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Q9XLW9 (COX3_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene names
Name:COX3
Encoded onMitochondrion
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces ›

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I, II and III form the functional core of the enzyme complex.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subunit structure

Composed of at least 11 subunits.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaerobic electron transport chain

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Cytochrome c oxidase subunit 3
PRO_0000183795

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane138 – 16023Helical; Potential
Transmembrane167 – 18721Helical; Potential
Transmembrane205 – 22521Helical; Potential
Transmembrane247 – 26721Helical; Potential

Experimental info

Sequence conflict321S → A in AAD29123. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9XLW9 [UniParc].

Last modified October 11, 2004. Version 2.
Checksum: 77DC8D1DE2A20C8F

FASTA26930,432
        10         20         30         40         50         60 
MTHLERSRHQ QFPFHLVAPS PWPIVVSFAL MSLALSLALT MHGYIGHMYL IYLSILTVTL 

        70         80         90        100        110        120 
SATLWFRDII AEATYLGDHT IAVRKGINLG FLLFVVSEIL IFAALFWAYF HSAMSPNIEL 

       130        140        150        160        170        180 
GGVWPPVGIQ AVQPTELPLL NTIILLSSGA TITYSHHGLV GGNRKNALSG LLITFWLIVI 

       190        200        210        220        230        240 
FVTCQYIEYT NATFTITDGV YGSVFYAGTG LHFLHMVMLA AMLGINYWRL RNYHLTATHH 

       250        260 
VGYETTVLYC HILDIIWLFL YIVFYWWGV

« Hide

References

« Hide 'large scale' references
[1]"Highly diverged homologs of Saccharomyces cerevisiae mitochondrial mRNA-specific translational activators have orthologous functions in other budding yeasts."
Costanzo M.C., Bonnefoy N., Williams E.H., Clark-Walker G.D., Fox T.D.
Genetics 154:999-1012(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.
[2]"Complete nucleotide sequence of the mitochondrial DNA from Kluyveromyces lactis."
Zivanovic Y., Wincker P., Vacherie B., Bolotin-Fukuhara M., Fukuhara H.
FEMS Yeast Res. 5:315-322(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF120716 Genomic DNA. Translation: AAD29123.1.
AY654900 Genomic DNA. Translation: AAT64954.1.
RefSeqYP_054504.1. NC_006077.1.

3D structure databases

ProteinModelPortalQ9XLW9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2914070.
KEGGkla:KllafMp08.

Phylogenomic databases

eggNOGCOG1845.
HOGENOMHOG000264954.
KOK02262.
OrthoDBEOG4578GM.

Family and domain databases

Gene3D1.20.120.80. 1 hit.
InterProIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR000298. Cyt_c_oxidase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
[Graphical view]
PANTHERPTHR11403. PTHR11403. 1 hit.
PfamPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMSSF81452. CytC_oxdse_III. 1 hit.
PROSITEPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX3_KLULA
AccessionPrimary (citable) accession number: Q9XLW9
Secondary accession number(s): Q6DN55
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 11, 2004
Last modified: May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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