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Q9XS79

- HEM1_DELLE

UniProt

Q9XS79 - HEM1_DELLE

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Protein
5-aminolevulinate synthase, nonspecific, mitochondrial
Gene
ALAS1, ALS1
Organism
Delphinapterus leucas (Beluga whale)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei217 – 2171Substrate By similarity
Binding sitei334 – 3341Substrate By similarity
Binding sitei353 – 3531Substrate By similarity
Binding sitei386 – 3861Pyridoxal phosphate By similarity
Binding sitei414 – 4141Pyridoxal phosphate By similarity
Binding sitei442 – 4421Pyridoxal phosphate By similarity
Active sitei445 – 4451 By similarity
Binding sitei474 – 4741Pyridoxal phosphate By similarity
Binding sitei475 – 4751Pyridoxal phosphate By similarity
Binding sitei562 – 5621Substrate By similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, nonspecific, mitochondrial (EC:2.3.1.37)
Short name:
ALAS-H
Alternative name(s):
5-aminolevulinic acid synthase 1
Delta-ALA synthase 1
Delta-aminolevulinate synthase 1
Gene namesi
Name:ALAS1
Synonyms:ALS1
OrganismiDelphinapterus leucas (Beluga whale)
Taxonomic identifieri9749 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiMonodontidaeDelphinapterus

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5656Mitochondrion By similarity
Add
BLAST
Chaini57 – 6405845-aminolevulinate synthase, nonspecific, mitochondrial
PRO_0000001229Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei445 – 4451N6-(pyridoxal phosphate)lysine Inferred

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9XS79.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG005954.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XS79-1 [UniParc]FASTAAdd to Basket

« Hide

METVVRRCPF LSRVPQAFLQ KAGKSLLFYA QNCPKMMEVG AKPAPRALSA    50
SAVLCQQVKE TPPANEKDKT AKAKVQQAPD GSQQTPDGTQ LPSGHPSLAA 100
SQGTASKCPF LAAQMSQGGS SVFCKASLEL QEDVQEMHAV REEVAQTSVN 150
PSVISVKTDG GELSGLLKNF QDIMRKQRPE GVSHLLQDNL PKSVSTFQYD 200
HFFEKKIDEK KNDHTYRVFK TVNRRAQFFP MADDYSDSLV TKKQVSVWCS 250
NDYLGMSCHP RVCGAVMDTL KQHGTGAGGT RNISGTSKFH VDLEQELADL 300
HGKDAALLFS SCFVANDSTL FTLAKMMPGC EIYSDSGNHA SMIQGIWNSR 350
VPKYIYRHND VDHLRELLQR SDPAVPKIVA FETVHSMDGA VCPLEELCDV 400
AHEFGAITFV DEVHAVGLYG AQGGGIGDRD GVMPKMDIIS GTLGKAFGCV 450
GGYIASTSSL IDTIRSYAAG FIFTTSLPPM LLAGALESVR ILKSTEGRVL 500
RRQHQRNVKL MRQMLMDASL PVVHCPSHII PVRVADAAKN TEVCNELMSR 550
HNIYVQAINY PTVRRGEELL RIAPTPHHTP QMMNYFVENL LATWKRVGLE 600
LKPHSSAECN FCRRPLHFEV MSEREKSYFF GMSKLVSAQD 640
Length:640
Mass (Da):70,620
Last modified:November 1, 1999 - v1
Checksum:i357BC41CE8EDBA91
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF073337 mRNA. Translation: AAD20806.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF073337 mRNA. Translation: AAD20806.1 .

3D structure databases

ProteinModelPortali Q9XS79.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005954.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of the beluga whale (Delphinapterus leucas) expressed genes for 5-aminolevulinate synthase with those in other vertebrates."
    Kreiling J.A., Duncan R., Faggart M.A., Cornell N.W.
    Comp. Biochem. Physiol. 123B:163-174(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiHEM1_DELLE
AccessioniPrimary (citable) accession number: Q9XS79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: October 16, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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