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Q9XS65

- PTGDS_CANFA

UniProt

Q9XS65 - PTGDS_CANFA

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Protein

Prostaglandin-H2 D-isomerase

Gene

PTGDS

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity).By similarity

Catalytic activityi

(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651NucleophileBy similarity

GO - Molecular functioni

  1. prostaglandin-D synthase activity Source: UniProtKB
  2. retinoid binding Source: UniProtKB
  3. small molecule binding Source: InterPro
  4. transporter activity Source: UniProtKB

GO - Biological processi

  1. prostaglandin biosynthetic process Source: UniProtKB
  2. regulation of circadian sleep/wake cycle, sleep Source: UniProtKB
  3. transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism, Transport

Enzyme and pathway databases

ReactomeiREACT_174506. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin-H2 D-isomerase (EC:5.3.99.2)
Alternative name(s):
Glutathione-independent PGD synthase
Lipocalin-type prostaglandin-D synthase
Prostaglandin-D2 synthase
Short name:
PGD2 synthase
Short name:
PGDS
Short name:
PGDS2
Gene namesi
Name:PTGDS
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 9

Subcellular locationi

Rough endoplasmic reticulum By similarity. Nucleus membrane By similarity. Golgi apparatus By similarity. Cytoplasmperinuclear region By similarity. Secreted By similarity
Note: Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted (By similarity).By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: UniProtKB
  3. Golgi apparatus Source: UniProtKB
  4. membrane Source: UniProtKB-KW
  5. nucleus Source: UniProtKB-KW
  6. rough endoplasmic reticulum Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 191167Prostaglandin-H2 D-isomerasePRO_0000017941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Pyrrolidone carboxylic acidBy similarity
Glycosylationi51 – 511N-linked (GlcNAc...)By similarity
Glycosylationi78 – 781N-linked (GlcNAc...)By similarity
Disulfide bondi89 ↔ 186By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000028880.

Structurei

3D structure databases

ProteinModelPortaliQ9XS65.
SMRiQ9XS65. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45731.
GeneTreeiENSGT00620000088005.
HOGENOMiHOG000231660.
HOVERGENiHBG106490.
InParanoidiQ9XS65.
KOiK01830.
OrthoDBiEOG78PVBH.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002972. PstgldnD_synth.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00179. LIPOCALIN.
PR01254. PGNDSYNTHASE.
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9XS65-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGALCTLWLG LVLLGVLGAL QTSAQAQVSL QPNFQQDKFL GRWFTSGLAS
60 70 80 90 100
NSSWFREKKN VLSMCMSVVA PTADGGLNLT STFLRKDQCE TRTLLLRPAG
110 120 130 140 150
TPGCYSYTSP HWGSTHDVWV VATNYEEYAL LYTAGSKGLG QDFHMATLYS
160 170 180 190
RTQTPKAEIK EKFSTFAKTQ GFTEDAIVFL PQTDKCMEEN K
Length:191
Mass (Da):21,142
Last modified:November 1, 1999 - v1
Checksum:i05DD17A63001C256
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91L → R.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026988 mRNA. Translation: BAA77690.1.
RefSeqiNP_001003131.1. NM_001003131.1.
UniGeneiCfa.39564.

Genome annotation databases

EnsembliENSCAFT00000031047; ENSCAFP00000028880; ENSCAFG00000019533.
GeneIDi403740.
KEGGicfa:403740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026988 mRNA. Translation: BAA77690.1 .
RefSeqi NP_001003131.1. NM_001003131.1.
UniGenei Cfa.39564.

3D structure databases

ProteinModelPortali Q9XS65.
SMRi Q9XS65. Positions 24-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9615.ENSCAFP00000028880.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000031047 ; ENSCAFP00000028880 ; ENSCAFG00000019533 .
GeneIDi 403740.
KEGGi cfa:403740.

Organism-specific databases

CTDi 5730.

Phylogenomic databases

eggNOGi NOG45731.
GeneTreei ENSGT00620000088005.
HOGENOMi HOG000231660.
HOVERGENi HBG106490.
InParanoidi Q9XS65.
KOi K01830.
OrthoDBi EOG78PVBH.

Enzyme and pathway databases

Reactomei REACT_174506. Synthesis of Prostaglandins (PG) and Thromboxanes (TX).

Miscellaneous databases

NextBioi 20817242.

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR002972. PstgldnD_synth.
[Graphical view ]
Pfami PF00061. Lipocalin. 1 hit.
[Graphical view ]
PRINTSi PR00179. LIPOCALIN.
PR01254. PGNDSYNTHASE.
SUPFAMi SSF50814. SSF50814. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Dog lipocalin-type prostaglandin D synthase cDNA."
    Nakau H., Nakajima H., Urade Y., Fujimori K., Oda H., Seiki K.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-9.
    Tissue: Brain.

Entry informationi

Entry nameiPTGDS_CANFA
AccessioniPrimary (citable) accession number: Q9XS65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3