Reviewed,
UniProtKB/Swiss-Prot Q9XSB8 (TPP1_CANFA)
Last modified
September 22, 2009.
Version 48.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Tripeptidyl-peptidase 1 Short name=TPP-1 EC=3.4.14.9 Alternative name(s): Tripeptidyl-peptidase I Short name=TPP-I Tripeptidyl aminopeptidase Lysosomal pepstatin-insensitive protease Short name=LPIC | ||||
| Gene names |
| ||||
| Organism | Canis familiaris (Dog) | ||||
| Taxonomic identifier | 9615 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis |
Protein attributes
| Sequence length | 563 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus By similarity. |
| Catalytic activity | Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity. |
| Subcellular location | Lysosome. Melanosome By similarity. |
| Post-translational modification | Activated by autocatalytic proteolytical processing upon acidification By similarity. |
| Sequence similarities | Belongs to the peptidase S53 family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | By similarity | ||||||
| Propeptide | 20 – 195 | 176 | Removed in mature form By similarity | PRO_0000027372 | |||||
| Chain | 196 – 563 | 368 | Tripeptidyl-peptidase 1 | PRO_0000027373 | |||||
Sites | |||||||||
| Active site | 272 | 1 | Charge relay system By similarity | ||||||
| Active site | 276 | 1 | Charge relay system By similarity | ||||||
| Active site | 475 | 1 | Charge relay system By similarity | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 210 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 222 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 286 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 313 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 443 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 427 | 1 | V → A | ||||||
Sequences
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References
| [1] | "Coding sequence and exon/intron organization of the canine CLN2 gene and its exclusion as the locus for ceroid lipofuscinosis in English setter dogs." Liu P.-C., Katz M.L., Siakotos A.N., Grob S.E., Johnson G.S. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Evaluation of the canine TPP1 gene as a candidate for neuronal ceroid lipofuscinosis in Tibetan terrier and Polish Owczarek Nizinny dogs." Droegemueller C., Woehlke A., Distl O. Anim. Genet. 36:178-179(2005) [PubMed: 15771740] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-427. Strain: Tibetan terrier. |
| [3] | "Coding sequence and exon/intron organization of the canine TTP-1 gene and exclusion of TPP-1 mutations as the cause of hereditary ceroid lipofuscinosis in English Setter and Tibetan Terrier dogs." Sanders D.N., Katz M.L., Johnson G.S. Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-427. Strain: Tibetan terrier. |
Cross-references
Sequence databases | |
|---|---|
| AF114167 Genomic DNA. Translation: AAD25043.1. DQ100344 Genomic DNA. Translation: AAZ38727.1. | |
| RefSeq | NP_001013869.1. XP_855613.1. |
| UniGene | Cfa.18923 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9XSB8. |
Protein family/group databases | |
| MEROPS | S53.003. |
Genome annotation databases | |
| Ensembl | ENSCAFT00000010498; ENSCAFP00000009732; ENSCAFG00000006502; Canis familiaris. [Genome view] |
| GeneID | 485337. |
| KEGG | cfa:485337. |
Organism-specific databases | |
| CTD | 485337. |
Phylogenomic databases | |
| HOVERGEN | Q9XSB8. |
Enzyme and pathway databases | |
| BRENDA | 3.4.14.9. 463. |
Family and domain databases | |
| InterPro | IPR015366. Peptidase_S53_propep. IPR000209. Peptidase_S8/S53. [Graphical view] |
| Gene3D | G3DSA:3.40.50.200. Pept_S8_S53. 1 hit. |
| Pfam | PF09286. Pro-kuma_activ. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TPP1_CANFA | ||||||||
| Accession | Primary (citable) accession number: Q9XSB8 Secondary accession number(s): Q45VT9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |
