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Q9XLW9

- COX3_KLULA

UniProt

Q9XLW9 - COX3_KLULA

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Protein

Cytochrome c oxidase subunit 3

Gene
COX3
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:COX3
Encoded oniMitochondrion
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121Helical; Reviewed predictionAdd
BLAST
Transmembranei45 – 6521Helical; Reviewed predictionAdd
BLAST
Transmembranei90 – 11021Helical; Reviewed predictionAdd
BLAST
Transmembranei138 – 16023Helical; Reviewed predictionAdd
BLAST
Transmembranei167 – 18721Helical; Reviewed predictionAdd
BLAST
Transmembranei205 – 22521Helical; Reviewed predictionAdd
BLAST
Transmembranei247 – 26721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Cytochrome c oxidase subunit 3PRO_0000183795Add
BLAST

Interactioni

Subunit structurei

Composed of at least 11 subunits.

Structurei

3D structure databases

ProteinModelPortaliQ9XLW9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000264954.
KOiK02262.
OrthoDBiEOG7V76HP.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9XLW9-1 [UniParc]FASTAAdd to Basket

« Hide

MTHLERSRHQ QFPFHLVAPS PWPIVVSFAL MSLALSLALT MHGYIGHMYL    50
IYLSILTVTL SATLWFRDII AEATYLGDHT IAVRKGINLG FLLFVVSEIL 100
IFAALFWAYF HSAMSPNIEL GGVWPPVGIQ AVQPTELPLL NTIILLSSGA 150
TITYSHHGLV GGNRKNALSG LLITFWLIVI FVTCQYIEYT NATFTITDGV 200
YGSVFYAGTG LHFLHMVMLA AMLGINYWRL RNYHLTATHH VGYETTVLYC 250
HILDIIWLFL YIVFYWWGV 269
Length:269
Mass (Da):30,432
Last modified:October 11, 2004 - v2
Checksum:i77DC8D1DE2A20C8F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321S → A in AAD29123. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF120716 Genomic DNA. Translation: AAD29123.1.
AY654900 Genomic DNA. Translation: AAT64954.1.
RefSeqiYP_054504.1. NC_006077.1.

Genome annotation databases

GeneIDi2914070.
KEGGikla:KllafMp08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF120716 Genomic DNA. Translation: AAD29123.1 .
AY654900 Genomic DNA. Translation: AAT64954.1 .
RefSeqi YP_054504.1. NC_006077.1.

3D structure databases

ProteinModelPortali Q9XLW9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2914070.
KEGGi kla:KllafMp08.

Phylogenomic databases

eggNOGi COG1845.
HOGENOMi HOG000264954.
KOi K02262.
OrthoDBi EOG7V76HP.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Highly diverged homologs of Saccharomyces cerevisiae mitochondrial mRNA-specific translational activators have orthologous functions in other budding yeasts."
    Costanzo M.C., Bonnefoy N., Williams E.H., Clark-Walker G.D., Fox T.D.
    Genetics 154:999-1012(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.
  2. "Complete nucleotide sequence of the mitochondrial DNA from Kluyveromyces lactis."
    Zivanovic Y., Wincker P., Vacherie B., Bolotin-Fukuhara M., Fukuhara H.
    FEMS Yeast Res. 5:315-322(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.

Entry informationi

Entry nameiCOX3_KLULA
AccessioniPrimary (citable) accession number: Q9XLW9
Secondary accession number(s): Q6DN55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 11, 2004
Last modified: September 3, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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