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Q9XNX8 (CYB_THANG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome b
Alternative name(s):
Complex III subunit 3
Complex III subunit III
Cytochrome b-c1 complex subunit 3
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Gene names
Name:MT-CYB
Synonyms:COB, CYTB, MTCYB
Encoded onMitochondrion
OrganismThaptomys nigrita (Blackish grass mouse) (Akodon nigrita)
Taxonomic identifier89133 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeSigmodontinaeThaptomys

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis By similarity.

Cofactor

Binds 2 heme groups non-covalently By similarity.

Subunit structure

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1) By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Miscellaneous

Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm By similarity.

Sequence similarities

Belongs to the cytochrome b family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Cytochrome b
PRO_0000255562

Regions

Transmembrane33 – 5321Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane115 – 13521Helical; Potential
Transmembrane150 – 17021Helical; Potential
Transmembrane178 – 19821Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane289 – 30921Helical; Potential
Transmembrane320 – 34021Helical; Potential
Transmembrane348 – 36821Helical; Potential

Sites

Metal binding831Iron 1 (heme b562 axial ligand)
Metal binding971Iron 2 (heme b566 axial ligand)
Metal binding1821Iron 1 (heme b562 axial ligand)
Metal binding1961Iron 2 (heme b566 axial ligand)

Sequences

Sequence LengthMass (Da)Tools
Q9XNX8 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 092387F205E3CA3C

FASTA37942,547
        10         20         30         40         50         60 
MKIMRKNHPL LKIINHSFID LPTPSNISSW WNFGSLLGAC LIIQILTGLF LAMHYTSDTT 

        70         80         90        100        110        120 
TAFSSVAHIC RDVNYGWLIR YLHANGASMF FICLSIHAGR GIYYGSYVLS ETWNIGIILF 

       130        140        150        160        170        180 
LTTMATAFVG YVLPWGQMSF WGATVITNLL SAIPYIGSTL FEWIWGGFSV DKATLTRFFA 

       190        200        210        220        230        240 
FHFILPFIIT AFVLVHLLFL HETGSNNPSG LNSNSDKIPF HPYYTIKDLL GVFLLLLALM 

       250        260        270        280        290        300 
ILALFFPDVL GDPDNFTPAN PLNTPAHIKP EWYFLFAYAI LRSIPNKLGG VLALILSILI 

       310        320        330        340        350        360 
LAAFPLLNVS KQHGLIFRPI TQTIYWIFIA NLLVLTWIGG QPVXYPFTMI GQIASITYFA 

       370 
IILILMPISN TIENNIIKL 

« Hide

References

[1]"Phylogenetic relationships and the radiation of Sigmodontine rodents in South America: evidence from cytochrome b."
Smith M.F., Patton J.L.
J. Mammal. Evol. 6:89-128(1999)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF108666 Genomic DNA. Translation: AAD45448.1.

3D structure databases

ProteinModelPortalQ9XNX8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG017694.

Family and domain databases

Gene3D1.20.810.10. 1 hit.
InterProIPR016175. Cyt_b/b6.
IPR005798. Cyt_b/b6_C.
IPR005797. Cyt_b/b6_N.
IPR027387. Cytb/b6-like.
IPR016174. Di-haem_cyt_TM.
[Graphical view]
PANTHERPTHR19271:SF0. PTHR19271:SF0. 1 hit.
PfamPF00032. Cytochrom_B_C. 1 hit.
PF13631. Cytochrom_B_N_2. 1 hit.
[Graphical view]
SUPFAMSSF81342. SSF81342. 1 hit.
SSF81648. SSF81648. 1 hit.
PROSITEPS51003. CYTB_CTER. 1 hit.
PS51002. CYTB_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYB_THANG
AccessionPrimary (citable) accession number: Q9XNX8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families