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Q9XS28

- CP19A_SHEEP

UniProt

Q9XS28 - CP19A_SHEEP

Protein

Aromatase

Gene

CYP19A1

Organism
Ovis aries (Sheep)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIX
    Cytochrome P-450AROM
    Cytochrome P450 19A1
    Estrogen synthase
    Gene namesi
    Name:CYP19A1
    Synonyms:CYP19
    OrganismiOvis aries (Sheep)
    Taxonomic identifieri9940 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
    ProteomesiUP000002356: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503AromatasePRO_0000051963Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9XS28.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG050750.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9XS28-1 [UniParc]FASTAAdd to Basket

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    MLLEVLNPRH YNVTSMVSEV VPIASIAILL LTGFLLLVWN YEDTSSIPGP    50
    SYFLGIGPLI SHCRFLWMGI GSACNYYNKM YGEFMRVWVC GEETLIISKS 100
    SSMFHVMKHS HYISRFGSKL GLQFIGMHEK GIIFNNNPAL WKAVRPFFTK 150
    ALSGPGLVRM VTICADSITK HLDRLEEVCN DLGYVDVLTL MRRIMLDTSN 200
    ILFLGIPLDE SAIVVKIQGY FDAWQALLLK PDIFFKISWL CRKYEKSVKD 250
    LKDAMEILIE EKRHRISTAE KLEDCIDFAT ELIFAEKRGE LTKENVNQCI 300
    LEMLIAAPDT MSVSVFFMLF LIAKHPQVEE AMMREIQTVV GERDIRIDDM 350
    QKLKVVENFI NESMRYQPVV DLVMRKALED DVIDGYPVKK GTNIILNLGR 400
    MHRLEFFPKP NEFTLENFAK NVPYRYFQPF GFGPRACAGK YIAMVMMKVI 450
    LVTLLRRFHV QTLQGRCVEK MQKKNDLSLH PDETSDRLEM IFIPRNSDKC 500
    LEC 503
    Length:503
    Mass (Da):57,970
    Last modified:November 1, 1999 - v1
    Checksum:iFA9FC7510691B3D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ012144
    , AJ012145, AJ012146, AJ012147, AJ012148, AJ012149, AJ012150, AJ012151, AJ012152 Genomic DNA. Translation: CAB40563.1.
    AJ012153 mRNA. Translation: CAB40543.1.
    RefSeqiNP_001116472.1. NM_001123000.1.
    UniGeneiOar.707.

    Genome annotation databases

    GeneIDi100144423.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ012144
    , AJ012145 , AJ012146 , AJ012147 , AJ012148 , AJ012149 , AJ012150 , AJ012151 , AJ012152 Genomic DNA. Translation: CAB40563.1 .
    AJ012153 mRNA. Translation: CAB40543.1 .
    RefSeqi NP_001116472.1. NM_001123000.1.
    UniGenei Oar.707.

    3D structure databases

    ProteinModelPortali Q9XS28.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100144423.

    Organism-specific databases

    CTDi 100144423.

    Phylogenomic databases

    HOVERGENi HBG050750.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of the aromatase cytochrome P450 encoding gene in cattle and sheep."
      Vanselow J., Furbass R., Zsolnai A., Kalbe C., Said H.M., Schwerin M.
      J. Steroid Biochem. Mol. Biol. 79:279-288(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

    Entry informationi

    Entry nameiCP19A_SHEEP
    AccessioniPrimary (citable) accession number: Q9XS28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3