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Protein

ATP synthase subunit alpha, mitochondrial

Gene

atp1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei382Required for activityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi188 – 195ATPBy similarity8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alpha, mitochondrial
Gene namesi
Name:atp1
ORF Names:DDB_G0294012
Encoded oniMitochondrion
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componenti: Mitochondrion

Organism-specific databases

dictyBaseiDDB_G0294012. atp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003123711 – 519ATP synthase subunit alpha, mitochondrialAdd BLAST519

Proteomic databases

PRIDEiQ9XPJ9.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9XPJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

InParanoidiQ9XPJ9.
KOiK02132.
OMAiPVFCIYV.
PhylomeDBiQ9XPJ9.

Family and domain databases

CDDicd01132. F1_ATPase_alpha. 1 hit.
Gene3Di2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01346. ATP_synth_alpha_bact. 1 hit.
InterProiIPR023366. ATP_synth_asu-like.
IPR000793. ATP_synth_asu_C.
IPR033732. ATP_synth_F1_a.
IPR005294. ATP_synth_F1_asu.
IPR020003. ATPase_a/bsu_AS.
IPR004100. ATPase_F1/V1/A1_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF3. PTHR15184:SF3. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMiSSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00962. atpA. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XPJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLEKMLTEV NIERSKFNTY NVLLQYIKAV TQKYNLNKVS SKYGKVLFIK
60 70 80 90 100
DGVVKVSGLS QIKIGEKVEF VGKNLYGMAL NLEATSVGIV IFGEDTAIYE
110 120 130 140 150
GVIVKRCEQN FAIKVDKTML GRVVDVLGQP IDGLGELKDT KTTRVMSVER
160 170 180 190 200
KAPGIVTRKS VHESMLTGVK IVDALLPIGR GQRELIIGDR QTGKSAIAVD
210 220 230 240 250
AILNQQVNKD IVCIYVAVGQ KKSTVRRLVE MLNTKGALEY TIVVVSTASD
260 270 280 290 300
AAPLQFLAPY TGCTIGEYFR DEGKHALIVY DDLSKHAVAY RQMSLLLRRP
310 320 330 340 350
PGREAYPGDV FYIHSRLLER AAKLNEKYGC GSLTAFPIVE TQAGDVSAYI
360 370 380 390 400
PTNIISITDG QIFLEKELFN KGIRPAVNVG LSVSRVGSAA QSAVMKKLAG
410 420 430 440 450
ALKLELAQYR ELARFEQFSS NADAVTTQIL KKGKLTIELL KQVNNNPMSI
460 470 480 490 500
GLEALMIYAM GTSYFQNLDL SLVRSEETKL LNYINSIASF KLYAACVDAV
510
KAFNPKDTVF AEMCQSYVK
Length:519
Mass (Da):57,237
Last modified:November 1, 1999 - v1
Checksum:iD4856399C917E4B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000109 Genomic DNA. Translation: BAA78060.1.
PIRiT43756.
RefSeqiNP_050078.1. NC_000895.1.

Genome annotation databases

GeneIDi2193895.
KEGGiddi:DidioMp11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000109 Genomic DNA. Translation: BAA78060.1.
PIRiT43756.
RefSeqiNP_050078.1. NC_000895.1.

3D structure databases

ProteinModelPortaliQ9XPJ9.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9XPJ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2193895.
KEGGiddi:DidioMp11.

Organism-specific databases

dictyBaseiDDB_G0294012. atp1.

Phylogenomic databases

InParanoidiQ9XPJ9.
KOiK02132.
OMAiPVFCIYV.
PhylomeDBiQ9XPJ9.

Miscellaneous databases

PROiQ9XPJ9.

Family and domain databases

CDDicd01132. F1_ATPase_alpha. 1 hit.
Gene3Di2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_01346. ATP_synth_alpha_bact. 1 hit.
InterProiIPR023366. ATP_synth_asu-like.
IPR000793. ATP_synth_asu_C.
IPR033732. ATP_synth_F1_a.
IPR005294. ATP_synth_F1_asu.
IPR020003. ATPase_a/bsu_AS.
IPR004100. ATPase_F1/V1/A1_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR15184:SF3. PTHR15184:SF3. 1 hit.
PfamiPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMiSSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00962. atpA. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATPA_DICDI
AccessioniPrimary (citable) accession number: Q9XPJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.