2_BOVIN
AccessioniPrimary (citable) accession number: Q9XSC9
Secondary accession number(s): Q0V8P0
, Q1RMV8, Q58CR7, Q58DL8, Q9TR25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health